Przeglad lekarski最新文献

{"title":"Secretory immunoglobulin A concentration in non-stimulated and stimulated saliva in relation to the status of smoking.","authors":"Marta Nakonieczna-Rudnicka,&nbsp;Teresa Bachanek,&nbsp;Wanda Piekarczyk,&nbsp;Elżbieta Kobyłecka","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Secretory immunoglobulin\u0000A (sIgA) is a dominant immunoglobulin\u0000in the saliva. It is the first\u0000line of defense against microorganisms.</p><p><strong>Aim of the study: </strong>Analysis of secretory\u0000immunoglobulin A concentration\u0000in non-stimulated and stimulated\u0000saliva. Assessment of sIgA concentration\u0000in relation to the status of cigarette\u0000smoking of the investigated.</p><p><strong>Material and methods: </strong>Survey and biochemical studies of saliva were\u0000conducted in the group of 109 people\u0000(smokers and non-smokers) aged\u000020-54. The smokers smoked from\u00005 to more than 20 cigarettes daily.\u0000The investigation material was nonstimulated\u0000and stimulated saliva collected\u0000from patients on the same day\u0000between 9.30 and 11.30 a.m, 1.5-2h\u0000after meal. Directly after non-stimulated\u0000and stimulated saliva collection\u0000Salivette tubes were placed in the ice\u0000container with the temperature of 4oC,\u0000then centrifuged at the temperature\u0000of 4oC for 12 minutes at 3000 r/min.\u0000The obtained supernatant was stored\u0000at the temperature of -75ºC until the\u0000assays were performed. sIgA concentration\u0000was determined using sIgA\u0000ELISA Kit (Immunodiagnostik AG,\u0000Germany). Statistical analysis was\u0000conducted with the use of Mann –\u0000Whitney test. While investigating the\u0000influence of age on the studied parameters\u0000Spearman correlation coefficient\u0000and its significance were used.\u0000Statistically significant test values\u0000were those of p<0.05.</p><p><strong>Results: </strong>In non-stimulated saliva\u0000sIgA concentration was significantly\u0000higher compared to stimulated saliva\u0000(Z = 4.00, p<0.001). No significant differences\u0000were stated in sIgA concentration\u0000in non-stimulated saliva between\u0000smokers and non-smokers (Z =\u00000.26, p>0.05). No essential differences\u0000were stated in sIgA concentration in\u0000stimulated saliva between non-smokers\u0000and smokers (Z = 0.23, p>0.05).\u0000Essential differences were stated between\u0000the groups. In men sIgA concentration in stimulated\u0000saliva was significantly higher compared to women (Z =\u00002.25, p<0.05).</p><p><strong>Conclusions: </strong>sIgA concentration in non-stimulated\u0000saliva is significantly higher in comparison to stimulated\u0000saliva. The status of cigarette smoking does not influence\u0000the essential differences in sIgA concentration in nonstimulated\u0000and stimulated saliva. In men sIgA concentration\u0000in stimulated saliva is significantly higher in comparison\u0000to women.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36037772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Acute poisoning with e-cigarette liquid – case report].","authors":"Ewa Gomółka,&nbsp;Monika Radomska,&nbsp;Dorota Emilia Bielska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Spreading e-cigarettes popularity\u0000comes from relief, the products are\u0000safe. They don’t contain carcinogenic\u0000substances, that are present in tobacco\u0000smoke. But nicotine present in\u0000e-liquid is a very toxic alkaloid, highly\u0000addictive.\u0000A case of acute, oral intoxication\u0000with e-liquid was described. A patient,\u000042-years old woman, e-cigarettes addicted,\u0000health thus far, by accident\u0000drunk a swig of e-liquid containing\u0000nicotine at concentration 6 mg/ml.\u0000At admission to Toxicology Department\u0000she was conscious, with symptoms:\u0000dizziness, flushed cheeks, dry\u0000skin, dry conjunctivas, medium-wide\u0000pupils, nervous twitch, tachycardia,\u0000elevated blood pressure. Concentration\u0000of cotinine – nicotine metabolite,\u0000in serum and urine were respectively\u00002077 and 10236 ng/ml. Applied treatment\u0000was: infusive liquids, intravenous\u0000alkalization, administration of\u0000electrolytes and propranolol. Gradually\u0000improvement was reached and\u0000on the third day of hospitalization,\u0000after psychiatric consultation she\u0000was deinstitutionalized in good medical\u0000condition to continue treatment in\u0000Neurology Clinic.