Reactive & Functional Polymers最新文献_第7页

UV-induced tack-loss adhesive without residual glue prepared by isocyanate small molecule and acrylate prepolymer containing photoinitiator 以异氰酸酯小分子和丙烯酸酯预聚物为光引发剂制备无残胶的紫外光致失胶胶

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-08-05 DOI: 10.1016/j.reactfunctpolym.2025.106431

Shumin Jiang , Hangzhou Wang , Jun Shi , Xiaobin Li , Xiaoyan Xiong , Chenguang Kong , Cunzhi Li , Youcheng Huang , Kun Wu , Li Yang

{"title":"UV-induced tack-loss adhesive without residual glue prepared by isocyanate small molecule and acrylate prepolymer containing photoinitiator","authors":"Shumin Jiang , Hangzhou Wang , Jun Shi , Xiaobin Li , Xiaoyan Xiong , Chenguang Kong , Cunzhi Li , Youcheng Huang , Kun Wu , Li Yang","doi":"10.1016/j.reactfunctpolym.2025.106431","DOIUrl":"10.1016/j.reactfunctpolym.2025.106431","url":null,"abstract":"<div><div>In the semiconductor precision device processing and wafer cutting industry, products are typically etched or sliced to meet specific requirements. During this process, a novel type of adhesive is often utilized for bonding and securing purposes. After processing, some methods, such as light exposure and thermal application, can be used to make the adhesive lose its adhesiveness, so as to facilitate the peeling of the product without damaging the product. In this work, acrylate prepolymers containing photopolymerization groups were synthesized from 4-acryloyloxybenzophenone (4-ABP) and other acrylic monomers. UV-induced tack-loss of the acrylate pressure-sensitive adhesive (PSA) was achieved by blending the acrylic prepolymer with a small molecule isocyanate compound in an appropriate ratio and then coating for heat curing. It was observed that the incorporation of multifunctional isocyanate small molecule groups can enhance the overall performance of the tape. An addition amount of 0.6 wt% hexamethylene diisocyanate (HDI) was found to be more suitable than isophorone diisocyanate (IPDI), as it maintained good bonding performance and resulted in less residual glue. The increase in 4-ABP initially led to an improvement in bonding performance of the pressure sensitive adhesive tape, followed by a decrease, with an optimal addition amount of 1.2 wt%. After UV curing, the 180° peel strength of the adhesive tape measured below 1.0 N/25 mm, exhibiting the most significant decrease in peel strength and minimal residual adhesive content. This characteristic categorized it as a UV-induced tack-loss easy peeling pressure-sensitive adhesive tape. These results contribute to the further research and development of UV-induced tack-loss PSA.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"216 ","pages":"Article 106431"},"PeriodicalIF":5.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable hydrogels as conductive platforms for neural applications 可持续水凝胶作为神经应用的导电平台

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-08-05 DOI: 10.1016/j.reactfunctpolym.2025.106427

Janani Sriramakrishnan , B.S. Ananya , Goutam Thakur , Pradeep Kumar

{"title":"Sustainable hydrogels as conductive platforms for neural applications","authors":"Janani Sriramakrishnan , B.S. Ananya , Goutam Thakur , Pradeep Kumar","doi":"10.1016/j.reactfunctpolym.2025.106427","DOIUrl":"10.1016/j.reactfunctpolym.2025.106427","url":null,"abstract":"<div><div>Conductive hydrogels, an emerging class of biopolymers and biomaterials, have gained significant attention because of their combination of water retention properties and electrical conductivity. The hydrogel consists of a water-based matrix capable of transporting charges, resulting in improved processability and desirable biochemical and electrochemical characteristics. Owing to their versatile and sensitive nature, these gels are ideal candidates for medical devices with enhanced biocompatibility and functionality. By integrating conductive materials such as polypyrrole, graphene, and carbon nanotubes, these gels exhibit remarkable flexibility, high water content, and electrical conductivity, making them suitable for applications across various fields. One area where these conductive gels have significant potential is the regeneration and repair of damaged neural tissue, a challenge that conventional methods often do not address owing to the complexity of replicating the intricate anatomical and functional characteristics of the nervous system. They offer a promising alternative by mimicking the natural microenvironment of glial, neuronal, and stromal cells, enhancing stem cell-based therapies. The hydrogel matrix's integration with conductive elements makes electrical signal transmission possible. By mimicking the elastic properties of brain tissues, these gels facilitate the normal flow of signals and encourage neuronal regeneration by enhancing synaptic connections and promoting cell proliferation. This review examines the impact of integrating conductive materials with gels in managing neural damage for improved therapeutic outcomes. Additionally, the classification, properties, and fabrication of sustainable gels are discussed. This review also discusses the immense potential of the conductive gels in cutting-edge neurological applications, such as brain-machine interfaces and prosthetic devices, and they offer promising platforms for treating neural damage.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"216 ","pages":"Article 106427"},"PeriodicalIF":5.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress and application of solvent-free technology, green catalysis and biomass resource strategy for the synthesis of benzoxazine 苯并恶嗪合成无溶剂技术、绿色催化及生物质资源策略的研究进展及应用

