Reproductive Medicine and Biology最新文献_第2页

Successful Live Birth Following Treatment of Persistent Endometrial Dysbiosis and Recurrent Chronic Endometritis: A Case Report. 治疗持续性子宫内膜失调和复发性慢性子宫内膜炎后成功活产1例。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-09-12 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70098

Pao-Lin Kuo, Chao-Kai Hsu, Yu-Chen Lin, Pei-Jane Tsai, Shih-Kai Chu, Kuan-Ru Chen

{"title":"Successful Live Birth Following Treatment of Persistent Endometrial Dysbiosis and Recurrent Chronic Endometritis: A Case Report.","authors":"Pao-Lin Kuo, Chao-Kai Hsu, Yu-Chen Lin, Pei-Jane Tsai, Shih-Kai Chu, Kuan-Ru Chen","doi":"10.1002/rmb2.70098","DOIUrl":"10.1002/rmb2.70098","url":null,"abstract":"Case: To study the cause of recurrent endometritis, which recurred after standard antibiotic therapy, we report the case of a 40-year-old woman with a history of recurrent pregnancy, preterm birth, and CE. The endometritis recurred following a standard antibiotic regimen.Outcome: Microbiome analysis via 16S rRNA gene sequencing revealed persistent dysbiosis in both vaginal and endometrial samples despite antibiotic regimens. Whole-exome sequencing (WES) identified rare variants in TRPV3 and CD36, potentially associated with epithelial barrier dysfunction. Following an extended course of antibiotic therapy, the woman gave birth to a healthy baby at GA 32 weeks.Conclusions: This case highlights the possibility that barrier gene variants may be associated with persistent endometrial dysbiosis and recurrence of CE. An intensive antibiotic regimen may help achieve a viable pregnancy in patients with recurrent CE following standard antibiotic therapy.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70098"},"PeriodicalIF":4.3,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Hyaluronan-Enriched Transfer Medium in Frozen-Thawed Embryo Transfer: A Retrospective Single-Center University Hospital Study Using a Historical Cohort. 富含透明质酸的移植培养基在冻融胚胎移植中的疗效：一项回顾性的单中心大学医院历史队列研究。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-09-11 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70074

Shoko Toyoda, Seung Chik Jwa, Suguru Kamishiro, Yumi Sato, Yoko Fujimoto, Keiko Kagawa, Mizuho Sugiyama, Mai Ohashi, Hiroyuki Fujiwara

{"title":"Efficacy of Hyaluronan-Enriched Transfer Medium in Frozen-Thawed Embryo Transfer: A Retrospective Single-Center University Hospital Study Using a Historical Cohort.","authors":"Shoko Toyoda, Seung Chik Jwa, Suguru Kamishiro, Yumi Sato, Yoko Fujimoto, Keiko Kagawa, Mizuho Sugiyama, Mai Ohashi, Hiroyuki Fujiwara","doi":"10.1002/rmb2.70074","DOIUrl":"10.1002/rmb2.70074","url":null,"abstract":"Objective: Since 2023, our university hospital has incorporated hyaluronan-enriched transfer medium (HETM) into all frozen-thawed embryo transfers (FETs). This study aimed to evaluate whether HETM improved clinical pregnancy rates in FET, particularly in patients with recurrent implantation failure (RIF).Methods: We analyzed 368 FET cycles using a conventional hyaluronan-free transfer medium and 358 FET cycles using HETM, in which thawed embryos were incubated for 2-4 h before transfer. The main outcome was clinical pregnancy. Multiple logistic regression was used to evaluate the effectiveness of HETM.Results: The mean age of patients was 37.4 years (standard deviation = 4.2), and RIF, defined as failure to achieve pregnancy after two or more previous embryo transfers, accounted for 51.2%. Clinical pregnancy rates were significantly higher in the HETM group (37.7%) than in the control group (27.2%) (p = 0.002). Stratified analyses showed that HETM was associated with higher clinical pregnancy rates in RIF cycles (adjusted odds ratio = 2.4 [95% confidence interval: 1.4-3.9]). An additional analysis restricted to patients with three or more previous failed embryo transfers showed similar results.Conclusion: This study demonstrates HETM use is associated with improved clinical pregnancy rates in FET, particularly in cases of RIF.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70074"},"PeriodicalIF":4.3,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13568728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbiome-Targeted Preventive Strategies for Polyendocrine Metabolic Ovarian Syndrome: Insights From the Prenatal and Early-Life Environment. 针对多内分泌代谢性卵巢综合征的肠道微生物预防策略：来自产前和早期生活环境的见解。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-09-09 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70097

