Research最新文献_第7页

Dihydroartemisinin Regulated the MMP-Mediated Cellular Microenvironment to Alleviate Rheumatoid Arthritis. 双氢青蒿素调节 MMP 介导的细胞微环境以缓解类风湿性关节炎

IF 11 1区综合性期刊

Research Pub Date : 2024-09-10 DOI: 10.34133/research.0459

Qiuyan Guo,Qixin Wang,Jiayun Chen,Minghong Zhao,Tianming Lu,Zuchang Guo,Chen Wang,Yin Kwan Wong,Xueling He,Lin Chen,Wenjing Zhang,Chuanhao Dai,Shengnan Shen,Huanhuan Pang,Fei Xia,Chong Qiu,Daoyuan Xie,Jigang Wang

{"title":"Dihydroartemisinin Regulated the MMP-Mediated Cellular Microenvironment to Alleviate Rheumatoid Arthritis.","authors":"Qiuyan Guo,Qixin Wang,Jiayun Chen,Minghong Zhao,Tianming Lu,Zuchang Guo,Chen Wang,Yin Kwan Wong,Xueling He,Lin Chen,Wenjing Zhang,Chuanhao Dai,Shengnan Shen,Huanhuan Pang,Fei Xia,Chong Qiu,Daoyuan Xie,Jigang Wang","doi":"10.34133/research.0459","DOIUrl":"https://doi.org/10.34133/research.0459","url":null,"abstract":"Rheumatoid arthritis (RA) is an autoimmune disease with features of synovial inflammation, cartilage erosion, bone destruction, and pain and is currently lacking a satisfactory treatment strategy. Dihydroartemisinin (DHA), the active metabolite of artemisinin, has exhibited outstanding suppressive effects on RA without obvious side effects. However, the underlying mechanisms remain unclear, which limits its further clinical application. The purpose of this study is to reveal the pharmacodynamic mechanism of DHA against RA by means of a combination of single-cell RNA sequencing (RNA-seq), proteomics, as well as transcriptomics both in vivo and in vitro. In our results, DHA effectively reduced the degree of redness, swelling, and pain in RA rats and dramatically changed the synovial tissue microenvironment under the pathological state. Within this microenvironment, fibroblasts, macrophages, B cells, and endothelial cells were the major affected cell types, primarily through DHA targeting the extracellular matrix (ECM) structural constituent signaling pathway. In addition, we confirmed that DHA regulated the ECM by modulating matrix metalloproteinase 2 (MMP2) and MMP3 in the synovial tissue of RA rats. Moreover, DHA induced apoptosis in MH7A cells, further validating the bioinformatics data. In conclusion, DHA effectively reduced the inflammatory response and improved the immune microenvironment in synovial tissue by inhibiting MMP2 and MMP3. Our findings provide a basis for the application of DHA in the treatment of RA.","PeriodicalId":21120,"journal":{"name":"Research","volume":"150 1","pages":"0459"},"PeriodicalIF":11.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal Inference Meets Deep Learning: A Comprehensive Survey. 因果推理与深度学习：全面调查。

IF 11 1区综合性期刊

Research Pub Date : 2024-09-10 DOI: 10.34133/research.0467

Licheng Jiao,Yuhan Wang,Xu Liu,Lingling Li,Fang Liu,Wenping Ma,Yuwei Guo,Puhua Chen,Shuyuan Yang,Biao Hou

{"title":"Causal Inference Meets Deep Learning: A Comprehensive Survey.","authors":"Licheng Jiao,Yuhan Wang,Xu Liu,Lingling Li,Fang Liu,Wenping Ma,Yuwei Guo,Puhua Chen,Shuyuan Yang,Biao Hou","doi":"10.34133/research.0467","DOIUrl":"https://doi.org/10.34133/research.0467","url":null,"abstract":"Deep learning relies on learning from extensive data to generate prediction results. This approach may inadvertently capture spurious correlations within the data, leading to models that lack interpretability and robustness. Researchers have developed more profound and stable causal inference methods based on cognitive neuroscience. By replacing the correlation model with a stable and interpretable causal model, it is possible to mitigate the misleading nature of spurious correlations and overcome the limitations of model calculations. In this survey, we provide a comprehensive and structured review of causal inference methods in deep learning. Brain-like inference ideas are discussed from a brain-inspired perspective, and the basic concepts of causal learning are introduced. The article describes the integration of causal inference with traditional deep learning algorithms and illustrates its application to large model tasks as well as specific modalities in deep learning. The current limitations of causal inference and future research directions are discussed. Moreover, the commonly used benchmark datasets and the corresponding download links are summarized.","PeriodicalId":21120,"journal":{"name":"Research","volume":"77 1","pages":"0467"},"PeriodicalIF":11.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal Stem Cell Exosome-Integrated Antibacterial Hydrogels for Nasal Mucosal Injury Treatment. 用于鼻黏膜损伤治疗的间充质干细胞外泌体整合抗菌水凝胶

