Reproductive Medicine and Biology最新文献

Histopathological Association Between Chronic Endometritis and Adenomyosis: Clinical Findings and Risk Factors. 慢性子宫内膜炎与子宫腺肌症的组织病理学关联：临床表现和危险因素。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-09-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12681

Batuhan Aslan, Cevriye Cansız Ersöz, Yavuz Emre Şükür, Batuhan Özmen, Murat Sönmezer, Bülent Berker, Ruşen Aytaç, Cem Somer Atabekoğlu

{"title":"Histopathological Association Between Chronic Endometritis and Adenomyosis: Clinical Findings and Risk Factors.","authors":"Batuhan Aslan, Cevriye Cansız Ersöz, Yavuz Emre Şükür, Batuhan Özmen, Murat Sönmezer, Bülent Berker, Ruşen Aytaç, Cem Somer Atabekoğlu","doi":"10.1002/rmb2.12681","DOIUrl":"10.1002/rmb2.12681","url":null,"abstract":"Purpose: To investigate the histopathological association between chronic endometritis (CE) and adenomyosis, focusing on basal endometrial alterations and the potential involvement of tissue injury and repair (TIAR) mechanisms.Methods: This retrospective case-control study included 146 propensity score-matched hysterectomy specimens (73 adenomyosis, 73 controls). CE was diagnosed via CD38 immunohistochemical staining, identifying ≥ 5 plasma cells per high-power field. Basal endometrial thickness was measured digitally at the endo-myometrial junction. Basal endometrial loss was defined as the absence of the basal layer in at least two of three regions.Results: CE was significantly more frequent in the adenomyosis group (23.3%) than in controls (9.6%; p = 0.028). Basal endometrial loss, observed in 23.3% of cases, was strongly associated with CE (47% vs. 7.1%; p < 0.001). In patients with measurable thickness, a 0.15 mm cutoff predicted CE with AUC 0.888 (sensitivity 83.3%, specificity 86.9%). In multivariate analysis, basal endometrial loss was an independent risk factor for CE (adjusted OR 10.45, 95% CI 4.12-26.51; p < 0.001).Conclusions: CE is significantly associated with adenomyosis. Basal endometrial loss may mediate this relationship through TIAR-related mechanisms, suggesting CE as a potential therapeutic target in adenomyosis.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12681"},"PeriodicalIF":3.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives on Preimplantation Genetic Testing for Monogenic Disorders Among Japanese Patients With Hereditary Breast Cancer Undergoing Fertility Preservation: Insights From the First Japanese Survey. 日本遗传性乳腺癌患者接受生育保留的单基因疾病植入前基因检测的观点：来自日本首次调查的见解。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-09-17 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12678

Haruhisa Konishi, Yoshiharu Nakaoka, Anmae Michiko, Sho Fujiwara, Rie Kitayama, Daisuke Kadogami, Naoharu Morimoto, Kanako Katsu, Satoko Fujioka, Tomoko Inoue, Aisaku Fukuda, Hiroki Kurahashi, Yoshiharu Morimoto

{"title":"Perspectives on Preimplantation Genetic Testing for Monogenic Disorders Among Japanese Patients With Hereditary Breast Cancer Undergoing Fertility Preservation: Insights From the First Japanese Survey.","authors":"Haruhisa Konishi, Yoshiharu Nakaoka, Anmae Michiko, Sho Fujiwara, Rie Kitayama, Daisuke Kadogami, Naoharu Morimoto, Kanako Katsu, Satoko Fujioka, Tomoko Inoue, Aisaku Fukuda, Hiroki Kurahashi, Yoshiharu Morimoto","doi":"10.1002/rmb2.12678","DOIUrl":"10.1002/rmb2.12678","url":null,"abstract":"Purpose: Preimplantation genetic testing for monogenic disorders (PGT-M) offers BRCA variant carriers the option of preventing hereditary cancer transmission. We investigated the awareness and attitudes toward PGT-M among patients with breast cancer who underwent fertility preservation.Methods: A questionnaire-based survey was administered to 264 patients with breast cancer who were eligible for oocyte or embryo cryopreservation at in vitro fertilization clinics between October 2024 and March 2025. A total of 161 valid responses were analyzed. The survey assessed BRCA testing status, PGT-M awareness, willingness to undergo PGT-M, and opinions on future availability.Results: The uptake rate of BRCA1/2 testing was 53.4%; 14% of the respondents were variant carriers. Only 16.8% had prior awareness of PGT-M, and 47.8% expressed a willingness to use PGT-M if available. Among BRCA-variant carriers, 3.3% reported that they would consider PGT-M, and 75% believed it should be made available upon request. Overall, 68.3% supported information sharing between oncology and fertility providers.Conclusion: These findings highlight the importance of expanding reproductive options and patient awareness of PGT-M in the care of patients with hereditary cancer. Discussions should focus on how best to provide accurate information and enable informed reproductive choices for those at genetic risk.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12678"},"PeriodicalIF":3.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility of SNP Genotyping Using Dried Blood Spot Samples Collected in an Epidemiological Study and Its Integration With Genetic Risk Analysis for Endometriosis. 流行病学研究中采集的干血斑样本SNP基因分型的可行性及其与子宫内膜异位症遗传风险分析的整合。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12675

