Research and Reports in Urology最新文献

{"title":"Elevated Prostate Specific Antigen is Associated with Prostate Disease, Lower Urinary Tract Symptoms, and Erectile Dysfunction: Findings from 5325 Men.","authors":"Mary Jo Kurth, Joanne Watt, Cormac Rice, Jack Cameron Green, John V Lamont, Laura Mooney, Le Roy Craig Dowey, Peter Fitzgerald, Mark W Ruddock","doi":"10.2147/RRU.S641514","DOIUrl":"10.2147/RRU.S641514","url":null,"abstract":"<p><strong>Background: </strong>Prostate specific antigen (PSA) testing is widely used for detection and monitoring of prostate disease. Age-specific thresholds are applied to improve clinical interpretation of PSA results. However, the demographic and clinical characteristics associated with elevated PSA in large population-based cohorts remain incompletely understood.</p><p><strong>Methods: </strong>A cohort of 5325 men underwent PSA testing applying NICE (NG12) age-specific thresholds. Participants were then classified as having normal or elevated PSA concentrations. Demographic characteristics, BMI, self-reported prostate disease, erectile dysfunction (ED), and lower urinary tract symptoms (LUTS) were compared between groups.</p><p><strong>Results: </strong>Of 5325 participants, n=186 (3.5%) had elevated PSA concentrations and n=5139 (96.5%) had PSA levels within the age-specific reference range. The prevalence of elevated PSA increased with age, with men aged 50-69 years representing 73% (136/186) of all elevated PSA cases. Men with elevated PSA had a higher median BMI and were more likely to be obese. A previous diagnosis of prostate disease was reported by 17% of men with elevated PSA compared with 2.9% of those with normal PSA. ED and LUTS were common among participants with elevated PSA.</p><p><strong>Conclusion: </strong>Elevated PSA concentrations were identified in a small proportion of men but were strongly associated with age, BMI, previous prostate disease, ED, and LUTS. These findings demonstrate that elevated PSA is associated with a clinically meaningful burden of urological symptoms and prostate disease-related morbidity. Future studies should evaluate independent predictors of elevated PSA and the utility of combining PSA measurements with symptom-based risk assessment for the identification of clinically significant prostate disease.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"641514"},"PeriodicalIF":2.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Sequential Cabozantinib and Axitinib After First-Line Nivolumab Plus Ipilimumab in Advanced Renal Cell Carcinoma: A Single-Center Exploratory Study.","authors":"Nobuki Furubayashi, Takehito Kojima, Yasuhiro Nakano, Akari Kataoka, Takahito Negishi","doi":"10.2147/RRU.S643958","DOIUrl":"10.2147/RRU.S643958","url":null,"abstract":"<p><strong>Background: </strong>Evidence regarding sequential vascular endothelial growth factor receptor tyrosine kinase inhibitor therapy after first-line nivolumab plus ipilimumab in advanced renal cell carcinoma (RCC) remains limited. This exploratory study described the clinical outcomes of sequential cabozantinib and axitinib administered as second- and third-line therapy, with additional analyses according to treatment order and early progressive disease (PD) status.</p><p><strong>Patients and methods: </strong>We retrospectively reviewed 12 patients with advanced RCC who sequentially received cabozantinib and axitinib as second- and third-line therapy after first-line nivolumab plus ipilimumab between September 2018 and January 2026. Patients were categorized into cabozantinib-to-axitinib (n=8) and axitinib-to-cabozantinib (n=4) groups. Tumor response was assessed according to the Response Evaluation Criteria in Solid Tumors version 1.1. Combined time to treatment failure (TTF) was measured from second-line initiation to progression during third-line therapy or death; event-free patients were censored at last follow-up.</p><p><strong>Results: </strong>Among patients receiving second-line cabozantinib, three (37.5%) had stable disease and five (62.5%) had PD; among those receiving axitinib, three (75.0%) had a partial response and one (25.0%) had stable disease. Median second-line TTF was 5.1 months (interquartile range [IQR], 2.6-8.6) with cabozantinib and 10.1 months (IQR, 8.9-10.4) with axitinib (p=0.154). Median third-line TTF was 3.0 months (IQR, 1.6-13.6) with cabozantinib and 3.5 months (IQR, 2.7-5.7) with axitinib (p=0.808). Median combined TTF was 14.2 months for axitinib-to-cabozantinib and 10.4 months for cabozantinib-to-axitinib (p=0.359), and 8.3 versus 13.9 months in patients with early versus non-early PD (p=0.113).