Reproductive Medicine and Biology最新文献_第3页

Potential for artificial intelligence in medicine and its application to male infertility. 人工智能在医学中的潜力及其在男性不育症中的应用。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2024-06-28 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12590

Hideyuki Kobayashi

{"title":"Potential for artificial intelligence in medicine and its application to male infertility.","authors":"Hideyuki Kobayashi","doi":"10.1002/rmb2.12590","DOIUrl":"10.1002/rmb2.12590","url":null,"abstract":"Background: The third AI boom, which began in 2010, has been characterized by the rapid evolution and diversification of AI and marked by the development of key technologies such as machine learning and deep learning. AI is revolutionizing the medical field, enhancing diagnostic accuracy, surgical outcomes, and drug production.Methods: This review includes explanations of digital transformation (DX), the history of AI, the difference between machine learning and deep learning, recent AI topics, medical AI, and AI research in male infertility.Main findings results: In research on male infertility, I established an AI-based prediction model for Johnsen scores and an AI predictive model for sperm retrieval in non-obstructive azoospermia, both by no-code AI.Conclusions: AI is making constant progress. It would be ideal for physicians to acquire a knowledge of AI and even create AI models. No-code AI tools have revolutionized model creation, allowing individuals to independently handle data preparation and model development. Previously a team effort, this shift empowers users to craft customized AI models solo, offering greater flexibility and control in the model creation process.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12590"},"PeriodicalIF":2.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of varicocele repair in the era of assisted reproductive technologies: Lessons from 2000 cases of microsurgical varicocele repair. 精索静脉曲张修复术在辅助生殖技术时代的作用：从 2000 例精索静脉曲张显微修复手术中汲取的教训。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12589

Koji Shiraishi

{"title":"Role of varicocele repair in the era of assisted reproductive technologies: Lessons from 2000 cases of microsurgical varicocele repair.","authors":"Koji Shiraishi","doi":"10.1002/rmb2.12589","DOIUrl":"10.1002/rmb2.12589","url":null,"abstract":"Backgrounds: In an era of advanced maternal age, there is less conclusive evidence regarding the treatment outcomes of varicocele repair for assisted reproductive technology (ART). Progress in basic research on varicocele is notable whereas there are many clinically relevant points to discuss.Methods: Based on our experience with more than 2000 cases of microsurgical varicocele repair, we focused on the effectiveness of varicocele repair, pathophysiology, surgical approaches, contributions to ART, sperm DNA fragmentation, and varicocele-associated azoospermia in this review with the aim of identifying clearer directions for basic and clinical research on varicocele.Results: Microsurgical low ligation for varicocele repair is expected to remain the gold standard for surgical therapy. Based on the findings from a number of systematic reviews and meta-analyses, negative opinions regarding the efficacy of microsurgical varicocele repair in male infertility treatment have become virtually nonexistent. However, the majority of evidence regarding surgical indications and effectiveness pertains to improvements in semen parameters or non-ART pregnancy rates.Conclusions: Further understandings regarding to pathophysiology of varicocele will likely be gained through comprehensive genetic, transcriptomic, and epigenetic analyses using blood and testicular samples from humans and we hope to develop new diagnostic methods and pharmacotherapy.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12589"},"PeriodicalIF":2.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11211092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KEAP1-NRF2 system regulates age-related spermatogenesis dysfunction. KEAP1-NRF2系统调控与年龄相关的精子发生功能障碍

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12595

Sohei Kuribayashi, Shinichiro Fukuhara, Hiroaki Kitakaze, Go Tsujimura, Takahiro Imanaka, Koichi Okada, Norichika Ueda, Kentaro Takezawa, Kotoe Katayama, Rui Yamaguchi, Koichi Matsuda, Norio Nonomura

