Reproductive Medicine and Biology最新文献

Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts. 胚胎植入的分子和细胞调控因子及其在提高体外受精囊胚植入潜力中的应用。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-24 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12633

Chunyan Liu, Emiko Fukui, Hiromichi Matsumoto

{"title":"Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF-derived blastocysts.","authors":"Chunyan Liu, Emiko Fukui, Hiromichi Matsumoto","doi":"10.1002/rmb2.12633","DOIUrl":"10.1002/rmb2.12633","url":null,"abstract":"Background: In vitro fertilization (IVF) and embryo transfer (ET) are widely used in reproductive biology. Despite the transfer of high-quality blastocysts, the implantation rate of IVF-derived blastocysts remains low after ET.Methods: This article provides a comprehensive review of current research on embryo implantation regulators and their application to improve the implantation potential of IVF-derived blastocysts.Main findings: The in vivo mouse model revealed selective proteolysis immediately after expression in activated blastocysts, that is, degradation of ERα expression in activated blastocysts regulated by the ubiquitin-proteasome pathway, followed by completion of blastocyst implantation. Treatment of blastocysts to induce appropriate protein expression during in vitro culture prior to ET is a useful approach for improving implantation rates. This approach showed that combined treatment with PRL, EGF, and 4-OH-E2 (PEC) improved the blastocyst implantation rates. Furthermore, arginine and leucine drive reactive oxygen species (ROS)-mediated integrin α5β1 expression and promote blastocyst implantation.Conclusion: Findings based on analysis of molecular and cellular regulators are useful for improving the implantation potential of IVF-derived blastocysts. These approaches may help to elucidate the mechanisms underlying the completion of the blastocyst implantation, although further investigation is required to improve the success of implantation and pregnancy.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12633"},"PeriodicalIF":2.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risks of neonatal anomalies and obstetric complications in 7378 singleton births after frozen-thawed and fresh embryo transfers in Japan: An analysis using doubly robust estimation.

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12623

Sanae Terada, Toshihiro Habara, Ryo Terada, Toshiharu Mitsuhashi, Ryuhei So, Nanako Yoshioka, Yumi Masumoto, Yukiko Kosaka, Rei Hirata, Nobuyoshi Hayashi

{"title":"Risks of neonatal anomalies and obstetric complications in 7378 singleton births after frozen-thawed and fresh embryo transfers in Japan: An analysis using doubly robust estimation.","authors":"Sanae Terada, Toshihiro Habara, Ryo Terada, Toshiharu Mitsuhashi, Ryuhei So, Nanako Yoshioka, Yumi Masumoto, Yukiko Kosaka, Rei Hirata, Nobuyoshi Hayashi","doi":"10.1002/rmb2.12623","DOIUrl":"10.1002/rmb2.12623","url":null,"abstract":"Purpose: To compare risks of neonatal anomalies and obstetric complications among frozen-thawed embryo transfer (FET), fresh embryo transfer (FreshET), and non-assisted reproductive technology (non-ART) treatments in infertile women.Methods: This retrospective cohort study analyzed 7378 singleton births (2643 non-ART, 4219 FET, 516 FreshET) from 2013 to 2022. Outcomes were compared using inverse probability weighting regression adjustment, with adjustment for maternal factors.Results: After adjustment, the risk of neonatal anomalies did not differ significantly between FET and non-ART, or FreshET and non-ART. FET was associated with increased risks of obstetric complications compared with non-ART, including placenta accreta (adjusted risk difference [ARD] 3.61%, 95% CI 2.95-4.28), placenta previa (ARD 0.55%, 95% CI 0.14-0.96), postpartum hemorrhage (ARD 7.08%, 95% CI 6.03-8.13), gestational hypertension (ARD 3.57%, 95% CI 2.47-4.68), gestational diabetes (ARD 0.96%, 95% CI 0.17-1.75), and preterm birth (ARD 2.13%, 95% CI 1.23-3.02). FET also showed higher risk of high birth weight (ARD 0.97%, 95% CI 0.42-1.52). FreshET showed no significant differences in obstetric complications.Conclusions: While the risk of neonatal anomalies did not differ among treatments, FET was associated with increased obstetric complication risks. These findings underscore the need for careful management of FET pregnancies and further research to improve treatment protocols.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12623"},"PeriodicalIF":2.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possible mechanisms of spermatogenic dysfunction induced by viral infections: Insights from COVID-19.

