Reproductive Medicine and Biology最新文献_第10页

The Three Pillars of ATP Production in Mammalian Sperm: Integrating Gluconeogenesis Into the Metabolic Framework. 哺乳动物精子中ATP产生的三大支柱：将糖异生整合到代谢框架中。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70017

Kosei Oishi, Reiji Tokito, Yasushi Yumura, Manabu Yoshida, Kaoru Yoshida, Masatsugu Asada, Koyuki Mikami, Hiroyuki Watanabe, Yuki Muranishi, Yasuyuki Kurihara

{"title":"The Three Pillars of ATP Production in Mammalian Sperm: Integrating Gluconeogenesis Into the Metabolic Framework.","authors":"Kosei Oishi, Reiji Tokito, Yasushi Yumura, Manabu Yoshida, Kaoru Yoshida, Masatsugu Asada, Koyuki Mikami, Hiroyuki Watanabe, Yuki Muranishi, Yasuyuki Kurihara","doi":"10.1002/rmb2.70017","DOIUrl":"10.1002/rmb2.70017","url":null,"abstract":"Purpose: Mammalian sperm require a large amount of ATP to sustain motility. While glycolysis and oxidative phosphorylation (OXPHOS) are established ATP sources, they cannot fully explain motility maintenance under glucose-deprived conditions. This study examined whether gluconeogenesis functions as a third metabolic pathway supporting sperm energy production.Methods: Sperm from mice, humans, cattle, and horses were comparatively analyzed under glucose-containing and glucose-free conditions with inhibitors of OXPHOS (FCCP) and fructose-1,6-bisphosphatase 1 (FBPase1). Motility and ATP levels were measured, and FBPase1 expression was assessed by Western blotting and immunofluorescence.Results: Mouse sperm maintained motility without glucose, and inhibition of FBPase1 significantly reduced ATP and rapid progressive motility. FBPase1 was expressed in the midpiece and principal piece, indicating active gluconeogenesis. Similar patterns were observed in human and bovine sperm, suggesting a conserved mechanism among mammals.Conclusion: Gluconeogenesis serves as a third metabolic platform that complements glycolysis and OXPHOS, enabling efficient substrate use and sustaining sperm motility. This discovery provides new insight into sperm metabolic flexibility and may contribute to treatments for male infertility and improved livestock reproduction.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70017"},"PeriodicalIF":4.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12811689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Both Oocyte Hyperresponse and Oocyte Vitrification Are Safe Procedures Regarding Embryo Euploidy: A Real-World Study Involving Almost 200 000 Oocytes. 卵母细胞高反应和卵母细胞玻璃化是处理胚胎整倍体的安全方法：一项涉及近20万个卵母细胞的真实世界研究。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70003

Roberto Matorras, Silvia Pérez-Fernández, Borja Santos-Zorrozua, Aila Coello, Silvia Sierra, Marcos Ferrando, Zaloa Larreategui, Iker Malaina, Carmen Rubio, Ana Cobo, Maitane Gantxegi

