Reproductive Medicine and Biology最新文献

{"title":"Epigenetic Changes in the Mature Uterus Following Neonatal Feeding of Tamoxifen in Female ICR Mice.","authors":"Yishan Chen, Ruiyun Chen, Sang Guo, Shunhe Lin, Xi Xie, Xishi Liu, Sun-Wei Guo","doi":"10.1002/rmb2.70076","DOIUrl":"10.1002/rmb2.70076","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate changes in immunoexpression of proteins involved in epigenetic regulation in the uterus in female ICR mice following neonatal exposure to tamoxifen.</p><p><strong>Methods: </strong>Thirty-two neonatal mice were randomly assigned to 2 groups: the control and the tamoxifen-treated group. At post-natal day 5 and 42, 8 mice each from the two groups were sacrificed and their uterine tissues were harvested and processed for histology and immunohistochemistry analyses. The immunostaining of Hdac1-3, Dnmt1, Dnmt3a, Kat2a, Ehmt2, Jmjd3, Setdb1, Ezh2, Suz12, Tet1-3, and Six1, an estrogen responsive protein known to regulate endometrial aberrations following developmental exposure to xenobiotic estrogens, was evaluated.</p><p><strong>Results: </strong>At adulthood, tamoxifen-exposed mice exhibited elevated endometrial staining of Hdac1, Setdb1, Suz12, Dnmt1, Dnmt3a, and Six1, but reduced staining of Hdac3, Kat2a, Ezh2, Jmjd3, and Tet1 in the endometrium. In the myometrium, Dnmt1, Dnmt3a, and Six1 staining was elevated, whereas Hdac3, Kat2a, and Jmjd3 staining was decreased.</p><p><strong>Conclusions: </strong>Neonatal tamoxifen exposure induces possibly lasting remodeling of uterine epigenetic regulators as well as Six1 overexpression in female ICR/CD-1 mice, especially in the endometrium. Collectively, these findings indicate that neonatal tamoxifen exposure in female ICR/CD-1 mice not only induces adenomyosis but also might sear a lasting exposure imprint on the reproductive tract.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70076"},"PeriodicalIF":4.3,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148423804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Endometriosis and an Increased Risk of Epithelial Ovarian Cancer and Cardiovascular Disease: Perspective on a Patient-Centered Approach to Endometriosis, a Heterogeneous Disease.","authors":"Sachiko Matsuzaki, Michel Canis","doi":"10.1002/rmb2.70075","DOIUrl":"10.1002/rmb2.70075","url":null,"abstract":"<p><p>A growing body of literature has revealed that patients with endometriosis are at an increased risk for epithelial ovarian cancer (EOC) and cardiovascular disease (CVD). Endometriosis is a heterogeneous disease in terms of its clinical symptoms and the locations of endometriotic lesions. More epidemiological studies investigating the relationship between endometriosis and the risk of EOC and CVD should incorporate location- and symptom-specific analyses of diverse populations according to geography and ancestry. Such analyses would allow us to more effectively prevent and treat these comorbidities for this heterogeneous disease in a patient-oriented manner and improve our understanding of endometriosis's pathophysiology.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70075"},"PeriodicalIF":4.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Omegaven Avoid the Destructive Effect of Procarbazine Over Ovarian Reserve?","authors":"A N Cakir Gungor, S Kara, K Keskinoglu, Basak Gunasti, Yurdun Kuyucu, Serhan Kupeli, Yusuf Karatas, Sevinc Puren Yucel","doi":"10.1002/rmb2.70073","DOIUrl":"10.1002/rmb2.70073","url":null,"abstract":"<p><strong>Purpose: </strong>Procarbazine, an alkylating agent, depletes ovarian reserve. Omegaven exhibits anti-apoptotic, anti-inflammatory, and antioxidant properties. We aimed to investigate the preventative benefits of Omegaven against the deleterious effects of Procarbazine on the ovaries.</p><p><strong>Methods: </strong>Thirty female rats were categorized into groups: Control, <i>n</i> = 6; Omegaven, <i>n</i> = 8; Procarbazine, <i>n</i> = 8; and Procarbazine+Omegaven, <i>n</i> = 8. Biochemical and histological analyses were conducted.