IF 11 1区综合性期刊

Research Pub Date : 2024-09-09 DOI: 10.34133/research.0469

Min Li,Rui Liu,Guopu Chen,Handong Wang,Jinglin Wang,Bin Kong,Chenjie Yu

{"title":"Mesenchymal Stem Cell Exosome-Integrated Antibacterial Hydrogels for Nasal Mucosal Injury Treatment.","authors":"Min Li,Rui Liu,Guopu Chen,Handong Wang,Jinglin Wang,Bin Kong,Chenjie Yu","doi":"10.34133/research.0469","DOIUrl":"https://doi.org/10.34133/research.0469","url":null,"abstract":"Hydrogels have emerged as appealing prospects for wound healing due to their superior biocompatible qualities. However, the integration of antibacterial active substances into hydrogels for effective wound repair remains challenging. Here, we present a novel double-network hydrogel for nasal mucosal injury repair with antibacterial and self-healing capabilities. This hydrogel is the result of mixing aldehyde polyethylene glycol (PEG) and a carboxymethyl chitosan (CMCS)-based hydrogel with a photocured methylacrylate gelatin (GelMA) hydrogel to envelop mesenchymal stem cell exosomes (MSC-Exos). CMCS is rich in amino groups and facilitates antibacterial repair. Given the dynamically reversible Schiff base connections between the amino group of chitosan and the aldehyde group of modified PEG, the hydrogel can be easily injected into the lesion site because of its excellent injection and shear thinning properties. GelMA introduces an additional network layer for the hydrogel, which enhances its strength and extends the duration of stem cell exosomes on the wound surface. On the basis of these characteristics, we provide evidence that this compound hydrogel can substantially increase cell proliferation and regeneration, inhibit scar hyperplasia, and stimulate angiogenesis in rabbit nasal septum mucosa trauma models. These results suggest that MSC exosome-loaded hydrogels (ME-Gel) have substantial clinical potential for the repair and regeneration of nasal mucosa after surgery or trauma.","PeriodicalId":21120,"journal":{"name":"Research","volume":"12 1","pages":"0469"},"PeriodicalIF":11.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monomeric, Oligomeric, Polymeric, and Supramolecular Cyclodextrins as Catalysts for Green Chemistry. 作为绿色化学催化剂的单体、低聚物、聚合物和超分子环糊精。

IF 11 1区综合性期刊

Research Pub Date : 2024-09-09 DOI: 10.34133/research.0466

Makoto Komiyama

{"title":"Monomeric, Oligomeric, Polymeric, and Supramolecular Cyclodextrins as Catalysts for Green Chemistry.","authors":"Makoto Komiyama","doi":"10.34133/research.0466","DOIUrl":"https://doi.org/10.34133/research.0466","url":null,"abstract":"This review comprehensively covers recent developments of cyclodextrin-mediated chemical transformations for green chemistry. These cyclic oligomers of glucose are nontoxic, eco-friendly, and recyclable to accomplish eminent functions in water. Their most important feature is to form inclusion complexes with reactants, intermediates, and/or catalysts. As a result, their cavities serve as sterically restricted and apolar reaction fields to promote the efficiency and selectivity of reactions. Furthermore, unstable reagents and intermediates are protected from undesired side reactions. The scope of their applications has been further widened through covalent or noncovalent modifications. Combinations of them with metal catalysis are especially successful. In terms of these effects, various chemical reactions are achieved with high selectivity and yield so that valuable chemicals are synthesized from multiple components in one-pot reactions. Furthermore, cyclodextrin units are orderly assembled in oligomers and polymers to show their cooperation for advanced properties. Recently, cyclodextrin-based metal-organic frameworks and polyoxometalate-cyclodextrin frameworks have been fabricated and employed for unique applications. Cyclodextrins fulfill many requirements for green chemistry and should make enormous contributions to this growing field.","PeriodicalId":21120,"journal":{"name":"Research","volume":"41 1","pages":"0466"},"PeriodicalIF":11.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes. 磁场增强间歇性禁食对严重糖尿病患者的影响