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-08-05 DOI: 10.1016/j.reactfunctpolym.2025.106434

Yu Luo, Liwu Zu, Shaobo Dong, Tianyu Lan, Lu Zhang, Wei Zhang, Jun Liu

引用次数: 0

Extracellular vesicles derived from nucleus pulposus mesenchymal stem cells combined with hydrogels promote bone defect repair 髓核间充质干细胞衍生的细胞外囊泡与水凝胶结合可促进骨缺损修复

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-08-05 DOI: 10.1016/j.reactfunctpolym.2025.106433

Yonggang You , Haichao Yu , Suli Chen , Zhen Zhang , Wenhao Hu , Chao Liu , Jing Yi , Xiaoqing Yang , Chengqi Jia , Hua Wang , Fanqi Hu , Xuesong Zhang

{"title":"Extracellular vesicles derived from nucleus pulposus mesenchymal stem cells combined with hydrogels promote bone defect repair","authors":"Yonggang You , Haichao Yu , Suli Chen , Zhen Zhang , Wenhao Hu , Chao Liu , Jing Yi , Xiaoqing Yang , Chengqi Jia , Hua Wang , Fanqi Hu , Xuesong Zhang","doi":"10.1016/j.reactfunctpolym.2025.106433","DOIUrl":"10.1016/j.reactfunctpolym.2025.106433","url":null,"abstract":"<div><div>In the case of large bone defects, the bone tissues cannot regenerate by themselves without extra surgical interventions. Recent studies showed that exosomes are a promising and relatively safe therapeutic tool for bone tissue engineering. Gelatin methacryloyl (GelMA)-based biomaterials can be used as a multifunctional matrix for bone tissue engineering scaffolds through various strategies to overcome major obstacles such as insufficient mechanical properties and uncontrollable degradation. Herein, we investigated the role and mechanism of human nucleus pulposus mesenchymal stem cells (hNPSCs) derived small extracellular vesicles (hNPSCs-EVs) on bone regeneration. EVs from the hNPSCs were initially extracted and identified. GelMA hydrogels were used to deliver hNPSCs-EVs, and the potential of hNPSCs-EVs in bone defect repair was investigated through in vivo and in vitro experiments on rat bone marrow-derived mesenchymal stem cells (BMSCs). In vitro results showed that hNPSCs-EVs offered substantial advantages in promoting BMSCs proliferation, migration, and angiogenesis. They significantly augmented the osteogenic ability of BMSCs by activating the mitogen-activated protein kinase signaling pathway, especially the extracellular regulated protein kinases 1/2 (ERK1/2) signaling pathway. In vivo results showed that hNPSCs-EVs containing GelMA hydrogel (hNPSCs-EVs/GelMA) effectively promoted bone regeneration. These results indicated that hNPSCs-EVs/GelMA offers a potential therapeutic option for bone defect management, and also provided valuable data for understanding the role and mechanism of hNPSCs-sEVs in bone regeneration.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"216 ","pages":"Article 106433"},"PeriodicalIF":5.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144842656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of multifunctional epoxy composites with excellent flame retardancy, UV shielding and low dielectric properties based on fluorinated bismaleimide structure 基于氟化双马来酰亚胺结构的高性能阻燃、紫外线屏蔽和低介电性能环氧复合材料的制备

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-08-05 DOI: 10.1016/j.reactfunctpolym.2025.106429

