α-亚麻酸和二十碳五烯酸对自发性高血压和正常高血压大鼠肝脏N-6和N-3脂肪酸的影响

Peter Singer, Ingrid Berger, Ute Gerhard, Manfred Wirth, Vera Moritz, Doris Förster
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引用次数: 5

摘要

在自发性高血压(SHR)和正常血压大鼠(WKY)中添加不同链长的n-3脂肪酸(α-亚麻酸,LNA - C 18:3, n-3添加亚麻籽油和二十碳五烯酸,EPA - C 20:5, n-3添加鱼肝油),饲喂22周。用市售颗粒饲料作为对照。富LNA饮食后,肝脏甘油三酯(TG)和游离脂肪酸(FFA)中LNA的增加最为明显,而磷脂中EPA的增加最为显著。乙醇胺(PE)和磷脂酰胆碱(PC)与对照组比较。二十二碳六烯酸(DHA)主要在中性脂质中减少。在n-6脂肪酸中,亚油酸(LA)在TG和FFA中表现出明显的下降,而在磷脂中表现出明显的上升。然而,花生四烯酸(AA)在所有脂质中都较低。饲喂富含EPA日粮的SHR和WKY的EPA和DHA显著高于饲喂颗粒日粮的对照组。相反,在所有脂类中均未检测到INA。LA和AA明显下降。二十二酚酸显著增加。P/s比值没有反映出20:5/20:4-和n-3/n-6比值的变化。数据表明,饮食中n-3脂肪酸的影响是不同的。不同链长的酸对其他n-3脂肪酸的供应。此外,在富含na的饮食后,中性脂质和磷脂中的LA发生了不同的变化。结果与在脂肪组织中获得的结果不同。在SHR和WKY中,血压没有受到饮食的影响。SHR或WKY。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Changes of N-6 and N-3 fatty acids in liver from spontaneously hypertensive (SHR) and normotensive rats after diets supplemented with α-linolenic or eicosapentaenoic acids

In spontaneously hypertensive (SHR) and normotensive rats (WKY), diets supplemented with n-3 fatty acids of different chain length (α-linolenic acid, LNA - C 18:3, n-3 with linseed oil and eicosapentaenoic acid, EPA - C 20:5, n-3 with cod liver oil) were fed over a period of 22 weeks. A diet with commercially available pellets served as control. After the LNA-rich diet the augmentation of LNA was most pronounced in liver triglycerides (TG) and free fatty acids (FFA), whereas the increase of EPA was most marked in phosphatid.lethanolamine (PE) and phosphatidylcholine (PC) when compared with the controls. Docosahexaenoic acid (DHA) was decreased mainly in neutral lipids. Of the n-6 fatty acids linoleic acid (LA) appeared significantly depressed in TG and FFA, but increased in phospholipids. Arachidonic acid (AA), however, was lower in all lipids.

In SHR and WKY fed the EPA-rich diet EPA and DHA were significantly higher as compared to the controls on a pellet diet. On the contrary, INA was not detectable in all lipid classes. LA and AA were markedly depressed. Docosenoic acids were significantly increased. The P/s-ratio did not reflect the changes in the 20:5/20:4- and n-3/n-6-ratios. The data indicate a differential effect of dietary n-3 fatty. acids of different chain length on the supply of other n-3 fatty acids. Moreover, after an LNA-rich diet divergent alterations of LA in neutral lipids and phospholipids occurred. The results are dissimilar to those obtained in adipose tissue. Blood pressure was not influenced by the diets in either SHR or WKY. SHR or WKY.

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