Research and Reports in Urology最新文献

{"title":"Androgen Receptor Signalling in Prostate Cancer: Mechanisms of Resistance to Endocrine Therapies.","authors":"Alberto Quistini, Francesco Chierigo, Giuseppe Fallara, Massimiliano Depalma, Marco Tozzi, Martina Maggi, Letizia Maria Ippolita Jannello, Francesco Pellegrino, Guglielmo Mantica, Daniela Terracciano, Rocco Papalia, Felice Crocetto, Rocco Damiano, Roberto Bianchi, Bernardo Maria Rocco, Matteo Ferro","doi":"10.2147/RRU.S388265","DOIUrl":"10.2147/RRU.S388265","url":null,"abstract":"<p><p>Prostate cancer (PCa) is a major global health concern. It ranks as the fifth leading cause of cancer-related mortality worldwide. While localized PCa is often indolent, with a nearly 100% five-year survival rate, prognosis worsens significantly in metastatic disease, where survival drops to approximately 30%. Androgen deprivation therapy (ADT) is initially effective in suppressing tumor growth. However, resistance eventually develops, resulting in castration-resistant prostate cancer (CRPC). The androgen receptor (AR) plays a central role in both PCa progression and treatment resistance. It promotes tumor growth by mediating the effects of testosterone and 5α-dihydrotestosterone (DHT). Several mechanisms contribute to resistance. These include AR gene mutations that reduce ligand specificity or convert antagonists into agonists. AR overexpression can maintain activity even at low androgen levels. Splice variants such as AR-V7 can activate AR signaling despite androgen depletion. AR transcriptional activity is also modulated by coregulators. Coactivators (such as the SRC family) and corepressors (such as NCOR1/2) contribute to the persistence of AR signaling. Beyond AR-dependent mechanisms, CRPC may develop through AR-independent pathways. These include glucocorticoid receptor (GR) bypass signaling and lineage plasticity leading to neuroendocrine prostate cancer (NEPC). In addition, intratumoral steroidogenesis sustains AR activation despite systemic suppression of androgens. Together, these resistance mechanisms underscore the biological complexity of CRPC. They also highlight the urgent need for innovative therapeutic approaches. This manuscript reviews emerging molecular targets and resistance pathways to inform the development of next-generation treatments.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"211-223"},"PeriodicalIF":2.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Reported Outcomes and Treatment-Associated Complications as a Consideration in Selecting Localized Prostate Cancer Management.","authors":"Tivoli Nguyen, Christine Lightfoot, David May, Jacob W Greenberg, Louis Spencer Krane","doi":"10.2147/RRU.S386383","DOIUrl":"10.2147/RRU.S386383","url":null,"abstract":"<p><p>Localized prostate cancer (PCa) remains the most common noncutaneous cancer in men, with numerous management options tailored to individual patient needs. This review examines the role of patient-reported outcomes (PROs) in guiding the management of localized PCa, focusing on the impact of various treatments on long-term quality of life. Standard therapies, including radical prostatectomy, radiotherapy, and active surveillance, are discussed alongside emerging focal therapies. Each treatment modality presents distinct risks, notably urinary incontinence, erectile dysfunction, bowel issues, and cancer recurrence. Understanding these adverse effects in terms of PROs is critical for patients and healthcare providers to engage in shared decision-making, enabling personalized treatment plans based on clinical outcomes and patient values. The incorporation of PROs into treatment selection emphasizes the significance of balancing oncologic control with functional outcomes, such as sexual, bowel, and urinary health. The importance of patient counseling is underscored, ensuring patients are fully informed about potential complications and long-term implications. This review advocates for personalized, evidence-based management strategies that align therapeutic decisions with individual patient preferences, optimizing both survival and quality of life. Enhanced communication between patients and clinicians, informed by PROs, is critical for minimizing decisional regret and maximizing satisfaction in the management of localized PCa.