Lu Li , Yongming Chen , Mengting Wei , Mingyuan Yang , Jiexiang Ren , Richeng Lian , Bifan Guo , Birong Zeng , Yiting Xu , Conghui Yuan , Lizong Dai

{"title":"Preparation of multifunctional epoxy composites with excellent flame retardancy, UV shielding and low dielectric properties based on fluorinated bismaleimide structure","authors":"Lu Li , Yongming Chen , Mengting Wei , Mingyuan Yang , Jiexiang Ren , Richeng Lian , Bifan Guo , Birong Zeng , Yiting Xu , Conghui Yuan , Lizong Dai","doi":"10.1016/j.reactfunctpolym.2025.106429","DOIUrl":"10.1016/j.reactfunctpolym.2025.106429","url":null,"abstract":"<div><div>Epoxy resin is widely used in modern industry, however, its inherent flammability and susceptibility to aging limit its applications. Based on molecular structure design, a fluorinated bismaleimide was first synthesized as the key intermediate. Subsequently, through the highly reactive addition between the P<img>H bond of 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and the maleimide double bonds, a novel epoxy modifier (BMFP) was successfully synthesized, which simultaneously exhibited both excellent ultraviolet (UV) shielding performance and better flame retardancy. The resulting modifier demonstrated good compatibility with epoxy resin. Notably, as the addition amount increased, the epoxy composites not only maintained excellent optical transparency but also exhibited better UV-shielding efficiency and flame retardancy. When the BMFP addition amount reached 8 wt%, the epoxy composite achieved a UL-94 V-0 rating with a limiting oxygen index (LOI) of 31 %. In addition, the peak heat release rate (pHRR) and total heat release (THR) were reduced by 21.1 % and 20.3 %, respectively, compared to neat EP. Additionally, the UV-shielding efficiency showed a 93.4 % enhancement relative to the unmodified epoxy matrix. In addition, the presence of -CF<sub>3</sub> in the modifier effectively improved the dielectric and surface hydrophobicity properties of the epoxy composites, reducing dielectric loss by 31.3 % and increasing the water contact angle from 97.2° to 108.2°.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"216 ","pages":"Article 106429"},"PeriodicalIF":5.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Shining a spotlight on recent advances in photopolymer science 社论：聚焦于光聚合物科学的最新进展

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-08-05 DOI: 10.1016/j.reactfunctpolym.2025.106421

Stefan Baudis , Patrick Knaack , Katharina Ehrmann

引用次数: 0

Epoxide-functionalized hyperbranched polyethylene and its applications in functional polymer synthesis and hot lithography photopolymer toughening 环氧化物官能化超支化聚乙烯及其在功能聚合物合成和热光刻光聚合物增韧中的应用

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-08-05 DOI: 10.1016/j.reactfunctpolym.2025.106425

Vojtěch Musil , Dominik Laa , Anatolij Sokolohorskyj , Robert Liska , Katharina Ehrmann , Jan Merna

{"title":"Epoxide-functionalized hyperbranched polyethylene and its applications in functional polymer synthesis and hot lithography photopolymer toughening","authors":"Vojtěch Musil , Dominik Laa , Anatolij Sokolohorskyj , Robert Liska , Katharina Ehrmann , Jan Merna","doi":"10.1016/j.reactfunctpolym.2025.106425","DOIUrl":"10.1016/j.reactfunctpolym.2025.106425","url":null,"abstract":"<div><div>The copolymerization behaviour of four epoxide-containing ene-functionalized monomers with ethene using palladium α-diimine catalyst was investigated. The linker separating oxirane and double bond played a crucial role in the process. High molar mass copolymers of ethene rich in glycidyl 10-undecenoate were obtained without a significant loss of catalyst activity. Allyl glycidyl ether was able to form copolymers with high comonomer incorporation as well, however, the copolymer molar mass and catalyst activity decreased severely. Therefore, we tuned the reaction conditions in order to achieve a better compromise between comonomer incorporation and product molar mass. Adjustments of reaction temperature, ethene pressure and used solvent were shown to impact the copolymer properties. Furthermore, the prepared copolymers were used in subsequent post-polymerization modifications. We have demonstrated that despite the steric hinderance of the polymer chain, pendent epoxide rings can be reacted with acids, O, C, N and Snucleophiles quantitatively to prepare hyperbranched molecules with a diverse range of functional groups. Finally, the prepared epoxide-functionalized hyperbranched polyethylene was tested as rubber toughening agent of brittle photopolymers revealing its potential for hot lithography 3D printing.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"216 ","pages":"Article 106425"},"PeriodicalIF":5.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144779539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced palladium-hybrid covalent organic framework: A highly efficient catalyst for sustainable Cascade synthesis of Chromeno[2,3-d]Pyrimidine-8-amines 先进的钯杂化共价有机骨架：可持续级联合成Chromeno[2,3-d]嘧啶-8胺的高效催化剂

