Reproductive Medicine and Biology最新文献

Rhabdomyosarcoma Requiring Ovarian Transposition Release for Recurrent Severe Ovulation Pain Following Laparoscopic Ovarian Transposition: A Case Report. 横纹肌肉瘤需要卵巢转位释放治疗腹腔镜卵巢转位后复发性严重排卵疼痛：1例报告。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-24 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12665

Yuko Shimoji, Keiko Mekaru, Akiko Ikemura, Natsuki Tamashiro, Shuko Chinen, Rie Nakamura, Chiaki Heshiki, Wataru Kudaka, Masayuki Sekine

{"title":"Rhabdomyosarcoma Requiring Ovarian Transposition Release for Recurrent Severe Ovulation Pain Following Laparoscopic Ovarian Transposition: A Case Report.","authors":"Yuko Shimoji, Keiko Mekaru, Akiko Ikemura, Natsuki Tamashiro, Shuko Chinen, Rie Nakamura, Chiaki Heshiki, Wataru Kudaka, Masayuki Sekine","doi":"10.1002/rmb2.12665","DOIUrl":"10.1002/rmb2.12665","url":null,"abstract":"Case: Ovarian transposition (OT) is performed to preserve ovarian function in patients undergoing pelvic or abdominal radiotherapy. Although complications, such as ovarian torsion and cyst formation, have been reported, ovulation-related peritoneal irritation requiring surgical intervention after pediatric OT has not been documented. In this case, a 12-year-old girl who underwent bilateral OT at the age of 6 years during treatment for recurrent rhabdomyosarcoma presented with severe pain in the right lower quadrant. Owing to prior pelvic radiotherapy, the assessment of menstrual history was unreliable. Considering the young age of the patient and the absence of a definitive diagnosis, hormonal therapy, such as low-dose estrogen-progestin therapy, was withheld. Conservative management with analgesics was initiated; however, the pain persisted and progressively worsened.Outcome: Emergent laparoscopic OT release was performed for diagnostic and therapeutic purposes, owing to the severity of pain. Intraoperative findings revealed corpus luteum in the retracted right ovary. Postoperatively, the patient's symptoms resolved immediately without recurrence.Conclusion: Ovulation-induced peritoneal irritation should be recognized as a potential postoperative complication following childhood OT. In adolescent patients with a history of pediatric OT and pelvic radiotherapy, ovulation-related complications should be carefully considered during the differential diagnosis of acute abdominal pain.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12665"},"PeriodicalIF":2.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Multiomics Analysis Reveals the Role of ANXA1 Methylation and miRNA-Targeted LDLR in Polycystic Ovary Syndrome. 联合多组学分析揭示了ANXA1甲基化和mirna靶向LDLR在多囊卵巢综合征中的作用

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-23 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12664

Yicen Ding, Lishi Huang, Mengju He, Fei Zhang, Yuanjun Jiang, Yani Kang

{"title":"Combined Multiomics Analysis Reveals the Role of ANXA1 Methylation and miRNA-Targeted LDLR in Polycystic Ovary Syndrome.","authors":"Yicen Ding, Lishi Huang, Mengju He, Fei Zhang, Yuanjun Jiang, Yani Kang","doi":"10.1002/rmb2.12664","DOIUrl":"10.1002/rmb2.12664","url":null,"abstract":"Purpose: Polycystic ovary syndrome (PCOS) is an endocrine syndrome that afflicts women of childbearing age, whose specific pathogenesis is unknown. Combined multiomics analysis on it is still lacking. The purpose of this study was to use combined multiomics analyses to learn about the development of PCOS.Methods: We randomly selected three PCOS mouse models and two control mice as the mouse group, as well as three PCOS patients and two normal women as the human group. The data were analyzed by multiomics analysis including methylomes, transcriptomics, and metabolomics. We explored the key genes involved in the occurrence and development of PCOS that were common in multiomics. Methylation-specific polymerase chain reaction (MSP) and real-time PCR (qPCR) experiments were performed to verify the reliability of the results.Results: The gene ANXA1 was hypomethylated and highly expressed in both mouse and human samples. Meanwhile, LDLR had a lower expression in both mouse and human samples, targeted by an upregulated microRNA (miRNA) called has-miR-106a-5p, which may relate to hyperandrogenemia.Conclusions: Epigenetic mechanisms have an impact on the development of PCOS. Both ANXA1 and LDLR play important roles in the pathological process of PCOS and have the potential to be diagnostic markers and therapeutic targets.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12664"},"PeriodicalIF":2.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Decidual Dysfunction and Infertility in Endometriosis: Roles of Prostaglandins and SASP. 子宫内膜异位症中蜕膜功能障碍和不孕的机制：前列腺素和SASP的作用。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-19 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12663

