Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI:10.1016/0364-7722(80)90066-1

Richard J Katz, Jerry Gelbart, Bernard J Carroll

引用次数: 1

Abstract

1.
1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice.
2.
2. This suggests that an adrenergic system normally inhibits drug induced activation and
3.
3. Points to an interaction between adrenaline and other catecholamines.

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苯乙醇胺- n -甲基转移酶抑制剂增强左旋多巴诱导的运动活性

1.1. 对肾上腺素合成酶苯乙醇胺- n -甲基转移酶(PNMT)的药理抑制导致3,4，-二羟基苯丙氨酸(L-DOPA)增强小鼠的行为激活。这表明肾上腺素能系统通常抑制药物诱导的激活和3.3。表明肾上腺素和其他儿茶酚胺相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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