Progress in neuro-psychopharmacology最新文献

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Chronic haloperidol treatment fails to alter the anorexic actions of dopaminergic agonists and cholinergic drugs 慢性氟哌啶醇治疗不能改变多巴胺能激动剂和胆碱能药物的厌食作用
Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90079-5
Martin D. Hynes , Harbans Lal
{"title":"Chronic haloperidol treatment fails to alter the anorexic actions of dopaminergic agonists and cholinergic drugs","authors":"Martin D. Hynes ,&nbsp;Harbans Lal","doi":"10.1016/0364-7722(81)90079-5","DOIUrl":"10.1016/0364-7722(81)90079-5","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Experimental rats were chronically treated with haloperidol and tested with dopaminergic and cholinergic drugs for their anorexic effects.</p></span></li><li><span>2.</span><span><p>2. All of the test drugs significantly reduced the compulsive eating that results from food deprivation.</p></span></li><li><span>3.</span><span><p>3. Chronic haloperidol failed to change sensitivity of the animals to dopaminergic or cholinergic drugs. There was a trend towards an increase in sensitivity to a peripheral effect of a cholinergic drug.</p></span></li><li><span>4.</span><span><p>4. In contrast to the present data, sensitivity to dopaminergic drugs in producing locomotor stimulation and stereotypy is increased after chronic haloperidol. These experiments suggest that alteration in neurotransmitter functioning after chronic neuroleptics markedly differs in different neurobehavioral systems.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 3","pages":"Pages 271-275"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90079-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18280705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study 阿莫沙平和乙醇对驾驶相关精神运动技能的影响:一项安慰剂和标准对照研究
Progress in neuro-psychopharmacology Pub Date : 1981-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(81)90078-3
W.H. Wilson, W.M. Petrie, T.A. Ban, D.E. Barry
{"title":"The effects of amoxapine and ethanol on psychomotor skills related to driving: A placebo and standard controlled study","authors":"W.H. Wilson,&nbsp;W.M. Petrie,&nbsp;T.A. Ban,&nbsp;D.E. Barry","doi":"10.1016/0364-7722(81)90078-3","DOIUrl":"10.1016/0364-7722(81)90078-3","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Eight normal male volunteers were tested under eight different treatment conditions: amoxapine 50 and 100 mg, amitriptyline 50 mg. and placebo—each condition with and without ethanol—(1.3 g/kg body weight), utilizing a double-blind repeated measures latin square design balanced for carry-over. Motor reflex, pursuit rotor and depth perception tests were conducted when blood levels of the active drugs and alocohol were simultaneously at or near peak.</p></span></li><li><span>2.</span><span><p>2. Analyses revealed significant effects of amitriptyline and ethanol on the motor reflex and pursuit rotor but not for depth perception tests, and the effects of ethanol appeared to be potentiated by amitriptyline on the pursuit rotor test; this was not true for amoxapine.</p></span></li><li><span>3.</span><span><p>3. Although the effects of 100 mg of amoxapine were consistently greater than for 50 mg or placebo, these differences did not reach a statistical significant level.</p></span></li><li><span>4.</span><span><p>4. Since amoxapine did not differ significantly from placebo, these results suggest that the effects of amoxapine on driving skills may not be as pronounced as those produced by amitriptyline.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"5 3","pages":"Pages 263-270"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90078-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18280704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Brain and platelet monoamine oxidase in mental disorders 1. Schizophrenics and cycloid psychotics. 脑与血小板单胺氧化酶在精神障碍中的作用精神分裂症和摆线型精神病患者。
Progress in neuro-psychopharmacology Pub Date : 1980-01-01
B Eckert, C G Gottfries, L Von Knorring, L Oreland, A Wiberg, B Winblad
{"title":"Brain and platelet monoamine oxidase in mental disorders 1. Schizophrenics and cycloid psychotics.","authors":"B Eckert,&nbsp;C G Gottfries,&nbsp;L Von Knorring,&nbsp;L Oreland,&nbsp;A Wiberg,&nbsp;B Winblad","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 1","pages":"57-68"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18412027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diazepam and human memory: Influence on acquisition, retrieval, and state-dependent learning 安定与人类记忆:对习得、检索和状态依赖学习的影响
Progress in neuro-psychopharmacology Pub Date : 1980-01-01 Epub Date: 2004-07-14 DOI: 10.1016/0364-7722(80)90064-8
Ronald C Petersen , Mohamed M Ghoneim
