Psychiatry Investigation最新文献

{"title":"Effect of the Interaction Between Depression and Sleep Disorders on Stroke Occurrence: A 17-Year Prospective Cohort Study in Korea.","authors":"Eujene Jung, Hyun Ho Ryu, Seok Jin Ryu","doi":"10.30773/pi.2024.0088","DOIUrl":"10.30773/pi.2024.0088","url":null,"abstract":"<p><strong>Objective: </strong>Previous studies have provided inconclusive results on the association between depression and stroke risk, and the potential modifying effect of comorbid insomnia on this association remains unclear. Our study aimed to clarify the independent roles of depression and insomnia as risk factors for stroke and to investigate the possibility of an interaction effect between these two conditions on stroke incidence.</p><p><strong>Methods: </strong>We used data from the Korean Genome and Epidemiology Study. The primary exposure was depression, measured by the Beck Depression Inventory. The secondary exposure was insomnia. The main outcome was the occurrence of stroke observed in biennial follow-up surveys. Cox proportional regression analysis was performed to estimate the effects of depression and insomnia on stroke incidence. We also conducted interaction analysis to investigate the interaction between depression and insomnia on stroke incidence.</p><p><strong>Results: </strong>During 16 years of follow-up involving 3,301 individuals, we documented 172 cases of new-onset stroke (4.3 cases per 1,000 person-years). Cox proportional logistic regression analysis showed that severe depression significantly increased the risk of stroke (hazard ratio [HR]: 2.06, 95% confidence interval [CI]: 1.13-3.75), whereas mild and moderate depression did not increase this risk. Interaction analysis demonstrated that stroke risk was increased with only moderate (HR: 2.04, 95% CI: 1.04-4.00) and severe (HR: 3.01, 95% CI: 1.43-6.31) depression among individuals without insomnia.</p><p><strong>Conclusion: </strong>Although general depression does not significantly increase stroke risk, moderate-to-severe depression may increase this risk, particularly in individuals without insomnia.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 12","pages":"1391-1397"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Longitudinal Efficacy of Suicide CARE (a Korean Standard Gatekeeper Training Program) in a General Community Sample: A Randomized Controlled Trial.","authors":"Jinmi Seol, Hwa-Young Lee, Sang Min Lee, Seon Wan Ki, Sung Joon Cho, Kang Seob Oh, Jong-Woo Paik","doi":"10.30773/pi.2024.0231","DOIUrl":"10.30773/pi.2024.0231","url":null,"abstract":"<p><strong>Objective: </strong>Suicide poses a significant public health concern with increasing prevalence in the general population, emphasizing the need for effective gatekeeper suicide prevention education. This study assesses the longitudinal effectiveness of the \"Suicide CARE\" gatekeeper training program within a general community sample. Suicide CARE is representative gatekeeper program in Korea. A total of 5 million individuals completed the training program of Suicide CARE in Korea to date.</p><p><strong>Methods: </strong>Participants were recruited through the Korea Suicide Prevention Association website, randomly assigned to the experimental (n=49) or control group (n=53). Pre- and post-training surveys, along with a 3-month follow-up, measured perceived knowledge, gatekeeper efficacy, preparedness, and attitudes toward suicide. Longitudinal effects were analyzed using repeated measures analysis of variance.</p><p><strong>Results: </strong>The experimental group showed significant improvement in perceived knowledge, gatekeeper efficacy, perceived preparedness, and some aspects of attitude towards suicide compared to the control group, with effects declining over time but remaining statistically significant at the 3-month follow-up test.</p><p><strong>Conclusion: </strong>This study is the first to evaluate the longitudinal effectiveness of Suicide CARE in a community population. Strategic integration of evidence-based gatekeeper training programs like Suicide CARE can contribute to community suicide prevention initiatives.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 12","pages":"1329-1337"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forbearance Coping, Community Resilience, Family Resilience and Mental Health During the Post-Pandemic in China: A Moderated Mediation Model.","authors":"Xiaoyu Zhuang, Qin Li, Susu Liu, Jieming Mo","doi":"10.30773/pi.2024.0162","DOIUrl":"10.30773/pi.2024.0162","url":null,"abstract":"<p><strong>Objective: </strong>This study is the first to adopt a cultural and contextual coping model to examine the impact of forbearance coping on compliance and psychological health and unravel the psychosocial mediator and moderator among community-dwelling residents in the post-pandemic era in China.</p><p><strong>Methods: </strong>A multistage cluster convenience sampling strategy was conducted to recruit 402 community-dwelling residents of ten cities in Guangdong province who completed an online survey measuring forbearance coping, anti-pandemic compliance behaviours, family resilience, community resilience and psychological distress.