{"title":"氯二氮环氧化物和安慰剂有反应和无反应:判别函数分析","authors":"Robert W. Downing , Karl Rickels","doi":"10.1016/0364-7722(80)90011-9","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Data from 356 anxious outpatients treated with either chlordiazepoxide or placebo in 4 week double-blind drug trials were analyzed in an attempt to determine predictors of treatment response using extreme groups and discriminant function analysis.</p></span></li><li><span>2.</span><span><p>2. Chlordiazepoxide response was found to be greater in younger female patients with lower levels of initial depression and a more favorable prognosis.</p></span></li><li><span>3.</span><span><p>3. Placebo response was found to be greater in younger, black, previously untreated or favorably drug treated patients and patients with lower initial somatization and depression.</p></span></li><li><span>4.</span><span><p>4. Discriminators between drug and placebo response included age, previous drug treatment, race, and initial level of somatic symptomatology.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90011-9","citationCount":"3","resultStr":"{\"title\":\"Responders and nonresponders to chlordiazepoxide and placebo: A discriminant function analysis\",\"authors\":\"Robert W. Downing , Karl Rickels\",\"doi\":\"10.1016/0364-7722(80)90011-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Data from 356 anxious outpatients treated with either chlordiazepoxide or placebo in 4 week double-blind drug trials were analyzed in an attempt to determine predictors of treatment response using extreme groups and discriminant function analysis.</p></span></li><li><span>2.</span><span><p>2. Chlordiazepoxide response was found to be greater in younger female patients with lower levels of initial depression and a more favorable prognosis.</p></span></li><li><span>3.</span><span><p>3. Placebo response was found to be greater in younger, black, previously untreated or favorably drug treated patients and patients with lower initial somatization and depression.</p></span></li><li><span>4.</span><span><p>4. Discriminators between drug and placebo response included age, previous drug treatment, race, and initial level of somatic symptomatology.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(80)90011-9\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772280900119\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772280900119","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Responders and nonresponders to chlordiazepoxide and placebo: A discriminant function analysis
1.
1. Data from 356 anxious outpatients treated with either chlordiazepoxide or placebo in 4 week double-blind drug trials were analyzed in an attempt to determine predictors of treatment response using extreme groups and discriminant function analysis.
2.
2. Chlordiazepoxide response was found to be greater in younger female patients with lower levels of initial depression and a more favorable prognosis.
3.
3. Placebo response was found to be greater in younger, black, previously untreated or favorably drug treated patients and patients with lower initial somatization and depression.
4.
4. Discriminators between drug and placebo response included age, previous drug treatment, race, and initial level of somatic symptomatology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
