Responders and nonresponders to chlordiazepoxide and placebo: A discriminant function analysis

Abstract

• 1.

  1. Data from 356 anxious outpatients treated with either chlordiazepoxide or placebo in 4 week double-blind drug trials were analyzed in an attempt to determine predictors of treatment response using extreme groups and discriminant function analysis.

• 2.

  2. Chlordiazepoxide response was found to be greater in younger female patients with lower levels of initial depression and a more favorable prognosis.

• 3.

  3. Placebo response was found to be greater in younger, black, previously untreated or favorably drug treated patients and patients with lower initial somatization and depression.

• 4.

  4. Discriminators between drug and placebo response included age, previous drug treatment, race, and initial level of somatic symptomatology.