{"title":"Diazepam and human memory: Influence on acquisition, retrieval, and state-dependent learning","authors":"Ronald C Petersen ,&nbsp;Mohamed M Ghoneim","doi":"10.1016/0364-7722(80)90064-8","DOIUrl":"10.1016/0364-7722(80)90064-8","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Diazepam's capacity to influence learning and memory processes in man was evaluated using five tasks involving free and cued recall and mental imagery.</p></span></li><li><span>2.</span><span><p>2. State-dependent learning was assessed by manipulating the drug condition (diazepam or placebo) during the learning and recall sessions.</p></span></li><li><span>3.</span><span><p>3. Results indicated that 0.3 mg/kg diazepam administered orally significantly impaired subjects' ability to learn new material using a variety of procedures.</p></span></li><li><span>4.</span><span><p>4. Retrieval of material once learned was not severely impaired by the drug.</p></span></li><li><span>5.</span><span><p>5. Some evidence for state dependency was found, but additional studies are required.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 1","pages":"Pages 81-89"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90064-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18412028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 59
Responders and nonresponders to chlordiazepoxide and placebo: A discriminant function analysis 氯二氮环氧化物和安慰剂有反应和无反应:判别函数分析
Progress in neuro-psychopharmacology Pub Date : 1980-01-01 Epub Date: 2004-05-06 DOI: 10.1016/0364-7722(80)90011-9
Robert W. Downing , Karl Rickels
{"title":"Responders and nonresponders to chlordiazepoxide and placebo: A discriminant function analysis","authors":"Robert W. Downing ,&nbsp;Karl Rickels","doi":"10.1016/0364-7722(80)90011-9","DOIUrl":"10.1016/0364-7722(80)90011-9","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Data from 356 anxious outpatients treated with either chlordiazepoxide or placebo in 4 week double-blind drug trials were analyzed in an attempt to determine predictors of treatment response using extreme groups and discriminant function analysis.</p></span></li><li><span>2.</span><span><p>2. Chlordiazepoxide response was found to be greater in younger female patients with lower levels of initial depression and a more favorable prognosis.</p></span></li><li><span>3.</span><span><p>3. Placebo response was found to be greater in younger, black, previously untreated or favorably drug treated patients and patients with lower initial somatization and depression.</p></span></li><li><span>4.</span><span><p>4. Discriminators between drug and placebo response included age, previous drug treatment, race, and initial level of somatic symptomatology.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 4","pages":"Pages 405-415"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90011-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18060072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Coronary heart disease: Treating the anxiety component 冠心病:治疗焦虑成分
Progress in neuro-psychopharmacology Pub Date : 1980-01-01 Epub Date: 2004-05-06 DOI: 10.1016/0364-7722(80)90026-0
David Wheatley
{"title":"Coronary heart disease: Treating the anxiety component","authors":"David Wheatley","doi":"10.1016/0364-7722(80)90026-0","DOIUrl":"10.1016/0364-7722(80)90026-0","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. A number of studies have been undertaken demonstrating that psychiatric factors are of importance in coronary heart disease (CHD). Accordingly a double-blind comparison was made between two groups of patients who had suffered their first myocardial infarction, one group being treated with clorazepate and the other with placebo, for three months.</p></span></li><li><span>2.</span><span><p>2. The patients made daily records of anginal attacks and other factors, and throughout the trial, the mean anginal attack rate and mean glyceryl trinitrate (GTN) requirement rates were less in those patients treated with clorazepate than in those treated with placebo. In the case of the GTN requirements, for the whole trial, the reduction was statistically significant in favour of clorazepate (p &lt; 0.01).</p></span></li><li><span>3.</span><span><p>3. On a number of other measures also, advantages were recorded for the patients treated with active medication. A new rating scale has been devised to assess psychiatric symptomatology in patients suffering from organic conditions which might otherwise cause symptoms which could be confused with the somatic items on established scales.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 4","pages":"Pages 537-544"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90026-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17178014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Classification of endorphins/enkephalins in brain physiology and pathology (based on EEG and clinical study of synthetically-modified methionine-enkephalin) 脑内啡肽/脑啡肽在脑生理病理中的分类(基于脑电图和合成修饰蛋氨酸-脑啡肽的临床研究)
Progress in neuro-psychopharmacology Pub Date : 1980-01-01 Epub Date: 2004-05-06 DOI: 10.1016/0364-7722(80)90021-1
Jiri Roubicek , Eva Krebs , Walter Poeldinger
