Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase

Richard J Katz, Jerry Gelbart, Bernard J Carroll
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引用次数: 1

Abstract

  • 1.

    1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice.

  • 2.

    2. This suggests that an adrenergic system normally inhibits drug induced activation and

  • 3.

    3. Points to an interaction between adrenaline and other catecholamines.

苯乙醇胺- n -甲基转移酶抑制剂增强左旋多巴诱导的运动活性
1.1. 对肾上腺素合成酶苯乙醇胺- n -甲基转移酶(PNMT)的药理抑制导致3,4,-二羟基苯丙氨酸(L-DOPA)增强小鼠的行为激活。这表明肾上腺素能系统通常抑制药物诱导的激活和3.3。表明肾上腺素和其他儿茶酚胺相互作用。
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