Research最新文献_第8页

Recent Advances in Indocyanine Green-Based Probes for Second Near-Infrared Fluorescence Imaging and Therapy. 吲哚菁绿基二次近红外荧光成像及治疗探针研究进展。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-17 eCollection Date: 2025-01-01 DOI: 10.34133/research.0583

Dehong Hu, Menglei Zha, Hairong Zheng, Duyang Gao, Zonghai Sheng

{"title":"Recent Advances in Indocyanine Green-Based Probes for Second Near-Infrared Fluorescence Imaging and Therapy.","authors":"Dehong Hu, Menglei Zha, Hairong Zheng, Duyang Gao, Zonghai Sheng","doi":"10.34133/research.0583","DOIUrl":"10.34133/research.0583","url":null,"abstract":"Fluorescence imaging, a highly sensitive molecular imaging modality, is being increasingly integrated into clinical practice. Imaging within the second near-infrared biological window (NIR-II; 1,000 to 1,700 nm), also referred to as shortwave infrared, has received substantial attention because of its markedly reduced autofluorescence, deeper tissue penetration, and enhanced spatiotemporal resolution as compared to traditional near-infrared (NIR) imaging. Indocyanine green (ICG), a US Food and Drug Administration-approved NIR fluorophore, has long been used in clinical applications, including blood vessel angiography, vascular perfusion monitoring, and tumor detection. Recent advancements in NIR-II imaging technology have revitalized interest in ICG, revealing its extended tail fluorescence beyond 1,000 nm and reaffirming its potential as a clinically translatable NIR-II fluorophore for in vivo imaging and theranostic applications for diagnosing various diseases. This review emphasizes the notable advances in the use of ICG and its derivatives for NIR-II imaging and image-guided therapy from both fundamental and clinical perspectives. We also provide a concise conclusion and discuss the challenges and future opportunities with NIR-II imaging using clinically approved fluorophores.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0583"},"PeriodicalIF":11.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratonsillar Immunotherapy: A Convenient and Effective Alternative to Subcutaneous Immunotherapy for Allergic Rhinitis. 扁桃腺内免疫治疗：一种代替皮下免疫治疗变应性鼻炎方便有效的方法。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.34133/research.0573

Tian Gu, Wei Zhang, Lu Tan, Rong Xiang, Peiqiang Liu, Jingyu Huang, Qin Deng, Yuqin Deng, Zezhang Tao, Shiming Chen, Yu Xu

{"title":"Intratonsillar Immunotherapy: A Convenient and Effective Alternative to Subcutaneous Immunotherapy for Allergic Rhinitis.","authors":"Tian Gu, Wei Zhang, Lu Tan, Rong Xiang, Peiqiang Liu, Jingyu Huang, Qin Deng, Yuqin Deng, Zezhang Tao, Shiming Chen, Yu Xu","doi":"10.34133/research.0573","DOIUrl":"10.34133/research.0573","url":null,"abstract":"Allergen-specific immunotherapy (AIT) is the only treatment that addresses the root cause of immunoglobulin E (IgE)-mediated allergies, but conventional methods face challenges with treatment duration, patient compliance, and adverse effects. In this study, we propose intratonsillar immunotherapy (ITIT) as a new effective and safer route for AIT. Prior to clinical trials, we analyzed tonsil samples from human subjects to assess immune responses, measuring interleukin-4 (IL-4), IL-21, total IgE (tIgE), and allergen-specific IgE concentrations using ELISA and BioIC. Our results indicated that tonsils contained higher levels of allergen-specific IgE compared to peripheral blood. In the clinical phase, 120 allergic rhinitis (AR) patients were treated with either 3 intratonsillar allergen injections over 2 months or conventional subcutaneous immunotherapy (SCIT) over 1 year. ITIT demonstrated superior and faster symptom relief, especially in younger patients, while requiring markedly fewer doses and injections than SCIT. Immunological analysis revealed reduced eosinophil counts, increased regulatory T (Treg) and follicular regulatory T (TFR) cell levels, and a favorable shift in cytokine profiles. Adverse events were minimal, and the treatment showed high patient compliance. These findings suggest that ITIT could provide an effective, safer, and more convenient alternative to AIT.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0573"},"PeriodicalIF":11.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Cellular Senescence Evaluation to Aid Targeted Therapies. 综合细胞衰老评价辅助靶向治疗。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.34133/research.0576

