Prostaglandins, leukotrienes, and medicine最新文献_第9页

Arachidonic acid metabolism by lipoxygenase pathways in uterine and intrauterine tissues of pregnant sheep 孕羊子宫和宫内组织中脂氧合酶途径对花生四烯酸代谢的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90071-0

M.D. Mitchell, C.F. Grzyboski, C.M. Dedhar, J.A. Hunter

引用次数: 9

Alteration of mercuric chloride-induced autoimmune glomerulonephritis in Brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor 鲱鱼油、月见草油和选择性txa合成酶抑制剂OKY-046对氯化汞诱导的褐挪威大鼠自身免疫性肾小球肾炎的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90066-7

Nikolaos Papanikolaou

{"title":"Alteration of mercuric chloride-induced autoimmune glomerulonephritis in Brown-Norway rats by herring oil, evening primrose oil and OKY-046 a selective TXA-synthetase inhibitor","authors":"Nikolaos Papanikolaou","doi":"10.1016/0262-1746(87)90066-7","DOIUrl":"10.1016/0262-1746(87)90066-7","url":null,"abstract":"<div>Repeated subcutaneous (SC) injections of mercuric chloride (MC) in Brown Norway (BN) rats induce an autoimmune glomerulonephritis (GN) due to antiglomerular basement membrane (BM) antibody deposition in the glomeruli. The aim of this study was to investigate the effects on MC-induced autoimmune GN of a) OKY-046,a selective TXA-synthetase inhibitor b) herring oil (HO), which is rich in eicosapentaenoic acid (EPA) (5.6%) precursor of the three series of prostaglandins (PGs) and of (inactive) thromboxane (TXA3),and c) evening primrose oil (EPO), which is rich in linoleic acid (LA) (72%) and gamma-linolenic acid (GLNA) (9%), precursors of the one series of PGs, mainly PGE1,and of (inactive) TXA1. The administration of OKY-046 significantly inhibited proteinuria, partially prevented fibrin thrombi (FT) formation in the glomeruli, decreased urinary TXB, enhanced 6ketoPGF excretion and, increased survival rate of the animals from 60% (group receiving only MC) to 86%. However, OKY-046 did not prevent body weight (BW) loss or the development and deposition of IgG in the glomeruli. Increased intake of HO (80 days prior and throughout the experiment) and avoidance of arachidonic acid (AA) intake prodused an effect comparable to that of OKY-046 in the rats. Furthermore, HO significantly inhibited the deposition of IgG in the glomeruli, increased the survival rate of the animals to 100% and further enhanced the increased urinary PGE excretion indused by MC. However, HO did not prevent BW loss in the animals. Increased intake of EPO and avoidance of AA intake prodused an effect comparable to that of HO. Additionally, EPO completely prevented BW loss induced by MC in these animals. These findings suggest that the metabolites of AA, EPA and GLNA play an important role either in the development or in the modulation of this model of MC indused GN.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90066-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

A comparison of the long-term effects of n-3 and n-6 polyunsaturated fatty acid dietary supplements and the action of indomethacin upon the mechanical performance and susceptibility of the rat heart to dysrhythmia n-3和n-6多不饱和脂肪酸膳食补充剂与吲哚美辛对大鼠心脏力学性能和心律失常易感性的长期影响比较

