Microbial Biotechnology最新文献_第3页

Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice 螺旋乳杆菌通过调节小鼠肠道微生态减轻酒精性肝损伤

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-21 DOI: 10.1111/1751-7915.70016

Jiawen Lv, Guanjing Lang, Qiangqiang Wang, Wenlong Zhao, Ding Shi, Ziyuan Zhou, Yangfan Shen, He Xia, Shengyi Han, Lanjuan Li

{"title":"Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice","authors":"Jiawen Lv, Guanjing Lang, Qiangqiang Wang, Wenlong Zhao, Ding Shi, Ziyuan Zhou, Yangfan Shen, He Xia, Shengyi Han, Lanjuan Li","doi":"10.1111/1751-7915.70016","DOIUrl":"10.1111/1751-7915.70016","url":null,"abstract":"Previous reports have demonstrated that alcohol consumption significantly reduces the abundance of Lactobacillus in the gut. In this study, we selected five species of the genus Lactobacillus, commonly found in fermented foods, and acknowledged them as safe, edible, and effective in preventing or treating certain diseases, to evaluate their effects on alcoholic liver disease (ALD). By comparing the liver damage indices in each group, we found that the type strain of Lactobacillus helveticus (LH, ATCC 15009) had the most marked alleviating effect on ALD-induced liver injury. Furthermore, experiments combining microbiomics and metabolomics were conducted to explore the mechanisms underlying the hepatoprotective effects of LH. Finally, we discovered that LH mitigated ethanol-induced liver steatosis and inflammation in ALD mice by altering the structure and function of the gut microbiome, increasing intestinal levels of short-chain fatty acids (SCFAs), and enhancing gut barrier integrity. These findings suggest a potential strategy for the clinical management of patients with ALD.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 promote infected wound healing via regulation of the wound microenvironment 鼠李糖乳杆菌 GG 和动物双歧杆菌亚种 BB-12 通过调节伤口微环境促进感染伤口愈合

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-18 DOI: 10.1111/1751-7915.70031

Zhe Yin, Yilin Wang, Xiaojuan Feng, Changqing Liu, Xiaoyang Guan, Shuyan Liu, Zhanyi Long, Zhonghua Miao, Fang He, Ruyue Cheng, Yanting Han, Ka Li

{"title":"Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 promote infected wound healing via regulation of the wound microenvironment","authors":"Zhe Yin, Yilin Wang, Xiaojuan Feng, Changqing Liu, Xiaoyang Guan, Shuyan Liu, Zhanyi Long, Zhonghua Miao, Fang He, Ruyue Cheng, Yanting Han, Ka Li","doi":"10.1111/1751-7915.70031","DOIUrl":"10.1111/1751-7915.70031","url":null,"abstract":"Infected wounds can result in complex clinical complications and delayed healing, presenting a significant global public health challenge. This study explored the effects of topical application of two probiotics, Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis subsp. lactis BB-12, on the microenvironment of infected wounds and their impact on wound healing. LGG and BB-12 were applied separately and topically on the Staphylococcus aureus (S. aureus)-infected skin wounds of the rat model on a daily basis. Both probiotics significantly accelerated wound healing, demonstrated by enhanced granulation tissue formation and increased collagen deposition, with BB-12 showing superior efficacy. LGG and BB-12 both effectively inhibited neutrophil infiltration and decreased the expression of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Notably, BB-12 markedly reduced IL-6 levels, while LGG significantly lowered TNF-α, transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF). Additionally, both probiotics promoted macrophage polarization towards the anti-inflammatory M2 phenotype. Microbiota analysis revealed that LGG and BB-12 significantly decreased the abundance of pathogenic bacteria (e.g. Staphylococcus and Proteus) and increased the proportion of beneficial bacteria (e.g. Corynebacterium). Particularly, BB-12 was more effective in reducing Staphylococcus abundance, whereas LGG excelled in promoting Corynebacterium growth. These findings suggest the ability of LGG and BB-12 to modulate the wound microenvironment, enhance wound healing and provide valuable insights for the management of infected wounds.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flagellate bacteria-mediated tumour antigen delivery: A novel approach to enhance dendritic cell activation for in situ cancer vaccination 鞭毛细菌介导的肿瘤抗原递送：增强树突状细胞活化以进行原位癌症疫苗接种的新方法

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-18 DOI: 10.1111/1751-7915.70028