{"title":"Both Oocyte Hyperresponse and Oocyte Vitrification Are Safe Procedures Regarding Embryo Euploidy: A Real-World Study Involving Almost 200 000 Oocytes.","authors":"Roberto Matorras, Silvia Pérez-Fernández, Borja Santos-Zorrozua, Aila Coello, Silvia Sierra, Marcos Ferrando, Zaloa Larreategui, Iker Malaina, Carmen Rubio, Ana Cobo, Maitane Gantxegi","doi":"10.1002/rmb2.70003","DOIUrl":"10.1002/rmb2.70003","url":null,"abstract":"Purpose: To ascertain whether ovarian hyperresponse and oocyte vitrification (OV) are associated with an increase in embryo aneuploidy.Methods: Retrospective study involving 197 629 retrieved oocytes. We studied the euploidy rate (ER), the ER according to the number of retrieved oocytes (ERaRO) and according to the number of metaphase II oocytes (MIIO) (ERaMII), and the quotient \"MIIO/retrieved oocytes\" or mature oocyte rate (MOR).Results: The maximal ERaRO corresponded when only one oocyte was recovered (27% ± 44%), and was somewhat lower when two oocytes were retrieved (14% ± 31%). From the 3rd oocyte until the 36th oocyte, the ERaRO remained constant at around 10%. Regarding MIIO, a similar pattern was observed. For a given number of oocytes, usually the ER was higher if MOR was 100%. Moreover, even when considering only cases with a 100% MOR, the ER was significantly higher in cases where there were 1-2 MIIO. Concerning OV, the regression analysis after adjustment showed that vitrified oocytes had a similar rate of aneuploidy to fresh oocytes.Conclusions: Both ovarian hyperresponse and OV are safe procedures concerning embryo euploidy. The better ER obtained, especially in cases with 1-2 oocytes, opens a new line of research concerning the superior oocyte quality from the point of view of the euploidy of cycles with 1-2 oocytes.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70003"},"PeriodicalIF":4.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12810404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Maternal Microbiome: Role in Improved Conception and Pregnancy Outcome. 优化母体微生物组：在改善受孕和妊娠结局中的作用。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-01-12 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70014

Eytan R Barnea, Amala Nazareth, Chittaranjan N Purandare, Anderson Pinheiro-Borovac, Ruth Dolmo Carluccio, Nikhil C Purandare, Fionnuala M McAuliffe

{"title":"Optimizing Maternal Microbiome: Role in Improved Conception and Pregnancy Outcome.","authors":"Eytan R Barnea, Amala Nazareth, Chittaranjan N Purandare, Anderson Pinheiro-Borovac, Ruth Dolmo Carluccio, Nikhil C Purandare, Fionnuala M McAuliffe","doi":"10.1002/rmb2.70014","DOIUrl":"10.1002/rmb2.70014","url":null,"abstract":"Purpose: To evaluate the role of optimizing the maternal microbiome in improving pregnancy outcomes, focusing on preconception and early gestation, and to propose practical diagnostic and preventive strategies, particularly in low- and middle-income countries (LMIC).Methods: A comprehensive review of peer-reviewed literature was conducted, analyzing the impact of vaginal, endometrial, gastrointestinal, urinary, and oral microbiomes on fertility and pregnancy. Key factors included microbial dysbiosis, sexually transmitted infections (STIs), and lifestyle interventions. Diagnostic approaches (cultures, gene sequencing) and preventive measures (nutrition, probiotics, vaccinations) were assessed for efficacy in optimizing the microbiome.Results: An optimized microbiome, particularly with Lactobacillus crispatus dominance, enhances fertility and reduces pregnancy complications like miscarriage, preterm birth, and congenital infections. Dysbiosis, linked to obesity, antibiotic overuse, and poor nutrition, increases STI susceptibility and pregnancy risks. Preconception screening and targeted treatments (e.g., antibiotics for STIs, probiotics) improve outcomes. Nutritional interventions, including Mediterranean diets and supplements, support microbial health. LMIC face challenges due to limited access to care and nutrition, exacerbating adverse outcomes to be addressed.Conclusions: Preconception microbiome optimization through diagnostics, lifestyle changes, and targeted therapies significantly improves pregnancy outcomes. Simple, cost-effective measures are critical also in LMIC to prevent and reduce maternal and fetal morbidity and mortality.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70014"},"PeriodicalIF":4.3,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12794029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Evaluation of Two Microfluidic Sperm Sorting Devices: Laboratory Assessment of Sperm Quality and Retrospective Analysis of Embryological Outcomes Following Intracytoplasmic Sperm Injection. 两种微流控精子分选装置的比较评价：精子质量的实验室评估和卵胞浆内单精子注射后胚胎学结果的回顾性分析。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-01-08 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70010

Ryota Tachibana, Hiroki Takeuchi, Miyu Yotsutani, Mikiko Nishioka, Erina Takayama, Eiji Kondo

