Reproductive Medicine and Biology最新文献

A Systematic Evidence-Based Review Regarding miRNA Polymorphisms in Recurrent Implantation Failure. 复发性植入失败中miRNA多态性的系统性循证综述。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-07-30 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12670

Bogdan Doroftei, Ovidiu-Dumitru Ilie, Ana-Maria Dabuleanu, Mara Doroftei, Ciprian Ilea, Sergiu Timofeiov, Anca Bivoleanu, Elena Tataranu

{"title":"A Systematic Evidence-Based Review Regarding miRNA Polymorphisms in Recurrent Implantation Failure.","authors":"Bogdan Doroftei, Ovidiu-Dumitru Ilie, Ana-Maria Dabuleanu, Mara Doroftei, Ciprian Ilea, Sergiu Timofeiov, Anca Bivoleanu, Elena Tataranu","doi":"10.1002/rmb2.12670","DOIUrl":"10.1002/rmb2.12670","url":null,"abstract":"Background: This systematic review aimed to evaluate whether specific single nucleotide polymorphisms (SNPs) in miRNAs are associated with recurrent implantation failure (RIF).Methods: A comprehensive literature search was conducted across PubMed-MEDLINE, Web of Science, Scopus, and the Excerpta Medica DataBASE.Results: The Newcastle-Ottawa Scale (NOS) yielded an intermediate to high quality, with one study rated with 6 stars, and the remaining four with 7 stars. RIF risk-related genotypes included miR-196a, miR-449b, miR-34a, miR-146aCG+GG-miR-196a2CC, miR-149TT-miR-196a2CC, miR-196a2CC-miR-499AA, miR-608GC-miR-938CC, miR-27aAG-miR-423CC/miR-604AG/GG and miR-34aC>A AA-miR-130aG>A GG. Protective combinations included miR-1302-3, miR-631II-miR-1302-3CT, and miR-938CC-miR-1302-3CT. Protective allele combinations G-T-T-A, C-T, T-T-G, T-T and G-C-A-G, G-A-G, A-G-G were less frequent in RIF cases, whereas A-T-C, T-C-C-T, T-C-T, A-C-G-A, A-A-G-G, G-A-A-A, A-A-C-A and G-G-A haplotypes were more commonly associated with increased risk. Notably, miR-608 GC+CC, miR-1302-3 CC, miR-27a AG+GG, miR-423 CA+AA, miR-604 AG+GG, miR-222 GT+TT, and miR-34a GA+AA were associated with altered coagulation parameters. Additionally, miR-222 correlated with decreased creatinine levels, the G>T mutation with elevated follicle-stimulating hormone (FSH), miR-34aC>A AA genotype with reduced thyroid-stimulating hormone (TSH) levels, and CA+AA with increased blood urea nitrogen (BUN) levels.Conclusions: This systematic review highlights that specific miRNA SNPs and haplotype combinations are significantly associated with either increased susceptibility to or protection against RIF.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12670"},"PeriodicalIF":3.3,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Significance of Biochemical Pregnancy Loss in Recurrent Pregnancy Loss Patients: Insights From Euploid Embryo Transfers Minimizing Embryonic Bias. 生化妊娠丢失在复发性妊娠丢失患者中的临床意义：来自整倍体胚胎移植最小化胚胎偏差的见解。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-07-23 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12668

Yoshimitsu Kuwabara, Tatsunori Shiraishi, Ryoko Kato, Shigeru Matsuda, Akiko Sakata, Yumene Kubota, Ryoko Yokote, Kimihiko Nakao, Mirei Yonezawa, Tomoko Ichikawa, Toshiyuki Takeshita, Shunji Suzuki

