Single-Atom Cu Anchored on a UiO-66 Surface-Enhanced Raman Scattering Sensor for Trace and Rapid Detection of Volatile Organic Compounds.

IF 10.7 1区 综合性期刊 Q1 Multidisciplinary
Research Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI:10.34133/research.0841
Yuening Wang, Xiangyu Meng, Wenxiong Shi, Yujiao Xie, Aochi Liu, Lei Xu, Lin Qiu, Xiaoyu Song, Mingjian Zhang, Jiahao Zhang, Jian Yu, Aiguo Wu, Xiaotian Wang, Jie Lin
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引用次数: 0

Abstract

Volatile organic compounds (VOCs) serve as critical biomarkers in exhaled breath for early-stage cancer patients, and their rapid, trace-level detection holds marked implications for cancer screening. Surface-enhanced Raman scattering (SERS) technology demonstrates strong potential for trace VOC gas detection due to its ultra-high sensitivity and immunity to water interference. However, while surface plasmon resonance (SPR)-free semiconductor substrates offer superior spectral stability and selectivity, their sensitivity toward VOC detection remains suboptimal. This study introduces a novel semiconductor-based SERS substrate composed of copper single atoms anchored on UiO-66 (Cu1/UiO-66), achieving a record-low detection limit of 10 parts per billion for VOC gases with a rapid 2-min response time, thereby elevating the gas-sensing performance of SPR-free substrates to unprecedented levels. The exceptional SERS activity originates from the highly delocalized electron properties of single-atomic copper, which effectively facilitates single-atom charge transfer processes. Concurrently, the incorporation of copper single atoms modulates the band structure of UiO-66, substantially enhancing the coupling resonance between the substrate and target molecules. In simulated breath tests mimicking lung cancer patients' exhalations, Cu1/UiO-66 exhibits remarkable VOC recognition capability and robust anti-interference performance. This work pioneers a new paradigm for ultra-sensitive, rapid detection of trace VOCs in exhaled breath, holding substantial promise for early cancer diagnostics and clinical translation.

UiO-66表面增强拉曼散射传感器上单原子Cu的痕量和快速检测挥发性有机化合物。
挥发性有机化合物(VOCs)是早期癌症患者呼出气体中的关键生物标志物,它们的快速、痕量检测对癌症筛查具有显著意义。表面增强拉曼散射(SERS)技术由于其超高灵敏度和抗水干扰能力,在痕量VOC气体检测中具有很强的潜力。然而,尽管无表面等离子体共振(SPR)的半导体衬底具有优越的光谱稳定性和选择性,但它们对VOC检测的灵敏度仍然不是最佳的。本研究介绍了一种新型的基于半导体的SERS衬底,该衬底由铜单原子锚定在UiO-66 (Cu1/UiO-66)上,对VOC气体的检测限达到了创纪录的十亿分之十,响应时间为2分钟,从而将无spro衬底的气敏性能提升到前所未有的水平。特殊的SERS活性源于单原子铜的高度离域电子性质,这有效地促进了单原子电荷转移过程。同时,铜单原子的掺入调节了UiO-66的能带结构,大大增强了底物与靶分子之间的耦合共振。在模拟肺癌患者呼出气体的呼吸测试中,Cu1/UiO-66具有显著的VOC识别能力和抗干扰能力。这项工作开创了一种超灵敏、快速检测呼出气体中痕量挥发性有机化合物的新范式,为早期癌症诊断和临床转化带来了巨大的希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Research
Research Multidisciplinary-Multidisciplinary
CiteScore
13.40
自引率
3.60%
发文量
0
审稿时长
14 weeks
期刊介绍: Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.
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