微环境干扰增强脑卒中后神经干细胞修复能力的研究。

IF 10.7 1区综合性期刊 Q1 Multidisciplinary

Research Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI:10.34133/research.0829

Hongfei Ge, Haomiao Wang, Rong Hu

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引用次数: 0

摘要

缺血性脑卒中是一种常见的神经系统疾病，在世界范围内缺乏令人满意的治疗方法。神经干细胞（NSC）治疗是一种很有前途的卒中治疗策略，而微环境干扰，包括但不限于酸中毒、氧化应激和过度神经炎症，限制了内源性和外源性NSC在is后的治疗潜力。本研究介绍了常见干扰对NSC的影响及其机制，以筛选出增强NSC在IS后修复能力的可行方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Focusing on Microenvironmental Disturbance to Potentiate Reparative Ability of Neural Stem Cell After Stroke.

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Focusing on Microenvironmental Disturbance to Potentiate Reparative Ability of Neural Stem Cell After Stroke.

Ischemic stroke (IS), a common neurological disease, lacks satisfactory treatments worldwide. Neural stem cell (NSC) therapy is a promising strategy for stroke, while microenvironmental disturbance, including but not limited to acidosis, oxidative stress, and excessive neuroinflammation, restricts the therapeutic potential of endogenous and exogenous NSC post-IS. The present study introduces the effect of common disturbance on NSC and the underlying mechanism to screen out feasible methods aiming to potentiate the reparative capacity of NSC following IS.

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来源期刊

Research Multidisciplinary-Multidisciplinary

CiteScore

13.40

自引率

3.60%

发文量

审稿时长

14 weeks

期刊介绍： Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.