{"title":"吲哚美辛对15（S）15甲基PGF2α诱导中期流产的注射流产间隔的影响——一项随机研究","authors":"P.G. Adaikan, R.N.U. Prasad, S.R. Kottegoda, S.S. Ratnam","doi":"10.1016/0262-1746(87)90068-0","DOIUrl":null,"url":null,"abstract":"<div><p>There have been conflicting reports on the effect of non-steroidal anti-inflammatory drugs on the abortifacient effect of prostaglandins. The efficacy of intra-amniotic 1.5 mg 15(S)15 methyl PGF<sub>2α</sub> (15 me PGF<sub>2α</sub>) in terminating mid-trimester pregnancy in 10 subjects has been compared with the effect of the same medication given to 10 others who had had indomethacin 25 mg and 50 mg orally three and one hour before the PG administration. In the subjects who had the PG analogue only the injection-abortion interval was,17.0 hours. This was significantly shorter (P < 0.01) than in those who had also received indomethacin (25.4 hours).</p></div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90068-0","citationCount":"0","resultStr":"{\"title\":\"Effect of indomethacin on the injection-abortion interval of 15(S)15 methyl PGF2α-induced mid-trimester abortions — A randomized study\",\"authors\":\"P.G. Adaikan, R.N.U. Prasad, S.R. Kottegoda, S.S. Ratnam\",\"doi\":\"10.1016/0262-1746(87)90068-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>There have been conflicting reports on the effect of non-steroidal anti-inflammatory drugs on the abortifacient effect of prostaglandins. The efficacy of intra-amniotic 1.5 mg 15(S)15 methyl PGF<sub>2α</sub> (15 me PGF<sub>2α</sub>) in terminating mid-trimester pregnancy in 10 subjects has been compared with the effect of the same medication given to 10 others who had had indomethacin 25 mg and 50 mg orally three and one hour before the PG administration. In the subjects who had the PG analogue only the injection-abortion interval was,17.0 hours. This was significantly shorter (P < 0.01) than in those who had also received indomethacin (25.4 hours).</p></div>\",\"PeriodicalId\":20720,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0262-1746(87)90068-0\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0262174687900680\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0262174687900680","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
关于非甾体抗炎药对前列腺素流产作用的影响，已有相互矛盾的报道。将10名受试者羊膜内1.5 mg 15（S）15甲基PGF2α（15 me PGF2α）终止妊娠中期的疗效与其他10名在PG给药前3小时和1小时口服吲哚美辛25 mg和50 mg的受试者相同药物的疗效进行了比较。在使用PG类似物的受试者中，只有注射流产间隔为17.0小时。这比同样接受吲哚美辛的患者（25.4小时）明显更短（P＜0.01）。
Effect of indomethacin on the injection-abortion interval of 15(S)15 methyl PGF2α-induced mid-trimester abortions — A randomized study
There have been conflicting reports on the effect of non-steroidal anti-inflammatory drugs on the abortifacient effect of prostaglandins. The efficacy of intra-amniotic 1.5 mg 15(S)15 methyl PGF2α (15 me PGF2α) in terminating mid-trimester pregnancy in 10 subjects has been compared with the effect of the same medication given to 10 others who had had indomethacin 25 mg and 50 mg orally three and one hour before the PG administration. In the subjects who had the PG analogue only the injection-abortion interval was,17.0 hours. This was significantly shorter (P < 0.01) than in those who had also received indomethacin (25.4 hours).
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