Akari Kusamoto, Yutaka Osuga, Yasushi Hirota, Miyuki Harada

{"title":"Gut Microbiome-Targeted Preventive Strategies for Polyendocrine Metabolic Ovarian Syndrome: Insights From the Prenatal and Early-Life Environment.","authors":"Akari Kusamoto, Yutaka Osuga, Yasushi Hirota, Miyuki Harada","doi":"10.1002/rmb2.70097","DOIUrl":"10.1002/rmb2.70097","url":null,"abstract":"Background: Polyendocrine metabolic ovarian syndrome (PMOS), the proposed new name for polycystic ovary syndrome (PCOS), is a complex endocrine and metabolic disorder influenced by genetic and environmental factors. Despite its high prevalence and familial aggregation, no effective preventive strategy is available. Prenatal androgen exposure is considered a key factor in PMOS pathogenesis, with studies indicating a significant role for the gut microbiome.Methods: This review summarizes evidence from human and animal studies exploring the association between PMOS and the gut microbiome, spotlighting the impact of the intrauterine environment, including prenatal androgen exposure and maternal gut microbiome, in PMOS development.Main findings: Gut microbiota dysbiosis is associated with features of PMOS pathophysiology, including hyperandrogenism, insulin resistance, neuroendocrine dysfunction, and ovarian dysfunction. Emerging evidence suggests that prenatal and early postnatal environments shape gut microbiota establishment and maturation, which may interact with multiple developmental pathways and potentially modify susceptibility to PMOS later in life.Conclusion: The gut microbiome may be involved in the developmental origins and pathophysiology of PMOS, although its precise role remains unclear. Understanding early-life host-microbiome interaction may provide a foundation for future preventive and personalized management strategies for PMOS, but further mechanistic studies and clinical validation are required.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70097"},"PeriodicalIF":4.3,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reassessing Semen Analysis: Clinical Insights Beyond Sperm Count and Motility. 重新评估精液分析：超越精子数量和活力的临床见解。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-09-08 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70096

Germar-Michael Pinggera, Pallav Sengupta, Taymour Mostafa, Fahmi Bahar, Aldo E Calogero, Sindhuja Srinivasan, Ashok Agarwal

{"title":"Reassessing Semen Analysis: Clinical Insights Beyond Sperm Count and Motility.","authors":"Germar-Michael Pinggera, Pallav Sengupta, Taymour Mostafa, Fahmi Bahar, Aldo E Calogero, Sindhuja Srinivasan, Ashok Agarwal","doi":"10.1002/rmb2.70096","DOIUrl":"10.1002/rmb2.70096","url":null,"abstract":"Background: Semen analysis (SA), recognized by the World Health Organization (WHO) as the cornerstone of male infertility evaluation, remains indispensable in reproductive medicine. However, advances in assisted reproductive technology (ART) and artificial intelligence (AI) have highlighted the limitations of relying solely on conventional semen parameters.Objective: To critically review the evolving clinical role of SA by integrating conventional assessment with emerging functional, molecular, and computational approaches that improve diagnostic accuracy and individualized patient care.Methods: A narrative review of contemporary evidence was conducted, focusing on conventional semen parameters, biofunctional sperm testing, omics technologies, AI-assisted analysis, and broader clinical applications of SA.Results: Conventional parameters, including sperm concentration, motility, and morphology, remain essential but inadequately reflect fertilizing capacity. Adjunctive assessments, including oxidative stress biomarkers and sperm DNA fragmentation, provide valuable insights into sperm function and reproductive potential. Omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, deepen mechanistic understanding, while AI enhances diagnostic precision, reproducibility, and standardization. Beyond infertility evaluation, SA also supports male contraceptive assessment, natural conception, ART, and patient counseling.Conclusions: Integrating conventional SA with functional, molecular, and AI-driven diagnostics provides a comprehensive framework for evaluating male fertility, advancing precision reproductive medicine and personalized clinical management.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70096"},"PeriodicalIF":4.3,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13555030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Reprogramming and Zygotic Genome Activation in Human Preimplantation Development: Mechanisms, Models, and Translational Prospects. 人类着床前发育中的表观遗传重编程和合子基因组激活：机制、模型和转化前景。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-09-04 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70095