IF 11 1区综合性期刊

Research Pub Date : 2024-09-05 eCollection Date: 2024-01-01 DOI: 10.34133/research.0468

Ying Wang, Chuanlin Feng, Biao Yu, Junjun Wang, Weili Chen, Chao Song, Xinmiao Ji, Ruowen Guo, Guofeng Cheng, Hanxiao Chen, Xinyu Wang, Lei Zhang, Zhiyuan Li, Jialiang Jiang, Can Xie, Haifeng Du, Xin Zhang

{"title":"Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes.","authors":"Ying Wang, Chuanlin Feng, Biao Yu, Junjun Wang, Weili Chen, Chao Song, Xinmiao Ji, Ruowen Guo, Guofeng Cheng, Hanxiao Chen, Xinyu Wang, Lei Zhang, Zhiyuan Li, Jialiang Jiang, Can Xie, Haifeng Du, Xin Zhang","doi":"10.34133/research.0468","DOIUrl":"10.34133/research.0468","url":null,"abstract":"Intermittent fasting (IF) is a convenient dietary intervention for multiple diseases, including type 2 diabetes. However, whether it can be used as a long-term antidiabetic approach is still unknown. Here, we confirm that IF alone is beneficial for both moderate and severe diabetic mice, but its antidiabetic effects clearly diminish at later stages, especially for severe diabetic db/db mice, which have obviously impaired autophagy. We found that static magnetic fields can directly promote actin assembly and boost IF-induced autophagy. Consequently, the pancreatic islet and liver were improved, and the antidiabetic effects of IF were boosted. In fact, at later stages, combined static magnetic field and IF could reduce the blood glucose level of moderate type 2 diabetic mice by 40.5% (P < 0.001) and severe type 2 diabetes by 34.4% (P < 0.05), when IF alone no longer has significant blood glucose reduction effects. Therefore, although IF is generally beneficial for diabetes, our data reveal its insufficiency for late-stage diabetes, which can be compensated by a simple, noninvasive, long-lasting, and nonpharmacological strategy for effective long-term diabetic control.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0468"},"PeriodicalIF":11.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone Loss. 骨骼肌线粒体蛋白稳态失衡导致骨质流失

IF 11 1区综合性期刊

Research Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.34133/research.0465

Zhen Jin, Yan Mao, Qiqi Guo, Yujing Yin, Abdukahar Kiram, Danxia Zhou, Jing Yang, Zheng Zhou, Jiachen Xue, Zhenhua Feng, Zhen Liu, Yong Qiu, Tingting Fu, Zhenji Gan, Zezhang Zhu

{"title":"Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone Loss.","authors":"Zhen Jin, Yan Mao, Qiqi Guo, Yujing Yin, Abdukahar Kiram, Danxia Zhou, Jing Yang, Zheng Zhou, Jiachen Xue, Zhenhua Feng, Zhen Liu, Yong Qiu, Tingting Fu, Zhenji Gan, Zezhang Zhu","doi":"10.34133/research.0465","DOIUrl":"10.34133/research.0465","url":null,"abstract":"Although microgravity has been implicated in osteoporosis, the precise molecular mechanism remains elusive. Here, we found that microgravity might induce mitochondrial protein buildup in skeletal muscle, alongside reduced levels of LONP1 protein. We revealed that disruptions in mitochondrial proteolysis, induced by the targeted skeletal muscle-specific deletion of the essential mitochondrial protease LONP1 or by the acute inducible deletion of muscle LONP1 in adult mice, cause reduced bone mass and compromised mechanical function. Moreover, the bone loss and weakness phenotypes were recapitulated in skeletal muscle-specific overexpressing ΔOTC mice, a known protein degraded by LONP1. Mechanistically, mitochondrial proteostasis imbalance triggered the mitochondrial unfolded protein response (UPRmt) in muscle, leading to an up-regulation of multiple myokines, including FGF21, which acts as a pro-osteoclastogenic factor. Surprisingly, this mitochondrial proteostasis stress influenced muscle-bone crosstalk independently of ATF4 in skeletal muscle. Furthermore, we established a marked association between serum FGF21 levels and bone health in humans. These findings emphasize the pivotal role of skeletal muscle mitochondrial proteostasis in responding to alterations in loading conditions and in coordinating UPRmt to modulate bone metabolism.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0465"},"PeriodicalIF":11.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coupling Chiral Cuboids with Wholly Auxetic Response. 手性立方体与全辅助响应的耦合

