Analysis of Antipsychotic Drug Use Patterns and Safety in Patients With Bipolar Disorder.

IF 1.8 4区医学 Q3 PSYCHIATRY

Psychiatry Investigation Pub Date : 2025-09-25 DOI:10.30773/pi.2025.0174

Liwei Cheng, Wenge Chu, Jie Yang, Bing Zhao, Tongli Wan

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引用次数: 0

Abstract

Objective: To investigate the pattern of antipsychotic drug use and safety in patients with bipolar disorder (BD).

Methods: A retrospective analysis was conducted using a convenience sampling method to collect medical records of 150 BD patients who attended our psychiatric outpatient clinic from July to December 2023. The treatment and follow-up period lasted for 12 months. Based on the use of antipsychotics during the follow-up period, patients were categorized into three subgroups: typical antipsychotics only atypical antipsychotics only, and concurrent use of both antipsychotics. Their medication use, adverse effects, and specific observation indicators including the number of antipsychotics used, the percentage of anticholinergics used, the incidence of somatic discomfort, cognitive impairment, memory loss, and decreased attention were compared.

Results: There was no statistically significant difference between the three groups in terms of gender, age, whether they worked or not, and comorbidities (p>0.05); the difference between the three groups was statistically significant in terms of the percentage of the number of antipsychotics used and the percentage of anticholinergics used (p<0.001), and there was no statistically significant difference in terms of the percentage of other adjunctive psychotropic medications or the percentage of the use of traditional Chinese medicines (p>0.05); during the follow-up period, all three groups of patients had symptoms of somatic discomfort, cognitive impairment, memory loss, and decreased attention, but the difference in their incidence was not statistically significant (p>0.05); moreover, none of the three groups of patients had impairments of liver and kidney functions during the follow-up period.

Conclusion: Antipsychotics play a crucial role in treating BD patients. This study provides insights into optimizing treatment strategies by highlighting the importance of considering both safety and efficacy when prescribing antipsychotics.

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双相情感障碍患者抗精神病药物使用模式及安全性分析。

目的：探讨双相情感障碍（BD）患者抗精神病药物的使用模式及安全性。方法：采用方便抽样法，对2023年7月至12月在我院精神科门诊就诊的150例BD患者病历进行回顾性分析。治疗随访12个月。根据随访期间抗精神病药物的使用情况，将患者分为3个亚组：仅使用典型抗精神病药物，仅使用非典型抗精神病药物，同时使用两种抗精神病药物。比较两组患者的用药情况、不良反应及具体观察指标，包括抗精神病药物使用次数、抗胆碱能药物使用百分比、躯体不适发生率、认知功能障碍、记忆丧失和注意力下降。结果：三组患者在性别、年龄、是否工作、合并症等方面差异均无统计学意义（p < 0.05）；三组患者抗精神病药物使用次数百分比、抗胆碱能药物使用百分比比较，差异均有统计学意义（p0.05）；随访期间，三组患者均出现躯体不适、认知障碍、记忆丧失、注意力下降等症状，但发生率差异无统计学意义（p < 0.05）；此外，三组患者在随访期间均未出现肝肾功能损害。结论：抗精神病药物在治疗双相障碍中起着至关重要的作用。本研究通过强调处方抗精神病药物时考虑安全性和有效性的重要性，为优化治疗策略提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.