{"title":"Clinical Significance of Biochemical Pregnancy Loss in Recurrent Pregnancy Loss Patients: Insights From Euploid Embryo Transfers Minimizing Embryonic Bias.","authors":"Yoshimitsu Kuwabara, Tatsunori Shiraishi, Ryoko Kato, Shigeru Matsuda, Akiko Sakata, Yumene Kubota, Ryoko Yokote, Kimihiko Nakao, Mirei Yonezawa, Tomoko Ichikawa, Toshiyuki Takeshita, Shunji Suzuki","doi":"10.1002/rmb2.12668","DOIUrl":"10.1002/rmb2.12668","url":null,"abstract":"Purpose: To evaluate the clinical relevance of biochemical pregnancy loss (BPL) in recurrent pregnancy loss (RPL) patients, using data from preimplantation genetic testing for aneuploidy (PGT-A) to minimize embryonic factors.Methods: This retrospective cohort study included 52 PGT-A cycles (48 patients) with single euploid embryo transfers between April 2020 and December 2022. Patients were stratified into three groups: Group A (ART failure without RPL, 18 cycles/17 patients), Group B (RPL following ART pregnancies, 12 cycles/10 patients), and Group C (RPL following natural pregnancies, 22 cycles/21 patients). This classification aimed to assess maternal factors contributing to BPL across different clinical backgrounds. The incidence of BPL, clinical pregnancy rate, and predictive performance of ART outcomes were analyzed, with and without BPL included, using ROC curve analysis.Results: Biochemical pregnancy loss occurred in 0% (A), 25.0% (B), and 37.5% (C) of patients (p = 0.037). Incorporating BPL into miscarriage history significantly improved ART outcome prediction (AUC 0.871 vs. 0.759).Conclusion: Biochemical pregnancy loss after euploid embryo transfer likely reflects maternal or endometrial pathology. Incorporating BPL into the diagnostic criteria for RPL may enhance clinical assessment and personalized care.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12668"},"PeriodicalIF":2.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Status of In Vitro Oocyte Growth and Development in Mammals. 哺乳动物体外卵母细胞生长发育的现状。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-07-17 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12669

Yuji Hirao

{"title":"Current Status of In Vitro Oocyte Growth and Development in Mammals.","authors":"Yuji Hirao","doi":"10.1002/rmb2.12669","DOIUrl":"10.1002/rmb2.12669","url":null,"abstract":"Background: In vitro-matured oocytes play an increasingly vital role in livestock production and fertility treatments. However, oocytes grown in vitro are not yet practical for widespread use. So far, only mouse oocytes have achieved full developmental competence granted in vitro from the early growth stage.Methods: This review provides an overview of established culture methods and conditions, analyzing their effects. When evaluating studies, outcomes specifically related to in vitro-grown (IVG) oocytes rather than the follicle were prioritized.Main findings: Neonatal mouse first-wave oocytes show a hypothesized linear volume increase, and IVG mouse oocytes have followed a similar developmental timeline across multiple studies. In other species, a proportion of bovine oocytes from early antral follicles achieved full size during 2-week cultures, with some producing viable offspring, confirming developmental competence. Preantral follicle culture systems are typically designed to address specific research parameters, such as developmental competence assessment. Preimplantation embryogenesis has been reported in several species, including humans.Conclusion: For species with oocytes ≥ 125 μm in diameter, normal growth can be achieved during the final 2 weeks of growth as shown in bovines. However, developing culture systems that can maintain follicle viability for the preceding 4-5 weeks remains a critical challenge.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12669"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian Function Restoration Using Autologous Platelet-Rich Plasma. 利用自体富血小板血浆恢复卵巢功能。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-07-16 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12666

