NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms.

IF 2.7 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Reproductive Medicine and Biology Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI:10.1002/rmb2.12621
Miki Inoue, Kanako Miyabayashi, Yuichi Shima
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引用次数: 0

Abstract

Background: NR5A1 plays essential roles in the development of various tissues, including the ventromedial hypothalamus, pituitary gonadotrope, adrenal cortex, spleen, testis, and ovary. Additionally, NR5A1-positive cells in these tissues exhibit developmental and functional heterogeneity.

Methods: This review summarizes recent knowledge on the relationships between physiological functions and gene cascades regulated by NR5A1 in each tissue. In addition, we also present several intriguing examples of disparities in Nr5a1 gene regulation within the same tissues, which are relevant to developmentally and functionally heterogeneous cell populations.

Main findings: The adrenal cortex and testicular Leydig cells exhibit clear biphasic developmental processes, resulting in functionally distinct fetal and adult cell populations in which Nr5a1 is regulated by distinct enhancers. Similar heterogeneity of cell populations has been suggested in other tissues. However, functional differences in each cell population remain unclear, and Nr5a1 gene regulation disparities have not been reported.

Conclusion: Some steroidogenic tissues demonstrate biphasic development, with fetal and adult cell populations playing distinct and crucial physiological roles. Nr5a1 regulation varies across cell populations, and analyses of gene cascades centered on NR5A1 will aid in understanding the mechanisms underlying the development and maturation of reproductive capabilities.

NR5A1和细胞群体异质性:对发育和功能差异和调控机制的见解。
背景:NR5A1在下丘脑腹内侧、垂体促性腺、肾上腺皮质、脾脏、睾丸、卵巢等多种组织的发育中发挥重要作用。此外,nr5a1阳性细胞在这些组织中表现出发育和功能的异质性。方法:本文综述了近年来NR5A1在各组织中调控的基因级联反应与生理功能之间的关系。此外,我们还提出了几个有趣的Nr5a1基因调控差异的例子,这些差异与发育和功能异质细胞群有关。主要发现:肾上腺皮质和睾丸间质细胞表现出明显的双相发育过程,导致Nr5a1受不同增强子调控的胎儿和成人细胞群功能不同。在其他组织中也发现了类似的细胞群异质性。然而,每种细胞群的功能差异尚不清楚,Nr5a1基因调控差异尚未报道。结论:某些甾体源性组织表现为双期发育,胎儿细胞群和成人细胞群在其中发挥着独特而关键的生理作用。Nr5a1的调控因细胞群而异,分析以Nr5a1为中心的基因级联将有助于理解生殖能力发育和成熟的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.70
自引率
5.90%
发文量
53
审稿时长
20 weeks
期刊介绍: Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.
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