Research最新文献_第9页

Finely Tailored Conjugated Small Molecular Nanoparticles for Near-Infrared Biomedical Applications. 精细定制的共轭小分子纳米颗粒近红外生物医学应用。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.34133/research.0534

Xiaozhen Li, Ruohan Zhang, Yanlong Yang, Wei Huang

{"title":"Finely Tailored Conjugated Small Molecular Nanoparticles for Near-Infrared Biomedical Applications.","authors":"Xiaozhen Li, Ruohan Zhang, Yanlong Yang, Wei Huang","doi":"10.34133/research.0534","DOIUrl":"10.34133/research.0534","url":null,"abstract":"Near-infrared (NIR) phototheranostics (PTs) show higher tissue penetration depth, signal-to-noise ratio, and better biosafety than PTs in the ultraviolet and visible regions. However, their further advancement is severely hindered by poor performances and short-wavelength absorptions/emissions of PT agents. Among reported PT agents, conjugated small molecular nanoparticles (CSMNs) prepared from D-A-typed photoactive conjugated small molecules (CSMs) have greatly mediated this deadlock by their high photostability, distinct chemical structure, tunable absorption, intrinsic multifunctionality, and favorable biocompatibility, which endows CSMNs with more possibilities in biological applications. This review aims to introduce the recent progress of CSMNs for NIR imaging, therapy, and synergistic PTs with a comprehensive summary of their molecular structures, structure types, and optical properties. Moreover, the working principles of CSMNs are illustrated from photophysical and photochemical mechanisms and light-tissue interactions. In addition, molecular engineering and nanomodulation approaches of CSMs are discussed, with an emphasis on strategies for improving performances and extending absorption and emission wavelengths to the NIR range. Furthermore, the in vivo investigation of CSMNs is illustrated with solid examples from imaging in different scenarios, therapy in 2 modes, and synergistic PTs in combinational functionalities. This review concludes with a brief conclusion, current challenges, and future outlook of CSMNs.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0534"},"PeriodicalIF":11.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-atoms: From Metamaterials to Metachips. 超原子：从超材料到超芯片。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.34133/research.0587

Hao Chi Zhang, Sen Gong, Le Peng Zhang, Yaxin Zhang, Tie Jun Cui

{"title":"Meta-atoms: From Metamaterials to Metachips.","authors":"Hao Chi Zhang, Sen Gong, Le Peng Zhang, Yaxin Zhang, Tie Jun Cui","doi":"10.34133/research.0587","DOIUrl":"10.34133/research.0587","url":null,"abstract":"Electromagnetic (EM) metamaterials represent a cutting-edge field that achieves anomalously macroscopic properties through artificial design and arrangement of microstructure arrays to freely manipulate EM fields and waves in desired ways. The unit cell of a microstructure array is also called a meta-atom, which can construct effective medium parameters that do not exist in traditional materials or are difficult to realize with traditional technologies. By deep integration with digital information, the meta-atom is evolved to a digital meta-atom, leading to the emergence of information metamaterials. Information metamaterials break the inherent barriers between the EM and digital domains, providing a physical platform for controlling EM waves and modulating digital information simultaneously. The concepts of meta-atoms and metamaterials are also introduced to high-frequency integrated circuit designs to address issues that cannot be solved by traditional methods, since lumped-parameter models become unsustainable at microscopic scales. By incorporating several meta-atoms to form a metachip, precise manipulation of the EM field distribution can be achieved at microscopic scales. In this perspective, we summarize the physical connotations and main classifications of meta-atoms and briefly discuss their future development trends. Through this article, we hope to draw more research attention to explore the potential values of meta-atoms, thereby opening up a broader stage for the in-depth development of metamaterials.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0587"},"PeriodicalIF":11.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-Optically Controlled Memristive Device Based on Cu₂O/TiO₂ Heterostructure Toward Neuromorphic Visual System. 面向神经形态视觉系统的Cu2O/TiO2异质结构全光控记忆器件。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.34133/research.0580