Zijia Guo, Kazuhiro Kawamura

{"title":"Ovarian Function Restoration Using Autologous Platelet-Rich Plasma.","authors":"Zijia Guo, Kazuhiro Kawamura","doi":"10.1002/rmb2.12666","DOIUrl":"10.1002/rmb2.12666","url":null,"abstract":"Background: With the trend of delayed childbearing, the incidence of poor ovarian response (POR) with diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI) has increased. Effective treatments for ovarian function restoration are limited. Platelet-rich plasma (PRP), an autologous regenerative therapy, shows potential for improving ovarian function; however, its mechanisms of action and optimal treatment protocols remain unclear.Methods: A literature review was conducted using PubMed and Google Scholar, covering studies published from January 2021 to March 2025, focusing on preclinical and clinical studies evaluating the effects of PRP on ovarian function.Main findings: Preclinical studies indicate that PRP promotes primordial follicle activation and growth. It also enhances oocyte quality by promoting angiogenesis, exerting anti-inflammatory and antioxidative effects, and modulating the extracellular matrix. Clinically, PRP may increase the number of retrieved oocytes and improve certain ovarian reserve markers, but its impact on oocyte quality and pregnancy rates remains inconclusive. The optimal dosage and treatment duration also require further investigation.Conclusions: PRP holds promise in reproductive medicine, but additional research is required to evaluate long-term effects, optimize treatment protocols, and standardize preparation methods.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12666"},"PeriodicalIF":2.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose-Induced Developmental Dynamics: Understanding Male Prevalence in Early Mouse Embryo Stages. 葡萄糖诱导的发育动力学：了解小鼠早期胚胎阶段的男性患病率。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-07-05 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12667

Fikri Ardhani, Asako Okamoto, Masayuki Shimada

{"title":"Glucose-Induced Developmental Dynamics: Understanding Male Prevalence in Early Mouse Embryo Stages.","authors":"Fikri Ardhani, Asako Okamoto, Masayuki Shimada","doi":"10.1002/rmb2.12667","DOIUrl":"10.1002/rmb2.12667","url":null,"abstract":"Purpose: Glucose plays a critical role in early embryonic development, influencing metabolic dynamics and developmental competence in a sex-specific manner. This study investigates the complex interplay between glucose availability, developmental competence, and sex-specific outcomes in preimplantation mouse embryos.Methods: Mouse embryos were cultured in a modified KSOM medium with varying glucose concentrations (0-20 mM), monitored via time-lapse microscopy, and analyzed for developmental competence, sex determination by PCR, and X-linked metabolic gene expression. Stage-specific glucose addition/removal experiments and PDHA1 immunofluorescence staining were performed to assess temporal glucose dependency and sex-specific metabolic patterns.Results: Glucose is essential during the morula-to-blastocyst transition. Analysis of developmental dynamics showed that glucose concentration affected the variability in developmental rates, particularly at the four-cell and eight-cell stages. Interestingly, sex ratio skewing was observed, with male embryos dominating the early developmental groups regardless of glucose levels. Expression analysis of X-linked metabolic genes revealed stage-specific patterns, with PDHA1 exhibiting the highest activity at the eight-cell stage.Conclusions: Glucose availability accelerated embryonic development and created sex-specific patterns of developmental timing, with male embryos exhibiting faster progression rates, which might be associated with differential X-linked PDHA1 metabolic gene expression during early mouse embryogenesis.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12667"},"PeriodicalIF":2.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhabdomyosarcoma Requiring Ovarian Transposition Release for Recurrent Severe Ovulation Pain Following Laparoscopic Ovarian Transposition: A Case Report. 横纹肌肉瘤需要卵巢转位释放治疗腹腔镜卵巢转位后复发性严重排卵疼痛：1例报告。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-24 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12665

Yuko Shimoji, Keiko Mekaru, Akiko Ikemura, Natsuki Tamashiro, Shuko Chinen, Rie Nakamura, Chiaki Heshiki, Wataru Kudaka, Masayuki Sekine