\u0000E-fluid intoxications are rare, poisoning\u0000course depends on nicotine\u0000dose, way of absorption, patient’s\u0000health state and age.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36037938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Tobacco smoking and e-cigarettes using among employees of educational units in Piotrkowski county].","authors":"Katarzyna Milcarz,&nbsp;Adam Rzeźnicki,&nbsp;Piotr Wojtysiak,&nbsp;Dorota Kaleta","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco related diseases\u0000in Poland generate very high\u0000costs, significantly contributing to\u0000the reduction of the development potential\u0000of the country. Despite the reduction\u0000in the prevalence of smoking\u0000over the past decades, in our country\u0000smokes nearly 10 million of adult\u0000citizens. The prevalence of smoking\u0000is different across socio-economic\u0000groups and among representatives\u0000of various professions. Employees\u0000of educational units are a particular\u0000occupational group as their attitudes\u0000toward smoking significantly may\u0000shape the health behaviors of students.\u0000The aim of the study was to assess\u0000the prevalence of smoking and\u0000use of e-cigarettes among employees\u0000of educational units in Piotrkowski\u0000county. Furthermore the prevalence\u0000of e-cigarettes was examined.</p><p><strong>Material and methods: </strong>During the\u0000period from November 2014 and May\u00002015, 1858 employees working in\u000060 schools (92,3% of all schools) in\u0000Piotrkowski county were examined.\u0000For the purpose of collecting empirical\u0000material among the personnel\u0000employed in schools included in the\u0000study, a questionnare survey adopted\u0000from the study Global School Personnel\u0000Survey (GSPS) was applied.</p><p><strong>Results: </strong>Among the teachers\u000017.3% of respondents (n=181) said\u0000they smoke tobacco daily, while 3.8%\u0000of respondents (n=40) claimed that\u0000smoke occasionally. In the group\u0000of administrative staff 26.0% of respondents\u0000(n=130) smoked tobacco\u0000daily and occasionally 3.8% of the\u0000respondents (n=10). Among all respondents\u00009.6% of school employees\u0000(n=148) said they had used e-cigarettes\u0000at least once in a lifetime.</p><p><strong>Conclusions: </strong>Popularity of tobacco\u0000smoking among personnel employed\u0000in the schools was alarmingly\u0000high, therefore, it is necessary to take\u0000actions aiming at reduction of this\u0000phenomenon by, inter alia: comprehensive\u0000information and educational\u0000activities, promoting pro-health behaviours.\u0000There is also a need for development of an adequate\u0000support system for smoking personnel who have\u0000to challenge their addiction.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36038955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of photodynamic therapy in dentistry – literature review].","authors":"Zuzanna Oruba,&nbsp;Maria Chomyszyn-Gajewska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is\u0000based on the principle that the target\u0000cells are destroyed by means of toxic\u0000reactive oxygen species generated\u0000upon the interaction of a photosensitizer,\u0000light and oxygen. This method\u0000is nowadays widely applied in various\u0000branches of medicine, mainly in\u0000oncology and dermatology. It is also\u0000applied in dentistry in the treatment\u0000of oral potentially malignant disorders\u0000(like lichen planus or leukoplakia) and\u0000infectious conditions (periodontitis,\u0000herpetic cheilitis, root canal disinfection).\u0000The application of the photodynamic\u0000therapy in the abovementioned\u0000indications is worth attention, as the\u0000method is noninvasive, painless, and\u0000the results of the published studies\u0000seem promising. The present article\u0000aims at presenting the principle of\u0000the photodynamic therapy and, based\u0000on the literature, the possibilities and\u0000results of its application in dentistry.