Xiaolan Zhou, Xiaofeng Zhu, Weixu Wang, Jing Wang, Haimei Wen, Yuqi Zhao, Jiayu Zhang, Qiushi Xu, Zhaozhao Zhao, Ting Ni

{"title":"Comprehensive Cellular Senescence Evaluation to Aid Targeted Therapies.","authors":"Xiaolan Zhou, Xiaofeng Zhu, Weixu Wang, Jing Wang, Haimei Wen, Yuqi Zhao, Jiayu Zhang, Qiushi Xu, Zhaozhao Zhao, Ting Ni","doi":"10.34133/research.0576","DOIUrl":"10.34133/research.0576","url":null,"abstract":"Drug resistance to a single agent is common in cancer-targeted therapies, and rational drug combinations are a promising approach to overcome this challenge. Many Food and Drug Administration-approved drugs can induce cellular senescence, which possesses unique vulnerabilities and molecular signatures. However, there is limited analysis on the effect of the combination of cellular-senescence-inducing drugs and targeted therapy drugs. Here, we conducted a comprehensive evaluation of cellular senescence using 7 senescence-associated gene sets. We quantified the cellular senescence states of ~10,000 tumor samples from The Cancer Genome Atlas and examined their associations with targeted drug responses. Our analysis revealed that tumors with higher cellular senescence scores exhibited increased sensitivity to targeted drugs. As a proof of concept, we experimentally confirmed that etoposide-induced senescence sensitized lung cancer cells to 2 widely used targeted drugs, erlotinib and dasatinib. Furthermore, we identified multiple genes whose dependencies were associated with senescence status across ~1,000 cancer cell lines, suggesting that cellular senescence generates unique vulnerabilities for therapeutic exploitation. Our study provides a comprehensive overview of drug response related to cellular senescence and highlights the potential of combining senescence-inducing agents with targeted therapies to improve treatment outcomes in lung cancer, revealing novel applications of cellular senescence in targeted cancer therapies.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0576"},"PeriodicalIF":11.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Active Interfaces on the Surface of Porous Single-Crystalline TiO₂ Monoliths for Enhanced Catalytic Activity and Stability. 在多孔单晶二氧化钛单体表面设计活性界面以增强催化活性和稳定性。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0579

Huang Lin, Cong Luo, Fangyuan Cheng, Kui Xie

{"title":"Engineering Active Interfaces on the Surface of Porous Single-Crystalline TiO2 Monoliths for Enhanced Catalytic Activity and Stability.","authors":"Huang Lin, Cong Luo, Fangyuan Cheng, Kui Xie","doi":"10.34133/research.0579","DOIUrl":"10.34133/research.0579","url":null,"abstract":"The engineering design and construction of active interfaces represents a promising approach amidst numerous initiatives aimed at augmenting catalytic activity. Herein, we present a novel approach to incorporate interconnected pores within bulk single crystals for the synthesis of macroscopic porous single-crystalline rutile titanium oxide (R-TiO2). The porous single crystal (PSC) R-TiO2 couples a nanocrystalline framework as the solid phase with pores as the fluid phase within its structure, providing unique advantages in localized structure construction and in the field of catalysis. We successfully construct well-defined Ni cluster/TiO2 active interfaces by directly confining Ni clusters on the continuous lattice surface of PSC R-TiO2. We confirm that the lattice oxygen connected to the Ni clusters exhibits exceptional activation capability at temperatures close to room temperature compared to the pure phase PSC R-TiO2 monoliths. The PSC Ni/TiO2 catalyst demonstrates complete CO oxidation and stable catalytic performance during continuous operation in air at ~80 °C for 200 h.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0579"},"PeriodicalIF":11.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Self-Powered Sensors Based on Ionic Hydrogels. 基于离子水凝胶的自供电传感器研究进展。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0571

Jianyu Yin, Peixue Jia, Ziqi Ren, Qixiang Zhang, Wenzhong Lu, Qianqian Yao, Mingfang Deng, Xubin Zhou, Yihua Gao, Nishuang Liu

