Prostaglandins, leukotrienes, and medicine最新文献_第7页

Glucocorticoid and prostaglandin: lack of an inhibitory effect by dexamethasone on the synthesis of 6-ketoprostaglandin F1α in rat lung 糖皮质激素与前列腺素:地塞米松对大鼠肺6-酮前列腺素F1α合成无抑制作用

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90157-0

Michael Y. Tsai

引用次数: 9

D-penicillamine effects on prostanoid production in adherent rheumatic synovial cells in primary culture d -青霉胺对原代培养的贴壁风湿性滑膜细胞产生前列腺素的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90159-4

Eeva Moilanen , Erkki Seppälä , Martti Nissilä , Heikki Vapaatalo

引用次数: 3

Increased thromboxane A2 and 5-HETE production following spinal cord ischemia in the rabbit 兔脊髓缺血后血栓素A2和5-HETE生成增加

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90161-2

E. Shohami , T.P. Jacobs , J.M. Hallenbeck , G. Feuerstein ∗

{"title":"Increased thromboxane A2 and 5-HETE production following spinal cord ischemia in the rabbit","authors":"E. Shohami , T.P. Jacobs , J.M. Hallenbeck , G. Feuerstein ∗","doi":"10.1016/0262-1746(87)90161-2","DOIUrl":"10.1016/0262-1746(87)90161-2","url":null,"abstract":"<div>Ischemia was induced for 25 min in the spinal cord of rabbits followed by a long term period of recirculation. At various time points of recirculation (5, 30 min, 4, 18 hr and 1 wk) slices were taken from the ischemic region and incubated for 45 min in Krebs-Ringer solution. The levels of the eicosanoids, PGE2, PGD2, PGF2α, TXB2, 6-keto-PGF1α and 5-HETE accumulated in the incubation medium were measured by radioimmunoassay.TXB2 release was found to be increased at an early (5 min) and late (1 wk) period of reperfusion. A seven-fold increase in the release of 5-HETE was found 5 min after reperfusion that tended to stay elevated at 18 hr and 1 week of recirculation. PGI2 synthetase activity decreased by 40% at 30 min, with return to normal at later time points. The ratio of TXA2/PGI2 was significantly higher than control at 30 min and 1 wk. T e synthesis of PGE , PGD2 and PGF2α was maintained at normal levels throughout the complete course of reperfusion. No changes in eicosanoid synthesis were noted in remote spinal cord regions.The significant increase of TXA2 synthesis at 5 min and 1 wk of reperfusion may point to a role of this arachidonate metabolite in the acute events and in the later stages of neurological dysfunction. The enhanced release of 5-HETE, a metabolite of 5-HETE, suggest an enhanced formation of leukotriene B4 and peptide leukotrienes and a potential role for these 5-lipoxygerase metabolites of arachidonate in ischemia injury to the brain and the spinal cord.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90161-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14601751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Urinary 6-keto-PGF1α level in patients with childhood leukemia/lymphoma; A possible indicator of vascular damage 儿童白血病/淋巴瘤患者尿6-酮- pgf1 α水平的研究这可能是血管损伤的迹象

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90166-1

Yoshihito Morioka, Kentaro Tsunamoto, Shinsaku Imashuku

{"title":"Urinary 6-keto-PGF1α level in patients with childhood leukemia/lymphoma; A possible indicator of vascular damage","authors":"Yoshihito Morioka, Kentaro Tsunamoto, Shinsaku Imashuku","doi":"10.1016/0262-1746(87)90166-1","DOIUrl":"10.1016/0262-1746(87)90166-1","url":null,"abstract":"<div>To determine the effect of anti-neoplastic chemotherapy on the vascular system(s) of children with leukemia/lymphoma, urinary excretion of 6-keto-PGF1α was measured by radioimmunoassay (RIA).In 4 patients receiving therapy, 6-keto-PGF1α increased to a mean of 148 (range; 126–170)% during therapy, la increased returned to pre-treatment level 3–5 days later. In 18 long-term survivors who had completedtherapy, 6-keto-PGF1α was determined to be a meanof 275 (range; 52–905) ng/g creatinine, and in the healthy control children the mean was 146 (range; 71–348) ng/g creatinine. These results were contrary to our hypothesis that chemotherapy might cause a decreased synthesis of PGI2, a precursor of 6-keto-PGF1α, and suggest that increased urinary 6-keto-PGF1α reflects a vascular response to acute exposure to chemotherapeutic drugs and possible vascular damage due to long-term intensive chemotherapy in pediatric patients with leukemia/lymphoma.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90166-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14601753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with α-linolenic or eicosapentaenoic acids α-亚麻酸和二十碳五烯酸对自发性高血压和正常高血压大鼠肝脏N-6和N-3脂肪酸的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90162-4

