Prostaglandins, leukotrienes, and medicine最新文献_第6页

Stimulation of prostacyclin synthesis in rats treated with phenobarbital 苯巴比妥对大鼠前列环素合成的刺激作用

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-08-01 DOI: 10.1016/0262-1746(87)90116-8

Ali Z. Haghighi, Thomas I. Pynadath

引用次数: 2

Prostaglandin and thromboxane levels during endotoxin-induced respiratory failure in pigs 内毒素引起的猪呼吸衰竭期间前列腺素和凝血素的水平

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-08-01 DOI: 10.1016/0262-1746(87)90115-6

E.M. Hardie, N.C. Olson

{"title":"Prostaglandin and thromboxane levels during endotoxin-induced respiratory failure in pigs","authors":"E.M. Hardie, N.C. Olson","doi":"10.1016/0262-1746(87)90115-6","DOIUrl":"10.1016/0262-1746(87)90115-6","url":null,"abstract":"<div>Arterial plasma concentrations of thromboxane B2 (TxB2), prostaglandin F2α (PGF2α) and 6-keto-prostaglandin Flα (PGF1α) were measured during endotoxin-induced acute respiratory failure (ARF) in anesthetized 10–12 wk old pigs. A 4.5 hour (hr) infusion of endotoxin resulted in a biphasic pattern of ARF. Phase 1 (0–2 hr) was characterized by increased pulmonary artery pressure, pulmonary vascular resistance (PVR), and alveolar-arterial O2 gradient (ΔA-aO2), and decreased cardiac index (CI) and lung dynamic compliance (LDC). Following a return of PVR and CI values towards baseline, a second phase (2–4.5 hr) of deteriorating function occurred and was characterized by additional increases in PVR and ΔA-aO2 and decreases in CI and LDC. Baseline (i.e., 0 hr) plasma TxB2 concentrations were 241 ± 24 pg/ml; these values peaked at 0.5 hr (3228 ± 712 pg/ml) and declined to 1635 ± 453 pg/ml at 4.5 hr. Plasma concentrations of PGF2α slowly increased from a baseline value of 154 ± 32 pg/ml to 2355 ± 738 pg/ml at 4.5 hr, while PGF1α values increased from 54 ± 2 pg/ml at 0 hr to 503 ± 172 pg/ml at 4.5 hr. Time-matched control pigs showed no changes in pulmonary hemodynamics or in plasma TxB2, PGF2α or PGF1α levels. These results indicate that cyclooxygenase products are increased during both phases of endotoxin-induced ARF in pigs.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90115-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14436063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

A low protein-high linoleate diet increases glomerular PGE2 and protects renal function in rats with reduced renal mass 低蛋白-高亚油酸饮食增加肾小球PGE2并保护肾肿块减少的大鼠肾功能

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-08-01 DOI: 10.1016/0262-1746(87)90117-X

Yasushi Ito, Uno Barcelli, Wataru Yamashita, Mark Weiss, James Deddens, Victor E. Pollak

引用次数: 12

Twice monthly bibliography on prostaglandins — Early April prepared by Sheffield University, Biomedical Information Service 4月初，谢菲尔德大学生物医学信息服务中心准备的前列腺素参考书目，每月两次

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-08-01 DOI: 10.1016/0262-1746(87)90123-5

引用次数: 0

Arachidonic acid metabolism by lipoxygenase pathways in intrauterine tissues of women at term of pregnancy 脂氧合酶途径在妊娠期妇女宫内组织中的花生四烯酸代谢

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-08-01 DOI: 10.1016/0262-1746(87)90119-3

Murray D. Mitchell, Camille F. Grzyboski

引用次数: 38

Effect of adrenergic agonists on eicosanoid output from isolated rabbit choroid plexus and iris-ciliary body 肾上腺素能激动剂对离体兔脉络膜丛和虹膜睫状体类二十烷输出的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-08-01 DOI: 10.1016/0262-1746(87)90112-0