{"title":"KEAP1-NRF2 system regulates age-related spermatogenesis dysfunction.","authors":"Sohei Kuribayashi, Shinichiro Fukuhara, Hiroaki Kitakaze, Go Tsujimura, Takahiro Imanaka, Koichi Okada, Norichika Ueda, Kentaro Takezawa, Kotoe Katayama, Rui Yamaguchi, Koichi Matsuda, Norio Nonomura","doi":"10.1002/rmb2.12595","DOIUrl":"10.1002/rmb2.12595","url":null,"abstract":"Purpose: The average fatherhood age has been consistently increasing in developed countries. Aging has been identified as a risk factor for male infertility. However, its impact on various mechanisms remains unclear. This study focused on the KEAP1-NRF2 oxidative stress response system, by investigating the relationship between the KEAP1-NRF2 system and age-related changes in spermatogenesis.Methods: For examination of age-related changes, we used 10-, 30-, 60-, and 90-week-old mice to compare sperm count, sperm motility, and protein expression. For assessment of Keap1 inhibition, 85-week-old C57BL/6J mice were randomly assigned to the following groups: control and bardoxolone methyl (KEAP1 inhibitor). Whole-exome sequencing of a Japanese cohort of patients with non-obstructive azoospermia was performed for evaluating.Results: Sperm count decreased significantly with aging. Oxidative stress and KEAP1 expression in the testes were elevated. Inhibition of KEAP1 in aging mice significantly increased sperm count compared with that in the control group. In the human study, the frequency of a missense-type SNP (rs181294188) causing changes in NFE2L2 (NRF2) activity was significantly higher in patients with non-obstructive azoospermia than in healthy control group.Conclusions: The KEAP1-NRF2 system, an oxidative stress response system, is associated with age-related spermatogenesis dysfunction.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12595"},"PeriodicalIF":2.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sperm morphology: Evaluating its clinical relevance in contemporary fertility practice. 精子形态学：评估其在当代生育实践中的临床意义。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12594

Daniel L Pelzman, Jay I Sandlow

{"title":"Sperm morphology: Evaluating its clinical relevance in contemporary fertility practice.","authors":"Daniel L Pelzman, Jay I Sandlow","doi":"10.1002/rmb2.12594","DOIUrl":"10.1002/rmb2.12594","url":null,"abstract":"Background: The World Health Organization (WHO) recommends reporting sperm morphology in a standard semen analysis. However, the clinical utility and prognostic value of morphology is often debated.Methods: We reviewed and summarized studies that assessed both the benefits and limitations of sperm morphology in the context of natural fertility, assisted reproductive technologies, and recurrent pregnancy loss. We additionally describe possible environmental and anatomical etiologies of teratozoospermia.Results: Sperm morphology evaluation has continuously evolved since the release of the first WHO manual in 1980. Initially, several large studies reported significant inverse associations between fertility outcomes and teratozoospermia. Most recent studies, however, fail to show an association between sperm morphology and natural or assisted fertility outcomes.Conclusion: Sperm morphology analysis may have limited diagnostic and prognostic value. Providers should be aware of these limitations when counseling or managing infertile patients.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12594"},"PeriodicalIF":2.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of functional hypothalamic amenorrhea in a cohort of women referred because of polycystic ovary syndrome. 因多囊卵巢综合征而转诊的一组妇女中功能性下丘脑闭经的患病率。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2024-06-19 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12591

Iris Holzer, Rodrig Marculescu, Vanessa Begemann, Sophie Haaser, Didier Dewailly, Johannes Ott

引用次数: 0

Reproductive outcomes of embryo cryopreservation and transfer at the start-up phase of fertility preservation in Japan. 日本生育力保存启动阶段胚胎冷冻和移植的生殖效果。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2024-06-19 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12581

Seido Takae, Miyuki Harada, Kentaro Nakamura, Sayako Furuyama, Masanori Ono, Yutaka Osuga, Nao Suzuki

{"title":"Reproductive outcomes of embryo cryopreservation and transfer at the start-up phase of fertility preservation in Japan.","authors":"Seido Takae, Miyuki Harada, Kentaro Nakamura, Sayako Furuyama, Masanori Ono, Yutaka Osuga, Nao Suzuki","doi":"10.1002/rmb2.12581","DOIUrl":"10.1002/rmb2.12581","url":null,"abstract":"Purpose: To verify the effectiveness of embryo transfer (ET) using cryopreserved embryo as fertility preservation (FP).Methods: This study was a questionnaire survey. The total number of embryo cryopreservation (EC) was investigated between 2014 and 2020. And for patients who underwent ET among study period, details of EC, outcome of ET, number of live births, and mortality were investigated.Results: Of the 150 facilities, 114 responded (76.0%). A total of 1420 EC were performed during the study period; and ET was performed for 417 patients. Breast cancer was the most common primary disease. A total of 199 live births (including prospective) were obtained by ET; 1.7 EC and 2.2 ET were performed per patient, and live birth rate was 21.4% per ET (28.1% on 35-37-year-old patients). The number of EC and ET increased with age. The final birth rate, including pregnancies other than FP, was 51.8%. Ovarian stimulation with aromatase inhibitors was commonly used, although with no effect on live birth rates. Random start stimulation was also common, experienced by 36.3% of breast cancer patients.Conclusion: Reproductive outcomes of ETs following EC as FP are acceptable. This research project was registered in the University Hospital Medical Information Network (UMIN000043664).","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12581"},"PeriodicalIF":2.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11185938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives. 子宫内膜异位症的孕酮抵抗：病理生理学视角和潜在的替代治疗方法。