</p><p><strong>Conclusion: </strong>Sequential cabozantinib and axitinib therapy after nivolumab plus ipilimumab was feasible in selected patients with advanced RCC. Given the small exploratory cohort, no firm conclusion regarding the comparative efficacy of the two sequences can be drawn. Patients with early PD showed a numerical trend toward shorter combined TTF, although this comparison was statistically inconclusive.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"643958"},"PeriodicalIF":2.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13676850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type D Polyorchidism as an Incidental Finding in an Adult with an Indirect Inguinal Hernia: A Case Report.","authors":"Tuqa Abou Alssil, Mahran Al-Ali Al-Khaleel, Basel Abdulrahman, Ali Abou Alsel","doi":"10.2147/RRU.S637723","DOIUrl":"https://doi.org/10.2147/RRU.S637723","url":null,"abstract":"<p><strong>Background: </strong>Polyorchidism (supernumerary testis) is an extremely rare congenital anomaly of three or more testes. Bergholz et al reported that ~65% occur on the left side, with a median patient age of 17 years.</p><p><strong>Case presentation: </strong>A 27-year-old man presented with a gradually enlarging right inguinal swelling and mild discomfort. Clinical examination revealed a right indirect inguinal hernia, two testes in the right hemiscrotum, and one on the left. Color Doppler ultrasound confirmed the hernia and polyorchidism, and also showed mild left varicocele (grade I). The patient underwent elective right inguinal exploration. Intraoperatively, an indirect hernia sac was isolated and ligated. Two separate right testes were found: the superior (supernumerary) testis was smaller but had its own epididymis, vas deferens, and viable blood supply. Hernia repair with mesh and right orchiopexy were performed successfully. Postoperative recovery was uneventful. A strict follow-up protocol (clinical exam + Doppler ultrasound every 6-12 months) was established. Fertility was preserved; the patient is married with three children, contrasting with reports of potential male infertility.</p><p><strong>Case discussion: </strong>Polyorchidism in a 27-year-old undergoing elective inguinal hernia repair is uncommon. Ultrasound with Doppler is the first-line evaluation. Management should be individualized based on anatomy, imaging, and fertility.</p><p><strong>Conclusion: </strong>Conservative management with orchiopexy of viable, scrotal, non-suspicious testes is preferred. Surgical orchiectomy is reserved for non-viable tissue.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"637723"},"PeriodicalIF":2.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Innovex RS Delivery Catheter as a Single-Platform Endoscopic System for Upper Urinary Tract Intervention: A Two-Case Report of Upper Ureteral Lithotripsy and Ablation of a Suspected Renal Pelvis Urothelial Lesion.","authors":"Mohamed Sayyaf Abdul Hakeem, Xiancheng Li","doi":"10.2147/RRU.S637404","DOIUrl":"https://doi.org/10.2147/RRU.S637404","url":null,"abstract":"<p><strong>Background: </strong>Conventional upper urinary tract endoscopy requires two instruments-a rigid ureteroscope for initial access and a flexible ureteroscope for intraluminal treatment-resulting in intraoperative scope exchange and dual-tower dependency. The Innovex RS delivery catheter is a rigid stainless-steel sheath that enables a single-use 7.5 Fr flexible ureteroscope to function in both rigid and flexible operative modes from one platform. To our knowledge this is the first report of a rigid-delivery sheath system used as the sole endoscopic instrument across two distinct upper urinary tract indications, and the first describing its use for ablation of a renal pelvis lesion.