Research and Reports in Urology最新文献

{"title":"Smoking Habits, Physical Activity and BMI as Predictors of Cognitive and Affective Function in Patients with Prostate Cancer.","authors":"Alicja Popiołek, Bartosz Brzoszczyk, Ewa Niemczuk, Alina Borkowska, Piotr Jarzemski, Maciej Bieliński","doi":"10.2147/RRU.S572735","DOIUrl":"10.2147/RRU.S572735","url":null,"abstract":"<p><strong>Objective: </strong>To assess modifiable risk factors for prostate cancer -smoking, physical activity, and obesity-in PC survivors, and their relationship with cognitive and affective functioning.</p><p><strong>Methods: </strong>The study included 118 prostate cancer survivors. Clinical and psychological data were collected. Participants completed questionnaires on health risk behaviors. Cognitive functions were assessed using the Neurotest battery; anxiety and depression were measured via the Hospital Anxiety and Depression Scale. Statistical analyses included correlations and between-group comparisons (with post hoc tests).</p><p><strong>Results: </strong>Smokers recalled fewer words in the Verbal Memory Test. Current smokers also performed worse on the second Verbal Memory Test trial (p=0.035) and had slower response times in the Visuospatial Memory Test (p=0.013). Obese individuals had slower Go/No-Go reaction times compared to non-obese participants (p=0.02). No other cognitive or affective differences were found.</p><p><strong>Conclusion: </strong>Our preliminary findings suggest that smoking may impair memory in prostate cancer survivors. The relationship between physical activity, obesity, and cognitive and affective outcomes appears more complex and warrants further investigation.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"572735"},"PeriodicalIF":2.4,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Cancer Screening in Somalia: A Perspective on Addressing a Critical Gap in Early Detection.","authors":"Mohamed Serar Yusuf, Rahmo Mohamed Ali","doi":"10.2147/RRU.S602286","DOIUrl":"10.2147/RRU.S602286","url":null,"abstract":"<p><p>Prostate cancer is one of the leading cancers affecting men worldwide, with a growing burden in sub-Saharan Africa where mortality-to-incidence ratios remain among the highest globally. In many countries within the region, a substantial proportion of patients present with advanced-stage disease, reflecting limited access to early detection and diagnostic services, and despite the demonstrated benefits of screening, these gains have not been equitably realized in low-resource settings. In Somalia, prostate cancer screening is largely absent, contributing to late-stage diagnosis and poor clinical outcomes. This perspective highlights the importance of early detection and examines the structural, clinical, and socio-cultural factors underlying screening gaps in the Somali context, including the absence of national screening policies, limited access to prostate-specific antigen testing, underutilization of digital rectal examination, workforce shortages, and weak diagnostic referral pathways. Drawing on regional evidence and emerging local data, this article proposes pragmatic, context-appropriate strategies to improve early detection within fragile health systems, emphasizing that strengthening prostate cancer screening in Somalia through feasible, primary care-based interventions is essential to reduce preventable morbidity, improve survival outcomes, and advance equity in men's health.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"602286"},"PeriodicalIF":2.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147779217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Growth and the Urology Workforce in West Java, Indonesia: A Distribution and Projection Study.","authors":"Aaron Tigor Sihombing, Antonia Kartika, Antoninus Hengky","doi":"10.2147/RRU.S572831","DOIUrl":"10.2147/RRU.S572831","url":null,"abstract":"<p><strong>Purpose: </strong>West Java, Indonesia's most populous province, faces escalating urological healthcare demands due to rapid population growth and an aging demographic. This study evaluates the adequacy and distribution of the urology workforce in West Java and examines whether current workforce trends are sufficient to meet projected population needs.</p><p><strong>Patients and methods: </strong>A cross-sectional study utilized secondary data from the Indonesian Central Bureau of Statistics (BPS), the Indonesian Urology Collegium, and the Indonesian Urology Association (West Java section). The distribution of urologists, urologist-to-population ratios, age structure, and workforce growth trends from 2009 to 2023 were analyzed. Descriptive statistics, ratio calculations, and spatial analysis were employed to assess workforce adequacy and distribution disparities.