{"title":"Comparative Evaluation of Two Microfluidic Sperm Sorting Devices: Laboratory Assessment of Sperm Quality and Retrospective Analysis of Embryological Outcomes Following Intracytoplasmic Sperm Injection.","authors":"Ryota Tachibana, Hiroki Takeuchi, Miyu Yotsutani, Mikiko Nishioka, Erina Takayama, Eiji Kondo","doi":"10.1002/rmb2.70010","DOIUrl":"10.1002/rmb2.70010","url":null,"abstract":"Purpose: Density gradient centrifugation (DGC) enriches motile sperm but may increase sperm DNA fragmentation (SDF), whereas microfluidic sperm sorting devices, such as ZyMōt and CA0, enable centrifugation-free selection with lower SDF. Direct comparisons are limited, and their relative clinical efficacy remains unclear. We compared sperm parameters and SDF after DGC, ZyMōt, and CA0 to evaluate sperm selection performance and assessed the clinical utility of ZyMōt and CA0 based on intracytoplasmic sperm injection (ICSI) outcomes.Methods: Seventeen semen samples were aliquoted into three groups and processed using DGC, ZyMōt, or CA0. Sperm parameters and SDF were evaluated before and after selection. ICSI was performed using ZyMōt or CA0-selected sperm, inseminating 108 oocytes with ZyMōt and 64 with CA0, followed by the comparative analysis of embryo development.Results: ZyMōt-selected sperm exhibited higher motility, average path velocity, and amplitude of lateral head displacement than DGC (p < 0.01); CA0-selected sperm showed higher linearity and wobble. ZyMōt achieved higher rates of fertilization, blastocyst formation, and good-quality blastocysts, and a lower percentage of poor-quality cleavage-stage embryos than CA0 (all p < 0.05).Conclusions: ZyMōt demonstrated superior sperm quality compared with DGC and CA0, and favorable ICSI outcomes further support its potential clinical applicability.Trial registration: The study (H2023-230) was registered in the Japan Registry of Clinical Trials (jRCT) Clinical Trials Registry in Japan (jRCT1040230045).","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70010"},"PeriodicalIF":4.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of Retained Products of Conception Following Hormone Replacement Versus Natural Cycles in Frozen Embryo Transfer. 冷冻胚胎移植中激素替代与自然周期后受孕残留产物的发生率。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2026-01-06 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70012

Akiko Shimada, Yoshikazu Kitahara, Mitsuo Obara, Akiko Suto, Nami Tateishi, Misato Motegi, Jun Okaniwa, Akira Iwase, Kiyoshi Kamioka

{"title":"Incidence of Retained Products of Conception Following Hormone Replacement Versus Natural Cycles in Frozen Embryo Transfer.","authors":"Akiko Shimada, Yoshikazu Kitahara, Mitsuo Obara, Akiko Suto, Nami Tateishi, Misato Motegi, Jun Okaniwa, Akira Iwase, Kiyoshi Kamioka","doi":"10.1002/rmb2.70012","DOIUrl":"10.1002/rmb2.70012","url":null,"abstract":"Purpose: This study examined whether the incidence of retained products of conception (RPOC) differs between hormone replacement cycles (HRC) and natural ovulation cycles (NC) in frozen-thawed embryo transfer (FET) pregnancies.Methods: We retrospectively analyzed 425 clinical pregnancies following FET at a single center from 2017 to 2021. Pregnancies were classified as HRC (n = 204) or NC (n = 221). The primary outcome was RPOC incidence, diagnosed by ultrasound, Doppler, and histopathology when available. Management approaches and perinatal outcomes were descriptively assessed. Exact tests and Firth's penalized logistic regression were applied given the small number of events.Results: RPOC occurred in 14/425 pregnancies (3.3%), with 11/204 (5.4%) in HRC and 3/221 (1.4%) in NC. The Cochran-Mantel-Haenszel odds ratio was 4.47 (95% confidence interval [CI] 1.29-16.39), and the adjusted Firth odds ratio was 3.92 (95% CI 1.18-12.96). Among RPOC cases, 5 were managed conservatively, 8 required uterine evacuation, and 1 required uterine artery embolization; histopathological confirmation was obtained in 7 cases. No significant associations were observed with embryo-transfer-related procedures.Conclusion: HRC was associated with a higher RPOC incidence than NC. These exploratory findings suggest potential protocol-related differences in placental separation and warrant validation in larger, prospective multicenter studies.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70012"},"PeriodicalIF":4.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12775346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence, Clinical Risk Factors, and Pregnancy Outcomes of Trophectoderm- and Inner Cell Mass-Poor-Quality Blastocysts in Single Blastocyst Transfer Cycles: A Retrospective Cohort Study. 单次胚泡移植周期中滋养外胚层和内胚层质量差胚泡的发生率、临床危险因素和妊娠结局：一项回顾性队列研究。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-12-30 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70006