</p><p><strong>Results: </strong>The study results showed an unexpected negative influence of forbearance coping on psychological distress. Nevertheless, forbearance coping facilitated personal compliance with coronavirus disease-2019 mitigation measures and improved psychological health. More importantly, meaning-making of adversity within families partially mediated the negative effect of forbearance on mental health only when respondents perceived higher levels of community resilience.</p><p><strong>Conclusion: </strong>This study is the first to apply the cultural and contextual model of coping to Chinese individuals during a significant public health crisis. It expands the model by uncovering mechanisms like behavioural compliance and family meaning-making, and highlights the moderating role of community resilience. The findings emphasize the importance of building resilient communities and supporting mental health, providing evidence for future policy interventions and pandemic/disaster prevention measures in China.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1349-1359"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translational Approach to Social Isolation During a Global Pandemic: Hippocampal Somatic Mutation and Stress.","authors":"Bomee Lee, Seri Maeng, Yuri Seo, Sohee Jung, Soojung Im, Hyung Jun Choi, Jae Nam Bae, Yangsik Kim","doi":"10.30773/pi.2024.0178","DOIUrl":"10.30773/pi.2024.0178","url":null,"abstract":"<p><strong>Objective: </strong>The coronavirus disease-2019 (COVID-19) pandemic's social isolation has significantly impacted mental health, increasing depression and anxiety. This study explores the effects of social isolation on both humans and mice, focusing on behavioral changes and hippocampal protein expression. It also investigates genetic alterations through single-cell RNA and whole-genome sequencing (WGS).</p><p><strong>Methods: </strong>Here we conducted behavioral studies, protein expression studies, single-nucleus sequencing (snRNAseq), and WGS of the hippocampus of mice that underwent early maternal separation and social isolation, and a demographic study of community populations who had been self-quarantined owing to COVID-19 exposure to investigate the link between somatic mutations and stress due to social isolation.</p><p><strong>Results: </strong>The demographic study demonstrated more negative mental health findings among individuals who live alone or are single. Mice subjected to early maternal separation and social isolation demonstrated increased anxiety-like behaviors and stress-related corticotropin-releasing hormone receptor 1, and neurogenesis-related sex-determining region Y-box 2 and doublecortin expression. In snRNA-seq, differences, such as transthyretin increase, were observed in the maternal separation group, and somatic mutations, including insertion in the intron site of Tmem267, were observed in the social isolation group on WGS.</p><p><strong>Conclusion: </strong>The results of this study suggest that stress, such as social isolation, can cause changes at the genetic level, as well as behavioral and brain protein changes.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 12","pages":"1360-1371"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 Infection and Related Social Concerns on Depressive Symptoms: Mediating Effects of Negative Changes in Daily Life and Moderating Effects of Age and Gender.","authors":"Dham Ho, Sun-Young Kim, Hye Ah Lee, Hyunsun Cho, Weon-Jeong Lim","doi":"10.30773/pi.2024.0159","DOIUrl":"10.30773/pi.2024.0159","url":null,"abstract":"<p><strong>Objective: </strong>This study examined the mediating effect of negative changes in daily life due to the coronavirus disease-2019 (COVID-19) pandemic on depressive symptoms, considering COVID-19 infection and related social concerns. Additionally, comparisons of path coefficients between the groups were conducted based on age and gender.</p><p><strong>Methods: </strong>A cross-sectional study design used data from the 2020 Korean Community Health Survey consisting of 229,269 individuals. This study used a self-reported questionnaire, including the Patient Health Questionnaire-9 and three items addressing social concerns related to COVID-19 infection. A single question assessed whether individuals had experienced COVID-19 infection within the last 3 months, and scores of negative changes in daily life due to the COVID-19 pandemic. Correlation analysis was performed on the variables. Structural equation model analysis was conducted to identify the mediating role of negative changes in daily life. Chi-square tests were also performed to compare the path coefficients based on age and gender.</p><p><strong>Results: </strong>The structural equation models revealed that COVID-19 infection and related social concerns had both significant direct effects on depressive symptoms and indirect effects through negative changes in daily life. When comparing the path coefficients by age and gender, the coefficients related to depressive symptoms were highest in those under 65 years and in females.</p><p><strong>Conclusion: </strong>Negative changes in daily life due to the COVID-19 pandemic serve as a partial mediator of the impact of COVID-19 infection and related social concerns on depressive symptoms. Special attention should be paid to depressive symptoms in those under 65 years of age and in females.