{"title":"Rhabdomyosarcoma Requiring Ovarian Transposition Release for Recurrent Severe Ovulation Pain Following Laparoscopic Ovarian Transposition: A Case Report.","authors":"Yuko Shimoji, Keiko Mekaru, Akiko Ikemura, Natsuki Tamashiro, Shuko Chinen, Rie Nakamura, Chiaki Heshiki, Wataru Kudaka, Masayuki Sekine","doi":"10.1002/rmb2.12665","DOIUrl":"10.1002/rmb2.12665","url":null,"abstract":"Case: Ovarian transposition (OT) is performed to preserve ovarian function in patients undergoing pelvic or abdominal radiotherapy. Although complications, such as ovarian torsion and cyst formation, have been reported, ovulation-related peritoneal irritation requiring surgical intervention after pediatric OT has not been documented. In this case, a 12-year-old girl who underwent bilateral OT at the age of 6 years during treatment for recurrent rhabdomyosarcoma presented with severe pain in the right lower quadrant. Owing to prior pelvic radiotherapy, the assessment of menstrual history was unreliable. Considering the young age of the patient and the absence of a definitive diagnosis, hormonal therapy, such as low-dose estrogen-progestin therapy, was withheld. Conservative management with analgesics was initiated; however, the pain persisted and progressively worsened.Outcome: Emergent laparoscopic OT release was performed for diagnostic and therapeutic purposes, owing to the severity of pain. Intraoperative findings revealed corpus luteum in the retracted right ovary. Postoperatively, the patient's symptoms resolved immediately without recurrence.Conclusion: Ovulation-induced peritoneal irritation should be recognized as a potential postoperative complication following childhood OT. In adolescent patients with a history of pediatric OT and pelvic radiotherapy, ovulation-related complications should be carefully considered during the differential diagnosis of acute abdominal pain.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12665"},"PeriodicalIF":2.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Multiomics Analysis Reveals the Role of ANXA1 Methylation and miRNA-Targeted LDLR in Polycystic Ovary Syndrome. 联合多组学分析揭示了ANXA1甲基化和mirna靶向LDLR在多囊卵巢综合征中的作用

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12664

Yicen Ding, Lishi Huang, Mengju He, Fei Zhang, Yuanjun Jiang, Yani Kang

{"title":"Combined Multiomics Analysis Reveals the Role of ANXA1 Methylation and miRNA-Targeted LDLR in Polycystic Ovary Syndrome.","authors":"Yicen Ding, Lishi Huang, Mengju He, Fei Zhang, Yuanjun Jiang, Yani Kang","doi":"10.1002/rmb2.12664","DOIUrl":"10.1002/rmb2.12664","url":null,"abstract":"Purpose: Polycystic ovary syndrome (PCOS) is an endocrine syndrome that afflicts women of childbearing age, whose specific pathogenesis is unknown. Combined multiomics analysis on it is still lacking. The purpose of this study was to use combined multiomics analyses to learn about the development of PCOS.Methods: We randomly selected three PCOS mouse models and two control mice as the mouse group, as well as three PCOS patients and two normal women as the human group. The data were analyzed by multiomics analysis including methylomes, transcriptomics, and metabolomics. We explored the key genes involved in the occurrence and development of PCOS that were common in multiomics. Methylation-specific polymerase chain reaction (MSP) and real-time PCR (qPCR) experiments were performed to verify the reliability of the results.Results: The gene ANXA1 was hypomethylated and highly expressed in both mouse and human samples. Meanwhile, LDLR had a lower expression in both mouse and human samples, targeted by an upregulated microRNA (miRNA) called has-miR-106a-5p, which may relate to hyperandrogenemia.Conclusions: Epigenetic mechanisms have an impact on the development of PCOS. Both ANXA1 and LDLR play important roles in the pathological process of PCOS and have the potential to be diagnostic markers and therapeutic targets.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12664"},"PeriodicalIF":2.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Decidual Dysfunction and Infertility in Endometriosis: Roles of Prostaglandins and SASP. 子宫内膜异位症中蜕膜功能障碍和不孕的机制：前列腺素和SASP的作用。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12663

