Prostaglandins, leukotrienes, and medicine最新文献_第10页

Twice monthly bibliography on prostaglandins — late January 每月两次的前列腺素参考书目——1月下旬

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90075-8

引用次数: 0

Effect of indomethacin on the injection-abortion interval of 15(S)15 methyl PGF2α-induced mid-trimester abortions — A randomized study 吲哚美辛对15（S）15甲基PGF2α诱导中期流产的注射流产间隔的影响——一项随机研究

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90068-0

P.G. Adaikan, R.N.U. Prasad, S.R. Kottegoda, S.S. Ratnam

引用次数: 0

Metabolism of leukotriene B4 by polymorphonuclear granulocytes of severely burned patients 严重烧伤患者多形核粒细胞对白三烯B4的代谢

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90072-2

J. Brom , W. König , M. Köller , W. Gross-Weege , G. Erbs , F. Müller

引用次数: 20

Cyclooxygenase and lipoxygenase metabolites during platelet aggregation: Quantitative measurement by negative ion chemical ionization — gas chromatography / mass spectrometry 血小板聚集过程中的环加氧酶和脂加氧酶代谢物:负离子化学电离-气相色谱/质谱法定量测定

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-04-01 DOI: 10.1016/0262-1746(87)90059-X

E. Malle , J. Nimpf , H.J. Leis , H. Wurm , H. Gleispach , G.M. Kostner

引用次数: 21

A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea 一种有效的凝血酶抑制剂刺激了未加工茶叶中血小板血栓素的形成

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-04-01 DOI: 10.1016/0262-1746(87)90055-2

M. Ali, M. Afzal

引用次数: 18

Effect of 16,16-dimethyl prostaglandin E2 on mucus glycoprotein biosynthesis in rat stomach and duodenal glands 16,16-二甲基前列腺素E2对大鼠胃和十二指肠腺粘液糖蛋白生物合成的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-04-01 DOI: 10.1016/0262-1746(87)90054-0

Thea Jentjens, Ger J. Strous

{"title":"Effect of 16,16-dimethyl prostaglandin E2 on mucus glycoprotein biosynthesis in rat stomach and duodenal glands","authors":"Thea Jentjens, Ger J. Strous","doi":"10.1016/0262-1746(87)90054-0","DOIUrl":"10.1016/0262-1746(87)90054-0","url":null,"abstract":"<div>The present study describes the effect of 16,16-dimethyl prostaglandin E2 (16,16-dmPGE2) on mucus glycoprotein biosynthesis in rat stomach and duodenal glands. After in vivo treatment with 16,16-dmPGE2 (10 μg/kg subcutaneously) for 1 h, the incorporation rate of [3H]galactose, [3H]glucosamine, and [3H]serine in the <math><mtext>ex</mtext></math> <math><mtext>vivo</mtext></math> vascularly perfused stomach was determined by light microscopic autoradiography.As was previously found by us for the surface mucous cells in the fundus of 16,16-dmPGE2-treated rats, the incorporation of [3H]galactose and [3H]glucosamine (indicative of mucus glycoprotein synthesis) in the isthmus was increased two- to fourfold. Small if any increases were detected in the mucous cells near the base of the glands of the fundus (neck cells), the mucous cells in the antrum and the mucous cells in the duodenal glands. Total protein synthesis as measured by [3H]serine incorporation was not increased in any of these cells.We conclude that 16,16-dmPGE2 has different effects on mucus glycoprotein biosynthesis in various regions of the rat stomach. Increased biosynthesis in the fundus points to a role for mucus in the prostaglandin-induced protection of the gastric mucosa against injury.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90054-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14596723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Twice monthly bibliography on prostaglandins - biology - late January 每月两次前列腺素参考书目-生物学- 1月底

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-04-01 DOI: 10.1016/0262-1746(87)90062-X

引用次数: 0

Characterization of the vasoconstrictor activity of indomethacin in the mesenteric vascular bed of the cat 猫肠系膜血管床中吲哚美辛血管收缩活性的表征

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-04-01 DOI: 10.1016/0262-1746(87)90061-8

