Reproductive Medicine and Biology最新文献_第2页

Effect of embryo cryopreservation before surgery on clinical outcomes in IVF patients with endometrioma. 子宫内膜异位瘤体外受精患者术前胚胎冷冻保存对临床结果的影响。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-05-06 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12654

Nozomi Takahashi, Yuma Kawahara, Miyuki Harada, Tomoko Makabe, Gentaro Izumi, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga

{"title":"Effect of embryo cryopreservation before surgery on clinical outcomes in IVF patients with endometrioma.","authors":"Nozomi Takahashi, Yuma Kawahara, Miyuki Harada, Tomoko Makabe, Gentaro Izumi, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga","doi":"10.1002/rmb2.12654","DOIUrl":"10.1002/rmb2.12654","url":null,"abstract":"Purpose: This study evaluated whether embryo cryopreservation before surgery (ECBS) improves clinical outcomes in in vitro fertilization (IVF) patients with endometrioma.Methods: This retrospective study included patients aged 28-42 years with endometrioma who underwent oocyte retrieval at our hospital from 2019 to 2022. Seventeen patients who underwent ECBS and 43 patients who underwent embryo transfer (ET) without surgery were included. Patient characteristics, reproductive outcomes, and obstetric outcomes were compared between the groups.Results: Maximum cyst size was significantly larger in the ECBS group than in the control group. The abortion rate per pregnancy was significantly lower (0% vs. 35.5%) in the ECBS group than in the control group. The ongoing pregnancy rate per case was significantly higher in the ECBS group than in the control group (88.2% vs. 58.1%), while the time to ongoing pregnancy was similar. Among patients in the ECBS group who experienced live births, 84.6% became pregnant following three or fewer ET attempts. Multivariate analysis revealed that ECBS was the only factor associated with ongoing pregnancy. The rates of perinatal complications are comparable between the groups.Conclusions: ECBS is an effective method to improve reproductive outcomes in IVF patients with endometrioma without prolonging the time to pregnancy.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12654"},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The quality of human eggs and its pre-IVF incubation. 人类卵子的质量及其体外受精前的孵化。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12652

Ri-Cheng Chian, Yi-Chun Guan, Xiao-Jin He, Jian Xu, Jin-Hui Shu, Jian-Hua Li

{"title":"The quality of human eggs and its pre-IVF incubation.","authors":"Ri-Cheng Chian, Yi-Chun Guan, Xiao-Jin He, Jian Xu, Jin-Hui Shu, Jian-Hua Li","doi":"10.1002/rmb2.12652","DOIUrl":"10.1002/rmb2.12652","url":null,"abstract":"Background: Multi-factors influence the success rate of infertility treatments, and one of the important points is to obtain good quality eggs.Methods: Based on the literatures and unpublished data, the factors affecting egg quality were summarized.Main findings results: Egg quality is an important determinant in successful infertility treatment. In addition to maternal age, controlled ovarian hyperstimulation (COH) protocols also play a key role in affecting the quality of the egg. After egg retrieval, the insemination occurs 3-6 h after collection, with a pre-IVF incubation time by in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) (39-42 h post-HCG injection). The pre-IVF incubation refers to the short period time of 3 to 6 h after oocyte retrieval and before the insemination by IVF or ICSI. The pre-IVF incubation of collected eggs in the designed culture medium improves egg quality in terms of maturation and early embryonic development.Conclusions: Pre-IVF incubation of the collected eggs contributes to the improvement of the quality of eggs; therefore, it may increase subsequent pregnancy and implantation rates following embryo transfer.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12652"},"PeriodicalIF":2.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative prospective study on the clinical utility of G-banding and next-generation sequencing for chromosomal analysis of products of conception under Advanced Medical Care A in Japan. 日本先进医疗A下妊娠产物染色体分析中g带和下一代测序临床应用的比较前瞻性研究。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12655