</p><p><strong>Results: </strong>Urologists were heavily concentrated in urban centers, particularly Bandung City, with marked shortages in rural and suburban regions. The overall urologist-to-population ratio remained far below levels considered adequate for specialist care. Although the annual growth of urologists exceeded population growth, the absolute number remained insufficient. Projections indicated a future decline in the proportion of urologists aged 30-45 years, suggesting an impending workforce gap. A strong positive correlation was observed between urologist availability and the West Java Health Index.</p><p><strong>Conclusion: </strong>West Java faces a substantial mismatch between urological healthcare needs and workforce availability. Uneven distribution and projected shortages threaten equitable access to care. Strategic workforce planning, expansion of specialist training capacity, targeted deployment policies, and telemedicine integration are essential to ensure sustainable and equitable urological services in this rapidly growing province.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"572831"},"PeriodicalIF":2.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Morphometric Response to Neoadjuvant Androgen-Deprivation Therapy and Its Prognostic Role After Radical Prostatectomy.","authors":"Yevhenii Afanasiev, Sergiy Vozianov, Rostyslav Danylets, Viacheslav Grygorenko, Oleksandr Shulyak, Mykola Sosnin","doi":"10.2147/RRU.S601959","DOIUrl":"10.2147/RRU.S601959","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant Androgen-Deprivation Therapy (Nadt) Prior to Radical Prostatectomy (Rp) Induces Heterogeneous Morphological Responses in Prostate Cancer (Pca). Complete Pathological Response Is Rare, Therefore, Quantitative Assessment of Residual Viable Tumor May Provide Additional Prognostic Information Beyond Conventional Clinicopathological Parameters.</p><p><strong>Materials and methods: </strong>In this retrospective single-center study conducted between 2015 and 2021, 84 patients with localized and locally advanced PCa treated with NADT followed by RP were analyzed. Residual tumor burden (RTB) and residual tumor area (RTA) were quantified using calibrated digital morphometry. Optimal cut-off values for biochemical recurrence (BCR) were determined using ROC analysis. Biochemical recurrence-free survival (BCRFS) and overall survival (OS) were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression models.</p><p><strong>Results: </strong>During a median follow-up of 56 months, 62 BCR events and 12 deaths were observed. ROC analysis identified cut-off values of 32.5% for RTB and 50.5 mm² for RTA. In univariable analysis, high RTB (HR 1.93, 95% CI 1.14-3.23, p=0.010) and high RTA (HR 2.11, 95% CI 1.24-3.62, p=0.006) were significantly associated with inferior BCRFS. However, in multivariable analysis, cribriform architecture (HR 1.85, 95% CI 1.05-3.27, p=0.035) and high NCCN risk category (HR 1.95, 95% CI 1.07-3.54, p=0.028) remained independent predictors of BCR, whereas RTB and RTA did not retain independent significance. No independent association between morphometric parameters and OS was observed.</p><p><strong>Discussion and conclusion: </strong>Quantitative assessment of residual viable tumor following NADT is associated with BCR risk, however, their prognostic impact appears largely driven by intrinsic tumor biology, particularly cribriform architecture and baseline risk stratification. Morphometric assessment may complement postoperative risk evaluation but should not be used as a standalone prognostic marker.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"601959"},"PeriodicalIF":2.4,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in Minimally Invasive Surgical Treatment for Upper Urinary Tract Stones: A Review.","authors":"Honghua Tong, Xiaoquan Wang","doi":"10.2147/RRU.S574047","DOIUrl":"10.2147/RRU.S574047","url":null,"abstract":"<p><p>In recent years, minimally invasive techniques have made significant advancements in the management of upper urinary tract stones and have become the mainstream treatment modality. The core procedures currently routinely performed include extracorporeal shock wave lithotripsy (SWL), percutaneous nephrolithotomy (PCNL), and flexible ureteroscopy with lithotripsy (FURL). SWL is widely adopted due to its non-invasive advantage; however, its stone-free rate (SFR) can be affected by factors such as stone hardness, anatomical location, and patient body type. FURL (or RIRS) is performed through natural body cavities, resulting in minimal trauma; meanwhile, PCNL demonstrates significant efficiency advantages in managing large stone burdens. Currently, PCNL