</p><p><strong>Cases: </strong>Two patients underwent upper urinary tract endoscopy using the RS catheter as the sole instrument: a 53-year-old male with a 12 mm impacted proximal ureteral stone (holmium:YAG lithotripsy), and a 76-year-old female with a 10 mm renal pelvis filling defect, radiologically suspected to represent urothelial pathology on the basis of CT attenuation, who underwent cold-cup biopsy followed by thulium:YAG ablation. No rigid ureteroscope, tower switching, or fluoroscopic guidance was used in either case; this reflected operator judgement rather than any intrinsic capability of the device.</p><p><strong>Results: </strong>Stone-free status was confirmed by non-contrast computed tomography on postoperative day 1 in Case 1. Macroscopic complete ablation was achieved in Case 2. Histopathological examination of the biopsy specimen demonstrated inflammatory exudate with focal urothelial mucosa and mild epithelial atypia, without definitive invasive malignancy. The ablated lesion therefore remains a radiologically suspected but histopathologically unconfirmed urothelial neoplasm, and the patient has entered a structured surveillance programme. Operative times were 55 and 90 minutes respectively; in Case 2, approximately 60 of the 90 minutes were attributable to intrapelvic clot evacuation. Clavien-Dindo grades were 0 and I respectively.</p><p><strong>Conclusion: </strong>The RS delivery catheter system enabled single-platform, single-tower ureteroscopy without scope exchange in two patients. These proof-of-concept observations establish technical feasibility only. They are not sufficient to demonstrate superiority, equivalent efficacy, improved safety, or cost-effectiveness relative to the conventional two-instrument workflow, and any such advantages remain hypotheses requiring prospective comparative evaluation.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"637404"},"PeriodicalIF":2.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149184147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative Review: Telemedicine for Reducing Travel-Related Out-of-Pocket Costs Among Hong Kong Urological Patients and a Customized Tiered Consultation Pathway.","authors":"Ka Ki Chan","doi":"10.2147/RRU.S645326","DOIUrl":"https://doi.org/10.2147/RRU.S645326","url":null,"abstract":"<p><strong>Purpose: </strong>The COVID-19 pandemic disrupted routine urological outpatient services in Hong Kong, imposing disproportionate travel burdens on outlying island and cross-border patients who rely on multi-stage ferry and bus journeys. Globally, existing teleurology cost evidence is dominated by Western private-vehicle models, and to date no peer-reviewed review has investigated teleurology cost outcomes in Hong Kong. This narrative review addresses this regional research gap by synthesizing international evidence and proposing a tiered workflow aligned with the Hospital Authority's 2022-2027 Smart Care strategy.</p><p><strong>Patients and methods: </strong>PubMed, CINAHL Complete and MEDLINE were searched for primary quantitative studies published between January 2012 and December 2022. Studies were screened following standard PRISMA protocols, and methodological quality was appraised using CASP and JBI checklists. Findings were aggregated via narrative thematic synthesis.</p><p><strong>Results: </strong>Eleven eligible studies (9 cohort studies, 1 randomized controlled trial, 1 cross-sectional survey) were included in the final analysis. Four core patient cost themes were identified by evidence strength: travel time savings (81.8% of studies), direct transport expenditure reduction (72.7%), travel distance reduction (54.5%), and lost work opportunity cost (45.5%). Western mileage-based cost frameworks have limited applicability to Hong Kong's ferry-dominated public transit ecosystem.</p><p><strong>Conclusion: </strong>Evidence drawn predominantly from Western populations suggests that teleurology may reduce travel-related time and financial burdens for urology patients, with potential applicability to Hong Kong's remote island and cross-border patient groups. The proposed tiered consultation pathway represents a theoretically evidence-informed framework aligned with local digital healthcare policy, to support future telehealth pilot implementation and service optimization. As all included studies were conducted in North America and the United Kingdom, and the pathway has not been locally validated, its real-world effectiveness and cost-saving magnitude in Hong Kong remain to be confirmed in future primary research. Although this study focuses on the public healthcare setting in Hong Kong, the proposed telemedicine consultation pathway may serve as a reference clinical and operational blueprint for other highly urbanized regions with outlying islands or cross-border patient demographics.