{"title":"脑内啡肽/脑啡肽在脑生理病理中的分类(基于脑电图和合成修饰蛋氨酸-脑啡肽的临床研究)","authors":"Jiri Roubicek , Eva Krebs , Walter Poeldinger","doi":"10.1016/0364-7722(80)90021-1","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Endorphins, substances isolated from the brain and the pituitary gland, were found to have opiate-like activity via opiate receptors in the brain. Special types of brain endorphins are the enkephalins, pentapeptides which have leucin or methionine as a terminal amino acid. Methionine-enkephalin was recognised as an amino acid sequence from a larger peptide hormone of the anterior pituitary gland, beta-lipotropin.</p></span></li><li><span>2.</span><span><p>2. FK 33-824, a synthetically-modified methionine-enkephalin, was the subject of our study. FK 33-824 induced a short-term improvement in the symptoms of 5 of 7 psychotic patients.</p></span></li><li><span>3.</span><span><p>3. An EEG investigation of this compound in 20 normal volunteers (compared with placebo in 8 of them) indicated typical changes in electrical activity in the conventional description and spectral-analytic evaluation, viz. an increase in alpha and beta activity with a simultaneous decrease in slow waves. The changes after FK 33-824 differ from placebo changes and from the well known changes seen after opioid alkaloids.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90021-1","citationCount":"2","resultStr":"{\"title\":\"Classification of endorphins/enkephalins in brain physiology and pathology (based on EEG and clinical study of synthetically-modified methionine-enkephalin)\",\"authors\":\"Jiri Roubicek , Eva Krebs , Walter Poeldinger\",\"doi\":\"10.1016/0364-7722(80)90021-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Endorphins, substances isolated from the brain and the pituitary gland, were found to have opiate-like activity via opiate receptors in the brain. Special types of brain endorphins are the enkephalins, pentapeptides which have leucin or methionine as a terminal amino acid. Methionine-enkephalin was recognised as an amino acid sequence from a larger peptide hormone of the anterior pituitary gland, beta-lipotropin.</p></span></li><li><span>2.</span><span><p>2. FK 33-824, a synthetically-modified methionine-enkephalin, was the subject of our study. FK 33-824 induced a short-term improvement in the symptoms of 5 of 7 psychotic patients.</p></span></li><li><span>3.</span><span><p>3. An EEG investigation of this compound in 20 normal volunteers (compared with placebo in 8 of them) indicated typical changes in electrical activity in the conventional description and spectral-analytic evaluation, viz. an increase in alpha and beta activity with a simultaneous decrease in slow waves. The changes after FK 33-824 differ from placebo changes and from the well known changes seen after opioid alkaloids.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(80)90021-1\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772280900211\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772280900211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Classification of endorphins/enkephalins in brain physiology and pathology (based on EEG and clinical study of synthetically-modified methionine-enkephalin)
1.
1. Endorphins, substances isolated from the brain and the pituitary gland, were found to have opiate-like activity via opiate receptors in the brain. Special types of brain endorphins are the enkephalins, pentapeptides which have leucin or methionine as a terminal amino acid. Methionine-enkephalin was recognised as an amino acid sequence from a larger peptide hormone of the anterior pituitary gland, beta-lipotropin.
2.
2. FK 33-824, a synthetically-modified methionine-enkephalin, was the subject of our study. FK 33-824 induced a short-term improvement in the symptoms of 5 of 7 psychotic patients.
3.
3. An EEG investigation of this compound in 20 normal volunteers (compared with placebo in 8 of them) indicated typical changes in electrical activity in the conventional description and spectral-analytic evaluation, viz. an increase in alpha and beta activity with a simultaneous decrease in slow waves. The changes after FK 33-824 differ from placebo changes and from the well known changes seen after opioid alkaloids.
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