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-07-30 DOI: 10.1016/j.reactfunctpolym.2025.106424

Ankit Verma , Bhojkumar Nayak , Pradumn Jaiswal , Suhag S. Sahay , Shivani Bhagat , Umesh R. Pratap

{"title":"Advanced palladium-hybrid covalent organic framework: A highly efficient catalyst for sustainable Cascade synthesis of Chromeno[2,3-d]Pyrimidine-8-amines","authors":"Ankit Verma , Bhojkumar Nayak , Pradumn Jaiswal , Suhag S. Sahay , Shivani Bhagat , Umesh R. Pratap","doi":"10.1016/j.reactfunctpolym.2025.106424","DOIUrl":"10.1016/j.reactfunctpolym.2025.106424","url":null,"abstract":"<div><div>Covalent organic frameworks account for an emerging class of porous crystalline organic polymers characterized by their modular architecture, facilitating functionalization. The well-defined pores of COFs serve as ideal platforms for stabilizing metal species and ensuring superior accessibility. Incorporating substrate-binding sites within COFs enables the formation of host-guest interactions, thereby promoting synergistic effects that enhance catalytic performance. Polyimide covalent organic framework (PI-COF) is remarkably crystalline, an imide-based COF synthesized via a solvothermal reaction of cost-effective melamine and pyromellitic dianhydride. This COF serves as a robust platform for immobilizing palladium (Pd<sup>2+</sup>) ions, enabling PI-COF catalytic applications. The successful fabrication of (PI-COF) with palladium, i.e.<em>,</em> Pd@PI-COF, has been comprehensively characterized using FTIR, PXRD, <sup>13</sup>C(CP/MAS) NMR, BET, TGA, XPS, FE-SEM, HR-TEM, and ICP-OES. The synthesized Pd@PI-COF is utilized as a heterogeneous catalyst for developing a highly efficient protocol of one-pot synthesis of chromeno[2,3-<em>d</em>] pyrimidine-8-amine via four-component reactions. Pd@PI-COF serves as a sustainable catalyst, facilitating the reaction in ethanol under mild reaction conditions, achieving an exceptional yield up to 93 % in just 50 min. . The catalyst exhibits excellent recyclability and reusability, retaining its catalytic efficiency across four consecutive cycles with negligible loss in activity, while maintaining good turnover numbers (TON) and turnover frequencies (TOF).</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"216 ","pages":"Article 106424"},"PeriodicalIF":5.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable nanocellulose recovery from newspaper waste to fabricate a composite for sensing and scavenging copper and iron in aqueous effluents and mining wastes 从报纸废物中可持续回收纳米纤维素，以制造一种复合材料，用于感应和清除废水和采矿废物中的铜和铁

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-07-28 DOI: 10.1016/j.reactfunctpolym.2025.106423

Nuha Y. Elamin , Mohamed R. Elamin , Laila S. Alqarni , Rana O. Yahya , Ahmed Shahat , Reda F.M. Elshaarawy