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"645326"},"PeriodicalIF":2.4,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Three Cranberry Formulations in Women with Recurrent Urinary Tract Infections: An Observational Study.","authors":"Damien Guillemet, Christine Juhel, Florian Rigaudier, Florent Herpin, Emmanuelle Meudec","doi":"10.2147/RRU.S613306","DOIUrl":"10.2147/RRU.S613306","url":null,"abstract":"<p><strong>Purpose: </strong>Although cranberry supplementation has been investigated for recurrent UTI prevention with heterogeneous demonstrations, direct comparisons of putative active compositions remain scarce. The present study aimed to compare three cranberry formulations differing in composition and PACs (Proanthocyanidins) profiles on recurrent UTI episodes, urinary symptoms and quality of life in women with recurrent UTIs.</p><p><strong>Patients and methods: </strong>Three extracts differing in the sources of their fruits, extraction process, solubility, and composition were characterized (40SD, 40G, and FG). A total of 219 women aged 18 to 65 years with recurrent UTI episodes were enrolled in an observational, comparative, open-label, parallel clinical study and allocated to receive one of three treatments for 6 months. Posology was standardized to provide equivalent amounts of PACs, and endpoints were assessed at baseline and after 6 months.</p><p><strong>Results: </strong>Extract characterization differed notably for organic acids, fibre, monomeric phenolic compounds, soluble and oligomeric forms of PACs, and the degree of polymerization. All three extracts significantly improved urinary comfort (VAS, 53.8 ± 16.2 → 80.9 ± 25.6; p < 0.001), symptomatic episodes (frequency: 2.9 → 0.8; p < 0.001; duration: 2.7 → 0.7 days; p < 0.001), global symptom intensity assessed using the ACSS, global quality of life assessed using the SF-Qualiveen, and psychosocial impact questionnaire scores, with no significant differences between groups. However, the 40G group showed a significantly greater improvement in ACSS-Differential scores (symptoms related to adjacent organs) during cystitis-like episodes, complementary ACSS items (eg, burden on daily activities), the \"Fears\" domain of SF-Qualiveen, and earlier onset of significant effects in these questionnaires.</p><p><strong>Conclusion: </strong>The standardization of posology based on total PACs (162 mg/day, including insoluble polymeric forms) rather than soluble oligomeric PACs (36 mg/day, BL-DMAC) appears relevant for the improvement of UTIs and related symptoms. Treatment with an extract (40G) with a specific ratio of insoluble/soluble fruit parts and, consequently, a distinct PACs profile resulted in greater improvements.</p><p><strong>Trial registration: </strong>NCT04962971.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"613306"},"PeriodicalIF":2.4,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13564458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Parenchymal Volume Loss and Functional Loss After Percutaneous Nephrolithotomy.","authors":"Warit Charukumchon, Worapat Attawettayanon, Sarayuth Boonchai, Teeravut Tubtawee, Kamonwon Cattapan, Choosak Pripatnanont, Chanatipat Boonyok, Virote Chalieopanyarwong","doi":"10.2147/RRU.S634955","DOIUrl":"10.2147/RRU.S634955","url":null,"abstract":"<p><strong>Purpose: </strong>Renal stone is a common global disease. Percutaneous nephrolithotomy (PCNL) is the standard treatment for large stones but may cause renal parenchymal injury. Most studies have focused on global renal function rather than localized renal changes. This study evaluated renal parenchymal volume and renal function after PCNL, hypothesizing modest ipsilateral volume loss with preserved global glomerular filtration rate (GFR).