Prostaglandins, leukotrienes, and medicine最新文献_第8页

Twice monthly bibliography on prostaglandins — Early March prepared by Sheffield University, biomedical information service Sheffield S10 2TN 3月初，谢菲尔德大学生物医学信息服务谢菲尔德s102tn编写了每月两次的前列腺素参考书目

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90052-7

引用次数: 0

Growth of an implanted fibrosarcoma in rats is associated with high levels of plasma prostaglandin-E2 and thromboxane-B2 大鼠植入式纤维肉瘤的生长与血浆前列腺素- e2和凝血素- b2的高水平有关

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90044-8

W.J. Kort , I.M. Weijma , A.M. Bijma , W.P. van Schalkwijk , F.J. Zijlstra , D.L. Westbroek

引用次数: 11

The effect of diphenylamine derivatives on arachidonic acid metabolism in rat peritoneal macrophages 二苯胺衍生物对大鼠腹腔巨噬细胞花生四烯酸代谢的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90043-6

Kazuo Ohuchi , Masako Watanabe , Yukari Fukui , Noriyasu Hirasawa , Tsuneo Ozeki , Susumu Tsurufuji

{"title":"The effect of diphenylamine derivatives on arachidonic acid metabolism in rat peritoneal macrophages","authors":"Kazuo Ohuchi , Masako Watanabe , Yukari Fukui , Noriyasu Hirasawa , Tsuneo Ozeki , Susumu Tsurufuji","doi":"10.1016/0262-1746(87)90043-6","DOIUrl":"10.1016/0262-1746(87)90043-6","url":null,"abstract":"<div>The effect of diphenylamine derivatives such as diclofenac sodium, mefenamic acid and lobenzarit disodium on arachidonic acid metabolism in rat peritoneal macrophages was examined. Lobenzarit disodium has no effect on prostaglandin E2 production as measured by radioimmunoassay although two other diphenylamine derivatives have a potent inhibito activity. Three diphenylamine derivatives have no effect on Ca2+ ionophore-stimulated release of radioactivity from (3H)arachidonic acid-labeled macrophages. HPLC analysis revealed that lobenzarit disodium had no effect on the synthesis of lipoxygenase products as observed in diclofenac sodium and mefenamic acid. It is concluded that lobenzarit disodium, although its fundamental chemical structure resembles diclofenac sodium and mefenamic acid, has no inhibitory activity on arachidonic acid metabolism, suggesting that immunomodulatory activities of lobenzarit disodium are manifested without interfering with arachidonic acid metabolism.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90043-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14244215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Antiatherogenic action of eicosapentaenoic acid (EPA) in multiple oral doses 多次口服二十碳五烯酸(EPA)的抗动脉粥样硬化作用

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90045-X

K. Yamaguchi , M. Mizota , H. Hashizume , A. Kumagai

{"title":"Antiatherogenic action of eicosapentaenoic acid (EPA) in multiple oral doses","authors":"K. Yamaguchi , M. Mizota , H. Hashizume , A. Kumagai","doi":"10.1016/0262-1746(87)90045-X","DOIUrl":"10.1016/0262-1746(87)90045-X","url":null,"abstract":"<div>The possible antiatherogenic action of eicosapentaenoic acid (EPA) was pharmacologically investigated using purified and ethylesterified fish oil containing 75% EPA (EPA-E) in multiple oral doses in rats and rabbits.EPA-E showed dose-dependent prevention of thrombus formation in a vascular shunt or sudden death caused by arachidonic acid injection in rats. EPA-E in daily doses ranging from 3 to 30 mg/kg slightly altered platelet aggregability and prostacyclin-like activity generated from arterial ring preparations of rats, but these alterations were not statistically significant. Further, EPA-E showed no effect on blood viscosity of rats. In cholesterol-fed rabbits, EPA-E in daily doses of 10 and 30 mg/kg moderately lowered the levels of plasma cholesterol, β-lipoprotein, triglyceride and phospholipid, but these changes showed neither dose-dependency nor time-dependency. In this experiment, EPA-E moderately altered atherogenic plaque formation and platelet aggregability, but these alterations were not statistically significant. EPA-E showed no effect on prostacyclin-like activity generated from arterial ring preparations and blood viscosity of cholesterol-fed rabbits. It is, therefore, proposed that the antithrombotic action of EPA-E may be partially related to its effects on platelet aggregability and prostacyclin generation, but the major mechanism remains unclear.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90045-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14171891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Development of a system for evaluating 5-lipoxygenase inhibitors using human whole blood 用人全血评价5-脂氧合酶抑制剂系统的建立