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 12","pages":"1318-1328"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Post-Traumatic Growth in Surviving Students of the Sewol Ferry Disaster: A Long-Term Follow-Up Study.","authors":"So Hee Lee, Kyoung-Beom Kim, Jin-Won Noh, Myong-Wuk Chon, Eun Ji Kim, Jeong-Ho Chae","doi":"10.30773/pi.2024.0201","DOIUrl":"10.30773/pi.2024.0201","url":null,"abstract":"<p><strong>Objective: </strong>Disaster survivors often experience negative impacts on their mental health, but some may also exhibit posttraumatic growth, overcoming adversity, and finding positive outcomes. This study aimed to identify psychological factors influencing posttraumatic growth (PTG) among students who survived the Sewol ferry disaster.</p><p><strong>Methods: </strong>The study used a longitudinal design. Data were collected at 6-month intervals between high school graduation and 6 years after the ferry disaster. Data were obtained from 48 adolescents who completed self-report measures of rumination, meaning in life, coping, PTG, family adaptability and cohesion. Generalized estimating equation models were fitted to 11 waves of follow-up data.</p><p><strong>Results: </strong>Intrusive rumination (coefficient [coef]=0.165; p<0.001; 95% confidence interval [CI] 0.081-0.250) and deliberate rumination (coef=0.554; p<0.001; 95% CI 0.376-0.732) were significantly associated with PTG. Concerning meaning in life, the presence of meaning (coef=0.312; p<0.001; 95% CI 0.189-0.435) and the search for meaning (coef=0.216; p=0.001; 95% CI 0.093-0.340) were also significantly associated with PTG. Finally, the problem-focused (coef=0.682; p=0.011; 95% CI 0.153-1.210) and emotion-focused (coef=0.736; p=0.009; 95% CI 0.186-1.285) coping strategies both showed significant associations with PTG.</p><p><strong>Conclusion: </strong>The results of this study indicate that rumination, meaning in life, and adaptive coping (including cognitive and emotional coping) were protective factors for mental health problems among adolescents who survived the Sewol ferry disaster. These psychological factors may promote PTG over time.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1279-1285"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of Work-Related Anxiety and Potential Causes of Anxiety in Healthcare Workers in the Emergency Department.","authors":"Turgut Dolanbay, Abdussamed Vural, Mustafa Cihan Altay, Nesibe Sultan Çınaroglu","doi":"10.30773/pi.2024.0265","DOIUrl":"10.30773/pi.2024.0265","url":null,"abstract":"<p><strong>Objective: </strong>The present study evaluated the work-related anxiety scores of healthcare workers in emergency departments (ED) and aimed to determine the factors affecting these scores.</p><p><strong>Methods: </strong>The data was obtained through a survey administered to the emergency staff. Beck's Anxiety Inventory (BAI) and the Mini-International Neuropsychiatric Interview (MINI) work anxiety interview were used to predict and determine the type of anxiety experienced by the participants. The survey was administered to 147 volunteers, and questionnaires from 130 participants were included in the study.</p><p><strong>Results: </strong>It was found that 43.8% of the participants had a BAI score greater than 7. The study results showed a negative correlation and a linear regression model between age and the BAI score. Additionally, the BAI score was significantly higher in female, singles, physicians, those who were dissatisfied with their jobs, and those who were dissatisfied with their salaries (p<0.05). The results also showed that having a history of anxiety disorder or depression, being a physician, and being dissatisfied with one's job were 6.277, 5.583, and 4.005 times higher, respectively, in terms of suspicion of anxiety (p<0.001). In the MINI job anxiety interview, work-related posttraumatic stress disorder (38.6%) was predicted most frequently, and indiscriminative work-related social phobia (5.3%) was predicted least frequently in participants at risk for anxiety according to the BAI score.</p><p><strong>Conclusion: </strong>This study suggests that teaching healthcare workers how to cope with workplace trauma and workplace-related situational phobias can be an effective solution to prevent anxiety disorders in healthcare workers working in ED.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1299-1307"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Causality Orientation and Internet Gaming Disorder, and the Role of Sensation Seeking, Anxiety, and Depression.","authors":"Yanjie Peng, Yuxiang Wang, Zhenlei Peng, Xiaoyuan Liao, Ke Gong, Cheng Qin, Mingyuan Tian, Xiaotong Cheng, Xinyi Zhou, Juan Deng, Yuwen Chen, Shuang Feng, Maomao Zhang, Kezhi Liu, Bo Xiang, Wei Lei, Jing Chen","doi":"10.30773/pi.2024.0122","DOIUrl":"10.30773/pi.2024.0122","url":null,"abstract":"<p><strong>Objective: </strong>Self-determination theory (SDT) deems that people have three causality orientations: autonomy orientation, control orientation, and impersonal orientation. Previous studies suggested that lower autonomy orientation or higher control and impersonal orientations may be associated with more addictive behaviors. Our study aimed to investigate if these associations exist in Internet gaming disorder (IGD), and if sensation seeking, anxiety, and depression could influence the associations between causality orientations and IGD symptoms.</p><p><strong>Methods: </strong>A total of 1,400 college students completed the Internet Gaming Disorder Scale, General Causality Orientation Scale, Brief Sensation Seeking Scale, Generalized Anxiety Disorder Scale, and Patient Health Questionnaire. Correlation, multiple linear regressions, structural equation model (SEM) analyses, and moderation analyses were conducted to explore the associations.