Differences in clinical outcomes between men with mosaic Klinefelter syndrome and those with non-mosaic Klinefelter syndrome.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2024-05-16 eCollection Date: 2024-01-01 DOI:10.1002/rmb2.12579

Juri Tsukamoto, Noritoshi Enatsu, Eri Nakahara, Kohyu Furuhashi, Koji Chiba, Yihsien Enatsu, Yuri Mizusawa, Eri Okamoto, Shoji Kokeguchi, Masahide Shiotani

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引用次数: 0

Abstract

Purpose: This study compared the clinical outcomes of men with Klinfelter syndrome based on karyotype.

Methods: The authors analyzed the outcomes of microdissection testicular sperm extraction (micro-TESE) performed on 57 patients with Klinfelter syndrome (KS) at our clinic.

Results: The average ages of the non-mosaic and mosaic KS groups were 32.2 ± 4.8 and 45.9 ± 13.1 years, respectively. The sperm retrieval rates of the non-mosaic and mosaic KS groups were 46.5% (20/43) and 50.0% (7/14), respectively. The fertilization rates after intracytoplasmic sperm injection did not significantly differ between the non-mosaic and mosaic KS groups. The mosaic KS group had higher cleavage and blastocyst development rates than the non-mosaic KS group (72.2% vs. 96.2% and 30.5% vs. 44.7%, respectively). The group using motile sperm had better outcomes than the group using immotile sperm. The embryo transfer outcomes of the non-mosaic and mosaic KS groups did not significantly differ (clinical pregnancy rate: 28.0% vs. 20.7%, miscarriage rate: 14.3% vs. 33.3%, production rate per transfer: 22.0% vs. 13.8%, and production rate per case: 58.8% vs. 57.1%).

Conclusions: Compared with the non-mosaic KS group, the mosaic KS group had significantly better intracytoplasmic sperm injection outcomes because of the higher utilization rate of motile sperm.

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患有镶嵌型 Klinefelter 综合征和非镶嵌型 Klinefelter 综合征的男性在临床结果上的差异。

目的：本研究根据核型对克林费尔特综合征男性患者的临床结果进行了比较：作者分析了本诊所对 57 名 Klinfelter 综合征（KS）患者进行显微解剖睾丸取精术（micro-TESE）的结果：结果：非镶嵌型和镶嵌型KS患者的平均年龄分别为（32.2 ± 4.8）岁和（45.9 ± 13.1）岁。非马赛克和马赛克 KS 组的取精率分别为 46.5%（20/43）和 50.0%（7/14）。卵胞浆内单精子注射后的受精率在非马赛克型和马赛克型KS组之间没有显著差异。镶嵌式 KS 组的卵裂率和囊胚发育率高于非镶嵌式 KS 组（分别为 72.2% 对 96.2% 和 30.5% 对 44.7%）。使用有活力精子的组比使用无活力精子的组结果更好。非镶嵌型 KS 组和镶嵌型 KS 组的胚胎移植结果没有显著差异（临床妊娠率：28.0% 对 20.7%，流产率：14.3% 对 33%）：14.3% vs. 33.3%，每次移植的生产率：22.0% vs. 13.8%，每例生产率：58.8% vs. 57.1%：结论：结论：与非镶嵌型 KS 组相比，镶嵌型 KS 组的卵胞浆内单精子注射结果要好得多，因为活力精子的利用率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.