Eeva Moilanen , Erkki Seppälä , Martti Nissilä , Heikki Vapaatalo
{"title":"d -青霉胺对原代培养的贴壁风湿性滑膜细胞产生前列腺素的影响","authors":"Eeva Moilanen , Erkki Seppälä , Martti Nissilä , Heikki Vapaatalo","doi":"10.1016/0262-1746(87)90159-4","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of D-penicillamine (DPA) on immunoreactive prostanoid concentrations was studied in a primary culture of adherent synovial cells from patients suffering from rheumatoid arthritis (RA). DPA in clinically achievable concentrations increased the levels of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) and thromboxane B2 (TXB<sub>2</sub>) and reduced those of 6-keto-prostaglandin F<sub>1α</sub> (6-keto-PGF<sub>1α</sub>) synthetized from endogenous substrate. The capacity for PGE<sub>2</sub> and 6-keto-PGF<sub>1α</sub> production in the presence of exogenous arachidonic acid was decreased by DPA. These effects may be connected with the antirheumatic and immunosuppressive action of DPA.</p></div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90159-4","citationCount":"3","resultStr":"{\"title\":\"D-penicillamine effects on prostanoid production in adherent rheumatic synovial cells in primary culture\",\"authors\":\"Eeva Moilanen , Erkki Seppälä , Martti Nissilä , Heikki Vapaatalo\",\"doi\":\"10.1016/0262-1746(87)90159-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effect of D-penicillamine (DPA) on immunoreactive prostanoid concentrations was studied in a primary culture of adherent synovial cells from patients suffering from rheumatoid arthritis (RA). DPA in clinically achievable concentrations increased the levels of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) and thromboxane B2 (TXB<sub>2</sub>) and reduced those of 6-keto-prostaglandin F<sub>1α</sub> (6-keto-PGF<sub>1α</sub>) synthetized from endogenous substrate. The capacity for PGE<sub>2</sub> and 6-keto-PGF<sub>1α</sub> production in the presence of exogenous arachidonic acid was decreased by DPA. These effects may be connected with the antirheumatic and immunosuppressive action of DPA.</p></div>\",\"PeriodicalId\":20720,\"journal\":{\"name\":\"Prostaglandins, leukotrienes, and medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0262-1746(87)90159-4\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins, leukotrienes, and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0262174687901594\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0262174687901594","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
D-penicillamine effects on prostanoid production in adherent rheumatic synovial cells in primary culture
The effect of D-penicillamine (DPA) on immunoreactive prostanoid concentrations was studied in a primary culture of adherent synovial cells from patients suffering from rheumatoid arthritis (RA). DPA in clinically achievable concentrations increased the levels of prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) and reduced those of 6-keto-prostaglandin F1α (6-keto-PGF1α) synthetized from endogenous substrate. The capacity for PGE2 and 6-keto-PGF1α production in the presence of exogenous arachidonic acid was decreased by DPA. These effects may be connected with the antirheumatic and immunosuppressive action of DPA.
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