Yoshikazu Kitahara, Yuki Ideno, Kensaku Tomiyoshi, Yoko Onizuka, Kazue Nagai, Akira Iwase, Junko Shimada, Hiroshi Ohnishi, Kunihiko Hayashi

{"title":"Feasibility of SNP Genotyping Using Dried Blood Spot Samples Collected in an Epidemiological Study and Its Integration With Genetic Risk Analysis for Endometriosis.","authors":"Yoshikazu Kitahara, Yuki Ideno, Kensaku Tomiyoshi, Yoko Onizuka, Kazue Nagai, Akira Iwase, Junko Shimada, Hiroshi Ohnishi, Kunihiko Hayashi","doi":"10.1002/rmb2.12675","DOIUrl":"10.1002/rmb2.12675","url":null,"abstract":"Purpose: This study evaluated the feasibility of single-nucleotide polymorphism (SNP) genotyping using dried blood spot (DBS) samples stored under various conditions, based on the genotyping success rate and concordance with whole blood results. It also examined associations between selected SNPs and endometriosis risk in Japanese women.Methods: DBS samples from 41 cohort participants and 28 hospital patients were used to assess genotyping feasibility. Five endometriosis-associated SNPs-rs10965235, rs12700667, rs12024204, rs16826658, and rs801112-were genotyped in 37 cases and 144 controls. Genotype distributions were evaluated for Hardy-Weinberg equilibrium (HWE) using Pearson's χ 2 test or, when appropriate, Fisher's exact test, with a significance threshold of p < 0.05. Fisher's exact test was used for association analysis.Results: SNP genotyping for rs12700667 showed 100% success and complete concordance between DBS and whole blood samples under all storage conditions. Four of five SNPs met HWE, while rs10965235 significantly deviated from it (p = 0.0225). The CC genotype of rs10965235 was potentially associated with lower endometriosis risk (odds ratio: 0.19), although this was not statistically significant after correction.Conclusions: DBS is a robust DNA source for SNP genotyping under various conditions and suitable for mail-based epidemiological studies. Population-specific validation is essential when applying GWAS findings.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12675"},"PeriodicalIF":3.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cumulative Live Birth Rate in Patients With Subtle Distal Fallopian Tube Abnormalities: A Retrospective Cohort Study. 输卵管远端异常患者的累积活产率：一项回顾性队列研究。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12677

Ju Shi Guo, Yi Huang, Yong Mei Liu, Tian Jin Gu, Jin Jin Yuan, Yuan Yang

{"title":"Cumulative Live Birth Rate in Patients With Subtle Distal Fallopian Tube Abnormalities: A Retrospective Cohort Study.","authors":"Ju Shi Guo, Yi Huang, Yong Mei Liu, Tian Jin Gu, Jin Jin Yuan, Yuan Yang","doi":"10.1002/rmb2.12677","DOIUrl":"10.1002/rmb2.12677","url":null,"abstract":"Purpose: Compare reproductive outcomes between patients with subtle distal fallopian tube abnormalities (SDFTA) and unexplained infertility (UI) undergoing in vitro fertilization (IVF), exploring influencing factors.Methods: This retrospective study analyzed 447 women undergoing their first IVF cycle after laparoscopic evaluation for UI between January 2019 and December 2021. Based on laparoscopic findings, 162 women were classified into the SDFTA group and 285 into the UI group. Propensity score matching (PSM) created 160 matched pairs. The primary outcome was the cumulative live birth rate (CLBR) over 24 months.Results: The CLBR per oocyte retrieval cycle, biochemical pregnancy rate, clinical pregnancy rate, live birth rate per transfer, and preterm birth rate were comparable between the two groups (p > 0.05). However, the SDFTA group had a significantly lower early miscarriage rate (8.3% vs. 16.1%, p = 0.036) but a higher ectopic pregnancy rate (5.8% vs. 1.3%, p = 0.033). Independent predictors of CLBR were age at retrieval, the number of oocytes retrieved, and the number of IVF cycles.Conclusions: In conclusion, despite an increased risk of ectopic pregnancy, patients with SDFTA undergoing IVF exhibit favorable cumulative reproductive outcomes.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12677"},"PeriodicalIF":3.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Preimplantation Genetic Testing for Aneuploidy and Chromosomal Structural Rearrangement: A Summary of a Nationwide Study by the Japan Society of Obstetrics and Gynecology". 更正“胚胎植入前基因检测非整倍体和染色体结构重排：日本妇产科学会的一项全国性研究总结”。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12676

