Effect of embryo cryopreservation before surgery on clinical outcomes in IVF patients with endometrioma.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2025-05-06 eCollection Date: 2025-01-01 DOI:10.1002/rmb2.12654

Nozomi Takahashi, Yuma Kawahara, Miyuki Harada, Tomoko Makabe, Gentaro Izumi, Osamu Wada-Hiraike, Yasushi Hirota, Yutaka Osuga

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引用次数: 0

Abstract

Purpose: This study evaluated whether embryo cryopreservation before surgery (ECBS) improves clinical outcomes in in vitro fertilization (IVF) patients with endometrioma.

Methods: This retrospective study included patients aged 28-42 years with endometrioma who underwent oocyte retrieval at our hospital from 2019 to 2022. Seventeen patients who underwent ECBS and 43 patients who underwent embryo transfer (ET) without surgery were included. Patient characteristics, reproductive outcomes, and obstetric outcomes were compared between the groups.

Results: Maximum cyst size was significantly larger in the ECBS group than in the control group. The abortion rate per pregnancy was significantly lower (0% vs. 35.5%) in the ECBS group than in the control group. The ongoing pregnancy rate per case was significantly higher in the ECBS group than in the control group (88.2% vs. 58.1%), while the time to ongoing pregnancy was similar. Among patients in the ECBS group who experienced live births, 84.6% became pregnant following three or fewer ET attempts. Multivariate analysis revealed that ECBS was the only factor associated with ongoing pregnancy. The rates of perinatal complications are comparable between the groups.

Conclusions: ECBS is an effective method to improve reproductive outcomes in IVF patients with endometrioma without prolonging the time to pregnancy.

查看原文本刊更多论文

子宫内膜异位瘤体外受精患者术前胚胎冷冻保存对临床结果的影响。

目的：本研究评估术前胚胎冷冻保存（ECBS）是否能改善体外受精（IVF）子宫内膜异位瘤患者的临床结果。方法：回顾性研究纳入2019 - 2022年在我院行取卵术的28-42岁子宫内膜异位瘤患者。17例接受ECBS的患者和43例未经手术接受胚胎移植（ET）的患者被纳入研究。比较两组患者的特征、生殖结局和产科结局。结果：ECBS组最大囊肿大小明显大于对照组。ECBS组每次妊娠流产率明显低于对照组（0% vs. 35.5%）。ECBS组每例持续妊娠率显著高于对照组（88.2% vs. 58.1%），而持续妊娠时间相似。在经历过活产的ECBS组患者中，84.6%的患者在三次或更少的ET尝试后怀孕。多因素分析显示，ECBS是唯一与持续妊娠相关的因素。两组之间围产期并发症的发生率具有可比性。结论：ECBS是在不延长妊娠时间的情况下改善子宫内膜异位症IVF患者生殖结局的有效方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.