Jun Xie, Xuanyu Shan, Ningbo Zou, Ya Lin, Zhongqiang Wang, Ye Tao, Xiaoning Zhao, Haiyang Xu, Yichun Liu

{"title":"All-Optically Controlled Memristive Device Based on Cu2O/TiO2 Heterostructure Toward Neuromorphic Visual System.","authors":"Jun Xie, Xuanyu Shan, Ningbo Zou, Ya Lin, Zhongqiang Wang, Ye Tao, Xiaoning Zhao, Haiyang Xu, Yichun Liu","doi":"10.34133/research.0580","DOIUrl":"10.34133/research.0580","url":null,"abstract":"The optoelectronic memristor integrates the multifunctionalities of image sensing, storage, and processing, which has been considered as the leading candidate to construct novel neuromorphic visual system. In particular, memristive materials with all-optical modulation and complementary metal oxide semiconductor (CMOS) compatibility are highly desired for energy-efficient image perception. As a p-type oxide material, Cu2O exhibits outstanding theoretical photoelectric conversion efficiency and broadband photoresponse. In this work, an all-optically controlled memristor based on the Cu2O/TiO2/sodium alginate nanocomposite film is developed. Optical potentiation and depression behaviors have been implemented by utilizing visible (680 nm) and ultraviolet (350 nm) light. Furthermore, a 7 × 9 optoelectronic memristive array with satisfactory device variation and environment stability is constructed to emulate the image preprocessing function in biological retina. The random noise can be reduced effectively by utilizing bidirectional optical input. Beneficial from the image preprocessing function, the accuracy of handwritten digit classification increases more than 60%. Our work presents a pathway toward high-efficient neuromorphic visual system and promotes the development of artificial intelligence technology.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0580"},"PeriodicalIF":11.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression. prmt5介导的ALKBH5甲基化通过增加CD276表达促进结直肠癌免疫逃避。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-08 eCollection Date: 2025-01-01 DOI: 10.34133/research.0549

Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai

{"title":"PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression.","authors":"Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai","doi":"10.34133/research.0549","DOIUrl":"https://doi.org/10.34133/research.0549","url":null,"abstract":"Numerous diseases have been connected to protein arginine methylations mediated by protein arginine methyltransferase 5 (PRMT5). Clinical investigations of the PRMT5-specific inhibitor GSK3326595 are currently being conducted, and the results are promising for preventing cancers. However, the detailed mechanism of PRMT5 promoting colorectal cancer (CRC) malignant progression remains unclear. Here, we found that PRMT5 directly catalyzes AlkB homologue 5 (ALKBH5) symmetric dimethylation at the R316 residue (meR316-ALKBH5), which enhances TRIM28-mediated ALKBH5 ubiquitination degradation. Then, an ALKBH5 decrease attenuates ALKBH5-mediated m6A demethylation on the CD276 transcript 3' untranslated region, which increases CD276 messenger RNA stability and its expression in CRC cells. Furthermore, a CD276 expression increase facilitates CRC immune evasion by inhibiting cytotoxic T-cell functions. Moreover, we revealed that PRMT5-mediated meR316-ALKBH5 activates CD276 transcription by increasing its messenger RNA m6A modification to increase CRC immune evasion in vitro and in vivo. Furthermore, we consistently showed a strong association between meR316-ALKBH5 and poor outcomes in patients with CRC. Finally, we demonstrated that combining an anti-PD1 antibody with the PRMT5 inhibitor GSK3326595 markedly halts the progression of CRC. Our findings could serve as a basis for the development of a PRMT5-meR316-ALKBH5-CD276 axis-targeting treatment approach for CRC.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0549"},"PeriodicalIF":11.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visualization of Hg²⁺ Stress on Plant Health at the Subcellular Level Revealed by a Highly Sensitive Fluorescent Sensor. 高灵敏度荧光传感器显示Hg2+胁迫对植物亚细胞健康的影响

IF 11 1区综合性期刊

Research Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI: 10.34133/research.0570