Kazuhiro Tamura, Mikihiro Yoshie, Kazuya Kusama, Atsuya Tsuru

{"title":"Mechanisms of Decidual Dysfunction and Infertility in Endometriosis: Roles of Prostaglandins and SASP.","authors":"Kazuhiro Tamura, Mikihiro Yoshie, Kazuya Kusama, Atsuya Tsuru","doi":"10.1002/rmb2.12663","DOIUrl":"10.1002/rmb2.12663","url":null,"abstract":"Background: Endometriosis is a challenging disease to treat and one of the leading causes of infertility. Impaired endometrial receptivity, and particularly inadequate decidualization of endometrial stromal cells (ESCs), is a crucial component. Multiple inflammatory factors disrupt decidualization.Methods: A comprehensive search of PubMed and Google Scholar (peer-reviewed journals only from 2000 to 2025) was performed in April 2025. The keyword \"decidualization\" was combined with \"endometriosis\", \"infertility\", and \"inflammation\". We summarize recent findings regarding the mechanisms of endometrial receptivity, focusing on the decidualization of ESCs, and discuss the impact of endometriosis, particularly in relation to PG metabolism and the senescence-associated secretory phenotype (SASP).Main findings: Endometriotic lesions demonstrate progesterone (P4) resistance and heightened inflammation due to elevated local estrogen levels and feedback loops involving PGE2 and steroidogenic enzymes. Oxidative stress secondary to inflammation and menstrual blood in ectopic locations promotes lesion growth. Excessive numbers of senescent cells with SASP contribute to fibrosis in the lesions. Impaired decidualization also occurs in eutopic ESCs, which show epigenetic dysregulation and inflammation, and these have effects through P4 and PGE2 signaling.Conclusion: Both endometriotic lesions and eutopic endometrium in endometriosis patients exhibit changes that contribute to infertility, with abnormal inflammation and epigenetic modifications leading to impaired decidualization.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12663"},"PeriodicalIF":2.7,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study of Intravenous Immunoglobulin and Lipid Emulsion in Patients With Reproductive Failures Associated With NK Cell Abnormalities. 静脉注射免疫球蛋白和脂质乳治疗生殖衰竭伴NK细胞异常的比较研究。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-18 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12662

Ayano Yamaya, Atsushi Fukui, Kiyotaka Kawai, Mizuho Yano, Haruka Honda, Kohei Nakagawa, Hidetake Kamei, Maya Omote, Yu Wakimoto, Seiji Mabuchi

{"title":"A Comparative Study of Intravenous Immunoglobulin and Lipid Emulsion in Patients With Reproductive Failures Associated With NK Cell Abnormalities.","authors":"Ayano Yamaya, Atsushi Fukui, Kiyotaka Kawai, Mizuho Yano, Haruka Honda, Kohei Nakagawa, Hidetake Kamei, Maya Omote, Yu Wakimoto, Seiji Mabuchi","doi":"10.1002/rmb2.12662","DOIUrl":"10.1002/rmb2.12662","url":null,"abstract":"Purpose: To compare the effects of intravenous immunoglobulin (IVIG) and lipid emulsion (LE) therapies on reproductive failure such as recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) associated with natural killer (NK) cell abnormalities.Methods: NK cell abnormalities were defined as peripheral blood NK (pNK) cell activity of 40% or higher and CD16+/CD56dim uterine NK (uNK) cells at 18% or higher. IVIG and LE were administered to RPL and RIF patients. In patients undergoing IVF-ET, treatment was initiated either before ET, on ET day, or after ET.Results: Implantation rates of 48.3% and 47.8% were revealed in the IVIG and LE groups, respectively, with no significant difference. For patients with RPL, live birth rates were 75.0% for the IVIG group and 72.5% for the LE group, with no significant difference. For timings of administration before ET, on ET day, or after ET, the clinical pregnancy rates were 47.6%, 0%, and 0%, respectively, in the IVIG group and 30.0%, 12.5%, and 0%, respectively, in the LE group. Higher clinical pregnancy rates were observed when each treatment was initiated before ET.Conclusions: Both treatments exhibited comparable therapeutic effects on reproductive disorders associated with NK cell abnormalities.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12662"},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How do fertility facilities in Japan perceive disclosing institutional success rates for IVF? A nationwide survey of registered assisted reproductive technology facilities. 日本的生育机构如何看待公开试管婴儿的机构成功率？在全国范围内对已登记的辅助生殖技术设施进行调查。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-12 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12653

