Progress in neuro-psychopharmacology最新文献_第10页

Prolactin levels and amphetamine-induced behavioural changes following fluphenazine decanoate administration 给药氟非那嗪后催乳素水平和安非他明引起的行为改变

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90056-4

Z. Merali

{"title":"Prolactin levels and amphetamine-induced behavioural changes following fluphenazine decanoate administration","authors":"Z. Merali","doi":"10.1016/0364-7722(81)90056-4","DOIUrl":"10.1016/0364-7722(81)90056-4","url":null,"abstract":"<div><ul><li>1.1. A single injection of fluphenazine decanoate (FD) antagonized effects of acute d-amphetamine (2.5 mg/kg) for a variable period of time (4 to 28 days), depending upon the dosage of the neuroleptic used (2.5 or 5.0 mg/kg) and the behavioural parameter(s) monitored.</li><li>2.2. Locomotion and rearing were antagonized for a longer duration than was sniffing. Normal locomotor response to amphetamine was attained 12 and 28 days following the administration of 2.5 and 5.0 mg/kg FD, respectively. However, the 2.5 mg/kg FD group displayed significantly more locomotor activity on days 20 and 24 post-treatment. A similar supersensitive response was not demonstrable with the higher dose of FD (5.0 mg/kg), or with the other behavioural measures.</li><li>3.3. The prompt and pronounced elevation of serum prolactin in response to the neuroleptic returned to within the normal range by days 4 and 14, following administration of 2.5 and 5.0 mg/kg FD, respectively.</li><li>4.4. These results indicate that the behavioural paradigm is more sensitive in monitoring the effects of FD and could serve as a useful model in investigating the dose- and time-related effects of other long-acting neuroleptics.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90056-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18351899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

News and intercommunications in neuropsychopharmacology 神经精神药理学的新闻与交流

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI: 10.1016/0364-7722(81)90011-4

引用次数: 0

Responders and nonresponders to chlordiazepoxide and placebo: A discriminant function analysis 氯二氮环氧化物和安慰剂有反应和无反应:判别函数分析

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI: 10.1016/0364-7722(80)90011-9

Robert W. Downing , Karl Rickels

引用次数: 3

Coronary heart disease: Treating the anxiety component 冠心病:治疗焦虑成分

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI: 10.1016/0364-7722(80)90026-0

David Wheatley

{"title":"Coronary heart disease: Treating the anxiety component","authors":"David Wheatley","doi":"10.1016/0364-7722(80)90026-0","DOIUrl":"10.1016/0364-7722(80)90026-0","url":null,"abstract":"<div><ul><li>1.1. A number of studies have been undertaken demonstrating that psychiatric factors are of importance in coronary heart disease (CHD). Accordingly a double-blind comparison was made between two groups of patients who had suffered their first myocardial infarction, one group being treated with clorazepate and the other with placebo, for three months.</li><li>2.2. The patients made daily records of anginal attacks and other factors, and throughout the trial, the mean anginal attack rate and mean glyceryl trinitrate (GTN) requirement rates were less in those patients treated with clorazepate than in those treated with placebo. In the case of the GTN requirements, for the whole trial, the reduction was statistically significant in favour of clorazepate (p < 0.01).</li><li>3.3. On a number of other measures also, advantages were recorded for the patients treated with active medication. A new rating scale has been devised to assess psychiatric symptomatology in patients suffering from organic conditions which might otherwise cause symptoms which could be confused with the somatic items on established scales.</li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90026-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17178014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Brain and platelet monoamine oxidase in mental disorders 1. Schizophrenics and cycloid psychotics. 脑与血小板单胺氧化酶在精神障碍中的作用精神分裂症和摆线型精神病患者。

Progress in neuro-psychopharmacology Pub Date : 1980-01-01

B Eckert, C G Gottfries, L Von Knorring, L Oreland, A Wiberg, B Winblad

引用次数: 0

Diazepam and human memory: Influence on acquisition, retrieval, and state-dependent learning 安定与人类记忆:对习得、检索和状态依赖学习的影响

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI: 10.1016/0364-7722(80)90064-8

Ronald C Petersen , Mohamed M Ghoneim

引用次数: 59

Classification of endorphins/enkephalins in brain physiology and pathology (based on EEG and clinical study of synthetically-modified methionine-enkephalin) 脑内啡肽/脑啡肽在脑生理病理中的分类(基于脑电图和合成修饰蛋氨酸-脑啡肽的临床研究)

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI: 10.1016/0364-7722(80)90021-1

Jiri Roubicek , Eva Krebs , Walter Poeldinger

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引用次数: 2

Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase 苯乙醇胺- n -甲基转移酶抑制剂增强左旋多巴诱导的运动活性

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI: 10.1016/0364-7722(80)90066-1

Richard J Katz, Jerry Gelbart, Bernard J Carroll

引用次数: 1

Lithium and cholinesterase 锂和胆碱酯酶

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI: 10.1016/0364-7722(80)90067-3

Sin J Choi , Robert M Derman

引用次数: 3

Diazepam: Human learning of different materials 安定:人类对不同材料的学习

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI: 10.1016/0364-7722(80)90036-3

Laurence Hartley

引用次数: 4