{"title":"Sustainable nanocellulose recovery from newspaper waste to fabricate a composite for sensing and scavenging copper and iron in aqueous effluents and mining wastes","authors":"Nuha Y. Elamin , Mohamed R. Elamin , Laila S. Alqarni , Rana O. Yahya , Ahmed Shahat , Reda F.M. Elshaarawy","doi":"10.1016/j.reactfunctpolym.2025.106423","DOIUrl":"10.1016/j.reactfunctpolym.2025.106423","url":null,"abstract":"<div><div>This study offers a straightforward and economical method for recovering cellulose nanoparticles (CNMs) from post-consumer newspaper trash in a sustainable manner. The recovered CNMs were subsequently utilized to fabricate a novel solid-state visual composite by immobilizing a newly synthesized fluorescent Schiff base ligand, (saldach(Et<sub>3</sub>N<sup>+</sup>PF<sub>6</sub><sup>−</sup>)<sub>2</sub>, H<sub>2</sub>L) (Saldach ligand). Both the quick and on-site visual identification of Cu<sup>2+</sup> and Fe<sup>3+</sup> ions in aqueous solutions and the effective elimination of these heavy metal pollutants from mining effluent were proved by the resultant Saldach-composite. The Schiff base ligand, characterized by FTIR, NMR, and ESI-MS, exhibited selective binding toward Cu<sup>2+</sup> and Fe<sup>3+</sup> ions, leading to quantifiable UV–Vis spectroscopy. The morphology and composition of the CNMs and the Saldach-composite were investigated using SEM, TEM, DLS, XRD, and XPS analysis, confirming the successful incorporation of the Schiff base onto the CNM matrix. Additionally, the binding mechanism between the Saldach-composite and the target metal ions was clarified by the use of density functional theory (DFT) calculations. For the simultaneous detection and removal of Cu<sup>2+</sup> and Fe<sup>3+</sup> from mine waste, the developed solid-state visual composite presents a viable, economical, and ecologically friendly alternative, especially addressing the difficulties related to mining waste management.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"216 ","pages":"Article 106423"},"PeriodicalIF":5.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144748606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of chitosan on 3D printed scaffolds with gelatin–hyaluronic acid, hydroxyapatite and magnetic nanoparticles for bone tissues defects repair 壳聚糖对明胶透明质酸、羟基磷灰石和磁性纳米颗粒3D打印骨组织缺损修复支架的影响

IF 5.1 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-07-27 DOI: 10.1016/j.reactfunctpolym.2025.106422

Iustina Apăvăloaiei , Isabella Nacu , Florina-Daniela Cojocaru , Vera Balan , Maria Bercea , Loredana Elena Niță , Liliana Vereștiuc

{"title":"Effect of chitosan on 3D printed scaffolds with gelatin–hyaluronic acid, hydroxyapatite and magnetic nanoparticles for bone tissues defects repair","authors":"Iustina Apăvăloaiei , Isabella Nacu , Florina-Daniela Cojocaru , Vera Balan , Maria Bercea , Loredana Elena Niță , Liliana Vereștiuc","doi":"10.1016/j.reactfunctpolym.2025.106422","DOIUrl":"10.1016/j.reactfunctpolym.2025.106422","url":null,"abstract":"<div><div>Bone is a dynamic and vascularized tissue, with self-healing abilities, efficient in treating minor defects. Bone tissue engineering has focused on materials used to reconstruct large orthopedics defects and 3D (bio)printing is a revolutionary technology able to design well-defined geometries. The paper details the preparation of printable inks based on methacrylated chitosan with different molecular weight, methacrylated gelatin, hyaluronic acid, hydroxyapatite and magnetic nanoparticle, and evaluates the inks printability, and scaffolds properties in correlation with bone repair requirements. The polymers homogenization with magnetic nanoparticles and hydroxyapatite led to gels with rheological characteristics for 3D printing (shear tests in oscillatory or rotational regimes); inks containing short chitosan chains and high hydroxyapatite concentrations showed suitable viscosity and elasticity. The yield stress results suggest that the inks are becoming more resistant to flow by increasing the Cs molecular weight. Scanning electron microscopy images confirmed the 3D printed architecture and the formation of 3D network with interconnected pores, varying from 50 μm to 150 μm, beneficial for bone cells migration and infiltration. Hydroxyapatite content, strongly influenced scaffolds mechanical features (Young modulus), and by tailoring the polymeric/hydroxyapatite phases, 3D printed scaffolds suitable for implantation in low-load bearing sites. On the other hand, the inclusion of magnetic nanoparticles induced ability to respond to external magnetic field and potential to activate complex pathways for osteogenic differentiation. The prepared scaffolds are cytocompatible, the cells preserved their normal morphology and interacted in uniform layers.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"216 ","pages":"Article 106422"},"PeriodicalIF":5.1,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0