technology continues to evolve toward minimally invasive (miniaturization) and precision-oriented approaches. Concurrently, FURL technology has achieved significant breakthroughs through the integration of key innovations such as intelligent pressure control systems and flexible negative pressure suction sheaths. Therefore, systematically reviewing the latest advancements in minimally invasive surgical treatments for upper urinary tract stones and objectively evaluating their efficacy based on evidence-based medicine (such as comparing the clinical efficacy of PCNL versus FURL combined with novel negative pressure devices) will provide valuable practical guidance for clinicians in developing individualized and optimized treatment plans.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"574047"},"PeriodicalIF":2.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Awareness About the Risk Factors of Urolithiasis Among the General Population in Makkah, Saudi Arabia.","authors":"Abdullah Krenshi, Walid Alkarmo, Aseel Omar Banasir, Ibrahim Klantan, Abdulaziz Nasir Alrougi, Mustafa Madani, Fahd Almalki, Laila A Alharbi, Manal E Alotaibi","doi":"10.2147/RRU.S575368","DOIUrl":"10.2147/RRU.S575368","url":null,"abstract":"<p><strong>Background: </strong>Stones in the urinary tract, or urolithiasis, are common and have significant health and economic impacts. In Saudi Arabia, the prevalence is around 9.1%, with limited knowledge about its risk factors and prevention. The United Arab Emirates has similarly high rates, with some estimates reaching 11%. Despite this, public awareness about risk factors and prevention remains lacking. Identifying knowledge gaps and misconceptions is key to developing effective prevention strategies for high-risk populations.</p><p><strong>Objective: </strong>This study aimed to assess the knowledge and awareness of urolithiasis risk factors among the general adult population in Makkah, Saudi Arabia, and to explore the relationship between awareness levels and demographic characteristics.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted from February to April 2025 involving 452 adult participants residing in Makkah. Data was collected using an online self-administered Arabic questionnaire that covered demographics, personal and family history of kidney stones, and knowledge regarding risk factors and preventive measures.</p><p><strong>Results: </strong>Most participants (40.3%) were aged 20-29 years, and 66.2% were male. About 10.6% had a personal history of kidney stones, while 47.3% reported a family history. Nearly two-thirds (64.8%) had previously received information about kidney stone prevention, primarily from physicians (36.1%). Of those informed, 60.5% reported making lifestyle or dietary changes based on the guidance received. Overall, only 24.1% of participants demonstrated good awareness of urolithiasis risk factors.</p><p><strong>Conclusion: </strong>The study found that knowledge about kidney stone risk factors among Makkah's population is generally low. Although many participants received preventive information, misconceptions remain, especially about lesser-known risk factors. Younger adults (20-29 years) had significantly better knowledge, while other demographics showed no significant impact. The results highlight the need for targeted education and public health efforts to improve awareness and prevention.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"575368"},"PeriodicalIF":2.4,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147582290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Validation of the QLQ-NMIBC24 in Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer.","authors":"Charles C Peyton, Rahul Dhanda, Tom Burke, Victoria Tsurutis, Nikky Ugwuoke, Anagha Nadkarni, Brent Burger, Veronica Lee, Michael J Louie, Angela M Stover","doi":"10.2147/RRU.S591097","DOIUrl":"10.2147/RRU.S591097","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the psychometric properties of the EORTC QLQ-NMIBC24 and to propose distribution-based minimal clinically important difference (MCID) thresholds in patients with low-grade, intermediate-risk NMIBC (LG-IR-NMIBC).</p><p><strong>Patients and methods: </strong>Patients with LG-IR-NMIBC from two phase 3 trials (ATLAS, n = 270; ENVISION, n = 240) completed the EORTC QLQ-C30 (ENVISION only) and QLQ-NMIBC24 questionnaires at baseline, Week 6, and Month 3. Psychometric evaluation of the QLQ-NMIBC24 in the LG-IR-NMIBC population included internal consistency, item convergence, known-groups validity, test-retest reliability and responsiveness to clinical change.