Peter Singer, Ingrid Berger, Ute Gerhard, Manfred Wirth, Vera Moritz, Doris Förster

{"title":"Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with α-linolenic or eicosapentaenoic acids","authors":"Peter Singer, Ingrid Berger, Ute Gerhard, Manfred Wirth, Vera Moritz, Doris Förster","doi":"10.1016/0262-1746(87)90162-4","DOIUrl":"10.1016/0262-1746(87)90162-4","url":null,"abstract":"<div>In spontaneously hypertensive (SHR) and normotensive rats (WKY), diets supplemented with n-3 fatty acids of different chain length (α-linolenic acid, LNA - C 18:3, n-3 with linseed oil and eicosapentaenoic acid, EPA - C 20:5, n-3 with cod liver oil) were fed over a period of 22 weeks. A diet with commercially available pellets served as control. After the LNA-rich diet the augmentation of LNA was most pronounced in liver triglycerides (TG) and free fatty acids (FFA), whereas the increase of EPA was most marked in phosphatid.lethanolamine (PE) and phosphatidylcholine (PC) when compared with the controls. Docosahexaenoic acid (DHA) was decreased mainly in neutral lipids. Of the n-6 fatty acids linoleic acid (LA) appeared significantly depressed in TG and FFA, but increased in phospholipids. Arachidonic acid (AA), however, was lower in all lipids.In SHR and WKY fed the EPA-rich diet EPA and DHA were significantly higher as compared to the controls on a pellet diet. On the contrary, INA was not detectable in all lipid classes. LA and AA were markedly depressed. Docosenoic acids were significantly increased. The P/s-ratio did not reflect the changes in the 20:5/20:4- and n-3/n-6-ratios. The data indicate a differential effect of dietary n-3 fatty. acids of different chain length on the supply of other n-3 fatty acids. Moreover, after an LNA-rich diet divergent alterations of LA in neutral lipids and phospholipids occurred. The results are dissimilar to those obtained in adipose tissue. Blood pressure was not influenced by the diets in either SHR or WKY. SHR or WKY.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90162-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14022899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effect of actinomycin D on prostaglandin synthesis by and output from the guinea-pig uterus 放线菌素D对豚鼠子宫前列腺素合成和分泌的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90160-0

N.L. Poyser, S.C. Riley

{"title":"Effect of actinomycin D on prostaglandin synthesis by and output from the guinea-pig uterus","authors":"N.L. Poyser, S.C. Riley","doi":"10.1016/0262-1746(87)90160-0","DOIUrl":"10.1016/0262-1746(87)90160-0","url":null,"abstract":"<div>The intra-uterine administration of actinomycin D on Day 10 reduced the output of prostaglandin (PG) F2α (the major PG released) from the Day 15 guinea-pig uterus <math><mtext>in vitro</mtext></math> by 80 to 85%. PGE2 output was reduced by 50%, while 6-keto-PGF1α output was unaffected. Plasma progesterone levels were high (3 to 15 ng/ml) on Day 15 due to the reduction in uterine PGF2α output. Endometrial PGF2α synthesizing capacity was reduced by 50% by actinomycin D treatment, while endometrial PGE2 and 6-keto-PGF1α synthesizing capacities were unaffected. Oestradiol treatment <math><mtext>in vivo</mtext></math> did not reverse the inhibitory effects of actinomycin D on uterine PG production.A23187 increased uterine PGF2α, 6-keto-PGF1α and PGE2 outputs irrespective of treatment, indicating that substrate supply was always rate limiting. Actinomycin D inhibited the uterotrophic action of oestradiol indicating that fresh protein synthesis had been inhibited. Overall, this study suggests that increased protein synthesis is involved in stimulating endometrial PGF2α synthesis and release.Previous studies have shown that increases in enzyme activities induced by oestradiol are only secondary events in the stimulation of endometrial PGF2α production. We propose that oestradiol induces the synthesis of a protein (‘lipostimulin’) which, acting on a progesterone-primed uterus, “switches on” endometrial PGF2α synthesis and release by causing the activation of endometrial phospholipase A2.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90160-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14245754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Do endogenous lipoproteins modulate the sensibility of animals against arrhythmogenic drugs? 内源性脂蛋白是否调节动物对致心律失常药物的敏感性?