David Yohai , Abraham Danon

{"title":"Effect of adrenergic agonists on eicosanoid output from isolated rabbit choroid plexus and iris-ciliary body","authors":"David Yohai , Abraham Danon","doi":"10.1016/0262-1746(87)90112-0","DOIUrl":"10.1016/0262-1746(87)90112-0","url":null,"abstract":"<div>Prostanoid production by rabbit choroid plexus (CP) and irisciliary body (ICB), and the effects of adrenergic agonists thereon, were studied in vitro. Immunoreactive prostaglandin (PG) E2 was the major prostanoid released by both tissues; the output from ICB was some two orders of magnitude greater than from CP. Immunoreactive 6-keto PGF1α and thromboxane (TX) B2, the dehydration products of prostacyclin and TXA2, respectively, were detected in smaller quantities.Epinephrine stimulated the outputs of PGE2 and 6-keto PGF1α, but not of TXB2, from both tissues.ICB responded to epinephrine concentrations of 10−4 and 10−5, while only 10−4 was effective in stimulating prostanoid synthesis in the CP. Phenylephrine, an adrenergic agonist, stimulated prostanoid output from the ICB, but not from the CP. It is concluded that adrenergic mechanisms stimulate the biosynthesis of prostanoids in the rabbit CP and ICB. The implications of such interactions to aqueous humor and cerebrospinal fluid dynamics, or to other processes in brain and ocular physiology, are discussed.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90112-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14600999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Taurine and icosanoids in the heart 心脏中的牛磺酸和二十烷酸

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-08-01 DOI: 10.1016/0262-1746(87)90114-4

Pham Huu Chanh, R. Chahine, A. Pham Huu Chanh, V. Dossou-Gbete, Ch. Navarro-Delmasure

{"title":"Taurine and icosanoids in the heart","authors":"Pham Huu Chanh, R. Chahine, A. Pham Huu Chanh, V. Dossou-Gbete, Ch. Navarro-Delmasure","doi":"10.1016/0262-1746(87)90114-4","DOIUrl":"10.1016/0262-1746(87)90114-4","url":null,"abstract":"<div>Experiments were carried out on non-working isolated rabbit hearts perfused by Tyrode solution: the effects of Taurine introduced into the coronary circulation were studied <ul><li>•- on the biosynthesis of the anti-thromboxane synthetase factor (“FATS”)</li><li>•- and on the TXA2 and PGI2 synthetase activities of cardiac tissue.</li></ul>The effects of Taurine were simultaneously studied on the biosynthesis of TXA2 and PGI2 <math><mtext>in vitro</mtext></math>.Experiments performed under the adopted conditions have shown that <ul><li>•- <math><mtext>in vitro</mtext></math> Taurine did not significantly modify the biosynthesis of TXA2 and PGI2</li><li>•- <math><mtext>ex vivo</mtext></math> Taurine did not change the biosynthesis of “FATS” but inhibited both TXA2 and PGI2 synthetase activities of the cardiac tissue: Taurine was more active on the TXA2 synthetase activity than on the PGI2 one.</li></ul>Thus Taurine promoted the formation of vasodilator and antiaggregating PGI2 at the expenses of vasoconstrictor and proaggregating TXA2. This could at least partly explain the beneficial effects of Taurine in the physiopethology of the heart.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90114-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14436062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Cardiovascular effects of high frequency ventilation - the possible involvement of thromboxane 高频通气对心血管的影响——可能涉及血栓素