</p><p><strong>Results: </strong>Total follicle count calculated from evaluated sections is significantly reduced in the Procarbazine group compared to other groups. Immunoreactivities of inflammatory and apoptotic markers were significantly elevated in the Procarbazine group and were diminished significantly in the Procarbazine+Omegaven group. In the Procarbazine group, ultrastructural alterations due to atresia were marked by the presence of lipid droplets, multivesicular bodies, and eosinophil infiltration. The ultrastructural alterations were less pronounced in the Procarbazine + Omegaven group. In the Procarbazine group, prooxidative, inflammatory, and apoptotic markers in ovarian tissue were elevated, while antioxidative indicators were significantly diminished. Blood chemistry analyses yielded comparable results. AMH levels were markedly reduced in the Procarbazine Group compared to the control group. The AMH levels in the Procarbazine + Omegaven group exhibit a rise significantly in blood serum samples.</p><p><strong>Conclusions: </strong>Omegaven is a promising pharmacological agent for mitigating the deleterious effects of Procarbazine on ovarian reserve.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70073"},"PeriodicalIF":4.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormone Replacement Cycle Frozen-Thawed Embryo Transfer Is Associated With Elevated Perinatal Risk Compared With Natural Ovulatory Cycle Frozen-Thawed and Fresh Embryo Transfers: Retrospective Analysis of 7,593 Live Birth Cycles.","authors":"Satoko Fujioka, Hiroshi Matsumoto, Haruhisa Konishi, Naoko Terawaki, Yoshiharu Nakaoka, Aisaku Fukuda, Yoshiharu Morimoto","doi":"10.1002/rmb2.70072","DOIUrl":"10.1002/rmb2.70072","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated whether perinatal complications in assisted reproductive technology are attributable to embryo cryopreservation or the specific endometrial preparation method, comparing Fresh Embryo Transfer (Fresh ET), Natural Cycle Frozen-thawed Embryo Transfer (NC-FET), and Hormone Replacement Cycle FET (HRC-FET).</p><p><strong>Methods: </strong>A retrospective cohort analysis of 7,593 live-birth cycles (908 Fresh ET, 4,707 HRC-FET, 1,978 NC-FET) performed from 2015 to 2023 was conducted. Multivariable analyses using generalized estimating equations, adjusted for endometrial preparation method, maternal age, BMI, history of delivery, and endometrial thickness, were conducted for the five major complications.</p><p><strong>Results: </strong>Compared with Fresh ET, HRC-FET was associated with significantly increased risks for hypertensive disorders of pregnancy, placenta accreta spectrum, and postpartum hemorrhage due to uterine atony. No significantly increased risks for these adverse outcomes were observed in association with NC-FET. No significant differences were observed for gestational diabetes or placenta previa across groups.</p><p><strong>Conclusions: </strong>The increased risks of adverse maternal and placental outcomes were associated with the HRC protocol rather than the cryopreservation process. These associations suggest that ovulatory-based endometrial preparation strategies, typically characterized by the presence of a corpus luteum, should be considered when medically and logistically feasible to enhance perinatal safety.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70072"},"PeriodicalIF":4.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta-Analysis of Randomized Controlled Trials.","authors":"Xinhong Liang, Xi Li, Liujing Huang, Zhibing Deng, Yihua Yang","doi":"10.1002/rmb2.70070","DOIUrl":"10.1002/rmb2.70070","url":null,"abstract":"<p><strong>Background: </strong>This meta-analysis evaluates the efficacy and safety of intrauterine autologous platelet-rich plasma (PRP) infusion in patients with recurrent implantation failure (RIF).</p><p><strong>Methods: </strong>Following PRISMA guidelines, we systematically searched major databases and included 10 randomized controlled trials (RCTs, <i>n</i> = 1 188). Study quality was assessed using the Cochrane RoB 2.0 tool.</p><p><strong>Results: </strong>PRP infusion significantly improved clinical pregnancy rate (RR = 2.23, 95% CI 1.84-2.69) and live birth rate (RR = 3.74, 95% CI 2.68-5.22) without increasing miscarriage risk. Subgroup analysis indicated that a 0.5 mL PRP volume was as effective as 0.5-1.0 mL, and a notably greater treatment effect was observed in blastocyst transfer cycles compared to cleavage-stage embryo transfers, suggesting potential enhanced benefit in this subgroup.</p><p><strong>Conclusion: </strong>Intrauterine PRP infusion is an effective and safe treatment for RIF. The findings on dose equivalence and differential efficacy by embryo stage offer valuable insights for optimizing clinical application.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70070"},"PeriodicalIF":4.