</p><p><strong>Results: </strong>Item-item (0.40-0.96) and item-scale correlations (0.44-0.96) indicated good convergent validity across most domains. Internal consistency was acceptable for all multi-item domains (Cronbach's α 0.78-0.93) except Malaise, which showed lower reliability (Cronbach's α 0.34-0.67). Known-groups comparisons supported the instrument's ability to distinguish patients by physical function (effect sizes up to 1.63) and sex-related domains. Test-retest reliability was generally good for Urinary Symptoms and Sexual Function (ICC 0.79-0.82). Selected domains (Urinary Symptoms, Sexual Intimacy, Malaise) demonstrated responsiveness to clinical change. Distribution-based MCID estimates varied across domains (4.37-16.29), providing potential thresholds for meaningful changes in HRQoL scores. Anchor-based analyses using QLQ-C30 change scores were explored, but correlations with QLQ-NMIBC24 domains (r = -0.37 to 0.01) did not meet the minimum threshold (0.37).</p><p><strong>Conclusion: </strong>The QLQ-NMIBC24 demonstrates valid, reliable, and interpretable measurement properties in patients with LG-IR-NMIBC. Although sensitivity varied across domains, the findings support its use in clinical trials and potentially routine practice. Distribution-based MCID thresholds provide guidance for interpreting meaningful HRQoL changes, though further studies using anchor-based methods are warranted.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"591097"},"PeriodicalIF":2.4,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147504869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Customized Reinforced 8-French Ureteral Stent with End-Piece to Decrease Ureteral Obstruction and Alleviate Stent-Related Symptoms: Evaluation of 92 Patients with 319 Ureteral Stent Procedures.","authors":"Benoît Vogt","doi":"10.2147/RRU.S586790","DOIUrl":"10.2147/RRU.S586790","url":null,"abstract":"<p><strong>Introduction: </strong>The most common method for releasing renal obstruction consists of the placement of an indwelling double-pigtail stent. However, adequate insertion of the stent through an obstructed ureter does not necessarily guarantee renal decompression. Most studies have concluded that the stiffness and lumen diameter of stents are major factors for maintaining their patency. Nonetheless, such stents are also poorly tolerated, severely impairing the patients' quality of life. We aimed to evaluate the efficiency and tolerance of a customized reinforced 8-French stent in a consecutive series of 92 patients.</p><p><strong>Materials and methods: </strong>Ninety-two consecutive patients with ureteral obstruction were fitted with a customized stent derived from the same reinforced 8-French double-pigtail stent (8F, Superglide Tumor DD Ureter Stent, Teleflex Medical, Ireland). The stent was modified by truncation and adjustment of its length to that of the patient's ureter, and the bladder loop was replaced with an end-piece. A ureteral stent procedure (USP) was performed every six months. Stent failure with ureteral obstruction was defined by the presence of renal colic or renal failure with increased serum creatinine or hydronephrosis confirmed by computerized tomography or ultrasound with/without pyelonephritis. Obstruction of the stents in less than six months motivated the switch to 8-French tandem stents. The Ureteral Stent Symptom Questionnaire (USSQ) was used to evaluate the results.</p><p><strong>Results: </strong>During the study period, 319 USPs were separately analyzed. The procedure was bilateral in 32.6% (428 ureteral units) of cases, and a tandem procedure was used in 21.7%. Stent failure with obstruction occurred in 5.0% (16/319) of USPs after a mean of 4.7 ± 2.4 months. Of the 69 patients with malignant disease, 43 (62.3%) died, with mean survival of 29.8 ± 25.7 months after the first USP. We encountered no difficulties in placing the customized stents. The results of the USSQ suggested the effectiveness of the customized stent in attenuating stent-related symptoms.</p><p><strong>Conclusion: </strong>Our results confirm that ureteral stent obstruction decreases with a larger lumen and a stiffer stent. The absence of repeated obstructions appears to improve the survival of patients with malignant disease, but this finding requires validation in a prospective randomized controlled trial. Future stents should integrate these important stent characteristics.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"586790"},"PeriodicalIF":2.