心脏中的牛磺酸和二十烷酸

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-08-01 DOI:10.1016/0262-1746(87)90114-4

Pham Huu Chanh, R. Chahine, A. Pham Huu Chanh, V. Dossou-Gbete, Ch. Navarro-Delmasure

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引用次数: 10

摘要

实验采用Tyrode溶液灌注兔心脏，观察牛磺酸进入冠状动脉循环后对抗血栓素合成酶因子(“fat”)的生物合成以及对心脏组织TXA2和PGI2合成酶活性的影响。同时研究牛磺酸对体外TXA2和PGI2生物合成的影响。在采用的条件下进行的实验表明:•-体外牛磺酸不显著改变TXA2和PGI2的生物合成•-离体牛磺酸不改变“脂肪”的生物合成，但抑制心脏组织中TXA2和PGI2合成酶的活性，牛磺酸对TXA2合成酶活性的影响大于对PGI2合成酶的影响。因此，牛磺酸促进血管舒张剂和抗聚集PGI2的形成，而牺牲血管收缩剂和促聚集TXA2的形成。这至少可以部分解释牛磺酸对心脏生理的有益作用。

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Taurine and icosanoids in the heart

Experiments were carried out on non-working isolated rabbit hearts perfused by Tyrode solution: the effects of Taurine introduced into the coronary circulation were studied

•
- on the biosynthesis of the anti-thromboxane synthetase factor (“FATS”)
•
- and on the TXA2 and PGI2 synthetase activities of cardiac tissue.

The effects of Taurine were simultaneously studied on the biosynthesis of TXA2 and PGI2 $in vitro$ .

Experiments performed under the adopted conditions have shown that

•
- $in vitro$ Taurine did not significantly modify the biosynthesis of TXA2 and PGI2
•
- $ex vivo$ Taurine did not change the biosynthesis of “FATS” but inhibited both TXA2 and PGI2 synthetase activities of the cardiac tissue: Taurine was more active on the TXA2 synthetase activity than on the PGI2 one.

Thus Taurine promoted the formation of vasodilator and antiaggregating PGI2 at the expenses of vasoconstrictor and proaggregating TXA2. This could at least partly explain the beneficial effects of Taurine in the physiopethology of the heart.

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Prostaglandins, leukotrienes, and medicine

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