Cumulative Live Birth Rate in Patients With Subtle Distal Fallopian Tube Abnormalities: A Retrospective Cohort Study.

IF 3.3 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI:10.1002/rmb2.12677

Ju Shi Guo, Yi Huang, Yong Mei Liu, Tian Jin Gu, Jin Jin Yuan, Yuan Yang

{"title":"Cumulative Live Birth Rate in Patients With Subtle Distal Fallopian Tube Abnormalities: A Retrospective Cohort Study.","authors":"Ju Shi Guo, Yi Huang, Yong Mei Liu, Tian Jin Gu, Jin Jin Yuan, Yuan Yang","doi":"10.1002/rmb2.12677","DOIUrl":null,"url":null,"abstract":"Purpose: Compare reproductive outcomes between patients with subtle distal fallopian tube abnormalities (SDFTA) and unexplained infertility (UI) undergoing in vitro fertilization (IVF), exploring influencing factors.Methods: This retrospective study analyzed 447 women undergoing their first IVF cycle after laparoscopic evaluation for UI between January 2019 and December 2021. Based on laparoscopic findings, 162 women were classified into the SDFTA group and 285 into the UI group. Propensity score matching (PSM) created 160 matched pairs. The primary outcome was the cumulative live birth rate (CLBR) over 24 months.Results: The CLBR per oocyte retrieval cycle, biochemical pregnancy rate, clinical pregnancy rate, live birth rate per transfer, and preterm birth rate were comparable between the two groups (p > 0.05). However, the SDFTA group had a significantly lower early miscarriage rate (8.3% vs. 16.1%, p = 0.036) but a higher ectopic pregnancy rate (5.8% vs. 1.3%, p = 0.033). Independent predictors of CLBR were age at retrieval, the number of oocytes retrieved, and the number of IVF cycles.Conclusions: In conclusion, despite an increased risk of ectopic pregnancy, patients with SDFTA undergoing IVF exhibit favorable cumulative reproductive outcomes.","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12677"},"PeriodicalIF":3.3000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423111/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reproductive Medicine and Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/rmb2.12677","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: Compare reproductive outcomes between patients with subtle distal fallopian tube abnormalities (SDFTA) and unexplained infertility (UI) undergoing in vitro fertilization (IVF), exploring influencing factors.

Methods: This retrospective study analyzed 447 women undergoing their first IVF cycle after laparoscopic evaluation for UI between January 2019 and December 2021. Based on laparoscopic findings, 162 women were classified into the SDFTA group and 285 into the UI group. Propensity score matching (PSM) created 160 matched pairs. The primary outcome was the cumulative live birth rate (CLBR) over 24 months.

Results: The CLBR per oocyte retrieval cycle, biochemical pregnancy rate, clinical pregnancy rate, live birth rate per transfer, and preterm birth rate were comparable between the two groups (p > 0.05). However, the SDFTA group had a significantly lower early miscarriage rate (8.3% vs. 16.1%, p = 0.036) but a higher ectopic pregnancy rate (5.8% vs. 1.3%, p = 0.033). Independent predictors of CLBR were age at retrieval, the number of oocytes retrieved, and the number of IVF cycles.

Conclusions: In conclusion, despite an increased risk of ectopic pregnancy, patients with SDFTA undergoing IVF exhibit favorable cumulative reproductive outcomes.

Abstract Image

查看原文本刊更多论文

输卵管远端异常患者的累积活产率：一项回顾性队列研究。

目的：比较体外受精（IVF）患者隐性远端输卵管异常（SDFTA）与不明原因不孕（UI）的生殖结局，探讨影响因素。方法：本回顾性研究分析了2019年1月至2021年12月期间447名妇女在腹腔镜下进行尿潴留评估后进行第一次试管婴儿周期。根据腹腔镜检查结果，将162名妇女分为SDFTA组，285名妇女分为UI组。倾向评分匹配（PSM）产生了160对匹配的配对。主要终点是24个月的累积活产率（CLBR）。结果：两组每次卵母细胞回收周期CLBR、生化妊娠率、临床妊娠率、每次移植活产率、早产率比较，差异均有统计学意义（p < 0.05）。SDFTA组早期流产率明显低于对照组（8.3%比16.1%,p = 0.036），异位妊娠率明显高于对照组（5.8%比1.3%,p = 0.033）。CLBR的独立预测因子是取卵时的年龄、取卵数和体外受精周期数。结论：综上所述，尽管异位妊娠的风险增加，但SDFTA患者接受体外受精的累积生殖结果良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.