Atsushi Fukuda

{"title":"Epigenetic Reprogramming and Zygotic Genome Activation in Human Preimplantation Development: Mechanisms, Models, and Translational Prospects.","authors":"Atsushi Fukuda","doi":"10.1002/rmb2.70095","DOIUrl":"10.1002/rmb2.70095","url":null,"abstract":"Purpose: Early human embryogenesis unfolds through a tightly coupled sequence of events-clearance of maternal transcripts, remodeling of parental chromatin, zygotic genome activation (ZGA), lineage segregation, implantation, and post-implantation patterning-accompanied by epigenetic reprogramming, including X-chromosome dosage compensation around the time of implantation. This review aims to synthesize recent advances in understanding this developmental program and to consider their implications for reproductive medicine.Methods: I review recent literature on human early embryogenesis, with particular emphasis on findings enabled by single-cell genomics and stem-cell-based embryo modeling, and integrate these insights to identify human-specific features of early development.Results: These approaches have made previously inaccessible aspects of human early embryogenesis experimentally tractable, revealing molecular and epigenetic features that distinguish human development from that of model organisms, including species-specific dynamics of ZGA, maternal transcript clearance, chromatin reprogramming, and X-chromosome dosage compensation.Conclusions: Advances in single-cell genomics and embryo modeling are transforming our understanding of human early embryogenesis. Building on these insights, while recognizing their current limitations, I propose a vision for improving reproductive medicine, including the potential for next-generation embryo selection strategies.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70095"},"PeriodicalIF":4.3,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13542833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Androgen-Driven Dysregulation of Lipolysis in Cumulus Cells: Molecular Evidence and Metabolic Implications in Polycystic Ovary Syndrome. 雄激素驱动的积云细胞脂肪分解失调：多囊卵巢综合征的分子证据和代谢意义。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-08-31 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70093

Reza Zarezadeh, Amir Fattahi, Kobra Hamdi, Saba Nikanfar, Mohammad Nouri, Masoud Darabi

{"title":"Androgen-Driven Dysregulation of Lipolysis in Cumulus Cells: Molecular Evidence and Metabolic Implications in Polycystic Ovary Syndrome.","authors":"Reza Zarezadeh, Amir Fattahi, Kobra Hamdi, Saba Nikanfar, Mohammad Nouri, Masoud Darabi","doi":"10.1002/rmb2.70093","DOIUrl":"10.1002/rmb2.70093","url":null,"abstract":"Objective: The present study aimed to investigate lipolytic function in cumulus cells (CCs) from women with polycystic ovary syndrome (PCOS), with a particular emphasis on the role of androgen excess.Study design: Samples of follicular fluid and CCs were collected from 30 PCOS and 30 control subjects. Human primary CCs were cultured and treated with high doses of testosterone. Androgen and gene expression levels were measured by chemiluminescent immunoassay and quantitative reverse transcription polymerase chain reaction, respectively. Oil Red O staining followed by spectrophotometric analysis was conducted to quantify intracellular neutral lipids.Main findings: CCs from PCOS patients showed significantly downregulated PNPLA2 and elevated G0S2 and HILPDA expression, with concomitant increased lipid droplet content (p < 0.05). The multivariable logistic regression model constructed from the combination of all three genes exhibited a superior diagnostic power (AUC = 0.837, p < 0.001). Only HILPDA expression was significantly correlated with intrafollicular testosterone (r = 0.395, p = 0.031), yet the main alterations observed in PCOS CCs were recapitulated in normal cells exposed to high doses of testosterone (p < 0.05).Conclusion: PCOS-associated hyperandrogenism appears to impair lipolysis in CCs, representing a potential mechanistic contributor to attendant compromised oocyte competence.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70093"},"PeriodicalIF":4.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Appraisal of "Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy". “微阴道孕酮剂量和血清孕酮阈值决定激素替代疗法冷冻解冻胚胎移植的生殖结局”的临床评价。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-08-19 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70088

I-Hsuan Wu, Juan-Enrique Schwarze, Christoph Helwig, Thomas D'Hooghe, Ilka Schellschmidt

引用次数: 0

Authors' Response to the Commentary on "Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy". 作者对“微阴道孕酮剂量和血清孕酮阈值决定激素替代疗法冷冻解冻胚胎移植的生殖结局”评论的回应。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-08-19 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70089