Sumeera Asghar, Zhenyang Yu, Zheng Zhu, Dengyue Zheng, Zimo Zhao, Yuming Xu, Xiao Liu, Chao Yuan, Yan Li, Wei Wang, Jianfeng Xu, Huailong Teng, Jun Li, Wen-Chao Yang, Chunli Chen

{"title":"Visualization of Hg2+ Stress on Plant Health at the Subcellular Level Revealed by a Highly Sensitive Fluorescent Sensor.","authors":"Sumeera Asghar, Zhenyang Yu, Zheng Zhu, Dengyue Zheng, Zimo Zhao, Yuming Xu, Xiao Liu, Chao Yuan, Yan Li, Wei Wang, Jianfeng Xu, Huailong Teng, Jun Li, Wen-Chao Yang, Chunli Chen","doi":"10.34133/research.0570","DOIUrl":"https://doi.org/10.34133/research.0570","url":null,"abstract":"The presence of Hg2+ causes substantial stress to plants, adversely affecting growth and health by disrupting cell cycle divisions, photosynthesis, and ionic homeostasis. Accurate visualization of the spatiotemporal distribution of Hg2+ in plant tissues is crucial for the management of Hg pollution; however, the related research is still at its early stage. Herein, a small-molecule amphiphilic fluorescent probe (termed LJTP2) was developed for the specific detection of Hg2+ with a high sensitivity (~16 nM). Fluorescent imaging applications with LJTP2 not only detected the dynamic distribution of Hg2+ within plant cells at the subcellular level but also enabled the understanding of cell membrane health under Hg2+ stress. This study introduces a valuable imaging tool for elucidating the molecular mechanism of Hg2+ stress in plants, demonstrating the potential of the application of small-molecule fluorescent probes in plant science.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0570"},"PeriodicalIF":11.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination. tRF-AspGTC通过控制trim29介导的半乳糖凝集素-3泛素化促进颅内动脉瘤形成。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI: 10.34133/research.0574

Chao Wang, Bing Yu, Han Zhou, Huanting Li, Shifang Li, Xiaolu Li, Wentao Wang, Yugong Feng, Tao Yu

{"title":"tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination.","authors":"Chao Wang, Bing Yu, Han Zhou, Huanting Li, Shifang Li, Xiaolu Li, Wentao Wang, Yugong Feng, Tao Yu","doi":"10.34133/research.0574","DOIUrl":"https://doi.org/10.34133/research.0574","url":null,"abstract":"Transfer RNA-derived small RNAs, a recently identified class of small noncoding RNAs, play a crucial role in regulating gene expression and are implicated in cerebrovascular diseases. However, the specific biological roles and mechanisms of transfer RNA-derived small RNAs in intracranial aneurysms (IAs) remain unclear. In this study, we identified that the transfer RNA-Asp-GTC derived fragment (tRF-AspGTC) is highly expressed in the IA tissues of both humans and mice. tRF-AspGTC promotes IA formation by facilitating the phenotypic switching of vascular smooth muscle cells, increasing of matrix metalloproteinase 9 expression, and inducing of oxidative stress and inflammatory responses. Mechanistically, tRF-AspGTC binds to galectin-3, inhibiting tripartite motif 29-mediated ubiquitination and stabilizing galectin-3. This stabilization activates the toll-like receptor 4/MyD88/nuclear factor kappa B pathway, further driving phenotypic switching and inflammation. Clinically, circulating exosomal tRF-AspGTC demonstrates strong diagnostic efficacy for IAs and is identified as an independent risk factor for IA occurrence. These findings highlight the potential of tRF-AspGTC as a promising diagnostic biomarker and therapeutic target for IAs.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0574"},"PeriodicalIF":11.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Phosphatase 2A Promotes CD8⁺ T Cell Effector Function through the Augmentation of CD28 Costimulation. 蛋白磷酸酶2A通过增强CD28共刺激促进CD8+ T细胞效应功能。

IF 11 1区综合性期刊

Research Pub Date : 2025-01-02 eCollection Date: 2025-01-01 DOI: 10.34133/research.0545