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"195-210"},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of Perioperative Factors on Biochemical Recurrence in Patients Undergoing Radical Prostatectomy.","authors":"Nikolaos Pyrgidis, Philipp Weinhold, Gerald Bastian Schulz, Michael Chaloupka, Elena Berg, Thilo Westhofen, Severin Rodler, Patrick Keller, Friedrich Jokisch, Christian G Stief, Julian Marcon, Robert Bischoff","doi":"10.2147/RRU.S500506","DOIUrl":"10.2147/RRU.S500506","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to assess the role of major perioperative risk factors (age, preoperative PSA values, body mass index, pathologic T-stage, resection status, and ISUP grade) in predicting biochemical recurrence (BCR) and survival after radical prostatectomy (RP) for prostate cancer (PC).</p><p><strong>Methods: </strong>An analysis of the prospective cohort of patients undergoing RP from 2013 to 2023 at our center was performed. Patients who received neoadjuvant or adjuvant therapies for PC or those with PSA persistence after RP were excluded. A Cox regression analysis was undertaken to evaluate the effect of major perioperative risk factors on the time to BCR. The role of the EAU BCR risk stratification on survival was also assessed. For all analyses, hazard ratios (HRs) with the corresponding 95% confidence intervals (CIs) were estimated.</p><p><strong>Results: </strong>A total of 1539 patients underwent RP for localized PC. At a median follow-up of 39 months (IQR: 25-60) from RP, 393 (26%) patients developed BCR. Of them, 266 (68%) were classified as EAU BCR high risk and 127 (32%) as EAU BCR low risk. In the multivariate Cox regression analysis, locally advanced PC (HR: 1.5, 95% CI: 1.2-1.9, p<0.001), positive surgical margins (HR: 1.4, 95% CI: 1.1-1.7, p=0.01), as well as ISUP grade 3 (HR: 2.4, 95% CI: 1.5-3.6, p<0.001) and 4 (HR: 2.4, 95% CI: 1.5-3.7, p<0.001) were associated with worse time to BCR. Overall, 16 (1%) patients died. Of them, 13 (81%) were classified as EAU BCR high risk and 3 (19%) as EAU BCR low risk (p<0.001). In the univariate Cox regression analysis, patients with EAU BCR high risk presented worse overall survival (HR: 4.9, 95% CI: 1.4-17, p=0.014).</p><p><strong>Conclusion: </strong>Locally advanced PC, positive surgical margins, and worse ISUP grade are independent risk factors for BCR. Accordingly, patients at BCR high-risk based on the EAU risk stratification present worse overall survival.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"185-194"},"PeriodicalIF":2.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urological Manifestation of Mpox Virus: A Scoping Review.","authors":"Guglielmo Mantica, Giovanni Drocchi, Francesco Chierigo, Giorgia Granelli, Giorgia Trani, Irene Paraboschi, Stefano Alba, Francesca Ambrosini, Cecelia De Klerk, Niccolò Riccardi, Silvia Nozza, André Van der Merwe, Carlo Terrone","doi":"10.2147/RRU.S519803","DOIUrl":"10.2147/RRU.S519803","url":null,"abstract":"<p><strong>Background: </strong>Mpox primarily presents with systemic and cutaneous symptoms. However, it can also lead to urological complications, necessitating specialized attention. The aim of this scoping review is to summarize the current evidence regarding the urological manifestations of Mpox, possible complications, and available treatments.</p><p><strong>Methods: </strong>An electronic systematic search of the current literature was conducted through the Medline and NCBI PubMed and Scopus databases on 18th August 2024. Our study search and inclusion criteria were in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 9 The search terms and keywords used were: \"monkeypox; Mpox\" (MeSH Terms), combined with different terms: \"urology\", \"kidney\", \"ureter\", \"bladder\", \"prostate\", \"genitals\", \"penis\", \"testicles\", \"urethra\", in all different possible combinations.