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90070-9

Peter L. McLennan, Mahinda Y. Abeywardena, John S. Charnock

{"title":"A comparison of the long-term effects of n-3 and n-6 polyunsaturated fatty acid dietary supplements and the action of indomethacin upon the mechanical performance and susceptibility of the rat heart to dysrhythmia","authors":"Peter L. McLennan, Mahinda Y. Abeywardena, John S. Charnock","doi":"10.1016/0262-1746(87)90070-9","DOIUrl":"10.1016/0262-1746(87)90070-9","url":null,"abstract":"<div>The effect of different dietary lipid supplements on the contractility and susceptibility to isoprenaline-induced dysrhythmia in rat papillary muscles was examined after one year's prefeeding of either a low fat (4%, w/w) standard laboratory diet or those supplemented with additional (12%, w/w) saturated animal fatty acids (sheep perirenal fat; SF) or n-6 or n-3 polyunsaturated fatty acids (PUFA's) from sunflower seed oil (SSO) or tuna fish oil (FO) respectively.The positive inotropic response to Ca++ and the incidence of spontaneous tachyarrhythmias under isoprenaline load were significantly less in the muscles from SSO and FO fed animals compared to either mature REF or SF fed groups. Indomethacin reduced the response to Ca++ in both the REF and SF groups, but was without effect upon the muscles from SSO and FO groups. In addition this drug also significantly reduced isoprenaline-induced dysrhythmia in the muscles from REF and SF fed animals, but had no effect upon those from SSO and FO groups which were already less suceptible to dysrhythmia than the muscles from animals in the former two groups.These results indicate that “<math><mtext>long-term</mtext></math>” feeding of either n-3 or n-6 PUFA's can significantly reduce arrhythmogenesis in this species <math><mtext>in vitro</mtext></math> by mechanisms that may involve eicosanoid metabolism.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90070-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Altered arachidonic acid metabolism in granulocytes of polytraumatized patients 多发性创伤患者粒细胞花生四烯酸代谢的改变

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90073-4

W. Schönfeld , J. Knöller , J. Brom , M. Raulf , M. Köller , T. Joka , W. König

引用次数: 6

Effect of dexamethasone or fetal lung 15-hydroxy-prostaglandin dehydrogenase: Possible mechanism for the prevention of patent ductus arteriosus by maternal dexamethasone therapy 地塞米松或胎儿肺15-羟基前列腺素脱氢酶的作用:母体地塞米松治疗预防动脉导管未闭的可能机制

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90074-6

Michael Y. Tsai , David M. Brown

{"title":"Effect of dexamethasone or fetal lung 15-hydroxy-prostaglandin dehydrogenase: Possible mechanism for the prevention of patent ductus arteriosus by maternal dexamethasone therapy","authors":"Michael Y. Tsai , David M. Brown","doi":"10.1016/0262-1746(87)90074-6","DOIUrl":"10.1016/0262-1746(87)90074-6","url":null,"abstract":"<div>Prenatal maternal glucocorticoid treatment has been reported to reduce the incidence of patent ductus arteriosus in prematurely born infants. Patency of the ductus arteriosus is thought to be maintained primarily by the vasodilatory effect of PGE, both in utero and in prematurely born infants, and lung is a major source of PGE, in fetuses and neonates. 15-Hydroxy-prostaglandin dehydrogenase (15-PGDH) catalyzes the initial reaction in converting biologically active PGE, to its inactive analogue, 15-keto-PGE2. In the present study, effect of prenatal dexamethasone treatment on the activity of fetal rat lung 15-PGDH was studied at 20, 21 and 22 days of gestation.Activity of fetal lung 15-PGDH more than doubled from 20 to 22 days of gestation. Dexamethasone treatment at 0.4 mg/kg and 0.8 mg/kg significantly increased the activity of 15-PGDH in both 20- and 21-day fetuses but had no effect on 2 22-day fetuses. We speculate that the clinical observation that prenatal glucocorticoid treatment reduces the incidence of patent ductus arteriosus in premature infants say in part be due to the stimulatory effect of glucocorticoid-on the activity of 15-PGDH in fetal and neonatal lung and possibly other organs.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90074-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Influence of leukotriene C4 and D4 on in vitro and in vivo motility of the oviduct in the domestic hen 白三烯C4和D4对国内母鸡输卵管内外运动的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90065-5

E. Wechsung, A. Houvenaghel

{"title":"Influence of leukotriene C4 and D4 on in vitro and in vivo motility of the oviduct in the domestic hen","authors":"E. Wechsung, A. Houvenaghel","doi":"10.1016/0262-1746(87)90065-5","DOIUrl":"10.1016/0262-1746(87)90065-5","url":null,"abstract":"<div>In in vitro experiments on the oviduct of the domestic hen LTC4 and LTD4, in a dose range from 1.10−10 to 1.10−6 M/1, significantly stimulated the motility of all oviductal parts. With the lower doses, however, vaginal motility was suppressed (p < 0.05). In vivo experiments on the anesthetized bird i.v. bolus injections of LTC4, 1, 3, and 10 μg/hem induced transient intrauterine pressure rises of up to 7±1 mm H2O. In the conscious animal i.v. bolus injections of LTD4, 10 μg/hem, resulted in a shortlasting increase in uterine myoelectrical activity (p <0.001), whereas vaginal and duodenal myoelectrical activities were inhibited. Intrauterine injections of 10 μg LTD4, however, had neither a significant effect on myoelectrical activity of the empty uterus nor induced premature oviposition. These experiments demonstrate for the first time that LTs exert pronounced effects on in vitro motility of the hens oviduct. The in vivo responses however, are rather unimportant regarding as well strength as duration.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90065-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mechanism of complement-mediated thromboxane production by the perfused rabbit liver: Lack of effect of dantrolene sodium 补体介导的灌注兔肝脏产生血栓素的机制:丹曲林钠缺乏作用