Longbin Chen, Yangqin Peng, Shuoping Zhang, Yifan Gu, Fei Gong, Ge Lin, Lizhi Leng

{"title":"Incidence, Clinical Risk Factors, and Pregnancy Outcomes of Trophectoderm- and Inner Cell Mass-Poor-Quality Blastocysts in Single Blastocyst Transfer Cycles: A Retrospective Cohort Study.","authors":"Longbin Chen, Yangqin Peng, Shuoping Zhang, Yifan Gu, Fei Gong, Ge Lin, Lizhi Leng","doi":"10.1002/rmb2.70006","DOIUrl":"10.1002/rmb2.70006","url":null,"abstract":"Purpose: To study incidence, clinical risk factors, and pregnancy outcomes of trophectoderm- and inner cell mass-poor-quality blastocysts in single blastocyst transfer cycles.Design: A retrospective cohort study included patients who underwent their first single blastocyst transfer cycle. A multivariate log-binomial regression model with COPY methods was performed.Results: The incidence of having no transferable high-quality blastocysts was 33.8% (15 685/46 433). Maternal age, BMI, infertility duration, cycle number, embryo developmental stage, and transfer strategies are independent risk factors that affect the quality of blastocysts (p < 0.05). After adjusting for 11 confounding factors, the CPR and LBR significantly decreased across the groups in the order of high-grade blastocysts, low TE grade, and low ICM grade. Late-term miscarriage, preterm birth, singleton live birth, low birth weight of singleton, and birth weight of singleton were not statistically different between three groups. Low TE grade blastocysts exhibited significantly higher rates of small gestational sacs compared to high-grade blastocysts, while low ICM grade blastocysts were associated with a significantly higher incidence of small yolk sacs compared to both high-grade blastocysts and those with low TE grade.Conclusions: Differential impacts of blastocyst component quality on early embryonic development.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70006"},"PeriodicalIF":4.3,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12754268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Arcuate Uterus in Infertility Using 3D Transvaginal Ultrasound: A Retrospective Cohort Study. 三维经阴道超声对不孕症弧形子宫的评价：一项回顾性队列研究。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-12-27 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70009

Tatsuya Yoshihara, Maki Ogi, Dai Miyashita, Kota Tanaka, Yuri Tada, Osamu Yoshino

{"title":"Evaluation of Arcuate Uterus in Infertility Using 3D Transvaginal Ultrasound: A Retrospective Cohort Study.","authors":"Tatsuya Yoshihara, Maki Ogi, Dai Miyashita, Kota Tanaka, Yuri Tada, Osamu Yoshino","doi":"10.1002/rmb2.70009","DOIUrl":"10.1002/rmb2.70009","url":null,"abstract":"Purpose: To determine the prevalence and clinical significance of arcuate uterus among infertile women using three-dimensional transvaginal ultrasound (3D-TVUS).Methods: This retrospective cohort included 327 women evaluated for infertility between January 2021 and May 2025. Arcuate uterus was defined as fundal indentation < 10 mm and angle ≥ 90°. The primary outcome was live birth, with subgroup analysis in assisted reproductive technology (ART) cases. Logistic regression was used to assess independent associations.Results: Arcuate uterus was found in 19% (62/327) of infertile women and was more frequent in unexplained infertility than in explained cases (32% vs. 14%; cOR 2.82, 95% CI 1.59-5.00, p = 0.001). Live birth rates did not differ significantly between arcuate and normal uterus, overall (17% vs. 14%; aOR 1.3, 95% CI 0.2-5.9) or in ART (65% vs. 63%; aOR 1.1, 95% CI 0.5-2.4). Reproducibility was excellent (κ = 0.94).Conclusions: Arcuate uterus was relatively common, especially in unexplained infertility, but did not independently affect live birth. 3D-TVUS assessment may help identify subgroups within unexplained infertility, warranting validation in multicenter studies.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70009"},"PeriodicalIF":4.3,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development, Live Birth and Fertility in Mouse Oocytes Penetrated by Spermatids Exposed to the HDAC Inhibitor Scriptaid. 暴露于HDAC抑制剂Scriptaid的精子穿透小鼠卵母细胞的发育、活产和生育能力。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-12-25 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70004

