Diazepam and human memory: Influence on acquisition, retrieval, and state-dependent learning

Abstract

• 1.

  1. Diazepam's capacity to influence learning and memory processes in man was evaluated using five tasks involving free and cued recall and mental imagery.

• 2.

  2. State-dependent learning was assessed by manipulating the drug condition (diazepam or placebo) during the learning and recall sessions.

• 3.

  3. Results indicated that 0.3 mg/kg diazepam administered orally significantly impaired subjects' ability to learn new material using a variety of procedures.

• 4.

  4. Retrieval of material once learned was not severely impaired by the drug.

• 5.

  5. Some evidence for state dependency was found, but additional studies are required.