Hidemine Honda, Tsuyoshi Takiuchi, Mika Handa, Nao Wakui, Saori Tsuji, Takeshi Goto, Shota Suzuki, Fumie Saji, Tatsuya Miyake, Sakae Goto, Satomi Okamura, Tomomi Yamada, Michiko Kodama, Tadashi Kimura

{"title":"Comparative prospective study on the clinical utility of G-banding and next-generation sequencing for chromosomal analysis of products of conception under Advanced Medical Care A in Japan.","authors":"Hidemine Honda, Tsuyoshi Takiuchi, Mika Handa, Nao Wakui, Saori Tsuji, Takeshi Goto, Shota Suzuki, Fumie Saji, Tatsuya Miyake, Sakae Goto, Satomi Okamura, Tomomi Yamada, Michiko Kodama, Tadashi Kimura","doi":"10.1002/rmb2.12655","DOIUrl":"10.1002/rmb2.12655","url":null,"abstract":"Purpose: To compare the clinical utility of G-banding and next-generation sequencing (NGS) for chromosomal analysis of products of conception (POC), a crucial tool for detecting fetal chromosomal abnormalities which are major causes of miscarriage and stillbirth.Methods: We evaluated the clinical utility of both techniques in a prospective analysis of 40 patients who experienced miscarriages or stillbirths between 6 and 36 weeks of gestation under Advanced Medical Care A in Japan. Both methods were applied to the same POC samples. The primary outcome was the proportion of patients with a presumed cause of miscarriage or stillbirth among all submitted samples.Results: NGS presumed the cause in 75.0% (30/40) of cases, significantly outperforming G-banding's 42.5% (17/40) (p < 0.01). G-banding could analyze 67.5% (27/40) of the samples owing to culture failure, whereas NGS successfully analyzed all samples (100%, 40/40) (p < 0.01). Among the successfully analyzed samples, NGS presumed the cause in 70.3% (19/27) of cases, compared with 62.9% (17/27) for G-banding (p = 0.31). For miscarriages before 12 weeks, NGS presumed the cause in 73.5% (25/34) of cases, significantly higher than the 44.1% (15/34) (p < 0.01) presumed using G-banding.Conclusions: These results highlight the superior efficacy of NGS over G-banding for presuming causes of miscarriage or stillbirth.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12655"},"PeriodicalIF":2.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study. 胚胎植入前基因检测对男性47xyy综合征患者可能没有必要：一项初步研究。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-04-22 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12650

Fan Dong, Zhong Zheng, Ying Ding, Yi Ma, Si-Qi Wang, Xiang-Feng Chen, Ping Ping

{"title":"Preimplantation genetic testing might not be the necessity for male patients with 47,XYY syndrome: A pilot study.","authors":"Fan Dong, Zhong Zheng, Ying Ding, Yi Ma, Si-Qi Wang, Xiang-Feng Chen, Ping Ping","doi":"10.1002/rmb2.12650","DOIUrl":"10.1002/rmb2.12650","url":null,"abstract":"Purpose: This pilot study aimed to explore the necessity for 47,XYY syndrome males (couples) to perform PGT rather than conventional In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) cycles.Methods: A retrospective cohort study was conducted with 36 nonmosaic and mosaic 47,XYY syndrome patients (couples) undergoing 43 oocyte retrieval cycles (37 planned for PGT and 6 for IVF/ICSI) between December 2017 and December 2023. The couples were given either next-generation sequencing-based PGT or conventional IVF/ICSI followed by 45 embryo transfer (ET) cycles (38 from PGT and 7 from IVF/ICSI). The detailed cytogenetic results of the 129 embryos from PGT were analyzed, and the pregnancy and neonatal outcomes between PGT-ET and conventional IVF/ICSI-ET cycles were compared.Results: The PGT results showed that the chance of sex chromosome abnormalities was low (1.55%), with chromosomal errors being observed more often in autosomes. Importantly, no differences were observed in the rates of biochemical pregnancy, implantation, clinical pregnancy, ongoing pregnancy, pregnancy loss, live birth, and preterm delivery between PGT-ET cycles and conventional IVF/ICSI-ET cycles. Comparable results regarding gestational age, birthweight, low birthweight rate, macrosomia rate, male rate, as well as the rate of congenital anomalies were also observed between the two groups.Conclusions: Preimplantation genetic testing might not be necessary to conduct for 47,XYY syndrome males unless there are other indications. Studies with large populations are in demand to confirm the present results.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12650"},"PeriodicalIF":2.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total-body irradiation or treosulfan-based conditioning regimens. 在接受造血干细胞移植的患者中优化治疗效果和保留生育能力：用全身照射或treosulan为基础的调节方案对卵巢屏蔽的叙述性回顾。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-04-17 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12648