Kaixiang Zhu, Deepak Rohila, Yuanling Zhao, Dmytro Shytikov, Lize Wu, Fan Zhao, Shurong Hu, Qin Xu, Xuexiao Jin, Linrong Lu

{"title":"Protein Phosphatase 2A Promotes CD8+ T Cell Effector Function through the Augmentation of CD28 Costimulation.","authors":"Kaixiang Zhu, Deepak Rohila, Yuanling Zhao, Dmytro Shytikov, Lize Wu, Fan Zhao, Shurong Hu, Qin Xu, Xuexiao Jin, Linrong Lu","doi":"10.34133/research.0545","DOIUrl":"https://doi.org/10.34133/research.0545","url":null,"abstract":"Protein phosphatase 2A (PP2A) is one of the most abundant serine/threonine phosphatases and plays critical roles in regulating cell fate and function. We previously showed that PP2A regulates the differentiation of CD4+ T cells and the development of thymocytes. Nevertheless, its role in CD8+ T cells remains elusive. By ablating the catalytic subunit α (Cα) of PP2A in CD8+ T cells, we revealed the essential role of PP2A in promoting the effector functions of CD8+ T cells. Notably, PP2A Cα-deficient CD8+ T cells exhibit reduced proliferation and decreased cytokine production upon stimulation in vitro. In vivo, mice lacking PP2A Cα in T cells displayed defective immune responses against lymphocytic choriomeningitis virus infection, associated with reduced CD8+ T cell expansion and decreased cytokine production. Consistently, the ablation of the PP2A Cα subunit in CD8+ T cells results in attenuated antitumor activity in mice. There is a notable decrease in the infiltration of PP2A Cα-deficient CD8+ T cells within the tumor microenvironment, and the cells that do infiltrate exhibit diminished effector functions. Mechanistically, PP2A Cα deficiency impedes CD28-induced AKT Ser473 phosphorylation, thus impairing CD8+ T cell costimulation signal. Collectively, our findings underscore the critical role of phosphatase PP2A as a propeller for CD28-mediated costimulation signaling in CD8+ T cell effector function by fine-tuning T cell activation.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0545"},"PeriodicalIF":11.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review on Multi-Scale Toughening and Regulating Methods for Modern Concrete: From Toughening Theory to Practical Engineering Application. 现代混凝土多尺度增韧调节方法综述：从增韧理论到工程实际应用。

IF 11 1区综合性期刊

Research Pub Date : 2024-12-26 eCollection Date: 2024-01-01 DOI: 10.34133/research.0518

Jinhui Tang, Chang Gao, Yi Li, Jie Xu, Jiale Huang, Disheng Xu, Zhangli Hu, Fangyu Han, Jiaping Liu

{"title":"A Review on Multi-Scale Toughening and Regulating Methods for Modern Concrete: From Toughening Theory to Practical Engineering Application.","authors":"Jinhui Tang, Chang Gao, Yi Li, Jie Xu, Jiale Huang, Disheng Xu, Zhangli Hu, Fangyu Han, Jiaping Liu","doi":"10.34133/research.0518","DOIUrl":"10.34133/research.0518","url":null,"abstract":"Concrete is the most widely used and highest-volume basic material in the word today. Enhancing its toughness, including tensile strength and deformation resistance, can boost the structural load-bearing capacity, minimize cracking, and decrease the amount of concrete and steel required in engineering projects. These advancements are crucial for the safety, durability, energy efficiency, and emission reduction of structural engineering. This paper systematically summarized the brittle characteristics of concrete and the various structural factors influencing its performance at multiple scales, including molecular, nano-micro, and meso-macro levels. It outlines the principles and impacts of concrete toughening and crack prevention from both internal and external perspectives, and discusses recent advancements and engineering applications of toughened concrete. In situ polymerization and fiber reinforcement are currently practical and highly efficient methods for enhancing concrete toughness. These techniques can boost the matrix's flexural strength by 30% and double its fracture energy, achieving an ultimate tensile strength of up to 20 MPa and a tensile strain exceeding 0.6%. In the future, achieving breakthroughs in concrete toughening will probably rely heavily on the seamless integration and effective synergy of multi-scale toughening methods.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0518"},"PeriodicalIF":11.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conformal Metamaterials with Active Tunability and Self-Adaptivity for Magnetic Resonance Imaging. 核磁共振成像中具有主动可调谐和自适应的共形超材料。

