Huy Phuong Tran, Nam Nhat Nguyen, Ngoc Thanh Truong, Tuyet Thi-Diem Hoang, Trang Nguyen-Khanh Huynh, Ha Le-Bao Tran
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The protocol for this review has been registered in PROSPERO.</p><p><strong>Results: </strong>A total of seven studies (2057 patients) were included in the analysis. Participants in the FT-CDB group demonstrated significantly higher odds of achieving clinical pregnancy (OR 1.24, 95% CI 1.03-1.49, <i>p</i> = 0.022, <i>I</i> <sup>2</sup> = 27%), and live birth (OR 1.31, 95% CI 1.08-1.60, <i>p</i> = 0.007, <i>I</i> <sup>2</sup> = 0%) compared to the DFB group. No significant differences were observed in the birth weights of infants between the groups (MD -87.05 g, 95% CI -293.77 to 119.67, <i>p</i> = 0.41, <i>I</i> <sup>2</sup> = 83%).</p><p><strong>Conclusion: </strong>Transferring blastocysts derived from frozen-thawed cleavage embryos is associated with higher odds of clinical pregnancy and live birth compared to frozen-thawed blastocyst transfers.</p><p><strong>Trial registration: </strong>PROSPERO number: CRD42024591620.</p>","PeriodicalId":21116,"journal":{"name":"Reproductive Medicine and Biology","volume":"24 1","pages":"e12673"},"PeriodicalIF":3.3000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329422/pdf/","citationCount":"0","resultStr":"{\"title\":\"Reproductive Outcomes of Transferring Blastocysts Derived From Frozen-Thawed Cleavage Embryos: A Systematic Review and Meta-Analysis.\",\"authors\":\"Huy Phuong Tran, Nam Nhat Nguyen, Ngoc Thanh Truong, Tuyet Thi-Diem Hoang, Trang Nguyen-Khanh Huynh, Ha Le-Bao Tran\",\"doi\":\"10.1002/rmb2.12673\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In in vitro fertilization (IVF), transferring frozen-thawed blastocysts is a widely adopted practice. 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引用次数: 0
摘要
背景：在体外受精（IVF）中，转移冻融囊胚是一种广泛采用的做法。本荟萃分析旨在评估冷冻解冻卵裂胚胎（FT-CDB组）与直接冷冻解冻囊胚（DFB组）移植的生殖结果。方法：检索PubMed/MEDLINE、EMBASE、Scopus、Web of Science等相关电子数据库。如果比较接受FT-CDB或DFB移植与玻璃化方法的IVF患者的临床和新生儿结局，则纳入研究。本次审查的方案已在普洛斯彼罗登记。结果：共纳入7项研究（2057例患者）。与DFB组相比，FT-CDB组的参与者实现临床妊娠（OR 1.24, 95% CI 1.03-1.49, p = 0.022, i2 = 27%）和活产（OR 1.31, 95% CI 1.08-1.60, p = 0.007, i2 = 0%）的几率显著更高。两组婴儿出生体重差异无统计学意义（MD -87.05 g, 95% CI -293.77 ~ 119.67, p = 0.41, i2 = 83%）。结论：冻融卵裂胚移植与冻融胚移植相比，临床妊娠和活产的几率更高。试验注册：PROSPERO号：CRD42024591620。
Reproductive Outcomes of Transferring Blastocysts Derived From Frozen-Thawed Cleavage Embryos: A Systematic Review and Meta-Analysis.
Background: In in vitro fertilization (IVF), transferring frozen-thawed blastocysts is a widely adopted practice. This meta-analysis aims to evaluate the reproductive outcomes of transferring blastocysts derived from frozen-thawed cleavage embryos (FT-CDB group) compared to direct frozen-thawed blastocyst (DFB group) transfers.
Methods: We searched the following electronic databases for relevant studies: PubMed/MEDLINE, EMBASE, Scopus, and Web of Science. Studies were included if they compared the clinical and neonatal outcomes of IVF patients receiving either FT-CDB or DFB transfer with vitrification method. The protocol for this review has been registered in PROSPERO.
Results: A total of seven studies (2057 patients) were included in the analysis. Participants in the FT-CDB group demonstrated significantly higher odds of achieving clinical pregnancy (OR 1.24, 95% CI 1.03-1.49, p = 0.022, I2 = 27%), and live birth (OR 1.31, 95% CI 1.08-1.60, p = 0.007, I2 = 0%) compared to the DFB group. No significant differences were observed in the birth weights of infants between the groups (MD -87.05 g, 95% CI -293.77 to 119.67, p = 0.41, I2 = 83%).
Conclusion: Transferring blastocysts derived from frozen-thawed cleavage embryos is associated with higher odds of clinical pregnancy and live birth compared to frozen-thawed blastocyst transfers.
期刊介绍：
Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.
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