Research最新文献_第8页

Photothermally Driven Ultrafast Polymerase Chain Reaction: Mechanisms, Nanomaterial Architectures, and System Integration. 光热驱动的超快速聚合酶链反应：机制、纳米材料结构和系统集成。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI: 10.34133/research.0839

Yile Fang, Lijun Cai, Ning Li, Feika Bian, Dagan Zhang, Nongyue He, Zhiyang Li, Hong Yan, Yuanjin Zhao

{"title":"Photothermally Driven Ultrafast Polymerase Chain Reaction: Mechanisms, Nanomaterial Architectures, and System Integration.","authors":"Yile Fang, Lijun Cai, Ning Li, Feika Bian, Dagan Zhang, Nongyue He, Zhiyang Li, Hong Yan, Yuanjin Zhao","doi":"10.34133/research.0839","DOIUrl":"10.34133/research.0839","url":null,"abstract":"As one of the most important technologies in molecular biology, polymerase chain reaction (PCR) has been widely recognized in many fields such as infectious disease diagnosis due to its high sensitivity, specificity, and accuracy. Attempts in this field are focused on developing efficient heating mechanism to achieve efficient thermal cycles. Recently, with the in-depth research into photothermal effects, photonic PCR technology based on photothermal nanomaterials has gradually demonstrated potential to develop a new generation of ultrafast PCR instrument. Herein, we first categorize the various photothermal nanomaterials and briefly introduce their photothermal conversion mechanisms. Then, we review the photonic PCR technologies based on different nanomaterials and various heating strategies, comparing their advantages and disadvantages. We also discuss the application of photonic PCR in point-of-care testing (POCT) of nucleic acid and summarize the prospects and challenges of photonic PCR technology in clinical diagnostic applications. Finally, we look forward to the promising future research focus of photonic PCR. With this review, researchers can get a comprehensive understanding of photonic PCR from the aspects of technical principles, material selection, equipment development strategies, and so on, paving the way for future research.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0839"},"PeriodicalIF":10.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Merged Hypergraph Neural Network for Explainable Solvation Gibbs Free Energy Prediction. 可解释溶剂化的分子合并超图神经网络吉布斯自由能预测。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI: 10.34133/research.0740

Wenjie Du, Shuai Zhang, Zhaohui Cai, Xuqiang Li, Zhiyuan Liu, Junfeng Fang, Jianmin Wang, Xiang Wang, Yang Wang

{"title":"Molecular Merged Hypergraph Neural Network for Explainable Solvation Gibbs Free Energy Prediction.","authors":"Wenjie Du, Shuai Zhang, Zhaohui Cai, Xuqiang Li, Zhiyuan Liu, Junfeng Fang, Jianmin Wang, Xiang Wang, Yang Wang","doi":"10.34133/research.0740","DOIUrl":"10.34133/research.0740","url":null,"abstract":"Solvation free energies play a fundamental role in various fields of chemistry and biology. Accurately determining the solvation Gibbs free energy ( <math><mi>Δ</mi> <msub><mi>G</mi> <mtext>solv</mtext></msub> </math> ) of a molecule in a given solvent requires a deep understanding of the intrinsic relationships between solute and solvent molecules. While deep learning methods have been developed for <math><mi>Δ</mi> <msub><mi>G</mi> <mtext>solv</mtext></msub> </math> prediction, few explicitly model intermolecular interactions between solute and solvent molecules. The molecular modeling graph neural network more closely aligns with real-world chemical processes by explicitly capturing atomic-level interactions, such as hydrogen bonding. It achieves this by initially establishing indiscriminate connections between intermolecular atoms, which are subsequently refined using an attention-based aggregation mechanism tailored to specific solute-solvent pairs. However, its sharply increasing computational complexity limits its scalability and broader applicability. Here, we introduce an improved framework, molecular merged hypergraph neural network (MMHNN), which leverages a predefined subgraph set and replaces subgraphs with supernodes to construct a hypergraph representation. This design effectively mitigates model complexity while preserving key molecular interactions. Furthermore, to handle noninteractive or repulsive atomic interactions, MMHNN incorporates an interpretation mechanism for nodes and edges within the merged graph, leveraging the graph information bottleneck theory to enhance model explainability. Extensive experimental validation demonstrates the efficiency of MMHNN and its improved interpretability in capturing solute-solvent interactions.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0740"},"PeriodicalIF":10.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12355008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Near-Infrared-Excitable Organic Afterglow Nanoparticles for Deep-Tissue Multimodal Imaging via Singlet Oxygen-Mediated Energy Transfer. 通过单线态氧介导的能量转移增强近红外可激发有机余辉纳米颗粒用于深层组织多模态成像。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0834