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90063-1

John T. Flynn

{"title":"Mechanism of complement-mediated thromboxane production by the perfused rabbit liver: Lack of effect of dantrolene sodium","authors":"John T. Flynn","doi":"10.1016/0262-1746(87)90063-1","DOIUrl":"10.1016/0262-1746(87)90063-1","url":null,"abstract":"<div>Activated components of the complement system have been shown to stimulate the arachidonic acid cascade. We have reported that hepatic thromboxane production in response to plasma activated with zymosan is self-limiting, not affected by nifedipine, but inhibited by mepacrine, a phospholipase inhibitor. To further study this relationship, we have tested the effects of dantrolene sodium, an agent reported to immobilize intracellular calcium. Control group livers were perfused with Krebs-Henseleit bicarbonate buffer at a rate of 120 ml/min in a nonrecirculating perfusion system and administered 1 ml/min of normal rabbit plasma for 10 minutes. This group of livers demonstrated stable wet weight, perfusion pressure, and rates of release of lactic dehydrogenase, thromboxane B2, and prostacyclin over a 150 minute experimental period. In contrast, the administration of 1 ml/min of zymosan-activated plasma resulted in significant increases in the rate of thromboxane B2 release at 1, 3, and 5 minutes after the start of the infusion. The rate of thromboxane production then returned to baseline values. Neither prostacyclin nor lactic dehydrogenase release changed significantly after ZAP. A similar change in thromboxane production following ZAP administration was seen in livers being continually perfused with 10 μM dantrolene sodium. Perfusion pressure was significantly elevated in this group during the ZAP infusion period. These results confirm complement-mediated thromboxane production in the isolated rabbit liver model but do not describe a definitive role of dantrolene-sensitive intracellular calcium release in the mechanism of ZAP-mediated thromboxane production.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90063-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Formation of leukotriene B4, 20-hydroxy leukotriene B4 and other arachidonic acid metabolites by macrophages during peritonitis in patients with continuous ambulatory peritoneal dialysis 持续动态腹膜透析患者腹膜炎期间巨噬细胞形成白三烯B4、20-羟基白三烯B4及其他花生四烯酸代谢物的研究

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90067-9

F.J. Zijlstra , A.M.W.C. van den Broek , J.E. Vincent , P.P.H.M. Diderich , A.M.C. op de Hoek-Fez , M. Claeys

{"title":"Formation of leukotriene B4, 20-hydroxy leukotriene B4 and other arachidonic acid metabolites by macrophages during peritonitis in patients with continuous ambulatory peritoneal dialysis","authors":"F.J. Zijlstra , A.M.W.C. van den Broek , J.E. Vincent , P.P.H.M. Diderich , A.M.C. op de Hoek-Fez , M. Claeys","doi":"10.1016/0262-1746(87)90067-9","DOIUrl":"10.1016/0262-1746(87)90067-9","url":null,"abstract":"<div>Macrophages, isolated from dialysis fluid of three patients with continuous ambulatory peritoneal dialysis (CAPD) at different times during peritonitis were labelled with 14C-arachidonic acid and stimulated with the calcium ionophore A23187. The main metabolites formed by 5-lipoxygenase activity were leukotriene B4 (LTB4) and 5-hydroxy-6,9,11,14-eicosatetraenoic acid (5-HETE). Smaller amounts of cyclooxygenase metabolites were present and also a major compound with an elution time between 6-keto-prostaglandin F1α (6-keto-PGF1α and thromboxane B2 (TxB2). This substance was isolated, analysed by GC-MS and identified as 20-hydroxy-leukotriene B4 (20-OH-LTB4). This indicates that human peritoneal macrophages obtained from CAPD not only produce leukotrienes and prostaglandins, but also the ω-hydroxylase product of LTB4, which has been demonstrated to be present in polymorphonuclear leucocytes. The activity of this enzyme was not correlated with the severity of the peritonitis.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90067-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14171887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Dissociation and diurnal variation of prostaglandin E2 6-keto-prostaglandin-F1-alpha, and thromboxane B2 excretion in healthy females 健康女性前列腺素E2、6-酮-前列腺素f1 - α和血栓素B2的解离和日变化