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12625

Keisuke Okada, Chanhyon Kin, Yosuke Yamashita, Shun Kawamura, Katsuya Sato, Koji Chiba, Hideaki Miyake

{"title":"Possible mechanisms of spermatogenic dysfunction induced by viral infections: Insights from COVID-19.","authors":"Keisuke Okada, Chanhyon Kin, Yosuke Yamashita, Shun Kawamura, Katsuya Sato, Koji Chiba, Hideaki Miyake","doi":"10.1002/rmb2.12625","DOIUrl":"10.1002/rmb2.12625","url":null,"abstract":"Background: As the COVID-19 pandemic nears resolution in 2024, the mechanisms by which SARS-CoV-2 and other viral infections induce spermatogenic dysfunction remain poorly understood. This review examines the mechanisms by which viral infections, particularly COVID-19, disrupt spermatogenesis and highlights the implications for male reproductive health. While reports suggest that spermatogenic dysfunction caused by COVID-19 is mild and transient, these findings may have broader applications in understanding and treating spermatogenic dysfunction caused by future viral infections.Methods: The PubMed database was searched to identify original and review articles investigating the mechanisms by which viral infections, particularly SARS-CoV-2, contribute to spermatogenic dysfunction.Main findings: SARS-CoV-2 affects the testis through multiple mechanisms, including ACE2 receptor-mediated entry, direct viral damage, inflammatory response, blood-testis barrier disruption, hormonal imbalance, oxidative stress, and impaired spermatogenesis. The combination of these factors can disrupt testicular function and highlights the complexity of the effects of COVID-19 on male reproductive health.Conclusion: COVID-19 may disrupt spermatogenesis through direct testicular infection, systemic inflammation, hormonal disruption, and oxidative stress. Ongoing research, vaccination efforts, and clinical vigilance are essential to address these challenges and develop effective treatment and prevention strategies.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12625"},"PeriodicalIF":2.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polycystic ovary syndrome: Criteria, phenotypes, race and ethnicity.

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12630

Tsuyoshi Baba

{"title":"Polycystic ovary syndrome: Criteria, phenotypes, race and ethnicity.","authors":"Tsuyoshi Baba","doi":"10.1002/rmb2.12630","DOIUrl":"10.1002/rmb2.12630","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a complex endocrinopathy, which leads to ovulation dysfunction and infertility, as well as metabolic and mental disorders. Women with PCOS exhibit several characteristic symptoms, with marked heterogeneity across different races and ethnicities.Methods: In this review, the author outlines the phenotypic disparities of PCOS among various racial and ethnic populations. First, the prevalence of major symptoms in different racial and ethnic groups with PCOS is summarized. Next, the effects of four phenotypes, derived from the Rotterdam criteria for PCOS, on metabolic and reproductive features are recapitulated.Main findings: A growing body of evidence suggests that East Asian populations exhibit less hirsutism and adiposity compared with other groups. However, hirsutism is more prevalent in South Asian, Middle Eastern, and Hispanic populations. Hispanic and African American populations have more frequent obesity and insulin resistance. With regard to the association between mental disorders and racial and ethnic differences, limited studies exist; therefore, no conclusions can be drawn.Conclusion: Race and ethnicity-specific factors related to PCOS must be considered in clinical practice. The diagnostic criteria of PCOS should be specific to race and ethnicity to avoid missing treatment opportunities.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12630"},"PeriodicalIF":2.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development.

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12626

Yorino Sato, Kazuhiro Kawamura

{"title":"C-type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development.","authors":"Yorino Sato, Kazuhiro Kawamura","doi":"10.1002/rmb2.12626","DOIUrl":"10.1002/rmb2.12626","url":null,"abstract":"Purpose: To investigate the effects of C-type natriuretic peptide (CNP) on human granulosa cell growth and elucidate its regulatory mechanisms.Methods: A human non-luteinizing granulosa cell line (HGrC) developed from small antral follicles was used to assess the impact of CNP on cell proliferation and estrogen synthesis. cGMP production via the guanylate cyclase domain of the CNP receptor, natriuretic peptide receptor 2 (NPR2), was confirmed. The regulation of CNP encoding natriuretic peptide C (NPPC) and NPR2 by estradiol and oocyte-derived factors (ODFs) was examined.Results: Besides detecting both NPPC and NPR2, CNP increased cellular proliferation. The specific action of CNP on cell proliferation was confirmed using siRNA transfection. CNP stimulated cGMP production, whereas a guanylate-cyclase inhibitor suppressed CNP-induced cell proliferation. Estradiol production was elevated by CNP treatment, accompanied by increased expression of estrogen synthetic enzymes. Furthermore, CNP upregulated NPR2 expression in cooperation with estradiol and ODFs, while estradiol increased NPPC expression.Conclusion: This study demonstrates CNP stimulation of human granulosa cell growth and suggests potential cross-talk between these cells and oocytes. Further research on the simultaneous administration of CNP and estradiol may offer a promising approach for promoting early-stage follicle development in infertility treatments for patients with poor ovarian reserve.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12626"},"PeriodicalIF":2.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embryologist staffing in assisted reproductive technology laboratories: An international comparative review.