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90158-2

William Durante, Fred A. Sunahara

{"title":"Cardiovascular effects of high frequency ventilation - the possible involvement of thromboxane","authors":"William Durante, Fred A. Sunahara","doi":"10.1016/0262-1746(87)90158-2","DOIUrl":"10.1016/0262-1746(87)90158-2","url":null,"abstract":"<div>Recent studies with high frequency ventilation (HFV) have noted that HFV-induced increases in mean airway pressure leads to a marked cardiovascular depression, especially in cardiac output (CO).Aside from mechanical events a negative inotropic agent possibly prostaglandin in nature may also be involved. This study examined the possible involvement of thromboxane A2 (TXA2) in the HFV-induced cardiovascular deterioration. Chloralose-anesthetized mechanically-ventilated dogs were subjected to HFV 4, 10, and 20 mm Hg for 30 min. Some animals were also treated with imidazole (25 mg/Kg/hr) prior to HFV. Arterial levels of TXB2 (stable metabolite of TXA2) where monitored by radioimmunoassay. During HFV, tracheal pressure-related decreases in both CO and stroke volume (SV) were noted. Imidazole treatment significantly reduced the decrement in SV. Application of HFV resulted in variable changes in circulating TXB2 levels. Overall, application of HFV did not result in a significant change from baseline levels.Furthermore there was no correlation between changes in CO and SV with changes in arterial TXB2 concentration. These results do not support the hypothesis that hyperexpansion of the lungs during HFV causes the release of a cardiodepressant prostanoid.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90158-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14245753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Increase in thromboxane B2 and decrease in prostaglandin E2 and 6-ketoprostaglandin F1α release into rat bronchoalveolar fluid as a consequence of cigarette smoking 吸烟导致大鼠支气管肺泡液中血栓素B2增加，前列腺素E2和6-酮前列腺素F1α释放减少

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90163-6

Hisayuki Tanizawa, Tomoaki Iwanaga, Hsin-Hsiung Tai

引用次数: 9

Assessment of bronchoalveolar lavage fluid and plasma for sulfidopeptide leukotrienes during endotoxemia in pigs 猪内毒素血症时支气管肺泡灌洗液和血浆中硫多肽白三烯含量的评估

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-07-01 DOI: 10.1016/0262-1746(87)90164-8

Neil C. Olson, Rick T. Dobrowsky, Lloyd N. Fleisher

{"title":"Assessment of bronchoalveolar lavage fluid and plasma for sulfidopeptide leukotrienes during endotoxemia in pigs","authors":"Neil C. Olson, Rick T. Dobrowsky, Lloyd N. Fleisher","doi":"10.1016/0262-1746(87)90164-8","DOIUrl":"10.1016/0262-1746(87)90164-8","url":null,"abstract":"<div>We hypothesized that sulfidopeptide leukotrienes (LTC4, LTD4, LTE4) might be important to the pathophysiology of endotoxin-induced acute respiratory failure (ARF) observed in young pigs. We used radioimmunoassay (RIA), reverse-phase high performance liquid chromatography (RP-HPLC) and guinea pig ileum bioassay techniques to determine the presence of sulfidopeptide leukotrienes in bronchoalveolar lavage fluid (BALF) and plasma of saline(n=12)- and endotoxin(n=12)-treated pigs. Endotoxin, infused at 5 μg/kg for 1 hr followed by 2 μg/kg/hr for 3.5 hrs, caused pulmonary hypertension, a biphasic increase in systemic and pulmonary vascular resistances, hypoxemia, bronchoconstriction and hemo-concentration. The levels of immunoreactive sulfidopeptide leukotrienes were not significantly increased in BALF recovered from endotoxemic pigs. Arterial plasma samples (collected at 0.5 hr intervals for 4.5 hrs) were below the detectable limits of the RIA. During RP-HPLC, ethanol extracted BALF failed to show an ultraviolet (UV) absorbance peak (280 nm) that was coincident with authentic standards. Concentrated BALF samples and BALF eluate fractions (collected at a retention time consistent with authentic LTC4) failed to cause a sustained contraction of guinea pig ileum. We conclude that sulfidopeptide leukotrienes are not increased in BALF or plasma recovered from endotoxemic pigs and that these lipoxygenase metabolites might not be important factors contributing to the pathophysiology of endotoxin-induced ARF. An alternate explanation is that the sulfidopeptide leukotrienes are rapidly metabolized so as to be undetectable by the methods employed.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90164-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13958330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4