The quality of human eggs and its pre-IVF incubation.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI:10.1002/rmb2.12652

Ri-Cheng Chian, Yi-Chun Guan, Xiao-Jin He, Jian Xu, Jin-Hui Shu, Jian-Hua Li

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引用次数: 0

Abstract

Background: Multi-factors influence the success rate of infertility treatments, and one of the important points is to obtain good quality eggs.

Methods: Based on the literatures and unpublished data, the factors affecting egg quality were summarized.

Main findings results: Egg quality is an important determinant in successful infertility treatment. In addition to maternal age, controlled ovarian hyperstimulation (COH) protocols also play a key role in affecting the quality of the egg. After egg retrieval, the insemination occurs 3-6 h after collection, with a pre-IVF incubation time by in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) (39-42 h post-HCG injection). The pre-IVF incubation refers to the short period time of 3 to 6 h after oocyte retrieval and before the insemination by IVF or ICSI. The pre-IVF incubation of collected eggs in the designed culture medium improves egg quality in terms of maturation and early embryonic development.

Conclusions: Pre-IVF incubation of the collected eggs contributes to the improvement of the quality of eggs; therefore, it may increase subsequent pregnancy and implantation rates following embryo transfer.

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人类卵子的质量及其体外受精前的孵化。

背景：影响不孕不育治疗成功率的因素很多，获得优质卵子是其中重要的一点。方法：根据文献和未发表的资料，总结影响鸡蛋品质的因素。结果：卵子质量是不孕不育治疗成功与否的重要决定因素。除了母亲的年龄，控制卵巢过度刺激（COH）方案也在影响卵子质量方面发挥关键作用。取卵后，采集后3-6小时进行授精，通过体外受精（IVF）或卵胞浆内单精子注射（ICSI）（注射hcg后39-42小时）进行体外受精前孵育。体外受精前孵育是指取卵后，体外受精或ICSI授精前的3 ~ 6h的短时间。收集的卵子在设计的培养基中进行体外受精前孵育，在成熟和早期胚胎发育方面提高卵子质量。结论：采集的卵子进行体外受精前孵育有助于提高卵子质量；因此，它可能会增加胚胎移植后的妊娠和着床率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.