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Long-Read Sequencing of CAH and ADPKD Provides Novel Insights Into the Genetic Diagnosis of Male Infertility\".","authors":"","doi":"10.1002/rmb2.70071","DOIUrl":"10.1002/rmb2.70071","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1002/rmb2.70038.].</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70071"},"PeriodicalIF":4.3,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Leukemia Inhibitory Factor on <i>Sirtuin1</i>, <i>Ilt-4</i>, and Related microRNAs Expression in a Mouse Model of Recurrent Pregnancy Loss.","authors":"Seyed Mohammad Seifati, Fateme Zare, Hossein Ansariniya, Farzaneh Fesahat, Samaneh Harimi, Maryam Imani, Hossein Hadinedoushan","doi":"10.1002/rmb2.70062","DOIUrl":"10.1002/rmb2.70062","url":null,"abstract":"<p><strong>Purpose: </strong>Leukemia Inhibitory Factor (LIF) plays a crucial role in implantation and early pregnancy maintenance. However, its regulatory relationships with molecular markers such as Sirtuin 1 (SIRT1), immunoglobulin-like transcript 4 (ILT-4), and specific microRNAs (miRNA) in recurrent pregnancy loss (RPL) remain underexplored.</p><p><strong>Methods: </strong>This study investigates the effect of LIF on the expression of <i>Sirt1</i>, <i>Ilt-4</i>, and related miRNAs using a mouse model of RPL. Female CBA/J mice mated with DBA/2 J males received LIF treatment. Gene and miRNA expression levels were assessed via quantitative PCR.</p><p><strong>Results: </strong>The LIF-treated group showed significant upregulation of <i>Sirt1</i> on Days 7 and 14. <i>Ilt-4</i> expression also increased significantly on Days 7 and 14 in the LIF group. Among miRNAs, <i>mir-138-5p</i> was significantly upregulated on Day 14 (<i>p</i> = 0.0001), while <i>mir-223-3p</i> was downregulated on Days 7 (<i>p</i> = 0.02) and 14 (<i>p</i> = 0.001). <i>mir-199a-5p</i> showed significant downregulation on Days 7 (<i>p</i> < 0.0001) and 14 (<i>p</i> = 0.0001). Additionally, <i>mir-155-5p</i> demonstrated a significant decrease in the LIF-treated group compared to the PBS group (<i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>These results suggest that LIF modulates critical molecular pathways in RPL by influencing the expression of essential genes and miRNAs, highlighting its potential as a therapeutic target for pregnancy-related complications.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70062"},"PeriodicalIF":4.3,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13279882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Oocyte Yield in Advanced Maternal Age: Toward Age- and Biology-Calibrated Counseling Targets in IVF.","authors":"Philippe Pinton","doi":"10.1002/rmb2.70069","DOIUrl":"10.1002/rmb2.70069","url":null,"abstract":"<p><p>This Commentary examines whether the longstanding concept of an \"optimal\" oocyte number applies equally to women of advanced reproductive age undergoing IVF. Evidence from randomized trials and real-world datasets shows that the relationship between oocyte yield and cumulative live birth rate (CLBR) is strongly age-dependent, with older women often requiring higher oocyte numbers to achieve comparable cumulative outcomes due to biological constraints not captured in current dosing algorithms. RCTs and meta-analyses in predominantly young, homogeneous populations show fresh live birth rates peaking at 8-14 oocytes and CLBR plateauing at 20-25 oocytes, forming the basis of AMH- and weight-based individualized dosing strategies; however, these datasets underrepresent women ≥ 38 years and lack ancestry diversity. This Commentary synthesizes mechanistic biology, randomized trials, registry-level analyses, and population-specific studies across multiple regions. Across products and populations, higher oocyte yield improves CLBR up to a plateau that shifts rightward with age. Advanced reproductive age is characterized by higher aneuploidy, steeper developmental attrition, and lower OHSS risk, supporting evaluation of age-specific oocyte targets. Limitations include sparse RCT data in women ≥ 38 years and incomplete understanding of ancestry-specific modifiers. Age- and population-specific oocyte targets may help refine future individualized dosing algorithms and clinical decision-making.