</p><p><strong>Results: </strong>A total of 32 articles included in the scoping review. A total of 116 patients were included, all males. The genitals were the most interested organs, associated with urethritis, while bladder and kidneys seemed to be not impacted by the disease. Patients were usually young, with a mean age of 36 years [31.5-40 years]. The most prevalent risk factor was sexual intercourse in the days/weeks before the appearance of symptoms. All patients had a molecular confirmatory diagnosis by a polymerase chain reaction (PCR) test. Five articles out of 32 (15.6%) reported the need for surgical debridement of penile and genital lesions due to their clinical worsening. However, in most reports, patients experienced spontaneous resolution of the lesions and symptoms.</p><p><strong>Conclusion: </strong>Awareness of Mpox and timely diagnosis are crucial for ensuring appropriate treatment and reducing the need for surgical management and the possible risk of long-term sequelae. Collaboration among dermatologists, infectious disease specialists, and urologists is pivotal to effectively managing Mpox patients.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"175-184"},"PeriodicalIF":2.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fresh Frozen Cadavers as a Novel Training Model for Percutaneous Nephrolithotomy (PCNL).","authors":"Guglielmo Mantica, Francesco Chierigo, Thomas Tailly, Petrus Venter Spies, Danelo Estienne Du Plessis, Federico Dotta, Cleve Oppel, Emmanuel Ugbede Oyibo, Cecelia De Klerk, Lonwabo Viwe Zuko Gqoli, Giovanni Drocchi, Johannes Eduard Delport, Ruzaan Marais, Hesma Van Heerden, Mohammed Riaz Osman, Winston P R Padayachee, Matteo Ferro, Carlo Terrone, André Van der Merwe","doi":"10.2147/RRU.S515072","DOIUrl":"10.2147/RRU.S515072","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate fresh-frozen cadavers (FFC) as a novel model for percutaneous nephrolithotomy (PCNL) training, focusing on ultrasound-guided supine PCNL.</p><p><strong>Methods: </strong>Sixteen urologists participated in a 2-day course at a tertiary center to assess the utility of an FFC model for ultrasound-guided supine PCNL. After the procedure, the participants completed a 24-question evaluation of the FFC model using a 5-point Likert scale. The questionnaire assessed tissue quality, US imaging, procedural steps, overall experience compared to live patient procedures, and suitability of the model for both basic and advanced supine PCNL training.</p><p><strong>Results: </strong>The tactile sensation, skin stiffness, and distensibility of the calyces resembled real-life scenarios as the cadavers thawed. Similarly, US quality was worse in frozen cadavers and improved after irrigation with the collection system. Valdivia-Galdakao positioning is considered more difficult than in real life, because of rigor mortis.</p><p><strong>Conclusion: </strong>FFC demonstrated robust content validity as a training model for PCNL. The model provides a realistic and effective training experience, offering a promising tool for developing critical surgical skills, while minimizing radiation exposure and procedural risks.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"167-173"},"PeriodicalIF":2.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravesical Ectopic Pregnancy in Vesicouterine Fistula Patient: A Very Rare Case Report and Literature Review.","authors":"Indra Jaya, Muhammad Hasan Bashari, Ferry Safriadi, Indra Wijaya, Rocci Jack Parse","doi":"10.2147/RRU.S510290","DOIUrl":"10.2147/RRU.S510290","url":null,"abstract":"<p><p>Vesicouterine fistula (VUF) is a rare form of urogenital fistula, accounting for approximately 4% of cases. It commonly arises as a complication of uterine interventions, especially previous cesarean sections (C-sections). Intravesical ectopic pregnancy complications are infrequent. We discuss a 39-year-old female with severe lower abdominal pain spreading to the flank, dysuria, hematuria, and urinary hesitancy one week after laparotomy for fetal demise at 17-18 weeks of gestation. A dead fetus in the urinary bladder along with the VUF was revealed in the imaging. The surgical operation identified a fistula between the posterior bladder wall and the lower uterine segment. Fetus evacuation and fistula repair were performed with symptom resolution achieved. A literature review was conducted and nine articles were extracted. These articles discussed the