Metal Nanomaterials: A Strategy to Combat Drug-Resistant Bacterial Infections.

IF 10.7 1区 综合性期刊 Q1 Multidisciplinary
Research Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI:10.34133/research.0853
Yaran Wang, Fan Wu, Yijin Ren, Yong Liu, Henny C Mei
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引用次数: 0

Abstract

Bacterial infections pose a major challenge today due to the rise of drug resistance in pathogenic bacteria, creating an urgent need for the development of nonantibiotic therapies. Metal nanomaterials are increasingly recognized as promising antibacterial agents due to their unique physical and chemical properties, which offer strong antibacterial capabilities and broad-spectrum activity against drug-resistant bacteria. Unlike traditional antibacterial therapies, metal nanomaterials rarely induce drug resistance because of their diverse antibacterial mechanisms, which destroy bacteria by directly damaging bacterial cells or generating oxidative stress. Metal nanomaterials have proven effective in treating various drug-resistant bacterial infections. This perspective highlights recent advances in metal nanomaterials for antimicrobial applications. Firstly, bacterial infections and the current dilemma are introduced. Next, recent progress in the antibacterial activity of metal nanomaterials against drug-resistant bacteria is summarized, along with the challenges in their antimicrobial applications. Finally, future prospects and remaining challenges associated with the use of metal nanomaterials to treat drug-resistant bacteria are discussed.

Abstract Image

金属纳米材料:对抗耐药细菌感染的策略。
由于致病菌耐药性的增加,细菌感染构成了今天的主要挑战,迫切需要开发非抗生素治疗方法。金属纳米材料由于其独特的物理和化学性质,对耐药细菌具有很强的抗菌能力和广谱活性,越来越被认为是一种有前景的抗菌剂。与传统的抗菌疗法不同,金属纳米材料由于其多种抗菌机制而很少引起耐药性,它们通过直接破坏细菌细胞或产生氧化应激来破坏细菌。金属纳米材料在治疗各种耐药细菌感染方面已被证明是有效的。这一观点强调了用于抗菌应用的金属纳米材料的最新进展。首先,介绍了细菌感染和目前的困境。其次,综述了近年来金属纳米材料对耐药菌抗菌活性的研究进展,以及其抗菌应用面临的挑战。最后,讨论了使用金属纳米材料治疗耐药细菌的未来前景和仍然存在的挑战。
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来源期刊
Research
Research Multidisciplinary-Multidisciplinary
CiteScore
13.40
自引率
3.60%
发文量
0
审稿时长
14 weeks
期刊介绍: Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.
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