H.L. Lippton, W.M. Armstead, A.L. Hyman, P.J. Kadowitz

{"title":"Characterization of the vasoconstrictor activity of indomethacin in the mesenteric vascular bed of the cat","authors":"H.L. Lippton, W.M. Armstead, A.L. Hyman, P.J. Kadowitz","doi":"10.1016/0262-1746(87)90061-8","DOIUrl":"10.1016/0262-1746(87)90061-8","url":null,"abstract":"<div>The effects of indomethacin on vascular resistance were investigated in the feline mesenteric vascular bed under conditions of constant blood flow. Indomethacin produced mesenteric vasoconstriction that was dose-dependent but was less active than U46619, the thromboxane mimic, angiotensin II, PGF2α and norepinephrine. The vasoconstrictor response to indomethacin was not altered by meclofenamate and phenoxybenzamine. Indomethacin, in a dose that blocked the systemic vasodepressor response to arachidonic acid, did not alter mesenteric vasoconstrictor responses to sympathetic nerve stimulation, norepinephrine, angiotensin II, U46619, and U44609. The present data suggest that in the feline intestinal vascular bed indomethacin has marked vasoconstrictor activity that occurs independent of activation of alpha-adrenoceptors and formation of cyclooxygenase products possessing pressor activity. The present data suggest that cyclooxygenase products do not modulate vasoconstrictor responses as well as the sympathetic nervous system in the intestinal vascular bed of the cat.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90061-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14596726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Arachi doni c acid metabolismin a cloned strain of rat pituitary tumor cells: Correlation between 15 hydroxyeicosatetraenoic acid release and the prolactin secretory process 大鼠垂体肿瘤细胞克隆株花生酸代谢蛋白:15羟二碳四烯酸释放与泌乳素分泌过程的相关性

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-04-01 DOI: 10.1016/0262-1746(87)90057-6

M. Rabier, C. Chavis, A.Crastes de Paulet, M. Damon

{"title":"Arachi doni c acid metabolismin a cloned strain of rat pituitary tumor cells: Correlation between 15 hydroxyeicosatetraenoic acid release and the prolactin secretory process","authors":"M. Rabier, C. Chavis, A.Crastes de Paulet, M. Damon","doi":"10.1016/0262-1746(87)90057-6","DOIUrl":"10.1016/0262-1746(87)90057-6","url":null,"abstract":"<div>We investigated the involvement of arachidonic acid metabolites in basal and thyrotropin releasing hormone (TRH) stimulated prolactin release by GH3 cells, a cloned strain of rat pituitary tumor cells.GH3 cells spontaneously released 9 and 154 HETEs and the 15 HETE release was greater than that of 9 HETE. When the cells were challenged by 10−5M AA, they were able to produce 5, 9, 12 and 15 HETEs. 10−6M TRH only stimulated the release of the two metabolites synthesized by the basal cells (15 and 9 HETEs). This release depended on the length of stimulation by TRH. When both AA and TRH were added, there was an increase in 15 and 9 HETE production. In all cases, more 15 HETE was released than other metabolites.In dose-response studies using TRH concentrations of 10−6M to 10−12M, the highest level of 9 HETE release was obtained at 10−11M TRH and the highest release of 15 HETE was at 10−9 M TRH. PRL secretion by GH3 cells challenged by TRH showed the same pattern as 15 HETE release, and the correlation between PRL and 15 HETE was significant (p <0.001).These data indicate that 15 HETE is the lipoxygenase metabolite released in the largest amounts by GH3 cells and suggest some physiological interaction between 15 HETE and TRH in the control of PRL secretion.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90057-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14240532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Microsomal arachidonate bioconversion in rat small intestine during maturation 成熟大鼠小肠微粒体花生四烯酸生物转化

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-04-01 DOI: 10.1016/0262-1746(87)90060-6

Chi-Ying Wu-Wang, Josef Neu

{"title":"Microsomal arachidonate bioconversion in rat small intestine during maturation","authors":"Chi-Ying Wu-Wang, Josef Neu","doi":"10.1016/0262-1746(87)90060-6","DOIUrl":"10.1016/0262-1746(87)90060-6","url":null,"abstract":"<div>This study was designed to compare prostaglandin (PG)-synthesizing activity in rat small intestinal microsomes in the lst, 3rd, and 6th weeks of life and at maturity (>100 days). When an incubation system was used containing 2 mg microsomal protein, 0.5 mM (−)-epinephrine and 1 mM reduced glutathione, the highest PG-synthesizing activity was achieved by incubating 0.157 mM 1-14C-arachidonate (specific activity 2.6 × 106 dpm/μmol) at 37°C for 5 min. The labeled metabolites were extracted and then separated with high performance liquid chromatography. The four PGs analyzed were 6 keto-prostaglandin F1α (6-keto-PGF1α), thromboxane B2, prostaglandin F2α and prostaglandin E2. Enzymatic activity for the synthesis of 6-keto-PGF1α was much higher than that for the other PGs. A significant difference was observed for the bioconversion from arachidonate to 6-keto-PGF1α and total PGs among the four age groups of rats. The postweanling groups (week 6 and adult) showed significantly higher enzymatic activities for the syntheses of 6-keto-PGF1α and total PGs than did the preweanling groups (weeks 1 and 3).</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90060-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14240534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3