</p><p><strong>Materials and methods: </strong>This study included 80 patients who underwent PCNL. All patients had preoperative and postoperative computed tomography (CT), with follow-up CT performed 3-6 months after surgery. Patients with postoperative complications related to stone burden were excluded. Renal parenchymal volume was measured using 3D volumetric software, and both volumetric and functional outcomes were analyzed.</p><p><strong>Results: </strong>The median age was 59 years, and 49% were male. Most patients had mild-to-moderate hydronephrosis with a median stone burden of 7.55mL. Single-tract PCNL was performed in 96% of cases, with a median estimated blood loss of 135mL. Amplatz sheath sizes of 28, 26, and 24Fr were used in 69%, 20%, and 7%, respectively. Median preoperative and new-baseline GFR values were 83.5 and 84.0mL/min/1.73m², indicating preserved global renal function. Acute kidney injury occurred in 10%. Ipsilateral GFR decreased slightly (39.7 to 36.6mL/min/1.73m²), while ipsilateral renal volume declined from 123.7 to 115.6cm³ (median loss 5.6cm³, 4.3%). Contralateral kidney volume remained stable Larger Amplatz sheath size and female were independently associated with ipsilateral renal volume loss >15%.</p><p><strong>Conclusion: </strong>PCNL caused modest ipsilateral renal volume loss while preserving global renal function. Larger Amplatz sheath size and female were associated with significant volume loss.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"634955"},"PeriodicalIF":2.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Lingual Mucosal Grafts with Different Thicknesses on Repair of Rabbit Bladder Defects.","authors":"Jiahao Lin, Tianmeng Gao, Changhao Hou, Lujie Song","doi":"10.2147/RRU.S595454","DOIUrl":"10.2147/RRU.S595454","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the survival of autologous lingual mucosal grafts of varying thicknesses within a rabbit bladder defect model, as well as their impact on vascularization, inflammatory response, and tissue contracture.</p><p><strong>Methods: </strong>Twelve male New Zealand white rabbits were selected to establish a bladder wall defect model. Autologous lingual mucosal patches (5.0 mm×5.0 mm) of thin, medium, and thick thicknesses were harvested, transplanted to the bladder defects, and fixed with interrupted sutures. The lingual defects were directly sutured. Animals were sacrificed at 4 days, 3 weeks, and 3 months postoperatively for gross and histological observations. Hematoxylin-eosin (HE) and Masson staining were used to evaluate graft integration, detect neovascular density, inflammatory cell infiltration, and graft surface area contracture rate. Data were analyzed using one-way analysis of variance (ANOVA) and the Tukey HSD test.</p><p><strong>Results: </strong>All three groups of lingual mucosal grafts survived in the bladder environment and formed continuous epithelial connections with the bladder mucosa. No significant differences were observed in neovascular density or inflammatory cell infiltration among grafts of different thicknesses at any postoperative time point. Neovascular density gradually increased, while inflammatory infiltration gradually decreased over time. At 3 months postoperatively, the contracture rate in the thick group (13.20%) was significantly lower than that of the thin group (35.33%) and the medium-thickness group (24.93%) (P < 0.01).</p><p><strong>Conclusion: </strong>Lingual mucosal grafts of different thicknesses can survive in the bladder environment with good vascularization and anti-inflammatory capabilities. The thickness of the graft mainly affects the tissue contracture rate. Therefore, moderately preserving submucosal tissue and avoiding excessive thinning may help improve the long-term stability of the graft.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"595454"},"PeriodicalIF":2.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glandular Density and Glandular Volume of the Peripheral Zone as Novel Pre-Biopsy Biometric Parameters: A Retrospective Pilot Study.","authors":"John M Wolpert, Jordan Kassab, Abdul Awal, Werner T W De Riese","doi":"10.2147/RRU.S616161","DOIUrl":"10.2147/RRU.S616161","url":null,"abstract":"<p><strong>Purpose: </strong>Currently most patients with elevated PSA and suspicious MRI findings either have no cancer or clinically insignificant cancer on fusion biopsies, driving the need for developing risk to better stratify patients prior to biopsies. This retrospective pilot study demonstrates a novel approach of the glandular tissue volume within the peripheral zone (GVPZ) using pre-operative MRI measurements validated against radical prostatectomy specimens, as the majority of prostate cancer originates within the peripheral zone.