IF 11 1区综合性期刊

Research Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI: 10.34133/research.0463

Jiajun Wang, Zhaochang Chen, Pengcheng Jiao, Amir H Alavi

{"title":"Coupling Chiral Cuboids with Wholly Auxetic Response.","authors":"Jiajun Wang, Zhaochang Chen, Pengcheng Jiao, Amir H Alavi","doi":"10.34133/research.0463","DOIUrl":"10.34133/research.0463","url":null,"abstract":"Auxetic materials have been extensively studied for their design, fabrication and mechanical properties. These material systems exhibit unique mechanical characteristics such as high impact resistance, shear strength, and energy absorption capacity. Most existing auxetic materials are two-dimensional (2D) and demonstrate half-auxetic behavior, characterized by a negative Poisson's ratio when subjected to either tensile or compressive forces. Here, we present novel three-dimensional (3D) auxetic mechanical metamaterials, termed coupling chiral cuboids, capable of achieving negative Poisson's ratio under both tension and compression. We perform experiments, theoretical analysis, and numerical simulations to validate the wholly auxetic response of the proposed coupling chiral cuboids. Parametric studies are carried out to investigate the effects of structural parameters on the elastic modulus and Poisson's ratio of the coupling chiral cuboids. The results imply that the Poisson's ratio sign-switching from negative to positive can be implemented by manipulating the thickness of Z-shaped ligaments. Finally, the potential application of the coupling chiral cuboids as inner cores for impact-resistant sandwich panels is envisioned and validated. Test results demonstrate a remarkable 49.3% enhancement in energy absorption compared to conventional solid materials.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0463"},"PeriodicalIF":11.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Octopus-Inspired Underwater Soft Robotic Gripper with Crawling and Swimming Capabilities. 受章鱼启发的具有爬行和游泳能力的水下软体机器人抓手。

IF 11 1区综合性期刊

Research Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.34133/research.0456

Mingxin Wu, Waqar Hussain Afridi, Jiaxi Wu, Rahdar Hussain Afridi, Kaiwei Wang, Xingwen Zheng, Chen Wang, Guangming Xie

{"title":"Octopus-Inspired Underwater Soft Robotic Gripper with Crawling and Swimming Capabilities.","authors":"Mingxin Wu, Waqar Hussain Afridi, Jiaxi Wu, Rahdar Hussain Afridi, Kaiwei Wang, Xingwen Zheng, Chen Wang, Guangming Xie","doi":"10.34133/research.0456","DOIUrl":"https://doi.org/10.34133/research.0456","url":null,"abstract":"Can a robotic gripper only operate when attached to a robotic arm? The application space of the traditional gripper is limited by the robotic arm. Giving robot grippers the ability to move will expand their range of applications. Inspired by rich behavioral repertoire observed in octopus, we implement an integrated multifunctional soft robotic gripper with 6 independently controlled Arms. It can execute 8 different gripping actions for different objects, such as irregular rigid/soft objects, elongated objects with arbitrary orientation, and plane/curved objects with larger sizes than the grippers. Moreover, the soft gripper can realize omnidirectional crawling and swimming by itself. The soft gripper can perform highly integrated tasks of releasing, crawling, swimming, grasping, and retrieving objects in a confined underwater environment. Experimental results demonstrate that the integrated capabilities of multimodal adaptive grasping and omnidirectional motions enable dexterous manipulations that traditional robotic arms cannot achieve. The soft gripper may apply to highly integrated and labor-intensive tasks in unstructured underwater environments, including ocean litter collecting, capture fishery, and archeological exploration.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0456"},"PeriodicalIF":11.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rocking-chair Rechargeable Seawater Battery. 摇椅式海水充电电池

IF 11 1区综合性期刊

Research Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI: 10.34133/research.0461

Jialong Wu, Yongshuo Zheng, Pengfei Zhang, Xiaoshuang Rao, Zhenyu Zhang, Jin-Ming Wu, Wei Wen

引用次数: 0

Erratum to "All-Biobased Hydrovoltaic-Photovoltaic Electricity Generators for All-Weather Energy Harvesting". 对 "用于全天候能量收集的全生物型水力光伏发电装置 "的勘误。

IF 11 1区综合性期刊

Research Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI: 10.34133/research.0454

Guoping Ren, Qichang Hu, Jie Ye, Andong Hu, Jian Lü, Shungui Zhou

引用次数: 0