Serum copper to zinc ratio and risk of endometriosis: Insights from a case-control study in infertile patients.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI:10.1002/rmb2.12644

Yanping Liu, Guihong Cheng, Hong Li, Qingxia Meng

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引用次数: 0

Abstract

Purpose: Endometriosis is a prevalent gynecological disorder, yet data on the role of trace metal elements in its risk remain limited. We aimed to investigate the relationship between serum copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) levels, and the Cu/Zn ratio with the risk of endometriosis.

Methods: This study involved 568 infertile patients diagnosed with endometriosis, compared to 819 infertile patients without endometriosis (Control group). Basic characteristics, hormonal parameters, and essential trace elements of the patients were measured and analyzed.

Results: The findings indicated a notable decrease in serum Zn levels in the endometriosis group compared to controls, alongside a significant increase in the Cu/Zn ratio (p < 0.001). Restricted cubic spline (RCS) analysis revealed a linear relationship between Zn levels and the Cu/Zn ratio and endometriosis risk. Moreover, Zn levels exhibited a negative correlation with endometriosis risk (p trend = 0.005), while the Cu/Zn ratio displayed a positive correlation with endometriosis risk, even after adjusting for age, body mass index (BMI), and baseline hormones (p trend < 0.001). Compared to the first quartile of Cu/Zn ratio after adjustment, the odds ratios (ORs) with 95% confidence intervals (CIs) for the second and fourth quartiles were 1.97 (1.37, 2.83) and 2.63 (1.80, 3.84), respectively.

Conclusions: This study provided evidence of decreased serum Zn levels and an increased Cu/Zn ratio being associated with an elevated risk of endometriosis among infertile patients. These findings offer valuable real-world data, enriching our understanding of endometriosis.

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血清铜锌比与子宫内膜异位症的风险：来自不孕症患者病例对照研究的见解。

目的：子宫内膜异位症是一种常见的妇科疾病，然而关于微量金属元素在其风险中的作用的数据仍然有限。我们旨在探讨血清铜（Cu）、锌（Zn）、铁（Fe）、镁（Mg）水平和Cu/Zn比值与子宫内膜异位症风险的关系。方法：本研究纳入568例诊断为子宫内膜异位症的不孕症患者，与819例无子宫内膜异位症的不孕症患者（对照组）进行比较。测量并分析患者的基本特征、激素参数及必需微量元素。结果：研究结果显示，与对照组相比，子宫内膜异位症组血清锌水平显著降低，同时Cu/Zn比显著升高（p趋势= 0.005），而Cu/Zn比与子宫内膜异位症风险呈正相关，即使在调整年龄、体重指数（BMI）和基线激素（p趋势）后也是如此。本研究提供的证据表明，在不孕症患者中，血清锌水平的降低和铜锌比的增加与子宫内膜异位症的风险增加有关。这些发现提供了有价值的真实数据，丰富了我们对子宫内膜异位症的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.