Yuzhen Yu, Zhe Li, Shiyi Liao, Baoli Yin, Qingpeng Zhang, Jiaqi Fu, Cheng Zhang, Ying Zhou, Guosheng Song

{"title":"Enhanced Near-Infrared-Excitable Organic Afterglow Nanoparticles for Deep-Tissue Multimodal Imaging via Singlet Oxygen-Mediated Energy Transfer.","authors":"Yuzhen Yu, Zhe Li, Shiyi Liao, Baoli Yin, Qingpeng Zhang, Jiaqi Fu, Cheng Zhang, Ying Zhou, Guosheng Song","doi":"10.34133/research.0834","DOIUrl":"10.34133/research.0834","url":null,"abstract":"Afterglow imaging offers exceptional signal-to-background ratios (SBRs) by circumventing real-time excitation and autofluorescence, yet conventional systems rely on visible-light excitation, limiting tissue penetration and signal intensity. Here, we report near-infrared-excitable organic afterglow nanoparticles (NOANPs) that leverage singlet oxygen (1O2)-mediated energy transfer to achieve prolonged, high-intensity emission with minimal photobleaching. The nanoparticles integrate a near-infrared-photoactive sensitizer (NAM-0), which generates abundant 1O2 under 808-nm laser excitation, and a triplenet-anthracene derivative (TD) as the afterglow substrate, which converts 1O2 into sustained luminescence. Co-encapsulation via one-step nanocoprecipitation ensures proximity between NAM-0 and TD, enabling efficient energy transfer and yielding exceptional afterglow brightness (>109 photons/s) at ultralow concentrations (10 μg/ml). NOANPs enable deep-tissue imaging (up to 3.0 cm ex vivo) by synergizing the superior penetration of near-infrared light with organic afterglow chemistry. The nanoparticles uniquely support three imaging modes: fluorescence, white light-activated afterglow, and near-infrared-triggered afterglow, which were validated in orthotopic murine models of pancreatic cancer and glioma. By synergizing near-infrared excitation with organic afterglow chemistry, this work overcomes longstanding limitations in penetration depth of excitation light, offering a versatile tool for precision imaging.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0834"},"PeriodicalIF":10.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-/Electrocatalytic Reduction of CO₂ Based on Ferroelectrics. 基于铁电体的光/电催化还原CO2。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0843

Rui Wei, Shun Li, Andy Li, Yuan-Hua Lin

引用次数: 0

Precision-Engineered Co-N_4-x -C _x Single Atoms Enhance Potential-Resolved Ru(bpy)₃ ²⁺ Electrochemiluminescence via Reactive Oxygen Species. 精密工程Co-N4-x -C x单原子通过活性氧增强电位分辨Ru(bpy) 32 +电化学发光。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0842

Ziqi Kang, Shu Zhu, Shijun Wang, Zhizhi Xiang, Zixin Deng, Xuehao Tong, Zixu Wang, Yanghan Sun, Xiancheng Liu, Guangchao Zang, Chenzhong Li, Guixue Wang, Yuchan Zhang

{"title":"Precision-Engineered Co-N4-x -C x Single Atoms Enhance Potential-Resolved Ru(bpy)3 2+ Electrochemiluminescence via Reactive Oxygen Species.","authors":"Ziqi Kang, Shu Zhu, Shijun Wang, Zhizhi Xiang, Zixin Deng, Xuehao Tong, Zixu Wang, Yanghan Sun, Xiancheng Liu, Guangchao Zang, Chenzhong Li, Guixue Wang, Yuchan Zhang","doi":"10.34133/research.0842","DOIUrl":"10.34133/research.0842","url":null,"abstract":"Electrochemiluminescence (ECL) immunoassays based on tris(bipyridine)ruthenium [Ru(bpy)3 2+] is the luminophore representing the most advanced and widely adopted approach in the field of in vitro diagnostics (IVD). However, the scarcity of potential-resolved ECL promoters for Ru(bpy)3 2+ markedly limits its application in clinical diagnostics. Here, we report the first application of cobalt single-atom catalysts (SACs) designed via density functional theory (DFT) calculations to boost the multi-signal ECL of Ru(bpy)3 2+. Mechanism investigations unveil that \"ROS accumulation\" induced by CoC4 and \"ROS surge\" driven by CoN4 are the key factors governing the cathodic and anodic ECL. As a proof of concept, a sandwich ratiometric immunosensor was developed to detect tumor marker CEA and demonstrated excellent clinical feasibility. This work provides insights into the development of tailored ECL promoters by introducing DFT prediction and elucidating the relationships between ORR/HPRR/OER processes and Ru(bpy)3 2+ ECL behavior, paving the way for designing precise immunoassays and advancing IVD techniques.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0842"},"PeriodicalIF":10.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