IF 11 1区综合性期刊

Research Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI: 10.34133/research.0560

Ke Wu, Xia Zhu, Xiaoguang Zhao, Stephan W Anderson, Xin Zhang

{"title":"Conformal Metamaterials with Active Tunability and Self-Adaptivity for Magnetic Resonance Imaging.","authors":"Ke Wu, Xia Zhu, Xiaoguang Zhao, Stephan W Anderson, Xin Zhang","doi":"10.34133/research.0560","DOIUrl":"10.34133/research.0560","url":null,"abstract":"Metamaterials hold great potential to enhance the imaging performance of magnetic resonance imaging (MRI) as auxiliary devices, due to their unique ability to confine and enhance electromagnetic fields. Despite their promise, the current implementation of metamaterials faces obstacles for practical clinical adoption due to several notable limitations, including their bulky and rigid structures, deviations from optimal resonance frequency, and inevitable interference with the radiofrequency (RF) transmission field in MRI. Herein, we address these restrictions by introducing a flexible and smart metamaterial that enhances sensitivity by conforming to patient anatomies while ensuring comfort during MRI procedures. The proposed metamaterial selectively amplifies the magnetic field during the RF reception phase by passively sensing the excitation signal strength, remaining \"off\" during the RF transmission phase. Additionally, the metamaterial can be readily tuned to achieve a precise frequency match with the MRI system through a controlling circuit. The metamaterial presented here paves the way for the widespread utilization of metamaterials in clinical MRI, thereby translating this promising technology to the MRI bedside.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0560"},"PeriodicalIF":11.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive Chemotactic Flasklike Colloidal Motors Propelled by Rotary F_oF₁-ATP Synthases. 旋转FoF1-ATP合酶驱动的正趋化瓶状胶体马达。

IF 11 1区综合性期刊

Research Pub Date : 2024-12-23 eCollection Date: 2024-01-01 DOI: 10.34133/research.0566

Yue Li, Yingjie Wu, Qiang He

{"title":"Positive Chemotactic Flasklike Colloidal Motors Propelled by Rotary FoF1-ATP Synthases.","authors":"Yue Li, Yingjie Wu, Qiang He","doi":"10.34133/research.0566","DOIUrl":"10.34133/research.0566","url":null,"abstract":"Living microorganisms can perform directed migration for foraging in response to a chemoattractant gradient. We report a biomimetic strategy that rotary FoF1-ATPase (adenosine triphosphatase)-propelled flasklike colloidal motors exhibit positive chemotaxis resembling the chemotactic behavior of bacteria. The streamlined flasklike colloidal particles are fabricated through polymerization, expansion, surface rupture, and re-polymerizing nanoemulsions composed of triblock copolymers and ribose. The as-synthesized particles enable the incorporation of thylakoid vesicles into the cavity, ensuring a geometric asymmetric nanoarchitecture. The chemical gradient in the neck channel across flasklike colloidal motors facilitates autonomous movement at a speed of 1.19 μm/s in a ΔpH value of 4. Computer simulations reveal the self-actuated flasklike colloidal motors driven by self-diffusiophoretic force. These flasklike colloidal motors display positive directional motion along an adenosine diphosphate (ADP) concentration gradient during adenosine triphosphate (ATP) synthesis. The positive chemotaxis is ascribed that the phosphorylation reaction occurring inside colloidal motors generates 2 distinct phoretic torques at the bottom and the opening owing to the diffusion of ADP, thereby a continuous reorientation motion. Such a biophysical strategy that nanosized rotary protein molecular motors propel the directional movement of a flasklike colloidal motor holds promise for designing new types of biomedical swimming nanobots.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0566"},"PeriodicalIF":11.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0