</p><p><strong>Patients and methods: </strong>MRI and clinical parameters of 68 patients were analyzed retrospectively and associated with automated imaging processing data of H&E slides obtained from the corresponding radical prostatectomy specimens.</p><p><strong>Results: </strong>The study results revealed a significant non-linear, inverse relationship between GVPZ and total prostate volume (TPV) (exp(b) = 0.963, SE = 0.008, p < 0.0001). GVPZ decreases as TPV rises, consistent with BPH-driven transition zone expansion progressively diluting glandular tissue content in the peripheral zone. Peripheral zone volume (PZV) was a significant positive predictor of GVPZ (exp(b) = 1.052, SE = 0.014, p < 0.0001). Differences in GDPZ and GVPZ were also observed across racial groups, though these findings are preliminary given the small subgroup sizes.</p><p><strong>Conclusion: </strong>Based on the presented data, total prostate volume is significantly and inversely associated with the glandular volume of the peripheral zone where most primary prostate cancer develops. These tissue-based anatomical markers represent candidate variables for incorporation into future risk calculators; prospective validation against biopsy-confirmed outcomes is required before clinical application.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"616161"},"PeriodicalIF":2.4,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13510222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Presentation as an Independent Predictor of Erectile Dysfunction After Ischemic Priapism: A Sub-Saharan Cohort Study.","authors":"Kirakoya Brahima, Yameogo Clotaire, Ziba Ouima Justin Dieudonné, Idogo Ouedan, Sawadogo Hassami, Kaboré Fasnéwindé Aristide","doi":"10.2147/RRU.S620060","DOIUrl":"10.2147/RRU.S620060","url":null,"abstract":"<p><strong>Background: </strong>Ischemic priapism is a time-sensitive urological emergency with significant consequences for erectile function. Real-world data from low-resource sub-Saharan settings, where delayed presentation is common, remain scarce.</p><p><strong>Objective: </strong>To determine outcomes of ischemic priapism management and to identify predictive factors for erectile dysfunction after treatment.</p><p><strong>Methods: </strong>Retrospective cross-sectional study conducted at the Urology Department of CHU Yalgado Ouédraogo, Ouagadougou, Burkina Faso (January 2019-December 2022). Consecutive patients aged ≥15 years with ischemic priapism were included. Erectile function was assessed using the International Index of Erectile Function 6-item version (IIEF-6), a validated 6-item questionnaire scored from 1 to 30, with scores ≥26 indicating no erectile dysfunction. IIEF-6 was recorded at diagnosis (recalled by the patient) and at last follow-up. Patients were stratified by treatment delay (<24 h, 24-48 h, >48 h). Multivariate logistic regression identified independent predictors of erectile dysfunction.</p><p><strong>Results: </strong>Of 58 patients admitted, 41 were included (mean age 31.2 ± 8.9 years). Sickle cell hemoglobinopathies (SS and SC genotypes) were identified in 46.3% of cases. The mean consultation delay was 85.3 hours. The mean IIEF-6 score declined significantly from 28.6 pre-event to 16.7 post-treatment (p<0.001). Only 29.3% of patients retained erectile function sufficient for intercourse. In multivariate analysis, treatment delay >48 hours was the sole independent predictor of erectile dysfunction (adjusted OR = 13.7; 95% CI: 2.4-76.4; p = 0.0005).</p><p><strong>Conclusion: </strong>Treatment delay beyond 48 hours is the primary independent predictor of erectile dysfunction following ischemic priapism, regardless of patient characteristics or treatment modality. These findings underscore the urgent need for patient education and improved access to emergency urological care in sub-Saharan Africa.</p>","PeriodicalId":21008,"journal":{"name":"Research and Reports in Urology","volume":"18 ","pages":"620060"},"PeriodicalIF":2.4,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}