{"title":"A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea","authors":"M. Ali, M. Afzal","doi":"10.1016/0262-1746(87)90055-2","DOIUrl":null,"url":null,"abstract":"<div><p>A ninhydrin positive compound (L2) from commercially available unfermented dry green tea (Thea sinesis) leaves is found to be a potent inhibitor of thrombin-stimulated thromboxane formation in rabbit whole blood. Its potency is compared with caffeine, a member of the methylxanthines family. Both caffeine and L2 inhibit thromboxane formation in whole blood in a dose dependent fashion. L2 inhibition when calculated as I<sub>50</sub>by a dose response curve is found to be more than 40 fold stronger tan caffeine as an inhibitor of thromboxane formation.</p><p>A concentration of L2 as low as 50 μM, supresses thromboxane formation (by 84%) whereas a concentration of 5000 u M is necessary to achieve the same inhibiton with caffeine. The potent inhibitory effect of L2 on the TXB<sub>2</sub> production maybe of benefit in the treatment of vascular disease.</p></div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90055-2","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0262174687900552","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 18
Abstract
A ninhydrin positive compound (L2) from commercially available unfermented dry green tea (Thea sinesis) leaves is found to be a potent inhibitor of thrombin-stimulated thromboxane formation in rabbit whole blood. Its potency is compared with caffeine, a member of the methylxanthines family. Both caffeine and L2 inhibit thromboxane formation in whole blood in a dose dependent fashion. L2 inhibition when calculated as I50by a dose response curve is found to be more than 40 fold stronger tan caffeine as an inhibitor of thromboxane formation.
A concentration of L2 as low as 50 μM, supresses thromboxane formation (by 84%) whereas a concentration of 5000 u M is necessary to achieve the same inhibiton with caffeine. The potent inhibitory effect of L2 on the TXB2 production maybe of benefit in the treatment of vascular disease.
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