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12628

Hiromitsu Shirasawa, Yukihiro Terada

{"title":"Embryologist staffing in assisted reproductive technology laboratories: An international comparative review.","authors":"Hiromitsu Shirasawa, Yukihiro Terada","doi":"10.1002/rmb2.12628","DOIUrl":"10.1002/rmb2.12628","url":null,"abstract":"Background: Embryologists are crucial in assisted reproductive technology (ART), yet their duties, education, and licensing requirements vary significantly across countries, complicating the determination of optimal staffing levels in ART laboratories. With anticipated advancements such as automation in ART laboratories, this review comprehensively analyzes factors necessary for appropriate future staffing.Main findings: A comprehensive literature search was conducted using PubMed to identify relevant articles up to July 2024, employing keywords such as \"embryologist,\" \"staffing,\" and \"certification.\" Articles were evaluated for content related to laboratory operations, and guidelines from five organizations regarding licensing and education were compared.Results: The review revealed significant international differences in embryologist certification, duties, and staffing recommendations. These disparities, along with the integration of advanced ART technologies and regulatory requirements, significantly impact future staffing needs in ART laboratories.Conclusion: The definitions of an ART cycle and required staffing levels vary across organizations, influenced by the certification and duties of embryologists in different countries. Adequate embryologist staffing is essential for ensuring laboratory quality control and impacting patient ART outcomes. As new technologies and automation reshape laboratory workflows, collaborative efforts among organizations, countries, and embryologist associations are essential for developing comprehensive educational curricula and determining appropriate staffing levels.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12628"},"PeriodicalIF":2.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of a 3D spheroid culture system to evaluate the responsiveness of uterine leiomyoma cells to female hormones.

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12627

Takahiro Sakai, Shun Sato, Tetsuro Tamehisa, Hitomi Takasaki, Takuya Kajimura, Isao Tamura, Norihiro Sugino

{"title":"Establishment of a 3D spheroid culture system to evaluate the responsiveness of uterine leiomyoma cells to female hormones.","authors":"Takahiro Sakai, Shun Sato, Tetsuro Tamehisa, Hitomi Takasaki, Takuya Kajimura, Isao Tamura, Norihiro Sugino","doi":"10.1002/rmb2.12627","DOIUrl":"10.1002/rmb2.12627","url":null,"abstract":"Purpose: Uterine leiomyomas (ULMs) are classified into those with and without MED12 mutations (MED12m(+) and MED12m(-), respectively). This study was undertaken to establish a culture system to evaluate the effect of female hormones on the growth of ULM cells in each ULM subtype.Methods: ULM cells isolated from MED12m(+) or MED12m(-) tissues were cultured in a monolayer for 7 days with four hormone treatments: estrogen (E) and progesterone (P) (E + P), E only (E), P only (P), and medium only (CTRL). They were also cultured in a 3D spheroid culture system with the above four treatments and a fifth treatment: E + P + selective progesterone receptor modulator (E + P + SPRM). The hormonal effects were evaluated based on cell number, spheroid size, and histology.Results: In the monolayer cultures, female hormones did not cause the proliferation of ULM cells of either subtype. In the spheroid cultures, spheroid sizes for both subtypes were significantly larger with the E + P and P treatments than with the CTRL and E treatments and were comparable in the E and E + P + SPRM treatments. Histological staining showed that collagen fibers were present only in the spheroids of the P-treated groups of MED12m(+).Conclusion: We established a 3D spheroid culture system to evaluate the effects of female hormones on ULM cells.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12627"},"PeriodicalIF":2.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromosome segregation errors during early embryonic development.

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12631

Hirohisa Kyogoku

{"title":"Chromosome segregation errors during early embryonic development.","authors":"Hirohisa Kyogoku","doi":"10.1002/rmb2.12631","DOIUrl":"10.1002/rmb2.12631","url":null,"abstract":"Background: Mitosis maintains a genome's genetic information in daughter cells by accurately segregating chromosomes. However, chromosome aberrations are common during early mammalian embryogenesis. Chromosomal abnormalities during the early stages of embryogenesis result in the formation of mosaic embryos, wherein cells with normal genomes coexist with cells exhibiting abnormal genomes. The precise frequency and etiology of such abnormalities remain unclear. It is postulated that these aberrations contribute to the etiology of a number of conditions, including infertility and congenital diseases such as Down's syndrome.Methods: This review synthesizes current literature and data to elucidate the causes and implications of chromosome aberrations in early mammalian embryos. It places particular emphasis on identifying patterns of mosaicism and investigating the underlying mechanisms responsible for these abnormalities.Main findings: The underlying causes of chromosome abnormalities in early embryos were examined in the context of DNA replication and embryonic development.Conclusion: A deeper understanding of chromosome abnormalities in early embryos could help develop new infertility treatments and advance research on cancers caused by these abnormalities. This article reviews current knowledge and gaps in understanding chromosome segregation abnormalities during embryogenesis and future directions in this field.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12631"},"PeriodicalIF":2.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sod1 deficiency in mouse oocytes during in vitro maturation increases chromosome segregation errors with a reduced BUBR1 at kinetochore.