引用次数: 0

Sperm Injection at the Para-Polar Body Site in Piezo-Intracytoplasmic Sperm Injection Improves Subsequent Early Development of Bovine Embryos. 压电胞浆内单精子注射中对极体部位的精子注射改善了随后的牛胚胎早期发育。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12660

Shiori Ashibe, Yoku Kato, Sarentonglaga Borjigin, Yoshikazu Nagao

{"title":"Sperm Injection at the Para-Polar Body Site in Piezo-Intracytoplasmic Sperm Injection Improves Subsequent Early Development of Bovine Embryos.","authors":"Shiori Ashibe, Yoku Kato, Sarentonglaga Borjigin, Yoshikazu Nagao","doi":"10.1002/rmb2.12660","DOIUrl":"10.1002/rmb2.12660","url":null,"abstract":"Purpose: In piezo-ICSI, the first polar body (PB) of a metaphase II (MII) oocyte is generally oriented in the 6 or 12 o'clock position relative to sperm injection at 3 o'clock. However, the ooplasmic cell membrane may be damaged during drilling of the zona pellucida by piezo pulses. Here, we tested a new piezo-ICSI method in which the PB is set at the 2 or 4 o'clock position, so that zona drilling is performed through the widest position in the perivitelline space (para-PB piezo).Methods: The effect of piezo pulse position was evaluated by propidium iodide staining and cytoplasmic Ca2+ levels. The effect of injection site on integrity and movement of the meiotic spindle was evaluated by microscopy and an Oosight imaging system. Bovine oocyte survival rate, developmental competence, and chromosomal integrity at the blastocyst stage were compared between para-PB piezo and conventional piezo groups.Results: Piezo pulses may induce slight changes in the ooplasmic cell; our piezo-ICSI method can improve oocyte survival by minimizing damage to the ooplasmic cell membrane during zona drilling and consequently increasing the number of embryos available for transfer.Conclusions: Para-PB site piezo-ICSI is an improvement on current ICSI technology for animal and human reproduction.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12660"},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation of Nucleated Red Blood Cells With Intact Genomic DNA From Cord Blood by Applying G&T-Seq. 应用gt - seq技术从脐带血中分离具有完整基因组DNA的有核红细胞。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12671

Noriko Ito, Tatsuya Fujii, Kosuke Taniguchi, Yuka Okazaki, Hiroko Ogata-Kawata, Haruhiko Sago, Kenichiro Hata, Kazuhiko Nakabayashi

{"title":"Isolation of Nucleated Red Blood Cells With Intact Genomic DNA From Cord Blood by Applying G&T-Seq.","authors":"Noriko Ito, Tatsuya Fujii, Kosuke Taniguchi, Yuka Okazaki, Hiroko Ogata-Kawata, Haruhiko Sago, Kenichiro Hata, Kazuhiko Nakabayashi","doi":"10.1002/rmb2.12671","DOIUrl":"10.1002/rmb2.12671","url":null,"abstract":"Purpose: Fetal cells in maternal blood are a pure source of fetal genomic DNA for noninvasive prenatal testing (NIPT), if successfully isolated. We assessed whether single-cell genome and transcriptome sequencing (G&T-seq) can be applied to efficiently isolate fetal nucleated red blood cells (fNRBCs) suitable for genetic testing.Methods: Using umbilical cord blood as a model, we isolated 165 single NRBC candidates from four samples and 12 single lymphocytes as controls from one sample. G&T-seq was used to estimate the maturation stage of each NRBC candidate from the transcriptome data, and genomic integrity was assessed using shallow whole-genome sequencing (WGS) data.Results: Multi-dimensional scaling (MDS) of the transcriptome data revealed that five NRBC candidates clustered separately, classifying them as primitive NRBCs. Two of these cells showed high yields of WGS libraries and high mapping rates comparable to control lymphocytes, suggesting an intact nuclear genome.Conclusions: G&T-seq effectively identified primitive NRBCs with high-quality DNA among candidate cells dominated by mature RBCs. Single-cell multi-omics technology may advance the development of fNRBC-based NIPT.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12671"},"PeriodicalIF":3.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Clinical Significance of Biochemical Pregnancy Loss in Recurrent Pregnancy Loss Patients: Insights From Euploid Embryo Transfers Minimizing Embryonic Bias". 评论“复发性妊娠丢失患者生化妊娠丢失的临床意义：来自整倍体胚胎移植的见解，最大限度地减少胚胎偏差”。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12674