Wen Xia, Jinhui Wu

{"title":"Flagellate bacteria-mediated tumour antigen delivery: A novel approach to enhance dendritic cell activation for in situ cancer vaccination","authors":"Wen Xia, Jinhui Wu","doi":"10.1111/1751-7915.70028","DOIUrl":"https://doi.org/10.1111/1751-7915.70028","url":null,"abstract":"In situ vaccination is a therapeutic approach aimed at exploiting tumour antigens available at a tumour site to induce tumour-specific adaptive immune responses. Antigens released from dying tumour cells are assumed to be taken up by activated dendritic cells and presented to T cells that seek out and destroy tumour cells. This process is significantly impeded in the immunosuppressive microenvironment of tumours. There is a growing trend in in situ vaccine strategies that utilize bacteria as natural adjuvants or as factories for cytokines, aiming to enhance the presentation of in situ antigens by antigen-presenting cells. Recently, a novel approach using flagellate bacteria-mediated antigen delivery to activate dendritic cells has been proposed. This method actively facilitates the delivery of intratumoral antigens, improving their presentation for in situ cancer vaccination. Here, we highlight how flagellate bacteria-mediated antigen delivery enhances the immune activation capabilities of in situ vaccines. Meanwhile, we provide perspectives and outlooks on these promising antigen delivery technologies.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production-optimized fermentation of antifungal compounds by bacillus velezensis LZN01 and transcriptome analysis velezensis LZN01 杆菌抗真菌化合物的生产优化发酵及转录组分析

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-17 DOI: 10.1111/1751-7915.70026

Jiale Hu, Zhigang Wang, Weihui Xu

{"title":"Production-optimized fermentation of antifungal compounds by bacillus velezensis LZN01 and transcriptome analysis","authors":"Jiale Hu, Zhigang Wang, Weihui Xu","doi":"10.1111/1751-7915.70026","DOIUrl":"https://doi.org/10.1111/1751-7915.70026","url":null,"abstract":"Fusarium wilt is one of the major constraints on global watermelon production, and Fusarium oxysporum f. sp. niveum (Fon) is the causative agent of Fusarium wilt in watermelon and results in severe yield and quality losses worldwide. The enhancement of antifungal activity from antagonistic bacteria against Fon is highly practical for managing Fusarium wilt in watermelon. The aim of this study was to maximize the antifungal activity of Bacillus velezensis LZN01 by optimizing fermentation conditions and analysing its regulatory mechanism via transcriptome sequencing. The culture and fermentation conditions for strain LZN01 were optimized by single-factor and response surface experiments. The optimum culture conditions for this strain were as follows: the addition of D-fructose at 35 g/L and NH4Cl at 5 g/L in LB medium, pH 7, and incubation at 30°C for 72 h. The fungal inhibition rate for strain LZN01 reached 71.1%. The improvement of inhibition rate for strain LZN01 in optimization fermentation was supported by transcriptomic analysis; a total of 491 genes were upregulated, while 736 genes were downregulated. Transcriptome analysis revealed that some differentially expressed genes involved in carbon and nitrogen metabolism, oxidation–reduction, fatty acid and secondary metabolism; This optimization process could potentially lead to significant alterations in the production levels and types of antimicrobial compounds by the strain. Metabolomics and UPLC/Q-Exactive Orbitrap MS analysis revealed that the production yields of antimicrobial compounds, such as surfactin, fengycin, shikimic acid, and myriocin, increased or were detected in the cell-free supernatant (CFS) after the fermentation optimization process. Our results indicate that fermentation optimization enhances the antifungal activity of the LZN01 strain by influencing the expression of genes responsible for the synthesis of antimicrobial compounds.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-engineered bacteria in drug development 药物开发中的表面工程细菌

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-15 DOI: 10.1111/1751-7915.70033

Charles Dahlsson Leitao, Stefan Ståhl, John Löfblom

引用次数: 0

Escherichia coli on colorectal cancer: A two-edged sword 大肠杆菌对大肠癌的影响：一把双刃剑

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-14 DOI: 10.1111/1751-7915.70029