Seung Chik Jwa, Eri Maeda, Osamu Ishihara, Akira Tsujimura, Yukihiro Terada, Yutaka Osuga

引用次数: 0

Potential Role of CREM in Diabetes-Associated Testicular Dysfunction: Current Evidence and Future Perspectives. CREM在糖尿病相关睾丸功能障碍中的潜在作用：当前证据和未来展望。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-06-05 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12661

Olabimpe Caroline Badejogbin, Oyedayo Phillips Akano, Oluwafisayo Elizabeth Boluwatife Julius, Mary Olaoluwa Agunloye, Makinde Vincent Olubiyi, Ojichukwuka Ebere Chijioke-Agu, Matthew Agene Obekpa, Adesina Paul Arikawe, Kehinde Samuel Olaniyi

{"title":"Potential Role of CREM in Diabetes-Associated Testicular Dysfunction: Current Evidence and Future Perspectives.","authors":"Olabimpe Caroline Badejogbin, Oyedayo Phillips Akano, Oluwafisayo Elizabeth Boluwatife Julius, Mary Olaoluwa Agunloye, Makinde Vincent Olubiyi, Ojichukwuka Ebere Chijioke-Agu, Matthew Agene Obekpa, Adesina Paul Arikawe, Kehinde Samuel Olaniyi","doi":"10.1002/rmb2.12661","DOIUrl":"10.1002/rmb2.12661","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic adenosine monophosphate (cAMP) response element modulator (CREM) playing a pivotal role in testicular function. Understanding the interplay between T2D and CREM dysregulation is essential for developing targeted therapies for diabetic testicular dysfunction.Methods: A systematic review of PubMed, Web of Science, Scopus, and Google Scholar was conducted to identify peer-reviewed studies, both preclinical and clinical, that explored CREM's role in diabetes-induced testicular dysfunction. Extracted data focused on CREM expression, oxidative stress, apoptosis, and spermatogenic impairment in diabetic models.Main findings: Research from studies on diabetic patients and animal models highlights the detrimental effects of diabetes on the reproductive system, including hypothalamic-pituitary-testicular (HPT) axis dysregulation. CREM regulates spermatogenic gene expression, influenced by luteinizing hormone (LH), follicle-stimulating hormone (FSH), and cAMP signaling.Conclusion: CREM has a therapeutic role in maintaining testicular function, and its disruption may contribute to testiculopathy in T2D, highlighting its potential therapeutic target for preserving male fertility in diabetic patients. Further research is needed to explore its molecular mechanisms and therapeutic implications.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12661"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice. KIF2C缺失导致小鼠减数分裂异常和非阻塞性无精子症。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-05-27 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12659

Hiroaki Kitakaze, Haruhiko Miyata, Yuki Oyama, Chen Pan, Yuma Kujime, Go Tsujimura, Takahiro Imanaka, Sohei Kuribayashi, Norichika Ueda, Kentaro Takezawa, Shinichiro Fukuhara, Norio Nonomura, Masahito Ikawa

{"title":"KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice.","authors":"Hiroaki Kitakaze, Haruhiko Miyata, Yuki Oyama, Chen Pan, Yuma Kujime, Go Tsujimura, Takahiro Imanaka, Sohei Kuribayashi, Norichika Ueda, Kentaro Takezawa, Shinichiro Fukuhara, Norio Nonomura, Masahito Ikawa","doi":"10.1002/rmb2.12659","DOIUrl":"10.1002/rmb2.12659","url":null,"abstract":"Purpose: Kinesin Family Member 2C (KIF2C) is a key regulator of microtubule dynamics and chromosome segregation in mitosis. However, its role in spermatogenesis remains unclear. Recent transcriptomic analyses suggest a potential link between KIF2C and male infertility. This study aimed to clarify KIF2C's roles in spermatogenesis using Kif2c knockout (KO) mice.Methods: To overcome the preweaning lethality associated with Kif2c deletion, we generated Kif2c KO mice with a mixed genetic background of 129X1/SvJ and B6D2. We assessed male fertility, epididymal sperm counts, and testicular sections of Kif2c KO mice.Results: Global Kif2c KO mice were obtained and showed male infertility. Histological analyses and epididymal sperm count revealed that Kif2c KO mice exhibited severely impaired spermatogenesis and absence of mature spermatozoa. These findings are consistent with those observed in patients with nonobstructive azoospermia (NOA). Our classification of Kif2c KO seminiferous tubules indicated that most spermatogenic cells were arrested at the early stages, particularly during meiosis.Conclusions: This study provides in vivo evidence that KIF2C is essential for spermatogenesis and male fertility in mice. The successful generation of global Kif2c KO mice establishes an animal model for NOA, supporting research on germ cell development and reproductive health.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12659"},"PeriodicalIF":2.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Oxidative Stress-Induced POI by Regulating Autophagic Homeostasis Through the AMPK Pathway. 人脐带间充质干细胞外泌体通过AMPK通路调节自噬稳态，减轻氧化应激诱导的POI。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12658