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36041932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Exposure to alder, hazel and birch pollen and PM10 dust concentration in Krakow in 2010-2015].","authors":"Monika Ziemianin,&nbsp;Dorota Myszkowska,&nbsp;Katarzyna Piotrowicz,&nbsp;Ewa Czarnobilska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>PM10, one of the air pollution\u0000components has a significant effect\u0000on plant pollen by the deposition on\u0000the surface of pollen grains, morphological\u0000changes of pollen walls\u0000and interference in the structure of\u0000the allergenic proteins. The aim of\u0000the study was to verify whether and\u0000in what weather conditions the concentration\u0000of pollen of alder, hazel\u0000and birch coincides with the elevated\u0000level of PM10 in Kraków, in 2010-2015.\u0000In the days when the alder pollen concentration\u0000exceeded 95 PG/m3, causing\u0000severe inhalant allergy symptoms\u0000and the concentration of hazel pollen\u0000was >80 PG/m3 and the admissible\u0000level of PM10 was exceeded, the maximum\u0000air temperature ranged from 5.1\u0000to 22.6oC, the days were dry (humidity\u0000<60%), without precipitation and\u0000mostly windless. High concentration\u0000of birch pollen and exceeded admissible\u0000level of PM10 concentration were\u0000found in more than 60% of the days in\u0000the city center. In 70.3% of the days\u0000in which the birch pollen concentration\u0000reached values that caused the\u0000symptoms of asthma (>155 PG/m3),\u0000the dust concentration was exceeded\u0000(>50μg/m3), and rainfall and wind\u0000speed of 1-3 m/s occurred. Symptoms\u0000in people allergic to trees pollen\u0000in Kraków can be exacerbated during\u0000periods when the standard limits of\u0000PM10 are exceeded. Such situations\u0000have occurred mostly in March (pollen\u0000of alder and hazel) and April (birch\u0000pollen), especially in the city center.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36042426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-DFS antibodies occur more commonly in patients following unprovoked venous thromboembolism.","authors":"Joanna Natorska,&nbsp;Marta Mazur,&nbsp;Elżbieta Papuga-Szela,&nbsp;Anetta Undas","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>It has been reported\u0000in a small group of patients that a significant\u0000percentage of patients with\u0000anti-DFS (dense fine speckled) antibodies\u0000has a history of idiopathic arterial\u0000or venous thrombosis and/or obstetric\u0000complications. To our knowledge there\u0000have been no larger studies regarding\u0000the prevalence of anti-DFS antibodies\u0000in provoked and unprovoked venous\u0000thromboembolism (VTE).</p><p><strong>Aim of the study: </strong>We investigated\u0000how common anti-DFS70 antibodies\u0000occur in patients following VTE and\u0000which factors affect their occurrence\u0000in this disease.</p><p><strong>Material and methods: </strong>We screened\u0000287 consecutive adult patients, aged\u0000below 60 years, with documented\u0000VTE treated for at least 3 months, and\u0000129 age-matched healthy controls.\u0000Patients with cancer, severe comorbidities,\u0000documented autoimmune\u0000diseases, including antiphospholipid\u0000syndrome were ineligible. The anti-\u0000-DFS70 antibodies were determined\u0000based on immunofluorescence on\u0000Hep-2 cells. The specific immunofluorescence\u0000pattern, characterized by\u0000dense fine speckles distributed the\u0000nucleus, observed at serum dilution\u0000equal to or greater than 1:100, was considered\u0000as positive and was confirmed\u0000using the semiquantitative ELISA-DFS\u0000that provided results as a ratio (RU/ml)\u0000with a cut-off of 1.</p><p><strong>Results: </strong>There was no difference\u0000in the prevalence of anti-DFS70 antibodies\u0000in the VTE and control patients\u0000(n=12, 4.18% vs. n=6, 4.65%, p=0.68).