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70069"},"PeriodicalIF":4.3,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13274313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Expert Consensus Statement on Chronic Endometritis: A Comprehensive Literature Review and Modified e-Delphi Study.","authors":"Kotaro Kitaya, Keiji Kuroda, Seung Chik Jwa, Michio Kitajima, Masanori Ono, Iwaho Kikuchi, Tomoko Nakamura, Fumio Yamasaki, Kaori Koga, Tadahiro Yasuo, Shunichiro Tsuji, Fuminori Kimura, Ayumu Ito, Yasushi Hirota, Mari Nomiyama, Nanako Iwami, Kanako Takimoto, Isao Takehara, Yusuke Sako, Kuniaki Ota, Lianghui Diao, Yuye Li, Lei Yan, Wei Huang, Shen Zhang, Qiong Wang, Fang Gu, Jing Shu, Mahvash Zargar, Vitaly A Kushnir, Claudio Benadiva, Constantin-Cristian Văduva, Brecht Geysenbergh, Orestis Tsonis, Tirso Pérez-Medina, Inmaculada Moreno, Sergio Haimovich, Amerigo Vitagliano, Ettore Cicinelli, Maki Kusumi","doi":"10.1002/rmb2.70066","DOIUrl":"10.1002/rmb2.70066","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop international expert consensus statements on chronic endometritis (CE) through a comprehensive literature review of existing evidence and a modified Delphi approach.</p><p><strong>Methods: </strong>Ten panelists of the Japan Society of Reproductive Medicine Female Reproductive Tract Special Interest Group on CE performed a comprehensive review of the literature and derived statements with related comments on six specific domains of interest on CE. A two-round modified e-Delphi questionnaire was conducted among 31 international experts to evaluate the statements.</p><p><strong>Results: </strong>Twenty-three out of 24 statements, including 43 detailed items, on epidemiology (associated diseases and risk factors), symptomatology (asymptomatic or oligosymptomatic nature with subtle and nondescript gynecologic manifestations), etiology and pathogenesis (inflammation, infection, and clinical course), microbiology (associated pathogens), diagnosis (histopathology, immunohistochemistry, hysteroscopy, and microbiome analysis), and treatment (antibiotics, surgery, and multidrug resistance) finally reached a consensus. Notably, for the histopathologic diagnosis of CE, a threshold of ≥ 5 endometrial stromal plasma cells/10 high-power fields received an agreement rate of 81%.</p><p><strong>Conclusions: </strong>This comprehensive literature review and Delphi study provide a real-world clinical perspective on CE from diverse international experts. These consensus statements have the potential to lay a foundation for diagnostic criteria and/or clinical guidelines on CE.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70066"},"PeriodicalIF":4.3,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Vitamins in Preconception Care and Infertility Treatment: A Narrative Review.","authors":"Kuniaki Ota, Toshifumi Takahashi","doi":"10.1002/rmb2.70068","DOIUrl":"10.1002/rmb2.70068","url":null,"abstract":"<p><strong>Background: </strong>Micronutrient supplementation is widely used in infertility care and preconception management, yet clinical evidence supporting its effectiveness differs among vitamins.</p><p><strong>Methods: </strong>This narrative review summarizes current evidence on water- and fat-soluble vitamins in women undergoing infertility treatment, with an emphasis on assisted reproductive technology (ART) outcomes, biological mechanisms, and clinical relevance from a preconception care perspective.</p><p><strong>Main findings: </strong>Among water-soluble vitamins, folate and vitamin B12 show the most consistent associations with ART outcomes, reflecting their central roles in one-carbon metabolism, DNA synthesis, and methylation. Genetic variation in folate metabolism, including methylenetetrahydrofolate reductase polymorphisms, may further modify reproductive outcomes and influence folate formulation choice. In contrast, clinical evidence for vitamins B6 and C remains limited despite biological plausibility. Vitamin D deficiency is highly prevalent among infertile women and has been associated with less favorable reproductive outcomes, although supplementation trials suggest modest and context-dependent benefits. Evidence supporting vitamin E or vitamin A use is largely confined to surrogate markers or specific phenotypes.</p><p><strong>Conclusion: </strong>Despite biological plausibility and widespread use, current evidence does not support routine vitamin supplementation in infertility care. A targeted approach based on documented deficiencies and clinical phenotype is more appropriate.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70068"},"PeriodicalIF":4.3,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13261685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}