IF 3.4 3区医学

Reproductive Medicine and Biology Pub Date : 2024-06-07 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12588

Hsiao-Chien Tang, Ting-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai

{"title":"Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives.","authors":"Hsiao-Chien Tang, Ting-Chien Lin, Meng-Hsing Wu, Shaw-Jenq Tsai","doi":"10.1002/rmb2.12588","DOIUrl":"10.1002/rmb2.12588","url":null,"abstract":"Background: Endometriosis is a common gynecological disease affecting women of reproductive age. Patients with endometriosis frequently experience severe chronic pain and have higher chances to experience infertility. Progesterone resistance is a major problem that develops during the medical treatment of endometriosis, which often leads to treatment failure of hormonal therapies. Previous studies indicated that the dysregulation of progesterone receptors (PR) is the primary factor leading to progesterone resistance in endometriosis.Methods: This review article systematically reviewed and summarized findings extracted from previously published papers available on PubMed, encompassing both experimental studies and clinical trials.Main findings: Various determinants influencing PR expression in endometriosis have been identified, including the environmental toxins, microRNAs, cell signaling pathways, genetic mutations, and the pro-inflammatory cytokines. The selective estrogen/progesterone receptor modulators have emerged as novel therapeutic approaches for treating endometriosis, offering potential improvements in overcoming progesterone resistance.Conclusion: Concerns and limitations persist despite the newly developed drugs. Therefore, studies on unraveling new therapeutic targets based on the molecular mechanisms of progesterone resistance is warranted for the development potential alternatives to overcome hormonal treatment failure in endometriosis.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12588"},"PeriodicalIF":3.4,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of single versus grouped culture of human cumulus-oocyte complexes in PCOS women treated with biphasic in vitro maturation: A sibling oocyte pilot study. 对接受双相体外成熟治疗的多囊卵巢综合征妇女进行人类精原细胞-卵母细胞复合体单个培养与分组培养的效果：同胞卵母细胞试验研究。

IF 3.4 3区医学

Reproductive Medicine and Biology Pub Date : 2024-06-07 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12587

Huy H Pham, Anh H Le, Tri C Nguyen, Mai P Q Ma, Nazli Akin, Toan D Pham, Minh H N Nguyen, Ho L Le, Bao G Huynh, Johan Smitz, Tuong M Ho, Lan N Vuong

{"title":"Effect of single versus grouped culture of human cumulus-oocyte complexes in PCOS women treated with biphasic in vitro maturation: A sibling oocyte pilot study.","authors":"Huy H Pham, Anh H Le, Tri C Nguyen, Mai P Q Ma, Nazli Akin, Toan D Pham, Minh H N Nguyen, Ho L Le, Bao G Huynh, Johan Smitz, Tuong M Ho, Lan N Vuong","doi":"10.1002/rmb2.12587","DOIUrl":"10.1002/rmb2.12587","url":null,"abstract":"Purpose: This study investigated the differences in the maturation rate of single versus grouped cumulus-oocyte complexes (COCs) culture methods for capacitation in vitro maturation (CAPA-IVM) in women with polycystic ovary syndrome (PCOS).Methods: This study was performed at My Duc Phu Nhuan Hospital, Vietnam from October 1, 2020 to October 24, 2021. Women aged 18-37 years with a diagnosis of PCOS were recruited. COCs from each woman were randomly divided into two groups: single or grouped culture during CAPA-IVM culture. The primary outcome was the maturation rate.Results: A total of 322 COCs from 15 eligible women included were randomly assigned to the two study groups. The maturation rate was comparable between the single and grouped culture groups (61.3% vs. 64.8%; p = 0.56). There were no significant differences in the number of 2-pronuclei fertilized oocytes, number of day-3 embryos, and number of good-quality embryos in the two culture method groups. In the single culture group, COCs morphology was associated with the day-3 embryo formation rate but not the maturation rate.Conclusions: Comparable oocyte maturation and embryology outcomes between single and grouped COCs culture utilizing sibling COCs derived from women with PCOS suggest the feasibility of both methods for CAPA-IVM culture.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12587"},"PeriodicalIF":3.4,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Verification of the utility of the gonadotropin starting dose calculator in progestin-primed ovarian stimulation: A comparison of empirical and calculated controlled ovarian stimulation. 验证促性腺激素起始剂量计算器在孕激素促排卵中的实用性：经验性和计算性控制卵巢刺激的比较。