</p><p><strong>Results: </strong>The control and impersonal orientations were positively associated with IGD symptoms, while the autonomy orientation was negatively associated with them. Moreover, SEM analyses showed that the autonomy-IGD relationship was totally mediated by anxiety and depression, the impersonal-IGD relationship was partially mediated by anxiety, and the control-IGD relationship was partially mediated by depression. Finally, the effects of causality orientations on IGD were moderated by sensation seeking.</p><p><strong>Conclusion: </strong>Overall, autonomy orientation is linked to fewer gaming problems, whereas control and impersonal orientations are associated with more gaming problems. Moreover, the relationships between causality orientations and IGD symptoms are mediated by anxiety and depression and moderated by sensation seeking. Our findings inform theory on the motivations of gaming behaviors and may shed light on the prevention and intervention of IGD from the perspective of SDT.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1268-1278"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health Status Profiles of Dentists in South Korea: A Latent Profile Analysis Approach.","authors":"Chisung Yuh, Sojin Yoon, Kyungwon Song, Heon-Jeong Lee, Young-Mee Lee, Chul-Hyun Cho","doi":"10.30773/pi.2024.0115","DOIUrl":"10.30773/pi.2024.0115","url":null,"abstract":"<p><strong>Objective: </strong>Dentists encounter unique occupational challenges, including stress, depression, and anxiety, that can impact their mental well-being. Therefore, it is essential to identify dentists' mental health statuses and the factors influencing them. Understanding the heterogeneity in dentists' mental health is crucial for tailored interventions. To investigate different mental health profiles within the dentist population and understand the characteristics of each type.</p><p><strong>Methods: </strong>In this cross-sectional study, we surveyed 261 Korean dentists from a sample of 1,520. Using latent profile analysis, participants were classified into distinct mental health profiles based on self-reported stress, depressive symptoms, anxiety, and sleep quality. Demographic and occupational variables were analyzed to explore their association with mental health profiles.</p><p><strong>Results: </strong>Three distinct mental health profiles were identified: high, moderate, and low. Factors such as drinking frequency, socioeconomic status, income, and work hours significantly influenced profile classification. Significant differences in job satisfaction were observed among the profiles.</p><p><strong>Conclusion: </strong>This study underscores the importance of personalized interventions to address the specific needs of each mental health profile, aiming to improve job satisfaction and overall mental health in the dental profession.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1193-1202"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear Magnetic Resonance Analysis Implicates Sex-Specific Dysregulation of the Blood Lipids in Alzheimer's Disease: A Retrospective Health-Controlled Study.","authors":"Yanzhe Li, Xue Yu, Zhonghui Ma, Qinghe Liu, Min Li, Xue Tian, Baozhu Li, Ran Zhang, Pei Gu, Fengfeng Bai, Guoshuai Luo, Meijuan Li, Daliang Sun","doi":"10.30773/pi.2024.0164","DOIUrl":"10.30773/pi.2024.0164","url":null,"abstract":"<p><strong>Objective: </strong>The aging demographic landscape worldwide portends a heightened prevalence of neurodegenerative disorders. Foremost among these is Alzheimer's disease (AD), the foremost cause of dementia in older adults. The shortage of efficacious therapies and early diagnostic indicators underscores the imperative to identify non-invasive biomarkers for early detection and disease monitoring. Recently, blood metabolites have emerged as promising candidates for AD biomarkers.</p><p><strong>Methods: </strong>Leveraging nuclear magnetic resonance (NMR) spectroscopy on plasma specimens, we conducted a cross-sectional study encompassing 35 AD patients and 35 age-matched healthy controls. Cognitive function was evaluated using the mini-mental state examination in all participants, followed by peripheral blood sample collection. We utilized univariate and multivariate analyses to perform targeted lipidomic profiling via NMR spectroscopy.</p><p><strong>Results: </strong>Our study revealed significant differences in the expression profiles of low-density lipoprotein-associated subfractions in females and high-density lipoprotein-associated subfractions in males between AD patients and healthy controls (all p<0.05). However, there was no significant metabolite overlap between males and females. Furthermore, receiver operating characteristic curve analysis demonstrated that the combination of lipid metabolites had good diagnostic values (all area under the curve>0.70; p<0.05).</p><p><strong>Conclusion: </strong>Our findings suggest that the blood plasma samples using NMR hold promise in distinguishing between AD patients and healthy controls, with significant clinical implications for advancing AD diagnostic methodologies.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":"21 11","pages":"1211-1220"},"PeriodicalIF":1.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}