{"title":"Classification of endorphins/enkephalins in brain physiology and pathology (based on EEG and clinical study of synthetically-modified methionine-enkephalin)","authors":"Jiri Roubicek ,&nbsp;Eva Krebs ,&nbsp;Walter Poeldinger","doi":"10.1016/0364-7722(80)90021-1","DOIUrl":"10.1016/0364-7722(80)90021-1","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Endorphins, substances isolated from the brain and the pituitary gland, were found to have opiate-like activity via opiate receptors in the brain. Special types of brain endorphins are the enkephalins, pentapeptides which have leucin or methionine as a terminal amino acid. Methionine-enkephalin was recognised as an amino acid sequence from a larger peptide hormone of the anterior pituitary gland, beta-lipotropin.</p></span></li><li><span>2.</span><span><p>2. FK 33-824, a synthetically-modified methionine-enkephalin, was the subject of our study. FK 33-824 induced a short-term improvement in the symptoms of 5 of 7 psychotic patients.</p></span></li><li><span>3.</span><span><p>3. An EEG investigation of this compound in 20 normal volunteers (compared with placebo in 8 of them) indicated typical changes in electrical activity in the conventional description and spectral-analytic evaluation, viz. an increase in alpha and beta activity with a simultaneous decrease in slow waves. The changes after FK 33-824 differ from placebo changes and from the well known changes seen after opioid alkaloids.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 4","pages":"Pages 507-518"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90021-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17178013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Tolerance development to phencyclidine by chronic administration 慢性给药对苯环利定的耐受性发展
Progress in neuro-psychopharmacology Pub Date : 1980-01-01 Epub Date: 2004-05-07 DOI: 10.1016/0364-7722(80)90042-9
Bryan A. Flint, Ing K. Ho
{"title":"Tolerance development to phencyclidine by chronic administration","authors":"Bryan A. Flint,&nbsp;Ing K. Ho","doi":"10.1016/0364-7722(80)90042-9","DOIUrl":"10.1016/0364-7722(80)90042-9","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Tolerance development to phencyclidine (PCP) was assessed in male ICR mice using motor coordination ability as an indicator.</p></span></li><li><span>2.</span><span><p>2. The ED50 of PCP for initiating motor incoordination was 13.8 mg/kg and the LD50 of PCP was estimated to be 78 mg/kg.</p></span></li><li><span>3.</span><span><p>3. The daily administration of PCP, ranging from 10 to 40 mg/kg, i.p., caused a gradual reduction of the duration of motor incoordination.</p></span></li><li><span>4.</span><span><p>4. The degree of tolerance development was observed to be in a dose-dependent fashion.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 3","pages":"Pages 233-239"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90042-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18444632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase 苯乙醇胺- n -甲基转移酶抑制剂增强左旋多巴诱导的运动活性
Progress in neuro-psychopharmacology Pub Date : 1980-01-01 Epub Date: 2004-07-14 DOI: 10.1016/0364-7722(80)90066-1
Richard J Katz, Jerry Gelbart, Bernard J Carroll
{"title":"Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase","authors":"Richard J Katz,&nbsp;Jerry Gelbart,&nbsp;Bernard J Carroll","doi":"10.1016/0364-7722(80)90066-1","DOIUrl":"10.1016/0364-7722(80)90066-1","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice.</p></span></li><li><span>2.</span><span><p>2. This suggests that an adrenergic system normally inhibits drug induced activation and</p></span></li><li><span>3.</span><span><p>3. Points to an interaction between adrenaline and other catecholamines.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 1","pages":"Pages 101-105"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90066-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18206029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Lithium and cholinesterase 锂和胆碱酯酶
Progress in neuro-psychopharmacology Pub Date : 1980-01-01 Epub Date: 2004-07-14 DOI: 10.1016/0364-7722(80)90067-3
Sin J Choi , Robert M Derman
{"title":"Lithium and cholinesterase","authors":"Sin J Choi ,&nbsp;Robert M Derman","doi":"10.1016/0364-7722(80)90067-3","DOIUrl":"10.1016/0364-7722(80)90067-3","url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Preliminary data show that lithium carbonate administered in patients with endogenous depression significantly inhibits serum cholinesterase.</p></span></li><li><span>2.</span><span><p>2. The interaction of lithium with cholinergic system could be envisaged as a possible mechanism of lithium therapeutic action in affective disorders.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 1","pages":"Pages 107-109"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90067-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18412024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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