Influence of lifestyle and the circadian clock on reproduction.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI:10.1002/rmb2.12641

Masanori Ono, Yidan Dai, Tomoko Fujiwara, Hiroshi Fujiwara, Takiko Daikoku, Hitoshi Ando, Naoaki Kuji, Hirotaka Nishi

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引用次数: 0

Abstract

Background: The biological reproductive process requires the precise coordination of annual and daily signals to adapt to environmental shifts. Humans and animals have developed shared neuroendocrine systems that have adapted to process daily and seasonal light signals within the hypothalamic-pituitary -gonadal axis. However, the stability of circadian and seasonal biological processes is at risk due to industrialization and contemporary round-the-clock lifestyles. These threats include skipping breakfast, excessive artificial illumination during inappropriate hours because of irregular work schedules, nighttime urban lighting, and widespread environmental pollution from endocrine-disrupting chemicals. This review aimed to explore the interplay between lifestyle factors, circadian rhythms, and reproductive functions.

Methods: This review examined the reciprocal influences of circadian clocks on reproductive hormones, exploring the underlying mechanisms and their implications for fertility and reproductive health. We emphasized key findings regarding molecular clock components, endocrine pathways, and the critical importance of synchronizing circadian rhythms with hormonal cycles.

Main findings: The intersection of reproductive endocrinology and circadian biology reveals complex interactions between hormonal regulation and circadian rhythms. Circadian rhythm misalignments due to environmental factors, including late-night work and skipping breakfast, negatively impact endocrine and reproductive functions.

Conclusions: More strategies are needed to mitigate the effects of circadian disruption on reproductive functions.

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生活方式和生物钟对生殖的影响。

背景：生物生殖过程需要精确协调年信号和日信号以适应环境变化。人类和动物已经发展出共同的神经内分泌系统，适应处理下丘脑-垂体-性腺轴内的日常和季节性光信号。然而，由于工业化和当代全天候的生活方式，昼夜节律和季节性生物过程的稳定性受到威胁。这些威胁包括不吃早餐，在不适当的时间过度人工照明，因为不规律的工作时间表，夜间城市照明，以及内分泌干扰化学物质造成的广泛环境污染。本文旨在探讨生活方式因素、昼夜节律和生殖功能之间的相互作用。方法：本文综述了生物钟对生殖激素的相互影响，探讨其潜在机制及其对生育和生殖健康的影响。我们强调了关于分子钟组成、内分泌途径以及昼夜节律与激素周期同步的关键重要性的关键发现。主要发现：生殖内分泌学和昼夜节律生物学的交叉揭示了激素调节和昼夜节律之间复杂的相互作用。环境因素造成的昼夜节律失调，包括深夜工作和不吃早餐，会对内分泌和生殖功能产生负面影响。结论：需要更多的策略来减轻昼夜节律中断对生殖功能的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.