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90049-7

Francis J. Sweeney, James D. Eskra, Thomas J. Carty

{"title":"Development of a system for evaluating 5-lipoxygenase inhibitors using human whole blood","authors":"Francis J. Sweeney, James D. Eskra, Thomas J. Carty","doi":"10.1016/0262-1746(87)90049-7","DOIUrl":"10.1016/0262-1746(87)90049-7","url":null,"abstract":"<div>A reliable system for evaluating 5-lipoxygenase (5-LO) pathway inhibitors employing human whole blood stimulated by the calcium ionophore, A-23187, and yeast cell walls (YCW) is described.In developing this system, we have shown that leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) can be recovered quantitatively from whole blood, and can be measured with accuracy and a precision (standard deviation) of ± 129% Apparent differences in LTB4/5-HETE levels between donors can be minimized by normalizing the LTB4/5-HETE production to neutrophil number. Variability in LTB4/5-HETE production among different donors was reduced by increasing the ionophore concentration. The kinetics of ionophore stimulated product production display a 1–4 min lag which is dependent on ionophore concentration. The lag is removed by pretreatment of blood with 5 μg/ml cytochalasin B. Likewise, the kinetics of product formation after stimulation with yeast cell walls demonstrated a lag period, which could be shortened by prior opsonization of the YCW. The amount of LTB4 metabolism to 20-OH-LTB4 and 20-COOH-LTB4 in this system is approximately 20%. Phenidone, nordihydroguaiaref acid, and nafazatrom, known inhibitors of the 5-LO pathway, display half-maximal inhibition points of 0.4, 1.5, and 9 μg/ml, respectively. In summary, we believe that this assay offers a guide for predicting systemic levels of drug needed to be achieved for effective inhibition of cellular LTB4/5-HETE synthesis/release in humans.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90049-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14171892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Prostaglandin associated mortality following intravenous injection of catfish epidermal secretions in rabbits 兔静脉注射鲶鱼表皮分泌物后前列腺素相关死亡率

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90050-3

Jassim M. Al-Hassan , Muslim Ali , Martha Thomson , Tasneem Fatima , Clark J. Gubler , Richard S. Criddle

引用次数: 14

Susceptibility of diabetic rat aorta to self-deactivation during prostacyclin synthesis 糖尿病大鼠主动脉在前列环素合成过程中自我失活的易感性

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90042-4

K. Kawamura , T. Dohi , T. Ogawa , M. Shirakawa , H. Okamoto , A. Tsujimoto

{"title":"Susceptibility of diabetic rat aorta to self-deactivation during prostacyclin synthesis","authors":"K. Kawamura , T. Dohi , T. Ogawa , M. Shirakawa , H. Okamoto , A. Tsujimoto","doi":"10.1016/0262-1746(87)90042-4","DOIUrl":"10.1016/0262-1746(87)90042-4","url":null,"abstract":"<div>The ability of aortic rings to produce PGI2 markedly decreased in streptozotocin-induced diabetic rats when compared with age-matched controls. Arachidonic acid dose-dependently stimulated the production of PGI2 both in normal and diabetic rat aorta during 5 min incubation. The deficiency in PGI2 production in diabetic rat aorta was temporarily corrected by the addition of 5–20 μM of arachidonic acid. However, when aortic rings were incubated over a period of 10 min in the presence of arachidonic acid, the ability of PGI production in diabetic rats markedly decreased. Repeated exposures A aortic rings to arachidonic acid also markedly reduced PGI2 production in diabetic rats. PGI2 production in diabetic rat aorta was inactivated more readily than in normal rat aorta by pre-incubation with t-butyl hydroperoxide. Phenol had a protective effect on incubation-induced inactivation of PGI2 generating activity in diabetic rat aorta. Serum markedly stimulate PGI2 synthesis in normal and diabetic rat aorta. The serum activity in diabetic rats was less potent than in normal rats. Melittin and dipyridamole were effective in stimulating PGI2 release from diabetic rat aorta.These results suggest that enzymes in the aorta involved in PGI2 synthesis from released arachidonic acid are susceptible to self inactivation in diabetic rats during the metabolism of arachidonic acid. This may contribute to the defect of PGI2 synthesis in diabetic rat aorta in addition to the decreased availability of the substrate.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90042-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14244212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

An in vitro method for assay of hormone or agonist-stimulated lipase activity 一种体外测定激素或激动剂刺激的脂肪酶活性的方法

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90046-1

Donald J. Fretland, Peter S. Cammarata

引用次数: 0

The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites 血小板活化因子(PAF)对实验性心律失常的影响及花生四烯酸代谢物的抑制作用

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90051-5

A. Riedel, H.-J. Mest

引用次数: 22

Inhibition of thromboxane A2 synthesis in rats treated with phenobarbital 苯巴比妥对大鼠血栓素A2合成的抑制作用

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90048-5

Thomas I. Pynadath, Ali Z. Haghighi

引用次数: 2