Chu Jian, Wu Yinhang, Zhuang Jing, Qu Zhanbo, Wang Zefeng, Han Shuwen

{"title":"Escherichia coli on colorectal cancer: A two-edged sword","authors":"Chu Jian, Wu Yinhang, Zhuang Jing, Qu Zhanbo, Wang Zefeng, Han Shuwen","doi":"10.1111/1751-7915.70029","DOIUrl":"https://doi.org/10.1111/1751-7915.70029","url":null,"abstract":"Escherichia coli (E. coli) is a ubiquitous symbiotic bacterium in the gut, and the diversity of E. coli genes determines the diversity of its functions. In this review, the two-edged sword theory was innovatively proposed. For the question ‘how can we harness the ambivalent nature of E. coli to screen and treat CRC?’, in terms of CRC screening, the variations in the abundance and subtypes of E. coli across different populations present an opportunity to utilise it as a biomarker, while in terms of CRC treatment, the natural beneficial effect of E. coli on CRC may be limited, and engineered E. coli, particularly certain subtypes with probiotic potential, can indeed play a significant role in CRC treatment. It seems that the favourable role of E. coli as a genetic tool lies not in its direct impact on CRC but its potential as a research platform that can be integrated with various technologies such as nanoparticles, imaging methods, and synthetic biology modification. The relationship between gut microflora and CRC remains unclear due to the complex diversity and interaction of gut microflora. Therefore, the application of E. coli should be based on the ‘One Health’ view and take the interactions between E. coli and other microorganisms, host, and environmental factors, as well as its own changes into account. In this paper, the two-edged sword role of E. coli in CRC is emphasised to realise the great potential of E. coli in CRC screening and treatment.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142435522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The climate change–pollution–aerobiome nexus: A ‘systems thinking’ mini-review 气候变化-污染-地球生物群的关系：系统思维 "小综述

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-14 DOI: 10.1111/1751-7915.70018

Jake M. Robinson, Craig Liddicoat, Xin Sun, Sunita Ramesh, Scott Hawken, Kevin Lee, Joel Brame, Nicole W. Fickling, Emma Kuhn, Claire Hayward, Sonali Deshmukh, Kate Robinson, Christian Cando-Dumancela, Martin F. Breed

{"title":"The climate change–pollution–aerobiome nexus: A ‘systems thinking’ mini-review","authors":"Jake M. Robinson, Craig Liddicoat, Xin Sun, Sunita Ramesh, Scott Hawken, Kevin Lee, Joel Brame, Nicole W. Fickling, Emma Kuhn, Claire Hayward, Sonali Deshmukh, Kate Robinson, Christian Cando-Dumancela, Martin F. Breed","doi":"10.1111/1751-7915.70018","DOIUrl":"https://doi.org/10.1111/1751-7915.70018","url":null,"abstract":"The interrelationship between climate change, pollution and the aerobiome (the microbiome of the air) is a complex ecological dynamic with profound implications for human and ecosystem health. This mini-review explores the multifaceted relationships among these factors. By synthesising existing research and integrating interdisciplinary perspectives, we examine the mechanisms driving interactions within the climate change–pollution–aerobiome nexus. We also explore synergistic and cascading effects and potential impacts on human health (including both communicable and non-communicable diseases) and that of wider ecosystems. Based on our mini-review results, climate change influences air pollution and, independently, air pollution affects the composition, diversity and activity of the aerobiome. However, we apply a ‘systems thinking’ approach and create a set of systems diagrams to show that climate change likely influences the aerobiome (including bacteria and fungi) via climate change–pollution interactions in complex ways. Due to the inherent complexity of these systems, we emphasise the importance of holistic and/or interdisciplinary approaches and collaborative efforts in understanding this nexus to safeguard planetary health in an era of rapid environmental change.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142435523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the impact of the gut microbiome on opioid use disorder: Pathways, mechanisms, and treatment insights 了解肠道微生物组对阿片类药物使用障碍的影响：途径、机制和治疗见解。

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-10 DOI: 10.1111/1751-7915.70030

Negin Kazemian, Sepideh Pakpour

{"title":"Understanding the impact of the gut microbiome on opioid use disorder: Pathways, mechanisms, and treatment insights","authors":"Negin Kazemian, Sepideh Pakpour","doi":"10.1111/1751-7915.70030","DOIUrl":"10.1111/1751-7915.70030","url":null,"abstract":"The widespread use of opioids for chronic pain management not only poses a significant public health issue but also contributes to the risk of tolerance, dependence, and addiction, leading to opioid use disorder (OUD), which affects millions globally each year. Recent research has highlighted a potential bidirectional relationship between the gut microbiome and OUD. This emerging perspective is critical, especially as the opioid epidemic intensifies, emphasizing the need to investigate how OUD may alter gut microbiome dynamics and vice versa. Understanding these interactions could reveal new insights into the mechanisms of addiction and tolerance, as well as provide novel approaches for managing and potentially mitigating OUD impacts. This comprehensive review explores the intricate bidirectional link through the gut–brain axis, focusing on how opiates influence microbial composition, functional changes, and gut mucosal integrity. By synthesizing current findings, the review aims to inspire new strategies to combat the opioid crisis and leverage microbiome-centred interventions for preventing and treating OUD.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking epidemic viruses in wastewaters 追踪废水中的流行病毒。