Ayumu Ito, Mami Sekiguchi, Yukiko Katagiri

{"title":"Authors' Response to the Commentary on \"Micronized Vaginal Progesterone Dose and Serum Progesterone Thresholds Determine Reproductive Outcomes in Frozen-Thawed Embryo Transfer With Hormone Replacement Therapy\".","authors":"Ayumu Ito, Mami Sekiguchi, Yukiko Katagiri","doi":"10.1002/rmb2.70089","DOIUrl":"https://doi.org/10.1002/rmb2.70089","url":null,"abstract":"Background: This response addresses the methodological concerns raised in a commentary on our study evaluating vaginal progesterone dose, serum progesterone concentrations, and reproductive outcomes in hormone replacement therapy-frozen embryo transfer cycles.Methods: We revisited the study objectives, analytical approach, interpretation of the proposed serum progesterone threshold, formulation-specific considerations, treatment-selection practices, and the potential influence of insurance reform.Main findings: We clarify that the proposed serum progesterone threshold should not be interpreted as a definitive clinical cutoff and that differences among progesterone formulations and non-random treatment selection may have influenced the observed associations. We also emphasize that several concerns raised in the commentary, including residual confounding and limitations inherent to the retrospective observational design, were acknowledged in the original manuscript.Conclusion: Our findings should be interpreted as exploratory observational associations rather than causal estimates. They may help generate hypotheses and inform the design of future prospective studies evaluating progesterone regimens and serum progesterone monitoring in hormone replacement therapy-frozen embryo transfer cycles.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70089"},"PeriodicalIF":4.3,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Vitamin D Analogs Doxercalciferol Induces Weight Loss and Improves Fertility in a Mouse Model of Polycystic Ovary Syndrome. 维生素D类似物多钙化醇在多囊卵巢综合征小鼠模型中诱导体重减轻和提高生育能力。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-08-18 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70082

Hang-Soo Park, Ana Corachan, Jin Seok, Farzana Liakath Ali, Mohammad Mousaei Ghasroldasht, Safia Akhtar, Hanaa Mohammed, Charlotte Manier, Abdullah Awartani, Nahed Ismail, Hyunho Kim, Ayman Al-Hendy

{"title":"The Vitamin D Analogs Doxercalciferol Induces Weight Loss and Improves Fertility in a Mouse Model of Polycystic Ovary Syndrome.","authors":"Hang-Soo Park, Ana Corachan, Jin Seok, Farzana Liakath Ali, Mohammad Mousaei Ghasroldasht, Safia Akhtar, Hanaa Mohammed, Charlotte Manier, Abdullah Awartani, Nahed Ismail, Hyunho Kim, Ayman Al-Hendy","doi":"10.1002/rmb2.70082","DOIUrl":"https://doi.org/10.1002/rmb2.70082","url":null,"abstract":"Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Several published studies demonstrated the therapeutic potential of vitamin D on PCOS condition, but vitamin D supplementation leads to only modest improvements. Doxercalciferol (Dox) is a highly potent vitamin D receptor (VDR) agonist that binds to VDR with at least 150 times greater affinity than other vitamin D compounds. In this study, we hypothesized that the therapeutic potential of Dox may reverse PCOS-related phenotypes more efficiently.Method: We first analyzed the regulatory potential of Dox in fat metabolism by comparing adipocyte proliferation and differentiation in our in vitro model. We also injected Dox into our mouse model of PCOS to analyze the therapeutic effect of Dox treatment on various PCOS-related parameters and fertility.Result: Dox treatment inhibited the proliferation of both adipose lineage cells and androgen-producing H295R cells in a dose-dependent manner. PCOS-related outcomes such as body weight and fertility rate were significantly reversed in Dox-treated PCOS mice model.Conclusion: Our study revealed that vitamin D analogs are a promising family of compounds for reducing body weight and reversing infertility in an animal model of PCOS.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70082"},"PeriodicalIF":4.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13482908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary Letter to the Editor Regarding Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta-Analysis of Randomized Controlled Trials. 关于子宫内输注自体富血小板血浆对反复植入失败患者辅助生殖结局的影响：随机对照试验的荟萃分析。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-08-18 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70091

Germar-Michael Pinggera, Bettina Toth, Giovanni Maria Colpi

{"title":"Commentary Letter to the Editor Regarding Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta-Analysis of Randomized Controlled Trials.","authors":"Germar-Michael Pinggera, Bettina Toth, Giovanni Maria Colpi","doi":"10.1002/rmb2.70091","DOIUrl":"https://doi.org/10.1002/rmb2.70091","url":null,"abstract":"We commend Liang et al. for their rigorous meta-analysis of intrauterine platelet-rich plasma infusion in ART, particularly for recurrent implantation failure, but note issues affecting interpretation. Forest plot axes label \"favors control/PRP\" using a harm-oriented convention, inverting standard visual interpretation. The methods state a random-effects model, yet reported effect sizes and heterogeneity statistics match fixed-effect estimation, likely narrowing confidence intervals and overstating precision for live birth rate. One figure omits two included studies without explanation, undermining transparency. Non-significant subgroup findings are described as clinically meaningful, risking overinterpretation absent pre-specified hypotheses or multiplicity correction. Accurate, outcome-specific labeling and internally consistent model reporting are essential safeguards against misreading otherwise sound evidence, given its direct bearing on patient counseling and clinical decisions. We encourage a clarifying erratum to preserve this work's scientific integrity and clinical utility.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70091"},"PeriodicalIF":4.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13487375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148797536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0