Ju Shi Guo, Yi Huang, Yong Mei Liu, Tian Jin Gu, Jin Jin Yuan, Yuan Yang
{"title":"输卵管远端异常患者的累积活产率：一项回顾性队列研究。","authors":"Ju Shi Guo, Yi Huang, Yong Mei Liu, Tian Jin Gu, Jin Jin Yuan, Yuan Yang","doi":"10.1002/rmb2.12677","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Compare reproductive outcomes between patients with subtle distal fallopian tube abnormalities (SDFTA) and unexplained infertility (UI) undergoing in vitro fertilization (IVF), exploring influencing factors.</p><p><strong>Methods: </strong>This retrospective study analyzed 447 women undergoing their first IVF cycle after laparoscopic evaluation for UI between January 2019 and December 2021. Based on laparoscopic findings, 162 women were classified into the SDFTA group and 285 into the UI group. Propensity score matching (PSM) created 160 matched pairs. The primary outcome was the cumulative live birth rate (CLBR) over 24 months.</p><p><strong>Results: </strong>The CLBR per oocyte retrieval cycle, biochemical pregnancy rate, clinical pregnancy rate, live birth rate per transfer, and preterm birth rate were comparable between the two groups (<i>p</i> > 0.05). However, the SDFTA group had a significantly lower early miscarriage rate (8.3% vs. 16.1%, <i>p</i> = 0.036) but a higher ectopic pregnancy rate (5.8% vs. 1.3%, <i>p</i> = 0.033). Independent predictors of CLBR were age at retrieval, the number of oocytes retrieved, and the number of IVF cycles.</p><p><strong>Conclusions: </strong>In conclusion, despite an increased risk of ectopic pregnancy, patients with SDFTA undergoing IVF exhibit favorable cumulative reproductive outcomes.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12677"},"PeriodicalIF":3.3000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423111/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cumulative Live Birth Rate in Patients With Subtle Distal Fallopian Tube Abnormalities: A Retrospective Cohort Study.\",\"authors\":\"Ju Shi Guo, Yi Huang, Yong Mei Liu, Tian Jin Gu, Jin Jin Yuan, Yuan Yang\",\"doi\":\"10.1002/rmb2.12677\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Compare reproductive outcomes between patients with subtle distal fallopian tube abnormalities (SDFTA) and unexplained infertility (UI) undergoing in vitro fertilization (IVF), exploring influencing factors.</p><p><strong>Methods: </strong>This retrospective study analyzed 447 women undergoing their first IVF cycle after laparoscopic evaluation for UI between January 2019 and December 2021. Based on laparoscopic findings, 162 women were classified into the SDFTA group and 285 into the UI group. Propensity score matching (PSM) created 160 matched pairs. The primary outcome was the cumulative live birth rate (CLBR) over 24 months.</p><p><strong>Results: </strong>The CLBR per oocyte retrieval cycle, biochemical pregnancy rate, clinical pregnancy rate, live birth rate per transfer, and preterm birth rate were comparable between the two groups (<i>p</i> > 0.05). However, the SDFTA group had a significantly lower early miscarriage rate (8.3% vs. 16.1%, <i>p</i> = 0.036) but a higher ectopic pregnancy rate (5.8% vs. 1.3%, <i>p</i> = 0.033). Independent predictors of CLBR were age at retrieval, the number of oocytes retrieved, and the number of IVF cycles.</p><p><strong>Conclusions: </strong>In conclusion, despite an increased risk of ectopic pregnancy, patients with SDFTA undergoing IVF exhibit favorable cumulative reproductive outcomes.</p>\",\"PeriodicalId\":21116,\"journal\":{\"name\":\"Reproductive Medicine and Biology\",\"volume\":\"24 1\",\"pages\":\"e12677\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423111/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reproductive Medicine and Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/rmb2.12677\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproductive Medicine and Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/rmb2.12677","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Cumulative Live Birth Rate in Patients With Subtle Distal Fallopian Tube Abnormalities: A Retrospective Cohort Study.
Purpose: Compare reproductive outcomes between patients with subtle distal fallopian tube abnormalities (SDFTA) and unexplained infertility (UI) undergoing in vitro fertilization (IVF), exploring influencing factors.
Methods: This retrospective study analyzed 447 women undergoing their first IVF cycle after laparoscopic evaluation for UI between January 2019 and December 2021. Based on laparoscopic findings, 162 women were classified into the SDFTA group and 285 into the UI group. Propensity score matching (PSM) created 160 matched pairs. The primary outcome was the cumulative live birth rate (CLBR) over 24 months.
Results: The CLBR per oocyte retrieval cycle, biochemical pregnancy rate, clinical pregnancy rate, live birth rate per transfer, and preterm birth rate were comparable between the two groups (p > 0.05). However, the SDFTA group had a significantly lower early miscarriage rate (8.3% vs. 16.1%, p = 0.036) but a higher ectopic pregnancy rate (5.8% vs. 1.3%, p = 0.033). Independent predictors of CLBR were age at retrieval, the number of oocytes retrieved, and the number of IVF cycles.
Conclusions: In conclusion, despite an increased risk of ectopic pregnancy, patients with SDFTA undergoing IVF exhibit favorable cumulative reproductive outcomes.
期刊介绍：
Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