Seiji Watanabe, Youichi Takemoto, Rei Inoue, Izumi Tanaka, Hironori Miyata, Yuya Makino, Motoi Nagayoshi, Daisuke Nakajima, Shigeki Fujimoto, Atsushi Tanaka

{"title":"Development, Live Birth and Fertility in Mouse Oocytes Penetrated by Spermatids Exposed to the HDAC Inhibitor Scriptaid.","authors":"Seiji Watanabe, Youichi Takemoto, Rei Inoue, Izumi Tanaka, Hironori Miyata, Yuya Makino, Motoi Nagayoshi, Daisuke Nakajima, Shigeki Fujimoto, Atsushi Tanaka","doi":"10.1002/rmb2.70004","DOIUrl":"10.1002/rmb2.70004","url":null,"abstract":"Purpose: In mouse embryos derived from round spermatid injection (ROSI), low developmental potential due to abnormal histone modification is improved by histone deacetylase (HDAC) inhibitors. However, some studies suggest that the use of such inhibitors leads to the birth of hypomorphic offspring. We examined the genetic risk of Scriptaid on mouse ROSI embryos over two generations.Methods: Oocytes were penetrated by spermatids treated with Scriptaid (250 nM 10 min) and transferred to host mothers. After the offspring were born and matured, some first-generation males and females were mated to obtain second-generation offspring. One-cell ROSI embryos treated with Scriptaid (250 nM 16 h) underwent the same process.Results: Scriptaid reduced H3K9me3 residues in the spermatid nuclei and in the male pronuclei of ROSI embryos, resulting in increased blastocyst formation and live birth rates compared with the untreated group. All offspring exposed to Scriptaid had normal body weight and external appearance and subsequently grew as well as the IVF offspring. Additionally, all second-generation offspring were also healthy.Conclusion: Scriptaid improved the developmental potential of ROSI embryos, and no clear teratogenic effect was observed in the live offspring, suggesting that Scriptaid is safer than Trichostatin-A, which has been reported to induce hypomorphic offspring in ROSI.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70004"},"PeriodicalIF":4.3,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12740194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Placenta Accreta Spectrum With Early Pregnancy Subchorionic Hematoma Location and Size in Hormone Replacement Cycles. 激素替代周期中胎盘增生谱与妊娠早期绒毛膜下血肿位置和大小的风险。

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-12-23 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70005

Shuhei So, Nao Murabayashi, Wakasa Yamaguchi, Naomi Miyano, Misa Namba, Fumiko Tawara

