Verification of the utility of the gonadotropin starting dose calculator in progestin-primed ovarian stimulation: A comparison of empirical and calculated controlled ovarian stimulation.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2024-05-31 eCollection Date: 2024-01-01 DOI:10.1002/rmb2.12586

Masato Kobanawa, Jouji Yoshida

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引用次数: 0

Abstract

Purpose: To validate the effectiveness of a gonadotropin starting dose calculator for progestin-primed ovarian stimulation (PPOS), we conducted a study comparing the outcomes of oocyte retrieval between a group assigned gonadotropin doses via the calculator and a control group, where doses were determined by the clinician's empirical judgment.

Methods: Patients underwent controlled ovarian stimulation (COS) using the PPOS method, followed by oocyte retrieval. We assessed and compared the results of COS and oocyte retrieval in both groups. Additionally, we examined the concordance rate between the number of oocytes actually retrieved and the target number of oocytes in each group.

Results: The calculated group demonstrated a significantly higher number of preovulation follicles and a higher ovarian sensitivity index than the control group. Furthermore, the discrepancy between the target and actual number of oocytes retrieved was notably smaller in the calculated group. The concordance rate between the target and actual number of oocytes was significantly greater in the calculated group.

Conclusions: The gonadotropin starting dose calculator proved to be effective within the PPOS protocol, offering a reliable method for predicting the approximate number of oocytes to be retrieved, irrespective of the COS protocol employed.

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验证促性腺激素起始剂量计算器在孕激素促排卵中的实用性：经验性和计算性控制卵巢刺激的比较。

目的：为了验证用于孕激素促排卵（PPOS）的促性腺激素起始剂量计算器的有效性，我们进行了一项研究，比较了通过计算器分配促性腺激素剂量组与对照组（剂量由临床医生的经验判断决定）的卵母细胞检索结果：方法：患者使用 PPOS 方法接受控制性卵巢刺激（COS），然后进行卵母细胞提取。我们对两组患者的 COS 和卵母细胞提取结果进行了评估和比较。此外，我们还检查了各组实际取回的卵母细胞数与目标卵母细胞数的吻合率：结果：计算组的排卵前卵泡数量和卵巢敏感指数均明显高于对照组。此外，计算组的目标卵母细胞数与实际获取卵母细胞数之间的差异明显较小。计算组的目标卵母细胞数与实际卵母细胞数的吻合率明显更高：事实证明，促性腺激素起始剂量计算器在 PPOS 方案中是有效的，无论采用何种 COS 方案，它都能提供一种可靠的方法来预测将要获取的卵母细胞的大致数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.