Research最新文献_第9页

A Wearable Integrated Microneedle Electrode Patch for Exercise Management in Diabetes. 用于糖尿病患者运动管理的可穿戴式集成微针电极贴。

IF 11 1区综合性期刊

Research Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI: 10.34133/research.0508

Boyu Zhu, Lihang Zhu, Xinru Li, Ziyi Zhao, Jiayi Cao, Min Qi, Zhigang Gao, Lin Zhou, Bin Su

引用次数: 0

Discovery of High-Risk Clinical Factors That Accelerate Brain Aging in Adults: A Population-Based Machine Learning Study. 发现加速成人大脑老化的高危临床因素：基于人群的机器学习研究。

IF 11 1区综合性期刊

Research Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI: 10.34133/research.0500

Jing Sun, Luyao Wang, Yiwen Gao, Ying Hui, Shuohua Chen, Shouling Wu, Zhenchang Wang, Jiehui Jiang, Han Lv

{"title":"Discovery of High-Risk Clinical Factors That Accelerate Brain Aging in Adults: A Population-Based Machine Learning Study.","authors":"Jing Sun, Luyao Wang, Yiwen Gao, Ying Hui, Shuohua Chen, Shouling Wu, Zhenchang Wang, Jiehui Jiang, Han Lv","doi":"10.34133/research.0500","DOIUrl":"10.34133/research.0500","url":null,"abstract":"Introduction: Brain age prediction using neuroimaging data and machine learning algorithms holds significant promise for gaining insights into the development of neurodegenerative diseases. The estimation of brain age may be influenced not only by the imaging modality but also by multidomain clinical factors. However, the degree to which various clinical factors in individuals are associated with brain structure, as well as the comprehensive relationship between these factors and brain aging, is not yet clear. Methods: In this study, multimodal brain magnetic resonance imaging data and longitudinal clinical information were collected from 964 participants in a population-based cohort with 16 years of follow-up in northern China. We developed a machine learning-based algorithm to predict multimodal brain age and compared the estimated brain age gap (BAG) differences among the 5 groups characterized by varying exposures to these high-risk clinical factors. We then estimated modality-specific brain age in the hypertension group based on hypertension-related regional imaging metrics. Results: The results revealed a significantly larger BAG estimated from multimodal neuroimaging in subjects with 4 or 5 risk factors compared to other groups, suggesting an acceleration of brain aging under cumulative exposure to multiple risk factors. The estimated T1-based BAG exhibited a significantly higher level in the hypertensive subjects compared to the normotensive individuals. Conclusion: Our study provides valuable insights into a range of health factors across lifestyle, metabolism, and social context that are reflective of brain aging and also contributes to the advancement of interventions and public health initiatives targeted at the general population aimed at promoting brain health.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0500"},"PeriodicalIF":11.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intelligent Transmissive Microwave Metasurface with Optical Sensing and Transparency. 具有光学传感和透明度的智能透射微波元表面。

IF 11 1区综合性期刊

Research Pub Date : 2024-10-21 eCollection Date: 2024-01-01 DOI: 10.34133/research.0514

Ya Lun Sun, Xin Ge Zhang, Zhixiang Huang, Han Wei Tian, Tie Jun Cui, Wei Xiang Jiang

{"title":"Intelligent Transmissive Microwave Metasurface with Optical Sensing and Transparency.","authors":"Ya Lun Sun, Xin Ge Zhang, Zhixiang Huang, Han Wei Tian, Tie Jun Cui, Wei Xiang Jiang","doi":"10.34133/research.0514","DOIUrl":"10.34133/research.0514","url":null,"abstract":"Transmissive metasurfaces are essentially conducive to stealth, absorbers, and communications. However, most of the current schemes only allow microwave to transmit and generally adopt multilayer structures or thick dielectric substrates to improve the electromagnetic performance, restricting optical transmission and conformal application. In addition, most metasurfaces still require metal wires and external power suppliers for programmability. Here, we propose and design an intelligent transmissive microwave metasurface with optical sensing and transparency, which provides both microwave and optical channels without redundant optical devices and power suppliers, and the 2 transmission channels are associated with each other. The metasurface is realized by validly integrating photosensitive materials into microwave meta-structures. As a demonstration, we fabricate an ultrathin optically transparent transmissive metasurface based on polyethylene terephthalate substrate and photoresistors, whose thickness is only 0.125 mm. We further construct cross-wavelength transmission links based on the metasurface sample and experimentally validate that the microwave transmissions vary with light intensities under full-polarization and large-angle incidences, and this metasurface possesses high optical transparency. The intelligent transmissive microwave metasurface with optical sensing and transparency has potential applications in optical-microwave hybrid transmission devices and stealth technology.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0514"},"PeriodicalIF":11.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compartmentalized Biomolecular Condensates via Controlled Nucleation. 通过受控成核实现分区化生物分子凝聚体