Yuji Tanaka, Tetsuro Hanada, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Shunichiro Tsuji, Takashi Murakami

{"title":"Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total-body irradiation or treosulfan-based conditioning regimens.","authors":"Yuji Tanaka, Tetsuro Hanada, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Shunichiro Tsuji, Takashi Murakami","doi":"10.1002/rmb2.12648","DOIUrl":"10.1002/rmb2.12648","url":null,"abstract":"Background: Pediatric and adolescent/young adult (AYA) patients with hematologic malignancies often require hematopoietic stem cell transplantation (HSCT) using conditioning regimens that pose high risks for gonadal toxicity. Traditional protocols, including total body irradiation (TBI) and busulfan-based regimens, can impair fertility. This review explores the potential of gonadal shielding during TBI and treosulfan-based conditioning as strategies to optimize treatment efficacy while preserving fertility.Methods: A PubMed search up to February 2025 was performed for English, peer-reviewed articles on hematologic malignancies, HSCT, shielding, and treosulfan. Studies on oncologic outcomes and fertility in pediatric and AYA patients were included.Main findings: Ovarian shielding during myeloablative conditioning with TBI effectively reduces ovarian radiation exposure, resulting in improved menstrual recovery and hormone profiles. A treosulfan-based regimen demonstrated higher antitumor activity than a reduced-intensity busulfan-based regimen in randomized controlled trials. In a retrospective analysis, the treosulfan-based regimen exhibited lower gonadal toxicity than the busulfan-based regimen, although careful attention must be paid to dosing settings of the regimens.Conclusion: Ovarian shielding during TBI and a treosulfan-based regimen hold the potential to preserve the reproductive capacity of patients undergoing HSCT. Future clinical studies that appropriately assess both oncological outcomes and fertility are needed to validate these findings.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12648"},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A machine learning model for predicting fertilization following short-term insemination using embryo images. 利用胚胎图像预测短期授精后受精的机器学习模型。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12649

Masato Saito, Hirofumi Haraguchi, Ikumi Nakajima, Shinya Fukuda, Chenghua Zhu, Norio Masuya, Kazunori Matsumoto, Yuya Yoshikawa, Tomoki Tanaka, Satoshi Kishigami, Leona Matsumoto