\u0000Anti-DFS antibodies represented\u00009.16% of all positive ANA patterns\u0000(n=131) in VTE patients, which was a\u0000much lower proportion compared with\u000026.1% of all 23 positive ANA patterns\u0000in healthy subjects (p=0.031). The presence\u0000of anti-DFS antibodies did not\u0000correlate with demographic or clinical\u0000variables including time since last VTE\u0000event, type of anticoagulation and its\u0000quality. The prevalence of anti-DFS70\u0000antibodies was higher in patients with\u0000ANA titer ≥1:320 compared to those\u0000with the titer < 1:320 (75% vs. 37%, p=0.01). Of importance,\u0000higher prevalence of anti-DFS antibodies was observed\u0000in patients with unprovoked VTE compared to those with\u0000provoked VTE (75% vs. 25%, p=0.01). Among the VTE patients\u0000with heritable thrombophilia, i.e. factor V Leiden or\u0000prothrombin G20210A mutations, 25.8% of subjects (n=8)\u0000had anti-DFS antibodies. Moreover, anti-DFS titer was\u0000associated with serum alpha and gamma globulin levels\u0000(r=0.47, p=0.027; and r=0.39, p=0.045, respectively), but\u0000not with inflammatory markers or D-dimer in VTE patients.</p><p><strong>Conclusions: </strong>Anti-DFS antibodies are present in <5%\u0000of VTE patients and are associated with unprovoked VTE\u0000including that related to heritable thrombophilia. It might\u0000suggest that these antibodies are involved in the pathogenesis\u0000of idiopathic VTE.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36042617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk factors and treatment of patients with ST-segment elevation myocardial infarction with cardiogenic shock].","authors":"Agnieszka Janion-Sadowska,&nbsp;Marcin Sadowski,&nbsp;Małgorzata Kołodziej,&nbsp;Jacek Kurzawski,&nbsp;Łukasz Zandecki,&nbsp;Łukasz Piątek,&nbsp;Anna Polewczyk,&nbsp;Marek Gierlotka,&nbsp;Lech Poloński,&nbsp;Mariusz Gąsior","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aim: </strong>To assess risk factors and\u0000prognosis in patients with ST-segment\u0000elevation myocardial infarction\u0000(STEMI) and cardiogenic shock (CS)\u0000in Poland.</p><p><strong>Methods: </strong>Data from The Polish\u0000Registry of Acute Coronary Syndromes\u0000(PL-ACS) were analysed in\u00002008-2012. A total of 57400 consecutive\u0000STEMI patients included. The results\u0000of treatment and prognosis of patients\u0000with and without CS were compared.\u0000An additional analysis of the prognosis\u0000of men and women with CS was\u0000performed.</p><p><strong>Results: </strong>There were 34.2% of\u0000women and 65.8% of men. CS was\u0000diagnosed in 3589 (6.3%) patients (females\u00007.3% vs. males 5.7%, p<0.003).\u0000In multivariate analysis CS was the\u0000strongest factor affecting both inhospital\u0000(OR 2.51; 95%CI 2.25-2.80;\u0000p<0.0001) and 12-month (OR 2.09;\u000095%CI 1.96-2.24; p<0.0001) mortality.\u0000The worst prognosis was associated\u0000with pulmonary edema, advanced age,\u0000left or right bundle branch block, atrial\u0000fibrillation, and anterior MI. An early\u0000invasive strategy up to six hours from\u0000the symptom onset were the only factors\u0000reducing in-hospital and 12-month\u0000mortality. Despite of high female ratio\u0000in the group with CS and higher mortality\u0000in the female group, the female\u0000sex did not influence the in-hospital\u0000prognosis.</p><p><strong>Conclusion: </strong>In spite of enormous\u0000progress in the treatment of STEMI cardiogenic\u0000shock remains an important\u0000complication affecting the in-hospital\u0000and long-term prognosis. A symptom\u0000onset-to-treatment time is the key element\u0000in the management of patients\u0000with CS. Proper diagnosis and management\u0000including wide interventional\u0000strategy implementation increase the\u0000survival chance. An intensive study\u0000on novel treatment modalities and on\u0000effective identification methods of patients\u0000at risk and are warranted.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39985780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Assessment of ECG and holter parameters among patients with systemic sclerosis].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of our study\u0000was to assess electrocardiographic\u0000abnormalities on the standard ECG\u0000and Holter monitoring in patients with\u0000systemic sclerosis.