IF 11 1区综合性期刊

Research Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI: 10.34133/research.0505

Chong Wang, Linyi Zhang, Luoran Shang

引用次数: 0

One-Dimensional Implantable Sensors for Accurately Monitoring Physiological and Biochemical Signals. 用于准确监测生理和生化信号的一维植入式传感器。

IF 11 1区综合性期刊

Research Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI: 10.34133/research.0507

Qianming Li, Wen Wang, Haotian Yin, Kuangyi Zou, Yiding Jiao, Ye Zhang

引用次数: 0

Intelligent Hydrogel-Assisted Hepatocellular Carcinoma Therapy. 智能水凝胶辅助肝癌治疗。

IF 11 1区综合性期刊

Research Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.34133/research.0477

Zixiang Tang, Lin Deng, Jing Zhang, Tao Jiang, Honglin Xiang, Yanyang Chen, Huzhe Liu, Zhengwei Cai, Wenguo Cui, Yongfu Xiong

{"title":"Intelligent Hydrogel-Assisted Hepatocellular Carcinoma Therapy.","authors":"Zixiang Tang, Lin Deng, Jing Zhang, Tao Jiang, Honglin Xiang, Yanyang Chen, Huzhe Liu, Zhengwei Cai, Wenguo Cui, Yongfu Xiong","doi":"10.34133/research.0477","DOIUrl":"10.34133/research.0477","url":null,"abstract":"Given the high malignancy of liver cancer and the liver's unique role in immune and metabolic regulation, current treatments have limited efficacy, resulting in a poor prognosis. Hydrogels, soft 3-dimensional network materials comprising numerous hydrophilic monomers, have considerable potential as intelligent drug delivery systems for liver cancer treatment. The advantages of hydrogels include their versatile delivery modalities, precision targeting, intelligent stimulus response, controlled drug release, high drug loading capacity, excellent slow-release capabilities, and substantial potential as carriers of bioactive molecules. This review presents an in-depth examination of hydrogel-assisted advanced therapies for hepatocellular carcinoma, encompassing small-molecule drug therapy, immunotherapy, gene therapy, and the utilization of other biologics. Furthermore, it examines the integration of hydrogels with conventional liver cancer therapies, including radiation, interventional therapy, and ultrasound. This review provides a comprehensive overview of the numerous advantages of hydrogels and their potential to enhance therapeutic efficacy, targeting, and drug delivery safety. In conclusion, this review addresses the clinical implementation of hydrogels in liver cancer therapy and future challenges and design principles for hydrogel-based systems, and proposes novel research directions and strategies.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0477"},"PeriodicalIF":11.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glycyrrhizic Acid Hydrogel Microparticles Encapsulated with Mesenchymal Stem Cell Exosomes for Wound Healing. 甘草酸水凝胶微粒包裹间充质干细胞外泌体用于伤口愈合

IF 11 1区综合性期刊

Research Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.34133/research.0496