{"title":"A machine learning model for predicting fertilization following short-term insemination using embryo images.","authors":"Masato Saito, Hirofumi Haraguchi, Ikumi Nakajima, Shinya Fukuda, Chenghua Zhu, Norio Masuya, Kazunori Matsumoto, Yuya Yoshikawa, Tomoki Tanaka, Satoshi Kishigami, Leona Matsumoto","doi":"10.1002/rmb2.12649","DOIUrl":"10.1002/rmb2.12649","url":null,"abstract":"Purpose: This study established a machine learning model (MLM) trained on embryo images to predict fertilization following short-term insemination for early rescue ICSI and compared its predictive performance with the embryologist's manual classification.Methods: Embryo images at 4.5 and 8 h post-insemination were preprocessed into vectors using ResNet50. The Light Gradient Boosting Machine (Light GBM) was employed for training vectors. Fertilization in the test dataset was assessed by MLM, with seven senior and 11 junior embryologists. Predictive metrics were analyzed using repeated measures ANOVA and paired t-tests.Results: Comparing MLM, senior embryologists, and junior embryologists, significant differences were observed in accuracy (0.71 ± 0.01, 0.75 ± 0.05, 0.61 ± 0.05), recall (0.84 ± 0.02, 0.84 ± 0.10, 0.61 ± 0.07), F1-score (0.78 ± 0.01, 0.81 ± 0.04, 0.66 ± 0.04), and area under the curve (0.73 ± 0.0 3, 0.73 ± 0.06, 0.61 ± 0.07), the MLM outperforming junior embryologists with <1 year of experience. No significant differences were observed between the MLM and senior embryologists with over 5 years of experience.Conclusions: MLM can effectively predict fertilization following short-term insemination by analyzing cytoplasmic changes in images. These results underscore the potential to enhance clinical decision-making and improve patient outcomes.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12649"},"PeriodicalIF":2.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toll-like receptors in mammalian sperm. 哺乳动物精子中的toll样受体。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-04-15 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12651

Takashi Umehara, Takahiro Yamanaka, Masayuki Shimada

{"title":"Toll-like receptors in mammalian sperm.","authors":"Takashi Umehara, Takahiro Yamanaka, Masayuki Shimada","doi":"10.1002/rmb2.12651","DOIUrl":"10.1002/rmb2.12651","url":null,"abstract":"Background: Toll-like receptors (TLRs) are critical components of the innate immune system and are expressed in various cells, including the reproductive system. Although their roles in female reproductive tissues such as the ovaries and uterus, including their involvement in fertilization and implantation, have been extensively reviewed, their expression and function in male germ cells, particularly in sperm, remain underexplored.Methods: This review provides a comprehensive summary of research on TLRs expressed in sperm, including findings from experimental models in mice, humans, and industrial livestock.Results: The activation of TLR2 and TLR4, which detect Gram-positive and Gram-negative bacteria, has been shown to reduce sperm motility and viability, thereby impairing fertilization. Conversely, low levels of TLR2 activation have been reported to promote the fertilization of bull sperm, suggesting that TLR2/4 may act as regulators of fertilization. TLR7 and TLR8, which are exclusively expressed in X chromosome-bearing sperm (X-sperm), have attracted increasing research interest. These receptors modulate sperm metabolism, selectively reduce the motility of X sperm, and enable the separation of X and Y sperm.Conclusion: TLRs in the sperm serve as immune receptors that detect bacterial and viral infections, thereby reducing sperm functionality, preventing miscarriage, protecting maternal health, and sex selection.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12651"},"PeriodicalIF":2.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Japanese reproductive medicine under health insurance: A brief review and prospects. 日本医疗保险下的生殖医学：简要回顾与展望。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12646

Akira Iwase

引用次数: 0

Serum copper to zinc ratio and risk of endometriosis: Insights from a case-control study in infertile patients. 血清铜锌比与子宫内膜异位症的风险：来自不孕症患者病例对照研究的见解。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12644