</p><p><strong>Materials and methods: </strong>70 patients with systemic sclerosis and 20\u0000healthy individuals were included in\u0000the study. Mean disease duration was\u0000100,8 ± 95,79 months. The following\u0000electrocardiographic parameters were\u0000assessed: driving rhythm, P wave, PQ\u0000interval, atrio-ventricular and intraventricular\u0000conduction disturbances,\u0000ST-T complex abnormalities, mean\u0000heart rate, presence of conduction\u0000disturbances, supraventricular and\u0000ventricular arrhythmias. We evaluated\u0000if there could be any relationship\u0000between the Raynaud’s phenomenon\u0000or disease duration and electrocardiographic\u0000abnormalities.</p><p><strong>Results: </strong>We found that patients\u0000with systemic sclerosis had higher\u0000burden of supraventricular and ventricular\u0000arrhythmias than individuals\u0000in the control group. The longer duration\u0000of the Raynaud’s phenomenon or\u0000systemic sclerosis the higher incidence\u0000of these arrhythmias could be\u0000found. Patients with supraventricular\u0000arrhythmias were more often in NYHA\u0000class I/II heart failure whilst patients\u0000with ventricular arrhythmias were in\u0000NYHA class II.</p><p><strong>Conclusions: </strong>Patients with the\u0000longstanding Raynaud’s phenomenon\u0000and systemic sclerosis are at a high\u0000risk of developing cardiac arrhythmias.\u0000It seems that a vigilant electrocardiographic\u0000monitoring could increase\u0000patients safety.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39985976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Vitamin D supply in adults with hypertension].","authors":"Agata Franczyk,&nbsp;Angelika Sadurska,&nbsp;Katarzyna Stolarz-Skrzypek,&nbsp;Danuta Czarnecka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The discovery of a receptor for vitamin D in most cells suggested a role in other body systems, not only the impact on the body's calcium economy. Epidemiological studies found that lower levels of cholecalciferol coexists with cardiovascular diseases. The aim of the study was to evaluate the factors influencing the serum concentration of vitamin in the population of the region of Cracow and to assess and compare the rate of consumption of food products rich in vitamin D in patients with hypertension and with normal blood pressure. In the studied population, the higher the age of the subjects, and the later the month of the year the sample was taken, the lower the vitamin D serum concentrations. Low body mass index and body fat were associated with higher levels of cholecalciferol. Additionally, deficiency of vitamin D was caused by insufficient supply of food products rich in cholecalciferol.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34308561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Treatment of secondary hyperparathyroidism in hemodialysed patients--paricalcitol with or without cinacalcet].","authors":"Jacek Zawierucha,&nbsp;Jolanta Małyszko,&nbsp;Jacek Małyszko,&nbsp;Teresa Dryl-Rydzyńska,&nbsp;Tomasz Prystacki,&nbsp;Wojciech Marcinkowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Secondary hyperparathyroidism (sHPT) is a common complication being a consequence of metabolic disorders associated with chronic kidney disease (CKD). Treatment of the sHPT should lead to calcium-phosphate management stabilization and parathyroid hormone levels reduction. The phosphate binders, synthetic vitamin D analogs and calcimimetics are used in sHPT treatment. In this paper we analyzed the results of three month paricalcitol treatment of 36 hemodialysis patients with sHPT (serum iPTH> 500 pg/ml). 11 patients have additionally received cinacalcet. Analysis of the results showes a statistically significant reduction in iPTH and alkaline phosphatase. Paricalcitol is effecitve in the tratment of SHPT with favourable profile of side effects. Alcaline phosphatase reduction may be a desirable additional therapeuctic effect. However, it appears that combined therapy with paricalcitol and cinacalcet shoud be offered to selected population of patients i.e. with hypocalcemia after calcimimetics.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34309046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}