Effect of indomethacin on the injection-abortion interval of 15(S)15 methyl PGF2α-induced mid-trimester abortions — A randomized study

P.G. Adaikan, R.N.U. Prasad, S.R. Kottegoda, S.S. Ratnam
{"title":"Effect of indomethacin on the injection-abortion interval of 15(S)15 methyl PGF2α-induced mid-trimester abortions — A randomized study","authors":"P.G. Adaikan,&nbsp;R.N.U. Prasad,&nbsp;S.R. Kottegoda,&nbsp;S.S. Ratnam","doi":"10.1016/0262-1746(87)90068-0","DOIUrl":null,"url":null,"abstract":"<div><p>There have been conflicting reports on the effect of non-steroidal anti-inflammatory drugs on the abortifacient effect of prostaglandins. The efficacy of intra-amniotic 1.5 mg 15(S)15 methyl PGF<sub>2α</sub> (15 me PGF<sub>2α</sub>) in terminating mid-trimester pregnancy in 10 subjects has been compared with the effect of the same medication given to 10 others who had had indomethacin 25 mg and 50 mg orally three and one hour before the PG administration. In the subjects who had the PG analogue only the injection-abortion interval was,17.0 hours. This was significantly shorter (P &lt; 0.01) than in those who had also received indomethacin (25.4 hours).</p></div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90068-0","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0262174687900680","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

There have been conflicting reports on the effect of non-steroidal anti-inflammatory drugs on the abortifacient effect of prostaglandins. The efficacy of intra-amniotic 1.5 mg 15(S)15 methyl PGF (15 me PGF) in terminating mid-trimester pregnancy in 10 subjects has been compared with the effect of the same medication given to 10 others who had had indomethacin 25 mg and 50 mg orally three and one hour before the PG administration. In the subjects who had the PG analogue only the injection-abortion interval was,17.0 hours. This was significantly shorter (P < 0.01) than in those who had also received indomethacin (25.4 hours).

吲哚美辛对15(S)15甲基PGF2α诱导中期流产的注射流产间隔的影响——一项随机研究
关于非甾体抗炎药对前列腺素流产作用的影响,已有相互矛盾的报道。将10名受试者羊膜内1.5 mg 15(S)15甲基PGF2α(15 me PGF2α)终止妊娠中期的疗效与其他10名在PG给药前3小时和1小时口服吲哚美辛25 mg和50 mg的受试者相同药物的疗效进行了比较。在使用PG类似物的受试者中,只有注射流产间隔为17.0小时。这比同样接受吲哚美辛的患者(25.4小时)明显更短(P<0.01)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信