USP53 Drives Ethanol-Induced Myocardial Injury by Promoting K63 Deubiquitination-Dependent RIPK1 Activation at K377. USP53通过促进K63去泛素化依赖性RIPK1在K377的激活来驱动乙醇诱导的心肌损伤。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0823

Jichen Pan, Xiaolin Liu, Xiao Li, Shanshan Wang, Yuliang Zhao, Chong Yuan, Dongdong Liu, Liyan Wang, Meng Zhang, Fengming Liu, Mei Zhang, Shen Dai

{"title":"USP53 Drives Ethanol-Induced Myocardial Injury by Promoting K63 Deubiquitination-Dependent RIPK1 Activation at K377.","authors":"Jichen Pan, Xiaolin Liu, Xiao Li, Shanshan Wang, Yuliang Zhao, Chong Yuan, Dongdong Liu, Liyan Wang, Meng Zhang, Fengming Liu, Mei Zhang, Shen Dai","doi":"10.34133/research.0823","DOIUrl":"10.34133/research.0823","url":null,"abstract":"Alcoholic cardiomyopathy (ACM) is a type of dilated cardiomyopathy unrelated to ischemia, which develops as a consequence of chronic alcohol consumption. While ethanol-induced irreversible cardiomyocyte death is implicated in ACM development and progression, the precise molecular mechanisms involved are still obscure. In the current study, we demonstrate that ethanol exposure promotes receptor-interacting serine/threonine-protein kinase 1 (RIPK1) autophosphorylation and enhances pRIPK1-associated apoptosis and necroptosis in ACM models both in vivo and in vitro. Through co-immunoprecipitation (Co-IP) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, we identified ubiquitin-specific protease 53 (USP53) as a pivotal deubiquitinase involved in modulating RIPK1 activation following ethanol stimulation in cardiomyocytes. Mechanistically, we found that ethanol induced up-regulation of USP53 via transcriptional induction by early growth response 1 (EGR1). Subsequently, USP53 interacted with the intermediate domain of RIPK1 and removed K63-linked ubiquitination at lysine-377 (K377), facilitating RIPK1 phosphorylation and triggering downstream apoptotic and necroptotic pathways in cardiac cells. Further, alcohol-fed cardiomyocyte-specific USP53 knockout (USP53CKO) mice exhibited improved survival rates and less cardiomyocyte death in hearts compared with the control group. Our study identifies USP53 as a novel regulator of RIPK1-dependent cell death and advances our understanding of the mechanistic pathways of ACM. These results highlight the USP53-RIPK1 signaling axis as a potential therapeutic target for mitigating ACM progression.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0823"},"PeriodicalIF":10.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light-Triggered Graphene/Black Phosphorus Heterostructure FET Platform for Ultrasensitive Detection of Alzheimer's Disease Biomarkers at the Zeptomole Level. 光触发石墨烯/黑磷异质结构场效应晶体管平台在Zeptomole水平超灵敏检测阿尔茨海默病生物标志物。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0772

Huide Wang, Meng Qiu, Chen Wang, Liding Zhang, Ning Fan, Zhi Chen, Yi Liu, Tianzhong Li, Ziqian Wang, Yihan Zhu, Yule Zhang, Xilin Tian, Yun Wang, Mingmin Yang, Dianyuan Fan, Qingming Luo, Ke Jiang, Haiming Luo, Han Zhang