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12622

Mitsuru Nago, Masumi Yanai, Mika Ishii, Yasuko Sato, Kazuharu Odajima, Naoko Kimura

{"title":"Sod1 deficiency in mouse oocytes during in vitro maturation increases chromosome segregation errors with a reduced BUBR1 at kinetochore.","authors":"Mitsuru Nago, Masumi Yanai, Mika Ishii, Yasuko Sato, Kazuharu Odajima, Naoko Kimura","doi":"10.1002/rmb2.12622","DOIUrl":"10.1002/rmb2.12622","url":null,"abstract":"Purpose: This study aimed to investigate the molecular mechanisms associated with chromosome segregation errors caused by intrinsic oxidative stress during in vitro oocyte maturation (IVM) using oocytes from Sod1-deficient (Sod1KO) mice.Methods: Ovulated or in vitro matured cumulus-cells oocyte complexes (COCs) were collected from wild-type (WT) and Sod1KO mice and evaluated chromosome alignment, chromosome segregation, meiotic progression, and BUBR1 and REC8 protein expression levels.Results: In 21% O2 IVM, the Sod1KO had significantly higher frequencies of chromosome misalignment and segregation errors compared to the WT, and they also reached Germinal Vesicle Break Down (GVBD) and M I stages peak earlier and showed a shorter M I stage residence time compared to the WT. These changes were associated with a decrease in the recruitment of BUBR1 to kinetochores at M I stage, but there were no differences in the expression of REC8 between the two genotypes. Furthermore, the addition of L-ascorbic acid (AsA) or N-acetyl-L-cysteine (NAC) during IVM reduced the frequency of chromosome segregation errors in Sod1KO oocytes.Conclusions: Oxidative stress caused by Sod1 deficiency during IVM impairs the spindle assembly checkpoint function due to a decrease in the recruitment of BUBR1 to M I stage kinetochores, leading to abnormalities in meiotic progression and chromosome segregation.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12622"},"PeriodicalIF":2.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of NKp46 and other activating inhibitory receptors on uterine endometrial NK cells in females with various reproductive failures: A review. 不同生殖失败女性子宫内膜NK细胞中NKp46及其他活化抑制受体的表达

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12610

Chuxian Mai, Atsushi Fukui, Shinichiro Saeki, Ryu Takeyama, Ayano Yamaya, Hiroaki Shibahara

{"title":"Expression of NKp46 and other activating inhibitory receptors on uterine endometrial NK cells in females with various reproductive failures: A review.","authors":"Chuxian Mai, Atsushi Fukui, Shinichiro Saeki, Ryu Takeyama, Ayano Yamaya, Hiroaki Shibahara","doi":"10.1002/rmb2.12610","DOIUrl":"10.1002/rmb2.12610","url":null,"abstract":"Background: Uterine endometrial natural killer (uNK) cells represent major leukocytes in the mid-secretory phase of the cell cycle, and their number is further increased during early pregnancy. The activating and inhibitory receptors expressed on their surface mediate various functions of uNK cells, such as cytotoxicity, cytokine production, spiral artery remodeling, and self-recognition.Methods: This study reviewed the most recent information (PubMed database, 175 articles included) regarding the activating and inhibitory receptors on uNK cells in human females with healthy pregnancies and the evidence indicating their significance in various reproductive failures.Main findings: Numerous studies have indicated that the natural cytotoxic receptors, killer cell immunoglobulin-like receptors, and C-type lectin receptors, particularly those expressed on uNK cells, play crucial roles in successful pregnancy.Conclusion: As studies on human uNK cells are limited owing to the low availability of fertile samples, and the extrapolation of animal models has certain limitations, the in vivo role of uNK cells has not yet been fully elucidated. However, immunotherapies focusing on modulating uNK cell function have been controversial in terms of pregnancy outcomes. Further research is required to elucidate the role of uNK cells in reproduction.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12610"},"PeriodicalIF":2.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0