Classification of endorphins/enkephalins in brain physiology and pathology (based on EEG and clinical study of synthetically-modified methionine-enkephalin)

Progress in neuro-psychopharmacology Pub Date : 1980-01-01 DOI:10.1016/0364-7722(80)90021-1

Jiri Roubicek , Eva Krebs , Walter Poeldinger

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引用次数: 2

Abstract

1.
1. Endorphins, substances isolated from the brain and the pituitary gland, were found to have opiate-like activity via opiate receptors in the brain. Special types of brain endorphins are the enkephalins, pentapeptides which have leucin or methionine as a terminal amino acid. Methionine-enkephalin was recognised as an amino acid sequence from a larger peptide hormone of the anterior pituitary gland, beta-lipotropin.
2.
2. FK 33-824, a synthetically-modified methionine-enkephalin, was the subject of our study. FK 33-824 induced a short-term improvement in the symptoms of 5 of 7 psychotic patients.
3.
3. An EEG investigation of this compound in 20 normal volunteers (compared with placebo in 8 of them) indicated typical changes in electrical activity in the conventional description and spectral-analytic evaluation, viz. an increase in alpha and beta activity with a simultaneous decrease in slow waves. The changes after FK 33-824 differ from placebo changes and from the well known changes seen after opioid alkaloids.

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脑内啡肽/脑啡肽在脑生理病理中的分类(基于脑电图和合成修饰蛋氨酸-脑啡肽的临床研究)

1.1. 内啡肽是一种从大脑和脑下垂体中分离出来的物质，通过大脑中的阿片受体被发现具有类似阿片的活性。特殊类型的脑内啡肽是脑啡肽，这是一种以亮氨酸或蛋氨酸为末端氨基酸的五肽。蛋氨酸-脑啡肽被认为是一个氨基酸序列，来自脑垂体前叶的一个更大的肽激素，β -脂素。本文以合成改性蛋氨酸-脑啡肽fk33 -824为研究对象。fk33 -824对7例精神病患者中5例的症状有短期改善。对20名正常志愿者进行的脑电图调查(其中8名与安慰剂相比)表明，在常规描述和频谱分析评估中，脑电活动发生了典型变化，即α和β活动增加，同时慢波减少。FK 33-824后的变化不同于安慰剂的变化，也不同于众所周知的阿片类生物碱后的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progress in neuro-psychopharmacology

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