risk factors and complications of VUF. The articles, selected for relevance and quality, highlighted cesarean sections as the most common risk factor, with hematuria being the most frequent complication. Only a small number of cases had fetal migration into the bladder documented, showcasing its rarity. This case represents a rare complication of VUF: intravesical ectopic pregnancy into the bladder. Surgical intervention led to favorable outcomes and is consistent with findings in the reviewed literature. The rare complication of VUF such as intravesical ectopic pregnancy requires proper diagnosis and treatment. This case emphasizes the importance of surgical management in achieving successful outcomes for VUF and its complications.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"159-165"},"PeriodicalIF":2.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cable Wire as a Nidus for Vesicolithiasis: A Case Report.","authors":"Johannes Cansius Prihadi, Antoninus Hengky, Leonardo Ongga","doi":"10.2147/RRU.S517497","DOIUrl":"https://doi.org/10.2147/RRU.S517497","url":null,"abstract":"<p><p>Bladder foreign bodies (BFBs) are an uncommon clinical occurrence, often resulting from trauma, self-insertion, iatrogenic causes, or organ migration. These objects can act as nidus for stone formation, leading to vesicolithiasis. Here, we present a rare case of a 61-year-old male with hematuria, dysuria, and abdominal pain. Initial evaluation, including imaging and cystoscopy, revealed a bladder stone encapsulating a foreign object identified as a blue cable wire. Despite denying self-insertion, his history suggested potential unreported trauma. Management involved cystoscopic lithotripsy and foreign body extraction. The case underscores how foreign objects act as nidus for stone formation through inflammatory and biochemical pathways, emphasizing the importance of early diagnosis and appropriate surgical management to prevent severe complications.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"153-157"},"PeriodicalIF":2.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Predictive Accuracy of the S.T.O.N.E. Score for Stone-Free Rates in Semirigid Pneumatic Ureteral Lithotripsy: Implications for Validation.","authors":"Faisal Ahmed, Khaled Al-Kohlany, Khalil Al-Naggar, Ibrahim Alnadhari, Abdulfattah Yahya Altam, Mohamed Badheeb","doi":"10.2147/RRU.S515846","DOIUrl":"https://doi.org/10.2147/RRU.S515846","url":null,"abstract":"<p><strong>Background: </strong>The lack of reliable predictive tools for outcomes following ureteral lithotripsy (ULT) presents significant challenges in clinical decision-making. This study evaluates the efficacy of the S.T.O.N.E. score-an assessment incorporating Size, Topography, Obstruction, Number, and Hounsfield units (HU)-in predicting the likelihood of achieving a stone-free rate (SFR) in patients undergoing semirigid pneumatic ULT.</p><p><strong>Methods: </strong>This retrospective analysis involved 266 patients with ureteral stones who underwent ULT at IBB University Hospitals from April 2021 to September 2023. The S.T.O.N.E. score was derived from preoperative CT scans, and a nomogram was created to predict SFR failure. Discrimination and calibration were assessed using the area under the receiver operating characteristic curve (AUC) and calibration curve, while decision curve analysis (DCA) evaluated clinical utility.</p><p><strong>Results: </strong>The cohort's mean age was 47.7 ± 15 years, with a predominance of males (72.2%). The mean S.T.O.N.E. score was 7.8 ± 1.8. The overall SFR of 85.3% and residual stones were detected in 39 patients (14.7%). Multivariate analysis identified higher HU (AOR: 1.01; 95% CI: 1.00-1.01; P < 0.001), proximal stone location (AOR: 15.13; 95% CI: 1.52-51.13; P = 0.020), moderate (AOR: 34.23; 95% CI: 8.28-141.45; P < 0.001) and severe hydronephrosis (AOR: 33.75; 95% CI: 4.55-250.36; P = 0.0006), and larger stone size (AOR: 1.51; 95% CI: 1.30-1.75; P < 0.0001) as significant predictors of SFR failure. The S.T.O.N.E. score effectively predicts SFR failure, with an optimal threshold of > 8 achieving 85.0% accuracy. The model demonstrated 72.0% sensitivity, 81.0% specificity, and strong calibration. DCA indicated clinical utility, differentiating between low- and high-risk patients based on their S.T.O.N.E. scores.