在澳大利亚三级医院实施高质量的睾丸癌腹膜后淋巴结清扫:挑战高需求地区的集中化模式。

IF 2.7 Q2 UROLOGY & NEPHROLOGY
Research and Reports in Urology Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI:10.2147/RRU.S474281
Prassannah Satasivam, Samith Alwis, Sudheshan Sundaralingam, Owen Niall
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引用次数: 0

摘要

背景:腹膜后淋巴结清扫术(RPLND)在转移性睾丸癌的治疗管理中起着不可或缺的作用。作为一项大手术,RPLND有明显并发症的风险,特别是在化疗后(PC-RPLND)的情况下。我们评估了在澳大利亚一家三级医院引入RPLND作为一项新服务的安全性。方法:实施严格的方案,优先考虑适当的病例选择,多学科的外科专业知识和随时进入重症监护设施,以引入RPLND。前瞻性数据收集于2020年10月至2022年10月在墨尔本北部医院接受PC-RPLND的患者。主要终点和次要终点分别为术后30天Clavien-Dindo (CD)分级、并发症发生率和围手术期质量指标。结果:6例患者行双侧开模板PC-RPLND,平均年龄28.7±4.3岁。中位淋巴结计数为17 (IQR = 16),组织病理学检查均发现转移性生殖细胞瘤。中位住院时间为6天(IQR = 3),其中重症监护1天。不需要输血,也没有遇到30天的CD并发症。中位随访22个月(IQR = 21),无复发或明显的延迟并发症。结论:在严格的协议下,RPLND作为一项新服务安全地引入了我们的高等教育机构。围手术期质量终点与高容量国际中心相匹配。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Implementing High-Quality Retroperitoneal Lymph Node Dissection for Testicular Cancer at an Australian Tertiary Hospital: Challenging the Centralisation Paradigm in High-Need Areas.

Implementing High-Quality Retroperitoneal Lymph Node Dissection for Testicular Cancer at an Australian Tertiary Hospital: Challenging the Centralisation Paradigm in High-Need Areas.

Implementing High-Quality Retroperitoneal Lymph Node Dissection for Testicular Cancer at an Australian Tertiary Hospital: Challenging the Centralisation Paradigm in High-Need Areas.

Background: Retroperitoneal lymph node dissection (RPLND) plays an integral role in the curative management of metastatic testicular cancer. As a major surgery, RPLND poses a risk of significant complications, particularly in the post-chemotherapy (PC-RPLND) setting. We assessed the safety of introducing RPLND as a new service at an Australian tertiary hospital.

Methods: A strict protocol prioritising appropriate case selection, multidisciplinary surgical expertise and ready access to intensive care facilities was implemented to introduce RPLND. Prospective data was collected on patients who underwent PC-RPLND between October 2020 and October 2022 at the Northern Hospital in Melbourne. Primary and secondary endpoints were 30-day postoperative Clavien-Dindo (CD) classification complication rate and perioperative quality measures, respectively.

Results: Six patients (mean age 28.7 ± 4.3 years) underwent bilateral template open PC-RPLND. Median node count was 17 (IQR = 16) with metastatic germ cell tumour identified in all patients on histopathology. Median length of stay was 6 days (IQR = 3) with 1 day in intensive care. No blood transfusions were required, and no 30-day CD complications were encountered. Median follow-up was 22 months (IQR = 21) with no recurrences or significant delayed complications.

Conclusion: Following a strict protocol, RPLND has been safely introduced as a new service at our tertiary institution. Perioperative quality endpoints match those of high-volume international centres.

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来源期刊
Research and Reports in Urology
Research and Reports in Urology UROLOGY & NEPHROLOGY-
CiteScore
3.40
自引率
0.00%
发文量
60
审稿时长
16 weeks
期刊介绍: Research and Reports in Urology is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of adult and pediatric urology in the clinic and laboratory including the following topics: Pathology, pathophysiology of urological disease Investigation and treatment of urological disease Pharmacology of drugs used for the treatment of urological disease Although the main focus of the journal is to publish research and clinical results in humans; preclinical, animal and in vitro studies will be published where they will shed light on disease processes and potential new therapies. Issues of patient safety and quality of care will also be considered.
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