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12994530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving Neurovascular Bundles Preserves the Mind: Cognitive, Functional, and Quality-of-Life Outcomes of Nerve-Sparing Radical Prostatectomy.","authors":"Bartosz Brzoszczyk, Alicja Popiołek, Piotr Jarzemski, Kinga Grzybowska, Wiktoria Tobolska, Filip Matusiak, Franciszek Domański, Alina Borkowska, Maciej Bieliński","doi":"10.2147/RRU.S576681","DOIUrl":"10.2147/RRU.S576681","url":null,"abstract":"<p><strong>Introduction: </strong>Radical prostatectomy (RP) is a standard curative treatment for localized Prostate cancer (PCa), but may negatively affect health-related quality of life (HRQoL) through urinary incontinence, erectile dysfunction, psychological distress, cognitive decline. Neurovascular bundle (NVB)-sparing techniques aim to preserve functional outcomes; however, their effects on neurocognitive performance remain unclear.</p><p><strong>Purpose: </strong>This study evaluated the impact of bilateral NVB-sparing RP on cognitive function, psychological status, HRQoL, and biochemical recurrence in patients with PCa.</p><p><strong>Methods: </strong>This retrospective study included 100 Caucasian patients who underwent laparoscopic RP between 2017 and 2022, either with bilateral intrafascial NVB preservation or without NVB sparing, according to European Association of Urology criteria. All surgeries were performed by high-volume surgeons with experience exceeding 250 RPs each. Cognitive function was assessed using a standardized computer-based test. Psychological and functional status was evaluated with the HADS Scale, ICIQ-UI SF and IIEF5 scale. HRQoL was measured with the EORTC QLQ-C30 and PR25 questionnaires. Serum prostate-specific antigen (PSA) and testosterone levels were analyzed.</p><p><strong>Results: </strong>Patients undergoing NVB-sparing RP demonstrated faster reaction times and better visual working memory compared with the non-NVB-sparing group. Postoperative erectile function, urinary continence, and testosterone levels were significantly superior following NVB preservation. HRQoL outcomes favored NVB-sparing RP, including higher global health status, physical, emotional, and cognitive functioning, and reduced fatigue. Anxiety and depression scores were lower but did not reach statistical significance. Lower postoperative PSA and absence of biochemical recurrence were associated with better verbal memory and executive functioning. No significant differences in BCR rates were observed between groups.</p><p><strong>Conclusion: </strong>Bilateral NVB-sparing RP preserves urinary and sexual function while supporting cognitive performance and psychosocial well-being, resulting in improved HRQoL without increasing the risk of BCR. These findings confirm the oncological safety of NVB-sparing RP and support the inclusion of neurocognitive and quality-of-life outcomes in surgical decision-making for patients with prostate cancer.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"576681"},"PeriodicalIF":2.4,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12990793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Peripheral White Blood Cell Count and Lower Urinary Tract Symptom Risk: A Population-Based Cross-Sectional Study of Chinese Men.","authors":"Zheng Lu, Jiange Zhang, Zhenyuan Yu, Jiawen Zhao, Zhifu Zhang, Shengzhu Huang, Min Qin, Chunlei Wu, Zengnan Mo, Ming Liao","doi":"10.2147/RRU.S569291","DOIUrl":"10.2147/RRU.S569291","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between peripheral white blood cell (WBC) count and lower urinary tract symptoms (LUTS) in a male population.</p><p><strong>Study design and setting: </strong>A population-based cross-sectional survey was conducted among males aged 18-88 years in Fangchenggang, Guangxi, China, from July to November 2011. Using multistage cluster sampling, 4,694 participants were enrolled. Multivariable logistic regression models assessed the WBC-LUTS association.</p><p><strong>Results: </strong>The prevalence of moderate/severe LUTS was 6.67%. Compared to men with none/mild LUTS, those with moderate/severe LUTS had significantly higher mean WBC counts (<i>P</i><0.01). Elevated WBC levels were independently associated with increased risks of overall LUTS (OR=1.93; 95% CI: 1.40-2.66) and voiding symptoms (OR=1.68; 95% CI: 1.19-2.35) after adjusting for confounders. Specifically, higher WBC quartiles (Q3-Q4) showed significantly greater prevalence of intermittency and urgency versus the lowest quartile (Q1). Additional risk factors for LUTS included age, hypertension, lower education, diabetes mellitus, and alcohol consumption.</p><p><strong>Conclusion: </strong>LUTS severity positively correlates with peripheral WBC counts, suggesting systemic inflammation may contribute to LUTS pathogenesis.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"569291"},"PeriodicalIF":2.4,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12992139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}