Wanqi Chen, Qi Feng, Chan Zhang, Lu Yang, Jingyi Qi

{"title":"Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Oxidative Stress-Induced POI by Regulating Autophagic Homeostasis Through the AMPK Pathway.","authors":"Wanqi Chen, Qi Feng, Chan Zhang, Lu Yang, Jingyi Qi","doi":"10.1002/rmb2.12658","DOIUrl":"10.1002/rmb2.12658","url":null,"abstract":"Background: Increased oxidative stress is a key factor in developing premature ovarian insufficiency (POI). Exosome therapy emerges as a promising cell-free treatment. However, research into the molecular mechanisms of exosome repair in ovarian diseases is still in its infancy. By establishing models of oxidative stress in ovarian granulosa cells and POI in mice, we aim to explore whether human umbilical cord mesenchymal stem cell exosomes can repair oxidative damage in ovarian granulosa cells and mouse ovaries, as well as identify potential targets of action. Our goal is to provide new ideas and methods for the clinical application of exosomes and the early prevention and treatment of POI.Methods: Hydrogen peroxide (H2O2) (200 μM, 2 h) and D-galactose (D-gal) (200 mg/kg, 56 days) were used to induce oxidative stress in ovarian granulosa cells and mice, respectively. Subsequently, exosomes were added to the injury model to validate the mechanism of exosome repair of oxidative damage. We evaluated senescence indicators, AMPK activation, and autophagy.Result: Through the execution of in vivo and in vitro experiments, it was observed that the activation of the AMP-activated protein kinase (AMPK) pathway is induced by exosome intervention, leading to a reduction in the accumulation of autophagic vesicles and the restoration of the patency of autophagic flow. This, in turn, results in the repair of oxidative stress-induced damage and the enhancement of the function of damaged cells and ovaries.Conclusion: Our findings indicate that exosomes derived from human umbilical cord stem cells have the beneficial effect of ameliorating oxidative stress-induced POI by activating AMPK and regulating autophagic homeostasis.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12658"},"PeriodicalIF":2.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Foundational basic animal experiments paved the way for the clinical development of uterus transplantation. 基础动物实验为子宫移植的临床发展奠定了基础。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-05-21 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12656

Iori Kisu, Makoto Mihara, Hisako Hara, Yojiro Kato, Yusuke Matoba, Yohei Yamada, Kentaro Matsubara, Hideaki Obara, Nobuhiko Suganuma, Kouji Banno

引用次数: 0

Effect of aging on semen and embryonic developmental scores in assisted reproductive technology. 衰老对辅助生殖技术中精液和胚胎发育评分的影响。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-05-21 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12647

Taiyo Yamamoto, Katsuya Mine, Hisataka Iwata

{"title":"Effect of aging on semen and embryonic developmental scores in assisted reproductive technology.","authors":"Taiyo Yamamoto, Katsuya Mine, Hisataka Iwata","doi":"10.1002/rmb2.12647","DOIUrl":"10.1002/rmb2.12647","url":null,"abstract":"Purpose: The effects of female aging on fertility have been extensively studied; however, this is not the case for aging males. Embryonic selection using time-lapse observations is helpful for successful embryo transfer; however, information on the effect of male aging on time-lapse is insufficient. We analyzed the impact of paternal aging on sperm characteristics, embryonic developmental kinetics, embryo evaluation score, and pregnancy outcomes.Methods: We used data from patients treated at our clinic between January 2020 and December 2022. We evaluated the effects of aging in men and women on semen data, in vitro fertilization (IVF) results, developmental kinetics, embryo evaluation scores, and embryo transfer outcomes using a retrospective approach.Results: Male aging adversely affected the semen characteristics. Although female aging had adverse effects on IVF, embryonic developmental kinetics, and embryo transfer outcomes, male aging did not have such a significant impact. Female aging decreased the iDAScore and Gardner criteria, whereas male aging did not affect the iDAScore.Conclusions: Aging in males had a negative effect on semen data. Contrary to the impact of aging on women, aging in men did not have a significant effect on embryo and gestation rates following embryo transfer.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12647"},"PeriodicalIF":2.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0