{"title":"Light-Triggered Graphene/Black Phosphorus Heterostructure FET Platform for Ultrasensitive Detection of Alzheimer's Disease Biomarkers at the Zeptomole Level.","authors":"Huide Wang, Meng Qiu, Chen Wang, Liding Zhang, Ning Fan, Zhi Chen, Yi Liu, Tianzhong Li, Ziqian Wang, Yihan Zhu, Yule Zhang, Xilin Tian, Yun Wang, Mingmin Yang, Dianyuan Fan, Qingming Luo, Ke Jiang, Haiming Luo, Han Zhang","doi":"10.34133/research.0772","DOIUrl":"10.34133/research.0772","url":null,"abstract":"Due to the low concentration of amyloid-beta (Aβ) in plasma and the high content of interfering factors, the conventional detection method for the quantification of Aβ still faces the problem of insufficient limit of detection (LOD). In this work, we propose a new light-triggered graphene-black phosphorus heterostructure (G-BP) field-effect transistor (FET) biosensing platform that achieves a marked reduction in the LOD. The LOD for Alzheimer's disease (AD) biomarker Aβ42 detection using the G-BP FET is as low as 235.1 zM (2.351 × 10-19 M), which is the lowest value reported to date and is approximately 2 to 3 orders of magnitude lower than other reported biosensing platforms. The G-BP FET platform provides precise, real-time guidance for non-invasive early diagnosis, disease monitoring, and personalized treatment plans for AD. Moreover, this method has good scalability and potential applications in other areas, including early detection of cancer and other major chronic diseases.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0772"},"PeriodicalIF":10.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isovalerylspiramycin I Reprograms the Immunosuppressive and Temozolomide-Resistant Microenvironment by Inhibiting the Frizzled-5/Wnt/β-Catenin Pathway in Glioblastoma. 异valerylspiramycin I通过抑制胶质母细胞瘤中frizzle5 /Wnt/β-Catenin通路重编程免疫抑制和替莫唑胺耐药微环境

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-13 eCollection Date: 2025-01-01 DOI: 10.34133/research.0828

Xin Luo, Xiangyang Zhong, Tianci Zeng, Xiaodie Li, Tao Yang, Qu Yue, Yufei Lan, Sui Chen, Zhao Wang, Manqing Zhang, Boming Zuo, Yuankai Wang, Yixiong Shen, Jiankun Lu, Boyang Liu, Hongbo Guo

{"title":"Isovalerylspiramycin I Reprograms the Immunosuppressive and Temozolomide-Resistant Microenvironment by Inhibiting the Frizzled-5/Wnt/β-Catenin Pathway in Glioblastoma.","authors":"Xin Luo, Xiangyang Zhong, Tianci Zeng, Xiaodie Li, Tao Yang, Qu Yue, Yufei Lan, Sui Chen, Zhao Wang, Manqing Zhang, Boming Zuo, Yuankai Wang, Yixiong Shen, Jiankun Lu, Boyang Liu, Hongbo Guo","doi":"10.34133/research.0828","DOIUrl":"10.34133/research.0828","url":null,"abstract":"Glioblastoma (GBM), the most prevalent and lethal primary brain malignancy in adults, currently lacks treatment effective options. Repurposing existing pharmaceutical agents as novel therapeutic modalities represents a viable strategy for efficiently utilizing resources. Here, we demonstrated that Isovalerylspiramycin I (ISP-I), the active component of a novel macrolide antibiotic, exerts a synergistic effect with temozolomide (TMZ) to enhance anti-GBM efficacy. ISP-I potently induced cytotoxicity and apoptosis through the induction of DNA double-strand breaks. The synergistic activity (combination index < 1) was confirmed for ISP-I in combination with TMZ against GBM. Additionally, ISP-I was found to induce immunogenic cell death, as evidenced by increased adenosine triphosphate release and calreticulin exposure. In murine models, ISP-I increased tumor-infiltrating CD8+ T cells, enhanced effector subsets, and reduced exhausted subsets. Mechanistically, ISP-I targeted the Frizzled-5 (FZD5)/Wnt/β-catenin signaling pathway, resulting in suppression of GSK-3β phosphorylation. This event subsequently increased β-catenin phosphorylation, reducing its translocation into the nucleus. Consequently, the binding of transcription factors (T-cell factor 1/lymphoid enhancer factor 1) to promoters of CD274 and O6-methylguanine-DNA methyltransferase (MGMT) was impeded, thereby enhancing GBM cell susceptibility to TMZ. These findings elucidate the mechanisms underlying ISP-I's therapeutic efficacy in GBM and provide essential evidence for its clinical translation and combinatorial therapeutic strategies.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0828"},"PeriodicalIF":10.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144848538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical Agitation-Assisted Transmembrane Drug Delivery by Magnetically Powered Spiky Nanorobots. 机械搅拌辅助磁动力刺状纳米机器人的跨膜药物递送。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-13 eCollection Date: 2025-01-01 DOI: 10.34133/research.0768

