{"title":"苯乙醇胺- n -甲基转移酶抑制剂增强左旋多巴诱导的运动活性","authors":"Richard J Katz, Jerry Gelbart, Bernard J Carroll","doi":"10.1016/0364-7722(80)90066-1","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice.</p></span></li><li><span>2.</span><span><p>2. This suggests that an adrenergic system normally inhibits drug induced activation and</p></span></li><li><span>3.</span><span><p>3. Points to an interaction between adrenaline and other catecholamines.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(80)90066-1","citationCount":"1","resultStr":"{\"title\":\"Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase\",\"authors\":\"Richard J Katz, Jerry Gelbart, Bernard J Carroll\",\"doi\":\"10.1016/0364-7722(80)90066-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice.</p></span></li><li><span>2.</span><span><p>2. This suggests that an adrenergic system normally inhibits drug induced activation and</p></span></li><li><span>3.</span><span><p>3. Points to an interaction between adrenaline and other catecholamines.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(80)90066-1\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772280900661\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772280900661","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
1.1. 对肾上腺素合成酶苯乙醇胺- n -甲基转移酶(PNMT)的药理抑制导致3,4，-二羟基苯丙氨酸(L-DOPA)增强小鼠的行为激活。这表明肾上腺素能系统通常抑制药物诱导的激活和3.3。表明肾上腺素和其他儿茶酚胺相互作用。
Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase
1.
1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice.
2.
2. This suggests that an adrenergic system normally inhibits drug induced activation and
3.
3. Points to an interaction between adrenaline and other catecholamines.
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