Luting Zhang, Zhiqiang Luo, Hanxu Chen, Xiangyi Wu, Yuanjin Zhao

{"title":"Glycyrrhizic Acid Hydrogel Microparticles Encapsulated with Mesenchymal Stem Cell Exosomes for Wound Healing.","authors":"Luting Zhang, Zhiqiang Luo, Hanxu Chen, Xiangyi Wu, Yuanjin Zhao","doi":"10.34133/research.0496","DOIUrl":"https://doi.org/10.34133/research.0496","url":null,"abstract":"Hydrogel microparticles have been proved to be curative to diabetic wounds. Current trends focus on the integration of bioactive matrix and their smart stimulus-responsive release to meet the complex demand of regeneration in diabetic wound. In this paper, we present novel stem cell exosome-encapsulated Chinese herb glycyrrhizic acid (GA) hydrogel microparticles for wound healing. The integrated GA endows the hydrogel microparticles with antibacterial properties, while the encapsulated exosomes impart them with pro-angiogenesis ability. In addition, as the black phosphorus is incorporated into these hybrid hydrogel microparticles, the release profile of GA and exosomes could be controllable under near-infrared irradiation due to the excellent photothermal effect of black phosphorus and the reversible phase transformation properties of GA. Based on these features, we have demonstrated that these microparticles can effectively kill bacteria, scavenge free radical, and promote angiogenesis from in vitro experiments. Besides, they could also markedly accelerate the wound healing process by down-regulating inflammation and promoting collagen deposition and angiogenesis in bacteria-infected in vivo diabetic wound. These results indicate that the proposed exosome-integrated GA hydrogel microparticles present great potential for clinical diabetic wound treatment.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0496"},"PeriodicalIF":11.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive Novel Transdermal Drug Delivery System for Deep Drug Permeability. 用于深层药物渗透的无创新型透皮给药系统

IF 11 1区综合性期刊

Research Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.34133/research.0504

Huijie Han, Hélder A Santos

引用次数: 0

Erratum to "Enhanced Effects of Intermittent Fasting by Magnetic Fields in Severe Diabetes". 对 "磁场增强间歇性禁食对严重糖尿病患者的影响 "的勘误。

IF 11 1区综合性期刊

Research Pub Date : 2024-10-11 eCollection Date: 2024-01-01 DOI: 10.34133/research.0501

Ying Wang, Chuanlin Feng, Biao Yu, Junjun Wang, Weili Chen, Chao Song, Xinmiao Ji, Ruowen Guo, Guofeng Cheng, Hanxiao Chen, Xinyu Wang, Lei Zhang, Zhiyuan Li, Jialiang Jiang, Can Xie, Haifeng Du, Xin Zhang

引用次数: 0

Adjustable Phase-Amplitude-Phase Acoustic Metasurface for the Implementation of Arbitrary Impedance Matrices. 用于实现任意阻抗矩阵的可调相位-振幅-相位声学元表面。

IF 11 1区综合性期刊

Research Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.34133/research.0502

Yu-Ze Tian, Zhuo-Run Wei, Yan-Feng Wang, Vincent Laude, Yue-Sheng Wang

{"title":"Adjustable Phase-Amplitude-Phase Acoustic Metasurface for the Implementation of Arbitrary Impedance Matrices.","authors":"Yu-Ze Tian, Zhuo-Run Wei, Yan-Feng Wang, Vincent Laude, Yue-Sheng Wang","doi":"10.34133/research.0502","DOIUrl":"https://doi.org/10.34133/research.0502","url":null,"abstract":"Impedance metasurfaces enable accurate regulation of acoustic fields. However, they can hardly supply a flexible response as such perfect operation is accompanied by stringent requirements on the design of unit cells. Actually, an arbitrary lossless and passive target impedance matrix requires the tuning of 3 independent real parameters. The set composed of a reflection phase, a transmission amplitude, and a transmission phase, enables the representation of an arbitrary impedance matrix, possibly possessing singular elements. In this paper, a mechanism of phase-amplitude-phase modulation (PAP modulation) is developed for the generic design of the unit cells of acoustic impedance metasurfaces. Adjustable acoustic impedance metasurfaces are further available under this framework. An impedance unit with 3 mobile parts is designed based on this idea. The assembled metasurface can handle different incidences for acoustic field manipulation at a given frequency. Beam steering and beam splitting are considered as demonstration examples and are verified by numerical simulation and experiment. PAP modulation enriches the design of acoustic impedance metasurfaces and extends the range of application of impedance theory.","PeriodicalId":21120,"journal":{"name":"Research","volume":"7 ","pages":"0502"},"PeriodicalIF":11.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0