Xiaojia Liu, Zihan Xu, Yanan Che, Zichang Guo, Dongdong Jin, Qianqian Wang, Ning Liu, Xing Ma, Zhilu Yang

{"title":"Mechanical Agitation-Assisted Transmembrane Drug Delivery by Magnetically Powered Spiky Nanorobots.","authors":"Xiaojia Liu, Zihan Xu, Yanan Che, Zichang Guo, Dongdong Jin, Qianqian Wang, Ning Liu, Xing Ma, Zhilu Yang","doi":"10.34133/research.0768","DOIUrl":"10.34133/research.0768","url":null,"abstract":"Breaking through cell membrane barriers is a crucial step for intracellular drug delivery in antitumor chemotherapy. Hereby, a magnetic nanorobot, capable of exerting mechanical agitation on cellular membrane to promote intracellular drug delivery, was developed. The main body of the nanorobots was composed of nano-scaled gold nanospikes that were deposited with Ni and Ti nanolayers for magnetic activation and biocompatibility, responsively. The nanorobots can be precisely navigated to target cancer cells under external magnetic field control. By virtue of the sharp nanospike structures, the magnetically powered rotation behavior of the nanorobots can impose mechanical agitation on the living cell membrane and thus improve the membrane permeability, leading to promoted transmembrane cargo delivery. Coarse-grained molecular dynamics simulation revealed that the mechanism of mechanical intervention regulated permeability of the bilayer lipid membrane, allowing for enhanced transmembrane diffusion of small cargo molecules. An in vitro study demonstrated that these nanorobots can markedly enhance the efficiency of drug entry into tumor cells, thus improving the effectiveness of tumor therapy under magnetic activation in vivo. This work paves a new way for overcoming cell membrane barriers for intracellular drug delivery by using a magnetic nanorobotic system, which is expected to promote further application of magnetically controlled nanorobot technology in the field of precision medicine.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0768"},"PeriodicalIF":10.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144848551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parity Metamaterials and Dynamic Acoustic Mimicry. 宇称超材料与动态声学模拟。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-08-13 eCollection Date: 2025-01-01 DOI: 10.34133/research.0826

Jinjie Shi, Hongchen Chu, Aurélien Merkel, Chenkai Liu, Johan Christensen, Xiaozhou Liu, Yun Lai

{"title":"Parity Metamaterials and Dynamic Acoustic Mimicry.","authors":"Jinjie Shi, Hongchen Chu, Aurélien Merkel, Chenkai Liu, Johan Christensen, Xiaozhou Liu, Yun Lai","doi":"10.34133/research.0826","DOIUrl":"10.34133/research.0826","url":null,"abstract":"While parity transformation represents a fundamental symmetry operation in physics, its implications remain underexplored in metamaterial science. Here, we introduce a framework leveraging parity transformation to construct parity-inverted counterparts of arbitrary 3-dimensional meta-atoms, enabling the creation of parity-engineered metamaterial slabs. We demonstrate that the synergy between reciprocity and parity transformation, distinct from mirror operation, guarantees undistorted wave transmission across exceptional bandwidths, independent of structural configuration or meta-atom design specifics. Furthermore, these metamaterials exhibit dynamic acoustic mimicry capability, enabling adaptive blending of reflected signatures into surrounding environments while preserving transmitted wavefront integrity. Validated through numerical simulations and experimental prototypes, this breakthrough offers transformative potential for acoustic camouflage applications, particularly for sonar systems. Our findings reveal fundamental implications of parity transformation in artificial materials, establishing parity engineering as a paradigm for designing ultrabroadband functional materials with unprecedented operational versatility.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0826"},"PeriodicalIF":10.7,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12349962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144848581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0