IF 3.4 3区医学

Reproductive Medicine and Biology Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12586

Masato Kobanawa, Jouji Yoshida

{"title":"Verification of the utility of the gonadotropin starting dose calculator in progestin-primed ovarian stimulation: A comparison of empirical and calculated controlled ovarian stimulation.","authors":"Masato Kobanawa, Jouji Yoshida","doi":"10.1002/rmb2.12586","DOIUrl":"10.1002/rmb2.12586","url":null,"abstract":"Purpose: To validate the effectiveness of a gonadotropin starting dose calculator for progestin-primed ovarian stimulation (PPOS), we conducted a study comparing the outcomes of oocyte retrieval between a group assigned gonadotropin doses via the calculator and a control group, where doses were determined by the clinician's empirical judgment.Methods: Patients underwent controlled ovarian stimulation (COS) using the PPOS method, followed by oocyte retrieval. We assessed and compared the results of COS and oocyte retrieval in both groups. Additionally, we examined the concordance rate between the number of oocytes actually retrieved and the target number of oocytes in each group.Results: The calculated group demonstrated a significantly higher number of preovulation follicles and a higher ovarian sensitivity index than the control group. Furthermore, the discrepancy between the target and actual number of oocytes retrieved was notably smaller in the calculated group. The concordance rate between the target and actual number of oocytes was significantly greater in the calculated group.Conclusions: The gonadotropin starting dose calculator proved to be effective within the PPOS protocol, offering a reliable method for predicting the approximate number of oocytes to be retrieved, irrespective of the COS protocol employed.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12586"},"PeriodicalIF":3.4,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility. 基于男性不育症患者精浆/血清中多种微量元素浓度比值的新聚类模型。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2024-05-28 eCollection Date: 2024-01-01 DOI: 10.1002/rmb2.12584

Takazo Tanaka, Kosuke Kojo, Yoshiyuki Nagumo, Atsushi Ikeda, Takuya Shimizu, Shunsuke Fujimoto, Toshiyuki Kakinuma, Masahiro Uchida, Tomokazu Kimura, Shuya Kandori, Hiromitsu Negoro, Hiroyuki Nishiyama

{"title":"A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility.","authors":"Takazo Tanaka, Kosuke Kojo, Yoshiyuki Nagumo, Atsushi Ikeda, Takuya Shimizu, Shunsuke Fujimoto, Toshiyuki Kakinuma, Masahiro Uchida, Tomokazu Kimura, Shuya Kandori, Hiromitsu Negoro, Hiroyuki Nishiyama","doi":"10.1002/rmb2.12584","DOIUrl":"10.1002/rmb2.12584","url":null,"abstract":"Purpose: To investigate whether seminal plasma (SP)/serum ratios of multiple trace elements (TEs) can classify patients with male subfertility.Methods: SP/serum ratios of 20 TEs (lithium, sodium, magnesium, phosphorus, sulfur, potassium, calcium, manganese, iron, cobalt, copper, zinc, arsenic, selenium, rubidium, strontium, molybdenum, cesium, barium, and thallium) were calculated for healthy volunteers (n = 4) and those consulting for male subfertility (n = 245). Volunteer semen samples were collected by split ejaculation into early and subsequent fractions, and SP/serum ratio data were compared between fractions. The patients' SP/serum ratio data were used in an unsupervised clustering analysis and qualitatively compared with the data from the fractions of ejaculation from the volunteers. Semen quality parameters and pregnancy outcomes were compared between patient clusters.Results: The early fraction of volunteers was characterized by lower phosphorus and arsenic and 18 other higher TEs than the subsequent fraction. Cluster analysis classified patients into four distinct clusters, one sharing characteristics with the early fraction and another with the subsequent fraction. One cluster with the early fraction characteristics had significantly lower semen volume and higher pregnancy rates from spontaneous pregnancies or intrauterine insemination.Conclusions: Classification of patients based on SP/serum ratios of multiple TEs represents the dominance of fractions of ejaculation samples.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"23 1","pages":"e12584"},"PeriodicalIF":2.7,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11131575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0