{"title":"Risk of Placenta Accreta Spectrum With Early Pregnancy Subchorionic Hematoma Location and Size in Hormone Replacement Cycles.","authors":"Shuhei So, Nao Murabayashi, Wakasa Yamaguchi, Naomi Miyano, Misa Namba, Fumiko Tawara","doi":"10.1002/rmb2.70005","DOIUrl":"10.1002/rmb2.70005","url":null,"abstract":"Purpose: To study whether subchorionic hematoma (SCH) location and size in early pregnancy affect placenta accreta spectrum (PAS) risk in hormone replacement cycles (HRC).Methods: Retrospective cohort study of 685 singleton live births following frozen-thawed embryo transfer in HRC (November 2018-September 2023) at a single fertility clinic. SCH location (cervical-side, mid-cavity, or fundal-side) and size (< 10% or > 50% of gestational sac), assessed by first-trimester ultrasound, were evaluated for association with PAS.Results: The presence of SCH showed a trend toward increased PAS frequency (adjusted Risk Ratio (RR) 1.56, 95% Confidence Interval (CI) 0.87-2.80). Location-specific analysis revealed that cervical-side SCH conferred significantly elevated PAS risk compared to those without cervical-side SCH (adjusted RR 2.21, 95% CI 1.18-4.15), whereas mid-cavity SCH (adjusted RR 1.74, 95% CI 0.94-3.22) and fundal-side SCH (adjusted RR 0.59, 95% CI 0.20-1.76) showed no significant association. Regarding SCH size, larger hematomas (> 50% of gestational sac) were not associated with increased PAS risk compared to smaller hematomas (< 10%) (adjusted RR 0.59, 95% CI 0.16-2.13).Conclusions: Cervical-side SCH, but not mid-cavity or fundal-side hematomas, was associated with increased PAS risk in HRC pregnancies. These findings suggest that SCH location may serve as a key prognostic marker in HRC.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70005"},"PeriodicalIF":4.3,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12728315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assisted Reproductive Technology in Japan: A Summary Report for 2023 by the Committee on Professional Scientific Conduct and Clinical Ethics of the Japan Society of Obstetrics and Gynecology. 日本辅助生殖技术：日本妇产科学会专业科学行为和临床伦理委员会2023年总结报告

IF 4.3 3区医学

Reproductive Medicine and Biology Pub Date : 2025-12-23 eCollection Date: 2026-01-01 DOI: 10.1002/rmb2.70008

Yukiko Katagiri, Seung Chik Jwa, Akira Kuwahara, Takeshi Iwasa, Masanori Ono, Keiichi Kato, Hiroshi Kishi, Yoshimitsu Kuwabara, Fuminori Taniguchi, Miyuki Harada, Akira Iwase, Norihiro Sugino

{"title":"Assisted Reproductive Technology in Japan: A Summary Report for 2023 by the Committee on Professional Scientific Conduct and Clinical Ethics of the Japan Society of Obstetrics and Gynecology.","authors":"Yukiko Katagiri, Seung Chik Jwa, Akira Kuwahara, Takeshi Iwasa, Masanori Ono, Keiichi Kato, Hiroshi Kishi, Yoshimitsu Kuwabara, Fuminori Taniguchi, Miyuki Harada, Akira Iwase, Norihiro Sugino","doi":"10.1002/rmb2.70008","DOIUrl":"10.1002/rmb2.70008","url":null,"abstract":"Purpose: To summarize assisted reproductive technology (ART) data for 2023 collected through the Japan Society of Obstetrics and Gynecology registry.Methods and results: 625 out of 638 registered ART facilities took part in the study, documenting 561 664 treatment cycles and 85 048 newborns (+3.3% and +10.2% increases from 2022). The average age of women undergoing treatment was 37.3 years (standard deviation: 4.8); 205 986 cycles (36.7%) involved women aged ≥ 40 years. Among fresh cycles, oocyte retrieval was performed in 281 665 cycles, including 168 343 freeze-all cycles (59.8%). A total of 2329 pregnancies and 3375 newborns resulted from in vitro fertilization and intracytoplasmic sperm injection cycles, yielding 1772 and 2502 newborns, respectively. The overall rates for single embryo transfer (SET) and singleton delivery were 80.5% and 96.5%. Frozen-thawed embryo transfer accounted for 271 361 cycles, resulting in 109 850 pregnancies and 80 774 newborns, with a SET rate of 84.7% and a singleton delivery rate of 96.3%.Conclusions: In 2023, the second year of insurance coverage, the registry recorded the highest numbers of treatment cycles and newborns. Effective registry systems planned for 2026 will enable comprehensive evaluation of emerging trends in Japanese ART practice.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"25 1","pages":"e70008"},"PeriodicalIF":4.3,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12728317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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