Focusing on Microenvironmental Disturbance to Potentiate Reparative Ability of Neural Stem Cell After Stroke.

Abstract

Ischemic stroke (IS), a common neurological disease, lacks satisfactory treatments worldwide. Neural stem cell (NSC) therapy is a promising strategy for stroke, while microenvironmental disturbance, including but not limited to acidosis, oxidative stress, and excessive neuroinflammation, restricts the therapeutic potential of endogenous and exogenous NSC post-IS. The present study introduces the effect of common disturbance on NSC and the underlying mechanism to screen out feasible methods aiming to potentiate the reparative capacity of NSC following IS.