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90165-X

J. Beitz, S. Schneider, A. Riedel, H.-J. Mest

引用次数: 2

The relative resistance of lymphokine activated killer cells to suppression by prostaglandins and glucocorticoids 淋巴因子激活的杀伤细胞对前列腺素和糖皮质激素抑制的相对抗性

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90156-9

T. Imir , W. Sibbitt, A. Bankhurst

{"title":"The relative resistance of lymphokine activated killer cells to suppression by prostaglandins and glucocorticoids","authors":"T. Imir , W. Sibbitt, A. Bankhurst","doi":"10.1016/0262-1746(87)90156-9","DOIUrl":"10.1016/0262-1746(87)90156-9","url":null,"abstract":"<div>The possibility that lymphokine-activated killer (LAK) cells versus spontaneous natural killer (NK) cells show relative resistance to the suppressive effects of the immunoregulatory molecules prostaglandin E2 (PGE2) and dexamethasone (DMO) was investigated. LAK cells were produced <math><mtext>in vitro</mtext></math> by the incubation of human peripheral mononuclear cells (PBMC) for three days in the presence of interleukin-2 (IL-2). Cytotoxicity of NK and LAK cells were measured by conventional 4 hour Cr51 release assays using K562 and Daudi target cells. LAK cells were relatively resistant to suppression by PGE2. For example, NK cytotoxicity was significantly suppressed by 10−6 M PGE2. In contrast, LAK cells required a 30 to 100 higher concentration of PGE2 according to the target used to achieve similar suppression. Likewise, a differential resistance to DMO was seen. NK cells were significantly suppressed by 10-3M DMO while a 1000 fold higher concentration was needed for similar suppression of LAK cytotoxicity. Overall, the results show that LAK cells are relatively resistant to immunoregulatory suppressive factors.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90156-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14622130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Twice monthly bibliography on prostaglandins - late March prepared by Sheffield University, Biomedical Information Service 3月下旬，谢菲尔德大学生物医学信息服务处准备的前列腺素每月两次参考书目

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90167-3

引用次数: 0

Peripheral prostaglandin metabolite levels in women undergoing therapeutic abortions in the first trimester with and without treatment with prostaglandin synthetase inhibitor 接受和不接受前列腺素合成酶抑制剂治疗的妊娠早期治疗性流产妇女外周血前列腺素代谢物水平

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-06-01 DOI: 10.1016/0262-1746(87)90047-3

W.M. Wolfe , Ch.V. Rao , E.M. McCracken , L.M. Demers

{"title":"Peripheral prostaglandin metabolite levels in women undergoing therapeutic abortions in the first trimester with and without treatment with prostaglandin synthetase inhibitor","authors":"W.M. Wolfe , Ch.V. Rao , E.M. McCracken , L.M. Demers","doi":"10.1016/0262-1746(87)90047-3","DOIUrl":"10.1016/0262-1746(87)90047-3","url":null,"abstract":"<div>The levels of 11-deoxy-13,14-dihydro-15-keto-11β,16ζ-cyclo prostaglandin E2 (bicyclo PGEM), 13,14-dihydro-15 keto-prostaglandin F2α (PGFM) and prolactin were measured in four serial plasma samples collected from thirty women undergoing therapeutic abortions in the first trimester by a suction curettage procedure. Eleven of these women received a preoperative loading dose of sodium meclofenamate, a PG synthetase inhibitor, before the abortion procedure was started and the rest received this medication after the last blood samples were drawn. Prolactin levels increased significantly during the procedure. Sodium meclofenamate treatment had no effect on this increase. Bicyclo PGFM levels did not increase during the procedure in untreated or treated women, whereas PGFM levels increased but only in untreated women. The lack of increase in treated women apparently was not a treatment effect because PGFM levels in corresponding samples of untreated and treated women were similar. Treatment significantly reduced the bicyclo PGEM levels immediately after completion of the procedure as compared to untreated women. This differential PG response to treatment is unprecedented and may be due to sodium meclofenamate inhibition of PGE2 and not PGF2α synthesis. Nevertheless, these data demonstrate that sodium meclofenamate treatment of patients undergoing first trimester therapeutic abortion to relieve pain involves selective suppression of PGE2 synthesis.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90047-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14244216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2