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90064-3

P.D. Rubin, V.S. Murthy, R.G. Hansen, C. Pietrowiak

{"title":"Dissociation and diurnal variation of prostaglandin E2 6-keto-prostaglandin-F1-alpha, and thromboxane B2 excretion in healthy females","authors":"P.D. Rubin, V.S. Murthy, R.G. Hansen, C. Pietrowiak","doi":"10.1016/0262-1746(87)90064-3","DOIUrl":"10.1016/0262-1746(87)90064-3","url":null,"abstract":"<div>The existence of diurnal variation in renal function is well described. Prostaglandins are intimately involved with renal physiology, yet a diurnal variation in their excretion is not well documented. We collected 12 consecutive 2 hour urine specimens from 10 young healthy females and measured prostaglandin E2 [PGE2], thromboxane B2 [TXB2], and 6-keto-prostaglandin-F1-alpha by radioimmunoassay for each specimen. We also measured urine volume, urine sodium, and urine creatinine levels. Regression analysis was used to determine the best sine curve for time versus each set of mean values. Only the urinary excretion of PGE2 and TXBZ, as well as water were found to significantly fit the generated sine curves. The curves for PGE2 and TXB2 showed a temporal dissociation in their peak and trough values. The excretion of PGE2 between 0800 hours and 2000 hours was significantly higher than during the hours of 2000 and 0800. The opposite was true for the TXB2 excretion. This data suggests that these two prostaglandins and water are excreted in a sine wave pattern. It also suggests that the excretion of PGE2 and TXB2 may respond to different time associated stimuli. We also showed a significant correlation between PGE2 excretion and both the excretion of water and sodium.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90064-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14598969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of multiple low doses of flunixin meglumine on repeated endotoxin challenge in the horse 多次低剂量氟尼辛大胺对马反复内毒素攻击的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-05-01 DOI: 10.1016/0262-1746(87)90069-2

Susan D. Semrad, James N. Moore

{"title":"Effects of multiple low doses of flunixin meglumine on repeated endotoxin challenge in the horse","authors":"Susan D. Semrad, James N. Moore","doi":"10.1016/0262-1746(87)90069-2","DOIUrl":"10.1016/0262-1746(87)90069-2","url":null,"abstract":"<div>Previous work has shown repeated low doses of flunixin meglumine (FM) inhibit thromboxane production in normal horses. Enhanced concentrations of thromboxane in serum occurred after the drug therapy was discontinued. Our study was performed to evaluate the effects of low doses of FM in horses repeatedly challenged with endotoxin. Group I horses received E. coli endotoxin (0.1 μ g/kg IV) at 0 and 90 h. Group II horses received endotoxin and were also treated with FM (0.25 mg/kg IV) at 2, 10, 18, 26, 34, and 42 h after the initial administration of endotoxin. Clinical signs of endotoxemia were observed in all horses, but FM treated horses recovered more rapidly. The leukopenic response after endotoxin was attenuated in Group II following the second dose.Serum thromboxane (TxB2) decreased after the initial administration of endotoxin and remained below baseline values throughout the study. Serum TxB2 concentrations were not different between the groups. Plasma TxB2 and 6-keto-PGF2α concentrations were increased after the initial endotoxin injection. In Group II, plasma TxB2 levels declined rapidly after FM administration and remained low. After the second dose of endotoxin, Group I horses had a mild rise and decline in TxB2 and 6-keto-PGF2α concentrations, respectively. Thromboxane B2 levels in Group II changed little after the second dose of endotoxin, but a dramatic increase in 6-keto-PGF2α concentrations occurred. These results suggest that multiple low doses of FM to horses with endotoxemia cause a selective and sustained suppression of TxB2 production and an enhancement of 6-keto-PGF2α.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90069-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14430768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34