Prajnasini Satapathy, Rachana Mehta, Ranjana Sah

引用次数: 0

Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies. 线粒体动力学在生殖生理学中的意义：辅助生殖技术中线粒体治疗的现状和新视野。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-08-17 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12672

Sanath Udayanga Kankanam Gamage, Yoshiharu Morimoto

{"title":"Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies.","authors":"Sanath Udayanga Kankanam Gamage, Yoshiharu Morimoto","doi":"10.1002/rmb2.12672","DOIUrl":"10.1002/rmb2.12672","url":null,"abstract":"Background: Mitochondria play a critical role in cellular bioenergetics and signaling, with particular importance in the context of reproductive biology. This review summarizes their role in reproduction and explores current and emerging mitochondrial therapies for fertility treatment.Methods: A comprehensive literature search using terms like mitochondria, infertility, reproduction, gametes, mitochondrial replacement, and mitochondrial transplantation identified relevant studies on mitochondria's role in gametogenesis, fertilization, and early embryonic development in relevant databases. Selected publications were reviewed and summarized to present current and future mitochondrial therapies for fertility.Main findings: Mitochondrial dynamics and functions are critical for meeting the energy requirements of essential reproductive processes, including gametogenesis, fertilization, and early embryonic development. Dysregulation of mitochondrial function has been associated with a range of reproductive disorders, such as infertility, recurrent pregnancy loss, and maternally inherited mitochondrial diseases. Emerging therapeutic strategies, such as mitochondrial replacement therapy, antioxidant supplementation, and mitochondrial transplantation, offer promising avenues for overcoming these challenges and improving reproductive outcomes.Conclusions: Utilizing mitochondrial-based therapies represents a promising and innovative approach in the advancement of fertility treatments. Ongoing research and clinical development in this area hold significant potential to enhance reproductive outcomes and improve the quality of life for individuals and couples facing fertility challenges.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12672"},"PeriodicalIF":3.3,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive Outcomes of Transferring Blastocysts Derived From Frozen-Thawed Cleavage Embryos: A Systematic Review and Meta-Analysis. 冷冻解冻卵裂胚胎移植囊胚的生殖结果：系统综述和荟萃分析。

IF 3.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-08-07 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12673

Huy Phuong Tran, Nam Nhat Nguyen, Ngoc Thanh Truong, Tuyet Thi-Diem Hoang, Trang Nguyen-Khanh Huynh, Ha Le-Bao Tran

{"title":"Reproductive Outcomes of Transferring Blastocysts Derived From Frozen-Thawed Cleavage Embryos: A Systematic Review and Meta-Analysis.","authors":"Huy Phuong Tran, Nam Nhat Nguyen, Ngoc Thanh Truong, Tuyet Thi-Diem Hoang, Trang Nguyen-Khanh Huynh, Ha Le-Bao Tran","doi":"10.1002/rmb2.12673","DOIUrl":"10.1002/rmb2.12673","url":null,"abstract":"Background: In in vitro fertilization (IVF), transferring frozen-thawed blastocysts is a widely adopted practice. This meta-analysis aims to evaluate the reproductive outcomes of transferring blastocysts derived from frozen-thawed cleavage embryos (FT-CDB group) compared to direct frozen-thawed blastocyst (DFB group) transfers.Methods: We searched the following electronic databases for relevant studies: PubMed/MEDLINE, EMBASE, Scopus, and Web of Science. Studies were included if they compared the clinical and neonatal outcomes of IVF patients receiving either FT-CDB or DFB transfer with vitrification method. The protocol for this review has been registered in PROSPERO.Results: A total of seven studies (2057 patients) were included in the analysis. Participants in the FT-CDB group demonstrated significantly higher odds of achieving clinical pregnancy (OR 1.24, 95% CI 1.03-1.49, p = 0.022, I 2 = 27%), and live birth (OR 1.31, 95% CI 1.08-1.60, p = 0.007, I 2 = 0%) compared to the DFB group. No significant differences were observed in the birth weights of infants between the groups (MD -87.05 g, 95% CI -293.77 to 119.67, p = 0.41, I 2 = 83%).Conclusion: Transferring blastocysts derived from frozen-thawed cleavage embryos is associated with higher odds of clinical pregnancy and live birth compared to frozen-thawed blastocyst transfers.Trial registration: PROSPERO number: CRD42024591620.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12673"},"PeriodicalIF":3.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0