{"title":"Recent Advances in Self-Powered Sensors Based on Ionic Hydrogels.","authors":"Jianyu Yin, Peixue Jia, Ziqi Ren, Qixiang Zhang, Wenzhong Lu, Qianqian Yao, Mingfang Deng, Xubin Zhou, Yihua Gao, Nishuang Liu","doi":"10.34133/research.0571","DOIUrl":"10.34133/research.0571","url":null,"abstract":"After years of research and development, flexible sensors are gradually evolving from the traditional \"electronic\" paradigm to the \"ionic\" dimension. Smart flexible sensors derived from the concept of ion transport are gradually emerging in the flexible electronics. In particular, ionic hydrogels have increasingly become the focus of research on flexible sensors as a result of their tunable conductivity, flexibility, biocompatibility, and self-healable capabilities. Nevertheless, the majority of existing sensors based on ionic hydrogels still mainly rely on external power sources, which greatly restrict the dexterity and convenience of their applications. Advances in energy harvesting technologies offer substantial potential toward engineering self-powered sensors. This article reviews in detail the self-powered mechanisms of ionic hydrogel self-powered sensors (IHSSs), including piezoelectric, triboelectric, ionic diode, moist-electric, thermoelectric, potentiometric transduction, and hybrid modes. At the same time, structural engineering related to device and material characteristics is discussed. Additionally, the relevant applications of IHSS toward wearable electronics, human-machine interaction, environmental monitoring, and medical diagnostics are further reviewed. Lastly, the challenges and prospective advancement of IHSS are outlined.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0571"},"PeriodicalIF":11.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Asymmetric Wettability Dressings for Wound Exudate Management. 非对称润湿性敷料用于伤口渗出液处理的最新进展。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0591

Fang Wang, Wenqing He, Bing Dai, Xueji Zhang, Yongqiang Wen

引用次数: 0

Transferrin Disassociates TCR from CD3 Signaling Apparatus to Promote Metastasis. 转铁蛋白使TCR与CD3信号装置分离，促进转移。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI: 10.34133/research.0578

Ruomei Cheng, Xiaopeng Tang, Qiyu Zhao, Yuming Wang, Wenlin Chen, Gan Wang, Chenxi Wang, James Mwangi, Qiumin Lu, Dawit Adisu Tadese, Xudong Zhao, Caiwen Ou, Ren Lai

{"title":"Transferrin Disassociates TCR from CD3 Signaling Apparatus to Promote Metastasis.","authors":"Ruomei Cheng, Xiaopeng Tang, Qiyu Zhao, Yuming Wang, Wenlin Chen, Gan Wang, Chenxi Wang, James Mwangi, Qiumin Lu, Dawit Adisu Tadese, Xudong Zhao, Caiwen Ou, Ren Lai","doi":"10.34133/research.0578","DOIUrl":"10.34133/research.0578","url":null,"abstract":"Immune recognition and activation by the peptide-laden major histocompatibility complex-T cell receptor (TCR)-CD3 complex is essential for anti-tumor immunity. Tumors may escape immune surveillance by dissembling the complex. Here, we report that transferrin, which is overexpressed in patients with liver metastasis, disassociates TCR from the CD3 signaling apparatus by targeting the constant domain (CD) of T cell receptor α (TCRα), consequently suppresses T cell activation, and inhibits anti-metastatic and anti-tumor immunity. In mouse models of melanoma and lymphoma, transferrin overexpression exacerbates liver metastasis, while its knockdown, antibody, designed peptides, and CD mutation interfering with transferrin-TCRα interaction inhibit metastasis. This work reveals a novel strategy of tumor evasion of immune surveillance by blocking the coupling between TCRs and the CD3 signaling apparatus to suppress TCR activation. Given the conservation of CD and transferrin up-regulation in metastatic tumors, the strategy might be a common metastatic mechanism. Targeting transferrin-TCRα holds promise for anti-metastatic treatment.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0578"},"PeriodicalIF":11.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Nanoengineered Terahertz Technology: Generation, Modulation, and Bio-Applications. 纳米工程太赫兹技术的进展：太赫兹产生、调制和生物应用。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI: 10.34133/research.0562