</p><p><strong>Conclusion: </strong>The S.T.O.N.E. score is a valuable tool for predicting post-ULT SFR, aiding preoperative decision-making and potentially improving surgical outcomes by identifying high-risk patients. Further validation in diverse populations is needed to confirm its clinical utility.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"139-152"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Ureteral Stone Treatment During COVID-19: A Single-Center Emergency Department Study.","authors":"Adrian Militaru, Catalin Andrei Bulai, Cosmin Victor Ene, Razvan Ionut Popescu, Cristian Mares, Stefan Marian Balacescu, Razvan Dragos Multescu, Dragos Adrian Georgescu, Petrisor Aurelian Geavlete, Bogdan Florin Geavlete","doi":"10.2147/RRU.S518331","DOIUrl":"https://doi.org/10.2147/RRU.S518331","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the hospitalization rate, length of stay, and management of patients with ureteric lithiasis admitted under emergency conditions at a single institution during the COVID-19 pandemic.</p><p><strong>Patients and methods: </strong>A retrospective study was conducted on 219 patients with ureteral lithiasis, divided into pre-COVID-19 (1.10.2019-29.02.2020) and COVID-19 groups (1.10.2020-29.02.2021). The study examined patient and stone characteristics, hospitalization duration, surgical interventions, creatinine levels, and associated urinary tract infections. It also evaluated the complications related to delayed treatment during the pandemic.</p><p><strong>Results: </strong>The study found a 73.41% reduction in admissions for obstructive ureteral lithiasis during the COVID-19 pandemic compared to the pre-pandemic period. Notable differences were observed in age (61.5 vs 46 years, p=0.000), gender (p=0.046), stone laterality (p=0.024), location (p=0.002), serum creatinine levels (1.59 vs 1.09 mg/dL, p=0.000), and urine cultures (45.65% vs 23.12%, p=0.002). During the pandemic period, the rate of primary stone extraction procedures decreased (32.6% vs 59%, p<0.001), while operative time (52.89 vs 39.84 minutes, p<0.001) and hospital stay significantly increased (13.09 vs 3.76 days, p<0.001).</p><p><strong>Conclusion: </strong>The pandemic resulted in fewer hospitalizations for ureteral lithiasis and an increase in complications, likely due to reduced access to medical care and a greater tendency for upper urinary tract drainage.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"129-138"},"PeriodicalIF":2.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Magnetic Resonance Imaging-Transperineal Ultrasound Fusion Prostate Biopsy with Use of a Urinary Catheter After Abdominoperineal Resection: A Novel Technique and Literature Review.","authors":"Harutake Sawazaki, Yosuke Kitamura, Atsushi Asano, Sadayoshi Suzuki","doi":"10.2147/RRU.S523114","DOIUrl":"https://doi.org/10.2147/RRU.S523114","url":null,"abstract":"<p><p>A standard prostate biopsy can be performed via a transrectal or transperineal approach using a transrectal ultrasound probe, but not in patients without a rectum. These patients pose a diagnostic challenge to urologists in terms of prostate cancer detection. We report use of a novel technique for cognitive magnetic resonance imaging (MRI)-transperineal ultrasound fusion prostate biopsy with a urinary catheter in two patients without a rectum after abdominoperineal resection. In both cases, a urinary catheter was inserted and clamped after injection of 250 mL of sterile saline into the bladder to improve visualization of the prostate. The inflated catheter balloon was placed to the level of the bladder neck to identify the base of the prostate. Cognitive MRI-transperineal ultrasound fusion biopsy was performed on the MRI-defined lesions after confirmation of anatomic landmarks, including the urethra and base of the prostate. Systemic 8-core biopsies were also obtained. In both patients, the targeted lesion was diagnosed as prostate cancer.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"17 ","pages":"119-127"},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}