Kazuhiro Tamura, Mikihiro Yoshie, Kazuya Kusama, Atsuya Tsuru

{"title":"Mechanisms of Decidual Dysfunction and Infertility in Endometriosis: Roles of Prostaglandins and SASP.","authors":"Kazuhiro Tamura, Mikihiro Yoshie, Kazuya Kusama, Atsuya Tsuru","doi":"10.1002/rmb2.12663","DOIUrl":"10.1002/rmb2.12663","url":null,"abstract":"Background: Endometriosis is a challenging disease to treat and one of the leading causes of infertility. Impaired endometrial receptivity, and particularly inadequate decidualization of endometrial stromal cells (ESCs), is a crucial component. Multiple inflammatory factors disrupt decidualization.Methods: A comprehensive search of PubMed and Google Scholar (peer-reviewed journals only from 2000 to 2025) was performed in April 2025. The keyword \"decidualization\" was combined with \"endometriosis\", \"infertility\", and \"inflammation\". We summarize recent findings regarding the mechanisms of endometrial receptivity, focusing on the decidualization of ESCs, and discuss the impact of endometriosis, particularly in relation to PG metabolism and the senescence-associated secretory phenotype (SASP).Main findings: Endometriotic lesions demonstrate progesterone (P4) resistance and heightened inflammation due to elevated local estrogen levels and feedback loops involving PGE2 and steroidogenic enzymes. Oxidative stress secondary to inflammation and menstrual blood in ectopic locations promotes lesion growth. Excessive numbers of senescent cells with SASP contribute to fibrosis in the lesions. Impaired decidualization also occurs in eutopic ESCs, which show epigenetic dysregulation and inflammation, and these have effects through P4 and PGE2 signaling.Conclusion: Both endometriotic lesions and eutopic endometrium in endometriosis patients exhibit changes that contribute to infertility, with abnormal inflammation and epigenetic modifications leading to impaired decidualization.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12663"},"PeriodicalIF":2.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of Intravenous Immunoglobulin and Lipid Emulsion in Patients With Reproductive Failures Associated With NK Cell Abnormalities. 静脉注射免疫球蛋白和脂质乳治疗生殖衰竭伴NK细胞异常的比较研究。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-18 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12662

Ayano Yamaya, Atsushi Fukui, Kiyotaka Kawai, Mizuho Yano, Haruka Honda, Kohei Nakagawa, Hidetake Kamei, Maya Omote, Yu Wakimoto, Seiji Mabuchi

{"title":"A Comparative Study of Intravenous Immunoglobulin and Lipid Emulsion in Patients With Reproductive Failures Associated With NK Cell Abnormalities.","authors":"Ayano Yamaya, Atsushi Fukui, Kiyotaka Kawai, Mizuho Yano, Haruka Honda, Kohei Nakagawa, Hidetake Kamei, Maya Omote, Yu Wakimoto, Seiji Mabuchi","doi":"10.1002/rmb2.12662","DOIUrl":"10.1002/rmb2.12662","url":null,"abstract":"Purpose: To compare the effects of intravenous immunoglobulin (IVIG) and lipid emulsion (LE) therapies on reproductive failure such as recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) associated with natural killer (NK) cell abnormalities.Methods: NK cell abnormalities were defined as peripheral blood NK (pNK) cell activity of 40% or higher and CD16+/CD56dim uterine NK (uNK) cells at 18% or higher. IVIG and LE were administered to RPL and RIF patients. In patients undergoing IVF-ET, treatment was initiated either before ET, on ET day, or after ET.Results: Implantation rates of 48.3% and 47.8% were revealed in the IVIG and LE groups, respectively, with no significant difference. For patients with RPL, live birth rates were 75.0% for the IVIG group and 72.5% for the LE group, with no significant difference. For timings of administration before ET, on ET day, or after ET, the clinical pregnancy rates were 47.6%, 0%, and 0%, respectively, in the IVIG group and 30.0%, 12.5%, and 0%, respectively, in the LE group. Higher clinical pregnancy rates were observed when each treatment was initiated before ET.Conclusions: Both treatments exhibited comparable therapeutic effects on reproductive disorders associated with NK cell abnormalities.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12662"},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How do fertility facilities in Japan perceive disclosing institutional success rates for IVF? A nationwide survey of registered assisted reproductive technology facilities. 日本的生育机构如何看待公开试管婴儿的机构成功率？在全国范围内对已登记的辅助生殖技术设施进行调查。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-12 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12653

Seung Chik Jwa, Eri Maeda, Osamu Ishihara, Akira Tsujimura, Yukihiro Terada, Yutaka Osuga

引用次数: 0