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-09 DOI: 10.1111/1751-7915.70020

Inés Girón-Guzmán, Gloria Sánchez, Alba Pérez-Cataluña

{"title":"Tracking epidemic viruses in wastewaters","authors":"Inés Girón-Guzmán, Gloria Sánchez, Alba Pérez-Cataluña","doi":"10.1111/1751-7915.70020","DOIUrl":"10.1111/1751-7915.70020","url":null,"abstract":"Classical epidemiology relies on incidence, mortality rates, and clinical data from individual testing, which can be challenging for many countries. Therefore, innovative, flexible, cost-effective, and scalable surveillance techniques are needed. Wastewater-based epidemiology (WBE) has emerged as a highly powerful tool in this regard. WBE analyses substances excreted in human fluids and faeces that enter the sewer system. This approach provides insights into community health status and lifestyle habits. WBE serves as an early warning system for viral surveillance, detecting the emergence of new pathogens, changes in incidence rates, identifying future trends, studying outbreaks, and informing the performance of action plans. While WBE has long been used to study different viruses such as poliovirus and norovirus, its implementation has surged due to the pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2. This has led to the establishment of wastewater surveillance programmes at international, national, and community levels, many of which remain operational. Furthermore, WBE is increasingly applied to study other pathogens, including antibiotic resistance bacteria, parasites, fungi, and emerging viruses, with new methodologies being developed. Consequently, the primary focus now is on creating international frameworks to enhance states' preparedness against future health risks. However, there remains considerable work to be done, particularly in integrating the principles of One Health into epidemiological surveillance to acknowledge the interconnectedness of humans, animals, and the environment in pathogen transmission. Thus, a broader approach to analysing the three pillars of One Health must be developed, transitioning from WBE to wastewater and environmental surveillance, and establishing this approach as a routine practice in public health.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic-producing plant-associated bacteria, anti-virulence therapy and microbiome engineering: Integrated approaches in sustainable agriculture 生产抗生素的植物相关细菌、抗病毒疗法和微生物组工程：可持续农业的综合方法。

IF 5.7 2区生物学

Microbial Biotechnology Pub Date : 2024-10-09 DOI: 10.1111/1751-7915.70025

Amalia Roca, Laura Monge-Olivares, Miguel A. Matilla

{"title":"Antibiotic-producing plant-associated bacteria, anti-virulence therapy and microbiome engineering: Integrated approaches in sustainable agriculture","authors":"Amalia Roca, Laura Monge-Olivares, Miguel A. Matilla","doi":"10.1111/1751-7915.70025","DOIUrl":"10.1111/1751-7915.70025","url":null,"abstract":"Plant health is crucial for maintaining the well-being of humans, animals and the environment. Plant pathogens pose significant challenges to agricultural production, global food security and ecosystem biodiversity. This problem is exacerbated by the impact of climate change, which is expected to alter the emergence and evolution of plant pathogens and their interaction with their plant hosts. Traditional approaches to managing phytopathogens involved the use of chemical pesticides, but alternative strategies are needed to address their ongoing decline in performance as well as their negative impact on the environment and public health. Here, we highlight the advancement and effectiveness of biocontrol strategies based on the use of antimicrobial-producing plant-associated bacteria, anti-virulence therapy (e.g. quorum quenching) and microbiome engineering as sustainable biotechnological approaches to promote plant health and foster sustainable agriculture. Notably, Enterobacterales are emerging as important biocontrol agents and as a source of new antimicrobials for potential agricultural use. We analysed here the genomes of over 250 plant-associated enterobacteria to examine their potential to synthesize secondary metabolites. Exploration of the plant microbiome is of major interest in the search for eco-friendly alternatives for reducing the use of chemical pesticides.","PeriodicalId":209,"journal":{"name":"Microbial Biotechnology","volume":"17 10","pages":""},"PeriodicalIF":5.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0