Yanping Liu, Guihong Cheng, Hong Li, Qingxia Meng

{"title":"Serum copper to zinc ratio and risk of endometriosis: Insights from a case-control study in infertile patients.","authors":"Yanping Liu, Guihong Cheng, Hong Li, Qingxia Meng","doi":"10.1002/rmb2.12644","DOIUrl":"10.1002/rmb2.12644","url":null,"abstract":"Purpose: Endometriosis is a prevalent gynecological disorder, yet data on the role of trace metal elements in its risk remain limited. We aimed to investigate the relationship between serum copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) levels, and the Cu/Zn ratio with the risk of endometriosis.Methods: This study involved 568 infertile patients diagnosed with endometriosis, compared to 819 infertile patients without endometriosis (Control group). Basic characteristics, hormonal parameters, and essential trace elements of the patients were measured and analyzed.Results: The findings indicated a notable decrease in serum Zn levels in the endometriosis group compared to controls, alongside a significant increase in the Cu/Zn ratio (p < 0.001). Restricted cubic spline (RCS) analysis revealed a linear relationship between Zn levels and the Cu/Zn ratio and endometriosis risk. Moreover, Zn levels exhibited a negative correlation with endometriosis risk (p trend = 0.005), while the Cu/Zn ratio displayed a positive correlation with endometriosis risk, even after adjusting for age, body mass index (BMI), and baseline hormones (p trend < 0.001). Compared to the first quartile of Cu/Zn ratio after adjustment, the odds ratios (ORs) with 95% confidence intervals (CIs) for the second and fourth quartiles were 1.97 (1.37, 2.83) and 2.63 (1.80, 3.84), respectively.Conclusions: This study provided evidence of decreased serum Zn levels and an increased Cu/Zn ratio being associated with an elevated risk of endometriosis among infertile patients. These findings offer valuable real-world data, enriching our understanding of endometriosis.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12644"},"PeriodicalIF":2.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of heparin-aspirin therapy in patients with recurrent pregnancy loss characterized by thrombophilia resistant to low-dose aspirin therapy: A retrospective study. 肝素-阿司匹林治疗对以血栓形成为特征的复发性流产患者对低剂量阿司匹林治疗的影响：一项回顾性研究。

IF 2.7 3区医学

Reproductive Medicine and Biology Pub Date : 2025-03-26 eCollection Date: 2025-01-01 DOI: 10.1002/rmb2.12643

Tomoko Ichikawa, Takami Watanabe, Yumene Kubota, Shigeru Matsuda, Daisuke Shigemi, Sayuri Kasano, Ryoko Yokote, Mirei Yonezawa, Nozomi Ouchi, Yasuyuki Negishi, Yoshimitsu Kuwabara, Toshiyuki Takeshita, Shunji Suzuki

{"title":"Impact of heparin-aspirin therapy in patients with recurrent pregnancy loss characterized by thrombophilia resistant to low-dose aspirin therapy: A retrospective study.","authors":"Tomoko Ichikawa, Takami Watanabe, Yumene Kubota, Shigeru Matsuda, Daisuke Shigemi, Sayuri Kasano, Ryoko Yokote, Mirei Yonezawa, Nozomi Ouchi, Yasuyuki Negishi, Yoshimitsu Kuwabara, Toshiyuki Takeshita, Shunji Suzuki","doi":"10.1002/rmb2.12643","DOIUrl":"10.1002/rmb2.12643","url":null,"abstract":"Purpose: Heparin and aspirin (HA) therapy is used for antiphospholipid syndrome (APS)-associated recurrent pregnancy loss (RPL). Low-dose aspirin (LDA) is recommended for thrombophilic predispositions, such as antiphospholipid antibodies that do not completely meet the Sydney classification criteria for APS, protein S deficiency, factor XII deficiency and increased platelet aggregation. However, no established strategy exists for cases where LDA is ineffective. Therefore, this study aimed to identify the characteristics of RPL cases unresponsive to LDA and to determine whether HA is more effective than LDA in such cases.Methods: A total of 913 LDA-treated pregnancies were categorized into live births and miscarriages, and their characteristics were retrospectively analyzed.Results: The live birth rates following one, two, or three or more LDA therapies were 78.5%, 61.5% and 16.7%, respectively. Live birth rates were significantly lower when lupus anticoagulant (LAC) aPTT was positive but did not qualify as obstetric APS following LDA therapy (birth rates: 33.3%, p = 0.048). Three or more LDA therapies decreased the live birth rate, whereas HA therapy significantly increased the live birth rate (p = 0.0019).Conclusions: HA therapy is recommended over repeated LDA treatment, particularly when LAC aPTT is positive but does not qualify as obstetric APS.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12643"},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0