Zhongwei Jin, Jing Lou, Fangzhou Shu, Zhi Hong, Cheng-Wei Qiu

{"title":"Advances in Nanoengineered Terahertz Technology: Generation, Modulation, and Bio-Applications.","authors":"Zhongwei Jin, Jing Lou, Fangzhou Shu, Zhi Hong, Cheng-Wei Qiu","doi":"10.34133/research.0562","DOIUrl":"10.34133/research.0562","url":null,"abstract":"Recent advancements in nanotechnology have revolutionized terahertz (THz) technology. By enabling the creation of compact, efficient devices through nanoscale structures, such as nano-thick heterostructures, metasurfaces, and hybrid systems, these innovations offer unprecedented control over THz wave generation and modulation. This has led to substantial enhancements in THz spectroscopy, imaging, and especially bio-applications, providing higher resolution and sensitivity. This review comprehensively examines the latest advancements in nanoengineered THz technology, beginning with state-of-the-art THz generation methods based on heterostructures, metasurfaces, and hybrid systems, followed by THz modulation techniques, including both homogeneous and individual modulation. Subsequently, it explores bio-applications such as novel biosensing and biofunction techniques. Finally, it summarizes findings and reflects on future trends and challenges in the field. Each section focuses on the physical mechanisms, structural designs, and performances, aiming to provide a thorough understanding of the advancements and potential of this rapidly evolving technology domain. This review aims to provide insights into the creation of next-generation nanoscale THz devices and applications while establishing a comprehensive foundation for addressing key issues that limit the full implementation of these promising technologies in real-world scenarios.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0562"},"PeriodicalIF":11.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finely Tailored Conjugated Small Molecular Nanoparticles for Near-Infrared Biomedical Applications. 精细定制的共轭小分子纳米颗粒近红外生物医学应用。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.34133/research.0534

Xiaozhen Li, Ruohan Zhang, Yanlong Yang, Wei Huang

{"title":"Finely Tailored Conjugated Small Molecular Nanoparticles for Near-Infrared Biomedical Applications.","authors":"Xiaozhen Li, Ruohan Zhang, Yanlong Yang, Wei Huang","doi":"10.34133/research.0534","DOIUrl":"10.34133/research.0534","url":null,"abstract":"Near-infrared (NIR) phototheranostics (PTs) show higher tissue penetration depth, signal-to-noise ratio, and better biosafety than PTs in the ultraviolet and visible regions. However, their further advancement is severely hindered by poor performances and short-wavelength absorptions/emissions of PT agents. Among reported PT agents, conjugated small molecular nanoparticles (CSMNs) prepared from D-A-typed photoactive conjugated small molecules (CSMs) have greatly mediated this deadlock by their high photostability, distinct chemical structure, tunable absorption, intrinsic multifunctionality, and favorable biocompatibility, which endows CSMNs with more possibilities in biological applications. This review aims to introduce the recent progress of CSMNs for NIR imaging, therapy, and synergistic PTs with a comprehensive summary of their molecular structures, structure types, and optical properties. Moreover, the working principles of CSMNs are illustrated from photophysical and photochemical mechanisms and light-tissue interactions. In addition, molecular engineering and nanomodulation approaches of CSMs are discussed, with an emphasis on strategies for improving performances and extending absorption and emission wavelengths to the NIR range. Furthermore, the in vivo investigation of CSMNs is illustrated with solid examples from imaging in different scenarios, therapy in 2 modes, and synergistic PTs in combinational functionalities. This review concludes with a brief conclusion, current challenges, and future outlook of CSMNs.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0534"},"PeriodicalIF":11.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-atoms: From Metamaterials to Metachips. 超原子：从超材料到超芯片。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.34133/research.0587

Hao Chi Zhang, Sen Gong, Le Peng Zhang, Yaxin Zhang, Tie Jun Cui

{"title":"Meta-atoms: From Metamaterials to Metachips.","authors":"Hao Chi Zhang, Sen Gong, Le Peng Zhang, Yaxin Zhang, Tie Jun Cui","doi":"10.34133/research.0587","DOIUrl":"10.34133/research.0587","url":null,"abstract":"Electromagnetic (EM) metamaterials represent a cutting-edge field that achieves anomalously macroscopic properties through artificial design and arrangement of microstructure arrays to freely manipulate EM fields and waves in desired ways. The unit cell of a microstructure array is also called a meta-atom, which can construct effective medium parameters that do not exist in traditional materials or are difficult to realize with traditional technologies. By deep integration with digital information, the meta-atom is evolved to a digital meta-atom, leading to the emergence of information metamaterials. Information metamaterials break the inherent barriers between the EM and digital domains, providing a physical platform for controlling EM waves and modulating digital information simultaneously. The concepts of meta-atoms and metamaterials are also introduced to high-frequency integrated circuit designs to address issues that cannot be solved by traditional methods, since lumped-parameter models become unsustainable at microscopic scales. By incorporating several meta-atoms to form a metachip, precise manipulation of the EM field distribution can be achieved at microscopic scales. In this perspective, we summarize the physical connotations and main classifications of meta-atoms and briefly discuss their future development trends. Through this article, we hope to draw more research attention to explore the potential values of meta-atoms, thereby opening up a broader stage for the in-depth development of metamaterials.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0587"},"PeriodicalIF":11.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0