白三烯C4和D4对国内母鸡输卵管内外运动的影响

E. Wechsung, A. Houvenaghel
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引用次数: 4

摘要

在国产母鸡的试管实验中,LTC4和LTD4在1.10−10 ~ 1.10−6 M/1的剂量范围内显著刺激了输卵管各部位的运动。然而,在较低剂量下,阴道运动受到抑制(p <0.05)。在体内实验中,麻醉鸟类静脉注射LTC4、1、3和10 μg/hem可引起短暂的宫内压升高,最高可达7±1 mm H2O。在清醒动物中静脉注射LTD4, 10 μg/hem,导致子宫肌电活动短暂增加(p <0.001),而阴道和十二指肠肌电活动受到抑制。然而,子宫内注射10 μg LTD4对空子宫肌电活动没有显著影响,也没有诱导早孕。这些实验首次证明了LTs对母鸡输卵管的体外运动有显著影响。然而,就强度和持续时间而言,体内反应相当不重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of leukotriene C4 and D4 on in vitro and in vivo motility of the oviduct in the domestic hen

In in vitro experiments on the oviduct of the domestic hen LTC4 and LTD4, in a dose range from 1.10−10 to 1.10−6 M/1, significantly stimulated the motility of all oviductal parts. With the lower doses, however, vaginal motility was suppressed (p < 0.05). In vivo experiments on the anesthetized bird i.v. bolus injections of LTC4, 1, 3, and 10 μg/hem induced transient intrauterine pressure rises of up to 7±1 mm H2O. In the conscious animal i.v. bolus injections of LTD4, 10 μg/hem, resulted in a shortlasting increase in uterine myoelectrical activity (p <0.001), whereas vaginal and duodenal myoelectrical activities were inhibited. Intrauterine injections of 10 μg LTD4, however, had neither a significant effect on myoelectrical activity of the empty uterus nor induced premature oviposition. These experiments demonstrate for the first time that LTs exert pronounced effects on in vitro motility of the hens oviduct. The in vivo responses however, are rather unimportant regarding as well strength as duration.

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